| Definition | Escherichia coli O157:H7 str. EC4115, complete genome. |
|---|---|
| Accession | NC_011353 |
| Length | 5,572,075 |
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The map label for this gene is kduD [H]
Identifier: 209400700
GI number: 209400700
Start: 3809295
End: 3810056
Strand: Reverse
Name: kduD [H]
Synonym: ECH74115_4111
Alternate gene names: 209400700
Gene position: 3810056-3809295 (Counterclockwise)
Preceding gene: 209399330
Following gene: 209400341
Centisome position: 68.38
GC content: 52.23
Gene sequence:
>762_bases ATGATTTTAAGTGCATTTTCTCTCGAAGGTAAAGTTGCGGTCGTCACTGGTTGTGATACTGGGCTGGGCCAGGGGATGGC GTTGGGGCTGGCGCAAGCGGGCTGTGACATTGTTGGCATTAACATCGTTGAACCGACTGAAACCATCAAGCAGGTCACGG CGCTGGGGCGTCGTTTTTTAAGCCTGACCGCCGATCTGCGAAAGATTGATGGTATTCCTGGACTGCTGGATCGCGCGGTA GCTGAGTTTGGTCATATTGATATCCTGGTGAATAACGCCGGATTGATTCGCCGCGAAGATGCTCTCGAGTTCAGCGAAAA GGACTGGGACGATGTCATGAACCTGAATATCAAGAGCGTATTCTTCATGTCTCAGGCAGCGGCGAAACACTTCATCGCGC AAGGCAATGGCGGCAAGATTATCAATATCGCGTCAATGCTCTCCTTCCAGGGCGGGATCCGTGTGCCTTCTTATACCGCA TCAAAAAGCGGCGTGATGGGCGTGACGCGATTGATGGCGAATGAATGGGCTAAACACAACATTAATGTTAATGCGATAGC TCCGGGTTACATGGCGACCAACAATACCCAACAACTGCGGGCAGATGAACAACGTAGCGCGGAAATTCTCGACCGCATTC CAGCTGGCCGTTGGGGACTGCCGAGTGACCTGATGGGGCCGGTAGTGTTTCTTGCCTCCAGCGCTTCAGATTATGTAAAT GGTTATACCATTGCTGTGGATGGCGGTTGGCTGGCGCGTTAA
Upstream 100 bases:
>100_bases TCTGGGGCATGGTCGGTGAAAACCAGGTCTTTGATGATATGGACCATGTGGCCGTTAAAGATTTGCGCTAGTTGTGGGCA TAAACGAATAAGGTATTGTT
Downstream 100 bases:
>100_bases TTCATTCCTCTTACTTTTATGACCCTGCCGCATGGCAGGGTTTTTTATATCTCTAGATCATCATAATCCATATCATGGTT ATGAAATAATCCATATCAAT
Product: 2-deoxy-D-gluconate 3-dehydrogenase
Products: NA
Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]
Number of amino acids: Translated: 253; Mature: 253
Protein sequence:
>253_residues MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIKQVTALGRRFLSLTADLRKIDGIPGLLDRAV AEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN GYTIAVDGGWLAR
Sequences:
>Translated_253_residues MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIKQVTALGRRFLSLTADLRKIDGIPGLLDRAV AEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN GYTIAVDGGWLAR >Mature_253_residues MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIKQVTALGRRFLSLTADLRKIDGIPGLLDRAV AEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN GYTIAVDGGWLAR
Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=32.2834645669291, Blast_Score=134, Evalue=7e-32, Organism=Homo sapiens, GI66933014, Length=249, Percent_Identity=31.3253012048193, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=30.8, Blast_Score=110, Evalue=2e-24, Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=29.1338582677165, Blast_Score=109, Evalue=2e-24, Organism=Homo sapiens, GI10190704, Length=251, Percent_Identity=31.8725099601594, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=27.2373540856031, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=31.2757201646091, Blast_Score=101, Evalue=8e-22, Organism=Homo sapiens, GI4504505, Length=258, Percent_Identity=27.1317829457364, Blast_Score=92, Evalue=6e-19, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=29.2490118577075, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=29.2682926829268, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI4503301, Length=253, Percent_Identity=28.8537549407115, Blast_Score=84, Evalue=9e-17, Organism=Homo sapiens, GI31542939, Length=205, Percent_Identity=28.780487804878, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI59889578, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=9e-14, Organism=Homo sapiens, GI40254986, Length=199, Percent_Identity=28.643216080402, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI4758504, Length=263, Percent_Identity=27.3764258555133, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI109715829, Length=241, Percent_Identity=26.5560165975104, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=27.4111675126904, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI209862901, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI19923983, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI224922801, Length=172, Percent_Identity=29.6511627906977, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=7e-11, Organism=Homo sapiens, GI20149619, Length=211, Percent_Identity=28.9099526066351, Blast_Score=64, Evalue=9e-11, Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=98.8142292490119, Blast_Score=512, Evalue=1e-146, Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=43.3070866141732, Blast_Score=198, Evalue=3e-52, Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=41.1290322580645, Blast_Score=177, Evalue=5e-46, Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=35.3658536585366, Blast_Score=145, Evalue=3e-36, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=34.6938775510204, Blast_Score=134, Evalue=4e-33, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=32.4110671936759, Blast_Score=119, Evalue=2e-28, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=31.9672131147541, Blast_Score=105, Evalue=2e-24, Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=26.8, Blast_Score=87, Evalue=7e-19, Organism=Escherichia coli, GI1789378, Length=247, Percent_Identity=25.5060728744939, Blast_Score=83, Evalue=1e-17, Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=28.1746031746032, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1789057, Length=188, Percent_Identity=27.1276595744681, Blast_Score=68, Evalue=5e-13, Organism=Escherichia coli, GI2367365, Length=176, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=9e-13, Organism=Escherichia coli, GI1787526, Length=192, Percent_Identity=26.5625, Blast_Score=65, Evalue=4e-12, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=33.469387755102, Blast_Score=127, Evalue=4e-30, Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=31.7073170731707, Blast_Score=123, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=33.7254901960784, Blast_Score=119, Evalue=1e-27, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=31.3725490196078, Blast_Score=114, Evalue=6e-26, Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=29.8804780876494, Blast_Score=113, Evalue=8e-26, Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=31.5175097276265, Blast_Score=109, Evalue=2e-24, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=27.5303643724696, Blast_Score=105, Evalue=3e-23, Organism=Caenorhabditis