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The map label for this gene is degA [H]

Identifier: 209549369

GI number: 209549369

Start: 1815148

End: 1816128

Strand: Reverse

Name: degA [H]

Synonym: Rleg2_1774

Alternate gene names: 209549369

Gene position: 1816128-1815148 (Counterclockwise)

Preceding gene: 209549371

Following gene: 209549362

Centisome position: 40.02

GC content: 68.09

Gene sequence:

>981_bases
ATGGCGACATTGCAGCAGGTTGCGTTCCGGGCCGGATGTTCGCTGGCGACCGCAAGCCGGGTTCTCAATAGCGACGGACC
GGCGAGCGACCTGATGGTGCGCAAGGTGCGCCGCGCCGCCGCAGAACTCGGCTACCGCCCGGCCAGCCACGCCGTCGGGC
GGATGGGGCGCAGGCCGGTGGTCGGCGTGCTGATTCCGAGCATCACCAATCCCGTCTTTGCCTCATCGCTGTCGAGCATC
CAGAACCGCATGCTGGTCGCCGGCCACGGCGTGTTGATCGCCCAGTCGAATTACGATCCGACGCGCGAGGCCGATGCCGT
CGCCGCCCTGCTCAACGACCGGCCGACCGGGCTCATACTCACCGTCTGCGATCCGTCGACCAGCGAGGCACTGCTGGCCA
GGCTGCCGCCGACCGTGCTGCTCAACAATCTGCCGACCGCGCAGTTTCCGGCGGCCGTCACCGCCGACAATCGCGGCGCG
GGCCGCGAGATCGCCACCTTCCTGACCGGCATGGGTCATCGCCGCATTCTCTTCCTCTCCGGCAATTTCGCCGCCTCCGA
CCGCGCCCGCCTGCGCTACCGTGGTTATCTCGACGCTATGGCCGAGAATGGGCTGCCATCGCTCGACGCCGTGCAGATCC
CCTTCGTCGGCGGCTATGACCAGATCGACCTCGGCACTGTGATGACCGCGCTTGCGCCGACGGCGATCATCGCCTCCAAC
GACCTTCTGGCGCTCGGCGTCATCGGTGCGCTGAAGCGCGAGGGACTGTCGGTGCCCGGGGATGTGTCGGTCGCCGGATT
CGACGGCATCGCCATCGGCCGGCTGATTGATCCGCCGCTGACGACAATCGAAATGCCGGATGCCAGCATGGGGGCGACGG
CCGCCTCGCTGCTCCTCGACATGGCGGAGAATGCCGCCCCTGCCCGCCATCTCGATGTCGCGTATACGCTTCGCCGCGGC
GGCACGGTGCGCGCCATCTGA

Upstream 100 bases:

>100_bases
GACGGCAAAACTCCGGCCAGCCGCTTGCGCCAATGTCAGACCAATGTCATCGAAACCTCCTAAGGGATTGCGCCTTATCT
GTCACCAGGAGGCGTTTTCG

Downstream 100 bases:

>100_bases
AGCTTCGAAACAAAAGGGCCGCCACGCGCTTGGCGTGACGGCCCGATCCTCTTTTCTGACGGGCAGGATAATCAGCTGCG
CGGCAGCATGCCCTCGACAT

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: Degradation activator [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MATLQQVAFRAGCSLATASRVLNSDGPASDLMVRKVRRAAAELGYRPASHAVGRMGRRPVVGVLIPSITNPVFASSLSSI
QNRMLVAGHGVLIAQSNYDPTREADAVAALLNDRPTGLILTVCDPSTSEALLARLPPTVLLNNLPTAQFPAAVTADNRGA
GREIATFLTGMGHRRILFLSGNFAASDRARLRYRGYLDAMAENGLPSLDAVQIPFVGGYDQIDLGTVMTALAPTAIIASN
DLLALGVIGALKREGLSVPGDVSVAGFDGIAIGRLIDPPLTTIEMPDASMGATAASLLLDMAENAAPARHLDVAYTLRRG
GTVRAI

Sequences:

