Click here to switch to the map view.

The map label for this gene is torC

Identifier: 209400451

GI number: 209400451

Start: 1241470

End: 1242642

Strand: Direct

Name: torC

Synonym: ECH74115_1232

Alternate gene names: 209400451

Gene position: 1241470-1242642 (Clockwise)

Preceding gene: 209395858

Following gene: 209399846

Centisome position: 22.28

GC content: 51.32

Gene sequence:

>1173_bases
ATGCGGAAACTCTGGAACGCGCTACGCCGACCCAGTGCTCGTTGGTCGGTACTGGCGCTGGTCGCTATTGGGATTGTGAT
TGGCATTGCGCTGATTGTATTGCCACACGTTGGGATCAAAGTCACCAGCACAACCGAATTTTGTGTCAGTTGCCACAGTA
TGCAACCAGTGTATGAAGAATATAAACAGTCGGTGCATTTCCAGAACGCCTCCGGCGTGCGAGCTGAATGCCATGACTGT
CATATCCCGCCGGATATTCCAGGCATGGTGAAGCGCAAACTGGAAGCGAGCAACGATATCTACCAGACCTTTATTGCCCA
CTCCATTGATACACCTGAAAAATTTGAAGCCAAACGCGCGGAACTTGCCGAGCGTGAATGGGCGCGAATGAAAGAAAACA
ACTCGGCAACCTGTCGCTCCTGCCATAACTACGATGCGATGGATCATGCGAAGCAGCATCCTGAAGCGGCACGTCAGATG
AAGGTGGCAGCGAAAGATAATCAATCCTGCATCGACTGTCATAAAGGTATTGCCCACCAGTTACCGGATATGAGTAGCGG
CTTCCGTAAGCAGTTCGATGAGCTGCGCGCCGGTGCTAATGACAGTGGTGACACGCTGTACTCTATTGATATTAAGCCAA
TTTATGCGGCGAAAGGCGATAAAGAAGCCTCTGGTTCTCTGCTGCCTGCCTCGGAAGTGAAAGTCCTTAAACGTGACGGC
GACTGGCTGCAAATTGAAATTACCGGCTGGACAGAAAGCGCCGGACGTCAGCGTGTACTCACCCAATTCCCAGGTAAACG
CATCTTTGTTGCCTCGATTCGTGGTGATGTGCAGCAGCAGGTAAAAACGCTGGAGAAAACCACCGTTGCCGACACCAATA
CCGAGTGGAGCAAGTTGCAGGCCACCGCGTGGATGAAGAAAGGTGACATGGTGAACGATATCAAACCGATCTGGGCTTAT
GCGGATTCGTTGTACAACGGCACCTGTAACCAGTGCCACGGCGCACCGGAAATCTCTCACTTTGACGCTAACGGCTGGAT
TGGCACGCTCAACGGCATGATCGGCTTTACCAGCCTCGATAAACGTGAAGAACGCACCTTGTTGAAATATCTGCAAATGA
ATGCGTCTGACACCGCAGGTAAGGCTCACGGCGATAAGAAGGAAGAAAAATAA

Upstream 100 bases:

>100_bases
TGTTCATATTCTGCCGTAAGCCGTTCATCCTGACCAGTGCCGCTGTTCATATTTACTCATTAAGATCGCTTCACTAAACC
ATAATTTTACAGGGGCTATT

Downstream 100 bases:

>100_bases
TGAACAATAACGATCTCTTTCAGGCATCACGTCGGCGTTTTCTGGCACAACTCGGCGGCTTAACCGTCGCCGGGATGCTG
GGGCCGTCATTGTTAACGTC

Product: cytochrome c-type protein torC

Products: H2O; trimethylamine; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MRKLWNALRRPSARWSVLALVAIGIVIGIALIVLPHVGIKVTSTTEFCVSCHSMQPVYEEYKQSVHFQNASGVRAECHDC
HIPPDIPGMVKRKLEASNDIYQTFIAHSIDTPEKFEAKRAELAEREWARMKENNSATCRSCHNYDAMDHAKQHPEAARQM
KVAAKDNQSCIDCHKGIAHQLPDMSSGFRKQFDELRAGANDSGDTLYSIDIKPIYAAKGDKEASGSLLPASEVKVLKRDG
DWLQIEITGWTESAGRQRVLTQFPGKRIFVASIRGDVQQQVKTLEKTTVADTNTEWSKLQATAWMKKGDMVNDIKPIWAY
ADSLYNGTCNQCHGAPEISHFDANGWIGTLNGMIGFTSLDKREERTLLKYLQMNASDTAGKAHGDKKEEK

Sequences:

>Translated_390_residues
MRKLWNALRRPSARWSVLALVAIGIVIGIALIVLPHVGIKVTSTTEFCVSCHSMQPVYEEYKQSVHFQNASGVRAECHDC
HIPPDIPGMVKRKLEASNDIYQTFIAHSIDTPEKFEAKRAELAEREWARMKENNSATCRSCHNYDAMDHAKQHPEAARQM
KVAAKDNQSCIDCHKGIAHQLPDMSSGFRKQFDELRAGANDSGDTLYSIDIKPIYAAKGDKEASGSLLPASEVKVLKRDG
DWLQIEITGWTESAGRQRVLTQFPGKRIFVASIRGDVQQQVKTLEKTTVADTNTEWSKLQATAWMKKGDMVNDIKPIWAY
ADSLYNGTCNQCHGAPEISHFDANGWIGTLNGMIGFTSLDKREERTLLKYLQMNASDTAGKAHGDKKEEK
>Mature_390_residues
MRKLWNALRRPSARWSVLALVAIGIVIGIALIVLPHVGIKVTSTTEFCVSCHSMQPVYEEYKQSVHFQNASGVRAECHDC
HIPPDIPGMVKRKLEASNDIYQTFIAHSIDTPEKFEAKRAELAEREWARMKENNSATCRSCHNYDAMDHAKQHPEAARQM
KVAAKDNQSCIDCHKGIAHQLPDMSSGFRKQFDELRAGANDSGDTLYSIDIKPIYAAKGDKEASGSLLPASEVKVLKRDG
DWLQIEITGWTESAGRQRVLTQFPGKRIFVASIRGDVQQQVKTLEKTTVADTNTEWSKLQATAWMKKGDMVNDIKPIWAY
ADSLYNGTCNQCHGAPEISHFDANGWIGTLNGMIGFTSLDKREERTLLKYLQMNASDTAGKAHGDKKEEK

Specific function: Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorA. Acts by transferring electrons from the membranous menaquinones to TorA. This transfer probably involves an electron transfer pathway from menaquinones to the N-terminal dom

COG id: COG3005

COG function: function code C; Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TorC/TorY family

Homologues:

Organism=Escherichia coli, GI1787230, Length=390, Percent_Identity=99.4871794871795, Blast_Score=817, Evalue=0.0,
Organism=Escherichia coli, GI1788181, Length=350, Percent_Identity=35.1428571428571, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1788530, Length=186, Percent_Identity=50, Blast_Score=184, Evalue=9e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TORC_ECO57 (P58359)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   C85635
- PIR:   G90772
- RefSeq:   NP_286932.1
- RefSeq:   NP_309178.1
- ProteinModelPortal:   P58359
- SMR:   P58359
- EnsemblBacteria:   EBESCT00000026297
- EnsemblBacteria:   EBESCT00000058262
- GeneID:   912595
- GeneID:   959059
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z1414
- KEGG:   ecs:ECs1151
- GeneTree:   EBGT00050000010586
- HOGENOM:   HBG303867
- OMA:   DAMDHAR
- ProtClustDB:   PRK15032
- BioCyc:   ECOL83334:ECS1151-MONOMER
- GO:   GO:0006810
- InterPro:   IPR009154
- InterPro:   IPR011031
- InterPro:   IPR005126
- PIRSF:   PIRSF000014
- TIGRFAMs:   TIGR02162

Pfam domain/function: PF03264 Cytochrom_NNT

EC number: NA

Molecular weight: Translated: 43593; Mature: 43593

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS51008 MULTIHEME_CYTC

Important sites: BINDING 48-48 BINDING 51-51 BINDING 77-77 BINDING 80-80 BINDING 138-138 BINDING 141-141 BINDING 170-170 BINDING 173-173 BINDING 329-329 BINDING 332-332

Signals:

None

Transmembrane regions:

HASH(0x268ac09c)-;

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLWNALRRPSARWSVLALVAIGIVIGIALIVLPHVGIKVTSTTEFCVSCHSMQPVYEE
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCHHHHH
YKQSVHFQNASGVRAECHDCHIPPDIPGMVKRKLEASNDIYQTFIAHSIDTPEKFEAKRA
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHH
ELAEREWARMKENNSATCRSCHNYDAMDHAKQHPEAARQMKVAAKDNQSCIDCHKGIAHQ
HHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
LPDMSSGFRKQFDELRAGANDSGDTLYSIDIKPIYAAKGDKEASGSLLPASEVKVLKRDG
CCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCEEEECCCCCCCCCCCCCHHHHHHEECCC
DWLQIEITGWTESAGRQRVLTQFPGKRIFVASIRGDVQQQVKTLEKTTVADTNTEWSKLQ
CEEEEEEECCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ATAWMKKGDMVNDIKPIWAYADSLYNGTCNQCHGAPEISHFDANGWIGTLNGMIGFTSLD
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCEECCCCCEEECCCCEECCCCC
KREERTLLKYLQMNASDTAGKAHGDKKEEK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MRKLWNALRRPSARWSVLALVAIGIVIGIALIVLPHVGIKVTSTTEFCVSCHSMQPVYEE
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCHHHHH
YKQSVHFQNASGVRAECHDCHIPPDIPGMVKRKLEASNDIYQTFIAHSIDTPEKFEAKRA
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHH
ELAEREWARMKENNSATCRSCHNYDAMDHAKQHPEAARQMKVAAKDNQSCIDCHKGIAHQ
HHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
LPDMSSGFRKQFDELRAGANDSGDTLYSIDIKPIYAAKGDKEASGSLLPASEVKVLKRDG
CCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCEEEECCCCCCCCCCCCCHHHHHHEECCC
DWLQIEITGWTESAGRQRVLTQFPGKRIFVASIRGDVQQQVKTLEKTTVADTNTEWSKLQ
CEEEEEEECCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ATAWMKKGDMVNDIKPIWAYADSLYNGTCNQCHGAPEISHFDANGWIGTLNGMIGFTSLD
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCEECCCCCEEECCCCEECCCCC
KREERTLLKYLQMNASDTAGKAHGDKKEEK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: trimethylamine-N-oxide; NADH [C]

Specific reaction: trimethylamine-N-oxide + NADH = H2O + trimethylamine + NAD [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796