Click here to switch to the map view.

The map label for this gene is dtpD

Identifier: 209398739

GI number: 209398739

Start: 820993

End: 822474

Strand: Reverse

Name: dtpD

Synonym: ECH74115_0799

Alternate gene names: 209398739

Gene position: 822474-820993 (Counterclockwise)

Preceding gene: 209395870

Following gene: 209395951

Centisome position: 14.76

GC content: 51.69

Gene sequence:

>1482_bases
ATGAATAAACACGCATCACAACCGCGCGCTATTTACTATGTCGTTGCGCTGCAAATCTGGGAATATTTTAGCTTTTACGG
CATGCGTGCCCTGCTGATTCTCTATCTCACCAATCAACTAAAATACAACGATACTCACGCCTACGAGTTATTTAGCGCCT
ACTGTTCGCTGGTGTATGTCACGCCAATCCTCGGTGGCTTTTTGGCGGATAAAGTTCTCGGCAATCGCATGGCGGTGATG
CTGGGGGCGTTATTGATGGCGATCGGTCATGTGGTGTTGGGTGCAAGTGAGATCCATCCGTCATTCCTCTATCTGTCCCT
GGCGATAATCGTTTGTGGCTATGGTCTGTTTAAATCCAATGTCAGTTGCCTGCTCGGCGAGCTGTATGAGCCAACCGATC
CGCGTCGTGATGGCGGTTTCTCGCTGATGTATGCAGCGGGTAACGTGGGGTCTATTATCGCACCTATTGCCTGTGGCTAC
GCCCAGGAAGAGTACAGTTGGGCGATGGGCTTTGGCCTGGCGGCGGTGGGTATGATCGCGGGTCTGGTTATTTTCTTATG
TGGCAATCGTCATTTCACACATACCCGCGGCGTTAACAAAAAAGTACTGCGTGCGACAAACTTTCTGCTGCCGAACTGGG
GATGGCTGCTGGTTCTGCTGGTGGCAACGCCTGCGCTGATTACCGTACTGTTCTGGAAAGAATGGTCGGTATACGCCTTG
ATTGTCGCGACTATCATTGGCCTGGGTGTACTGGCAAAAATTTATCGCAAAGCAGAAAACCAGAAACAGCGGAAGGAGCT
GAGGCTGATTGTGACGCTCACCTTCTTCAGTATGTTGTTCTGGGCCTTCGCACAACAGGGCGGTAGCTCGATTAGCCTTT
ATATCGACCGCTTCGTTAATCGCGATATGTTTGGTTATACCGTTCCGACCGCGATGTTCCAGTCGATTAATGCCTTCGCA
GTTATGCTGTGCGGTGTGTTCCTGGCGTGGGTGGTAAAAGAGAGTGTCGCGGGTAATCGTACCGTGCGCATCTGGGGAAA
ATTTGCTCTTGGCCTTGGCCTGATGAGCGCCGGATTCTGCATTCTGACCTTAAGCGCCCGCTGGTCCGCAATGTATGGTC
ACTCTTCTCTGCCACTGATGGTATTAGGCCTGGCGGTGATGGGCTTTGCGGAACTGTTTATCGACCCGGTTGCTATGTCG
CAGATTACGCGCATTGAAATCCCCGGTGTGACCGGCGTATTAACCGGCATTTATATGCTGCTTTCCGGCGCGATTGCGAA
CTATCTGGCGGGCGTGATTGCCGATCAGACATCGCAGGCTTCGTTTGATGCTTCCGGGGCGATCAACTACTCCATCAATG
CATATATTGAAGTATTTGATCAAATTACCTGGGGCGCACTGGCGTGTGTAGGAGTGGTACTGATGATTTGGCTGTATCAG
GCGCTGAAATTCAGAAACCGCGCGCTGGCGCTGGAGTCTTAA

Upstream 100 bases:

>100_bases
TTGCATAAATAATCAGATCTGTATCAAAGTTTTAACTTTAAGGAAACACAAGCACGCCGCGCAACTATTACGTGACGTTG
CCGTCAATTGTGGAATTATT

Downstream 100 bases:

>100_bases
TAGGCCAGCACCGATGCCTGATGCGACGCTTGACGCGTCTTATCAGGCCTACGTATTTCCTGCAATTTATTGAATTTGCA
CAAATTTGTAGGCTGGATAA

Product: amino acid/peptide transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVM
LGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGY
AQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
IVATIIGLGVLAKIYRKAENQKQRKELRLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQSINAFA
VMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMS
QITRIEIPGVTGVLTGIYMLLSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
ALKFRNRALALES

Sequences:

>Translated_493_residues
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVM
LGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGY
AQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
IVATIIGLGVLAKIYRKAENQKQRKELRLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQSINAFA
VMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMS
QITRIEIPGVTGVLTGIYMLLSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
ALKFRNRALALES
>Mature_493_residues
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVM
LGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGY
AQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
IVATIIGLGVLAKIYRKAENQKQRKELRLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQSINAFA
VMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMS
QITRIEIPGVTGVLTGIYMLLSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
ALKFRNRALALES

Specific function: Probable proton-dependent permease that transports dipeptides

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily

Homologues:

Organism=Homo sapiens, GI4827008, Length=318, Percent_Identity=26.1006289308176, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI226371746, Length=337, Percent_Identity=25.8160237388724, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI226371748, Length=329, Percent_Identity=24.6200607902736, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786927, Length=493, Percent_Identity=99.3914807302231, Blast_Score=994, Evalue=0.0,
Organism=Escherichia coli, GI1790572, Length=474, Percent_Identity=57.5949367088608, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1787922, Length=482, Percent_Identity=28.4232365145228, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789911, Length=479, Percent_Identity=27.1398747390397, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17569141, Length=196, Percent_Identity=32.6530612244898, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71987453, Length=222, Percent_Identity=28.3783783783784, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17541704, Length=337, Percent_Identity=26.1127596439169, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24639581, Length=201, Percent_Identity=32.8358208955224, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24639585, Length=201, Percent_Identity=32.8358208955224, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24639583, Length=201, Percent_Identity=32.8358208955224, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28571098, Length=349, Percent_Identity=24.6418338108883, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28571102, Length=349, Percent_Identity=24.6418338108883, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571100, Length=349, Percent_Identity=24.6418338108883, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTPD_ECO57 (Q8X9D3)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   D85571
- PIR:   F90720
- RefSeq:   NP_286424.1
- RefSeq:   NP_308761.1
- ProteinModelPortal:   Q8X9D3
- EnsemblBacteria:   EBESCT00000024160
- EnsemblBacteria:   EBESCT00000056307
- GeneID:   917103
- GeneID:   957800
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z0860
- KEGG:   ecs:ECs0734
- GeneTree:   EBGT00050000010038
- HOGENOM:   HBG586603
- OMA:   YALFSAY
- ProtClustDB:   PRK15462
- HAMAP:   MF_01880
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456
- PANTHER:   PTHR11654:SF6
- TIGRFAMs:   TIGR00924

Pfam domain/function: PF00854 PTR2; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 54231; Mature: 54231

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50850 MFS; PS01022 PTR2_1; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x4064bec8)-; HASH(0x24a55d34)-; HASH(0x24dea220)-; HASH(0x24b007ec)-; HASH(0x25e00d34)-; HASH(0x252d542c)-; HASH(0x23b4ec08)-; HASH(0x4062efd8)-; HASH(0x25acc350)-; HASH(0x24c3f874)-; HASH(0x258efdf4)-; HASH(0x25d1828c)-; HASH(0x25bbdbf4)-; HASH(0x25c680a0)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TPILGGFLADKVLGNRMAVMLGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHCCHHHHHC
VSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGYAQEEYSWAMGFGLAAVGMIA
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GLVIFLCGNRHFTHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IVATIIGLGVLAKIYRKAENQKQRKELRLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHC
RDMFGYTVPTAMFQSINAFAVMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHH
ILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMSQITRIEIPGVTGVLTGIYML
EEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHH
LSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKFRNRALALES
HHHHHCCCCCCCH
>Mature Secondary Structure
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TPILGGFLADKVLGNRMAVMLGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHCCHHHHHC
VSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGYAQEEYSWAMGFGLAAVGMIA
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GLVIFLCGNRHFTHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IVATIIGLGVLAKIYRKAENQKQRKELRLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHC
RDMFGYTVPTAMFQSINAFAVMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHH
ILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMSQITRIEIPGVTGVLTGIYML
EEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHH
LSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKFRNRALALES
HHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796