>Translated_326_residues
MATLQQVAFRAGCSLATASRVLNSDGPASDLMVRKVRRAAAELGYRPASHAVGRMGRRPVVGVLIPSITNPVFASSLSSI
QNRMLVAGHGVLIAQSNYDPTREADAVAALLNDRPTGLILTVCDPSTSEALLARLPPTVLLNNLPTAQFPAAVTADNRGA
GREIATFLTGMGHRRILFLSGNFAASDRARLRYRGYLDAMAENGLPSLDAVQIPFVGGYDQIDLGTVMTALAPTAIIASN
DLLALGVIGALKREGLSVPGDVSVAGFDGIAIGRLIDPPLTTIEMPDASMGATAASLLLDMAENAAPARHLDVAYTLRRG
GTVRAI
>Mature_325_residues
ATLQQVAFRAGCSLATASRVLNSDGPASDLMVRKVRRAAAELGYRPASHAVGRMGRRPVVGVLIPSITNPVFASSLSSIQ
NRMLVAGHGVLIAQSNYDPTREADAVAALLNDRPTGLILTVCDPSTSEALLARLPPTVLLNNLPTAQFPAAVTADNRGAG
REIATFLTGMGHRRILFLSGNFAASDRARLRYRGYLDAMAENGLPSLDAVQIPFVGGYDQIDLGTVMTALAPTAIIASND
LLALGVIGALKREGLSVPGDVSVAGFDGIAIGRLIDPPLTTIEMPDASMGATAASLLLDMAENAAPARHLDVAYTLRRGG
TVRAI

Specific function: Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=308, Percent_Identity=31.4935064935065, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI48994940, Length=333, Percent_Identity=31.8318318318318, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790369, Length=342, Percent_Identity=30.4093567251462, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789202, Length=298, Percent_Identity=29.5302013422819, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1788474, Length=308, Percent_Identity=31.4935064935065, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1790715, Length=333, Percent_Identity=28.5285285285285, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787948, Length=311, Percent_Identity=28.9389067524116, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789068, Length=300, Percent_Identity=27.6666666666667, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1786540, Length=313, Percent_Identity=28.4345047923323, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787906, Length=318, Percent_Identity=24.8427672955975, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787580, Length=335, Percent_Identity=22.9850746268657, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 34032; Mature: 33900

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLQQVAFRAGCSLATASRVLNSDGPASDLMVRKVRRAAAELGYRPASHAVGRMGRRPV
CCHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCE
VGVLIPSITNPVFASSLSSIQNRMLVAGHGVLIAQSNYDPTREADAVAALLNDRPTGLIL
EEEECCCCCCHHHHHHHHHHHHCEEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEE
TVCDPSTSEALLARLPPTVLLNNLPTAQFPAAVTADNRGAGREIATFLTGMGHRRILFLS
EEECCCCHHHHHHHCCHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCEEEEEE
GNFAASDRARLRYRGYLDAMAENGLPSLDAVQIPFVGGYDQIDLGTVMTALAPTAIIASN
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEECCCCCCHHHHHHHHHHCHHEEECC
DLLALGVIGALKREGLSVPGDVSVAGFDGIAIGRLIDPPLTTIEMPDASMGATAASLLLD
CCHHHHHHHHHHHCCCCCCCCEEEECCCCEEECCCCCCCCCEEECCCCCCHHHHHHHHHH
MAENAAPARHLDVAYTLRRGGTVRAI
HHHCCCCCHHHHEEEEEECCCEEECC
>Mature Secondary Structure 
ATLQQVAFRAGCSLATASRVLNSDGPASDLMVRKVRRAAAELGYRPASHAVGRMGRRPV
CHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCE
VGVLIPSITNPVFASSLSSIQNRMLVAGHGVLIAQSNYDPTREADAVAALLNDRPTGLIL
EEEECCCCCCHHHHHHHHHHHHCEEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEE
TVCDPSTSEALLARLPPTVLLNNLPTAQFPAAVTADNRGAGREIATFLTGMGHRRILFLS
EEECCCCHHHHHHHCCHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCEEEEEE
GNFAASDRARLRYRGYLDAMAENGLPSLDAVQIPFVGGYDQIDLGTVMTALAPTAIIASN
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEECCCCCCHHHHHHHHHHCHHEEECC
DLLALGVIGALKREGLSVPGDVSVAGFDGIAIGRLIDPPLTTIEMPDASMGATAASLLLD
CCHHHHHHHHHHHCCCCCCCCEEEECCCCEEECCCCCCCCCEEECCCCCCHHHHHHHHHH
MAENAAPARHLDVAYTLRRGGTVRAI
HHHCCCCCHHHHEEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407808; 9353932; 9384377 [H]