elegans, GI17562910, Length=257, Percent_Identity=29.9610894941634, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=29.0076335877863, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=30.188679245283, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=29.6153846153846, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=29.6992481203008, Blast_Score=97, Evalue=6e-21, Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=29.6992481203008, Blast_Score=97, Evalue=9e-21, Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=29.8449612403101, Blast_Score=97, Evalue=9e-21, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=9e-21, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=28.6259541984733, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=27.9693486590038, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=29.6577946768061, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=30.2325581395349, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=28.6458333333333, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17563726, Length=275, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=28.3524904214559, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17565030, Length=258, Percent_Identity=31.0077519379845, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=27.906976744186, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17536025, Length=255, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17538486, Length=260, Percent_Identity=29.2307692307692, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=25.968992248062, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=29.7435897435897, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=30.0518134715026, Blast_Score=80, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17561272, Length=254, Percent_Identity=29.5275590551181, Blast_Score=80, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17564282, Length=200, Percent_Identity=28.5, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=29.1338582677165, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17555612, Length=222, Percent_Identity=28.3783783783784, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI71982365, Length=190, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17508651, Length=160, Percent_Identity=30.625, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI32563809, Length=217, Percent_Identity=23.963133640553, Blast_Score=64, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17507613, Length=217, Percent_Identity=23.963133640553, Blast_Score=64, Evalue=7e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=30.3030303030303, Blast_Score=86, Evalue=4e-18, Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=26, Blast_Score=74, Evalue=2e-14, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=33.1983805668016, Blast_Score=133, Evalue=1e-31, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=30.4347826086957, Blast_Score=111, Evalue=5e-25, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=29.3172690763052, Blast_Score=110, Evalue=9e-25, Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=29.2, Blast_Score=108, Evalue=3e-24, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=30.8300395256917, Blast_Score=107, Evalue=5e-24, Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=28.6885245901639, Blast_Score=98, Evalue=5e-21, Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=27.1317829457364, Blast_Score=94, Evalue=8e-20, Organism=Drosophila melanogaster, GI18859837, Length=258, Percent_Identity=31.7829457364341, Blast_Score=91, Evalue=6e-19, Organism=Drosophila melanogaster, GI24644337, Length=206, Percent_Identity=27.6699029126214, Blast_Score=83, Evalue=1e-16, Organism=Drosophila melanogaster, GI24649181, Length=198, Percent_Identity=30.3030303030303, Blast_Score=81, Evalue=8e-16, Organism=Drosophila melanogaster, GI21358495, Length=196, Percent_Identity=29.0816326530612, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=28.0155642023346, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI21357673, Length=192, Percent_Identity=28.125, Blast_Score=75, Evalue=6e-14, Organism=Drosophila melanogaster, GI24640492, Length=214, Percent_Identity=27.1028037383178, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24665243, Length=223, Percent_Identity=27.3542600896861, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI221331218, Length=220, Percent_Identity=27.7272727272727, Blast_Score=72, Evalue=2e-13, Organism=Drosophila melanogaster, GI24665247, Length=226, Percent_Identity=26.9911504424779, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI221331216, Length=223, Percent_Identity=27.3542600896861, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24648944, Length=201, Percent_Identity=29.3532338308458, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24580925, Length=201, Percent_Identity=26.3681592039801, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI161076933, Length=196, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI24584748, Length=196, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI281364892, Length=173, Percent_Identity=28.3236994219653, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011286 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.127 [H]
Molecular weight: Translated: 27041; Mature: 27041
Theoretical pI: Translated: 5.74; Mature: 5.74
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.6 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIKQVTALGRRFL CEEEEEECCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRKIDGIPGLLDRAVAEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSV HHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCEEECCHHCCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHN HHHHHHHHHHHEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN CCEEEECCCEEECCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHC GYTIAVDGGWLAR CEEEEECCCEECC >Mature Secondary Structure MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIKQVTALGRRFL CEEEEEECCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRKIDGIPGLLDRAVAEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSV HHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCEEECCHHCCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHN HHHHHHHHHHHEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN CCEEEECCCEEECCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHC GYTIAVDGGWLAR CEEEEECCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9278503; 2836407; 1766386 [H]