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The map label for this gene is fimE [H]

Identifier: 209398596

GI number: 209398596

Start: 5470593

End: 5471189

Strand: Direct

Name: fimE [H]

Synonym: ECH74115_5819

Alternate gene names: 209398596

Gene position: 5470593-5471189 (Clockwise)

Preceding gene: 209400483

Following gene: 209396019

Centisome position: 98.18

GC content: 46.73

Gene sequence:

>597_bases
GTGAGTAAACGTCGTTATCTTACCGGTAAAGAAGTTCAGGCCATGATGCAGGCGGTTTGTTACGGGGCAACGGGAGCCAG
AGATTATTGTCTTATTCTGTTGGCATATCGGCATGGGATGCGTATTAGTGAACTGCTTGATCTGCATTATCAGGATCTTG
ACCTTAATGAAGGCCGAATAAATATTCGCCGACTGAAGAACGGATTTTCTACCGTTCACCCGTTACGTTTTGATGAGCGT
GAAGCTGTGGAACGCTGGACCCTAGAACGTGCTAACTGGAAAGGCGCTGACCGGACCGACGCCATATTTATTTCTCGCCG
CGGGAGTCGGCTTTCTCGCCAGCAGGCCTATCGCATTATTCGTGATGCCGGTATTGAAGCTGGAACCGTAACGCAGACTC
ATCCTCATATGTTAAGGCATGCTTGCGGTTATGAACTGGCGGAGCGTGGTGCAGATACTCGTTTAATTCAGGATTATCTC
GGGCATCGAAATATTCGCCATACTGTACGTTATACCGCCAGTAATGCTGCTCGTTTTGCCGGATTATGGGAAAGAAATAA
TCTCATAAACGAAAAATTAAAAAGAGAAGAAGTTTGA

Upstream 100 bases:

>100_bases
TCGTGTGTGGTTATCTTTTTATCTATTGGGCTAATTTTGACCGATTGAGGTTTCCTATAGGTATTCATTCAAATATATCT
CAGTTAGGAGTACTACTATT

Downstream 100 bases:

>100_bases
TTTAACTTATTGATAATAAAGTTAAAAAACAAATAAATACAAGACAATTGGGGCCAAACTGTCCATATCATAAATAAGTT
ACGTATTTTTTCTCAAGCAT

Product: tyrosine recombinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MSKRRYLTGKEVQAMMQAVCYGATGARDYCLILLAYRHGMRISELLDLHYQDLDLNEGRINIRRLKNGFSTVHPLRFDER
EAVERWTLERANWKGADRTDAIFISRRGSRLSRQQAYRIIRDAGIEAGTVTQTHPHMLRHACGYELAERGADTRLIQDYL
GHRNIRHTVRYTASNAARFAGLWERNNLINEKLKREEV

Sequences:

>Translated_198_residues
MSKRRYLTGKEVQAMMQAVCYGATGARDYCLILLAYRHGMRISELLDLHYQDLDLNEGRINIRRLKNGFSTVHPLRFDER
EAVERWTLERANWKGADRTDAIFISRRGSRLSRQQAYRIIRDAGIEAGTVTQTHPHMLRHACGYELAERGADTRLIQDYL
GHRNIRHTVRYTASNAARFAGLWERNNLINEKLKREEV
>Mature_197_residues
SKRRYLTGKEVQAMMQAVCYGATGARDYCLILLAYRHGMRISELLDLHYQDLDLNEGRINIRRLKNGFSTVHPLRFDERE
AVERWTLERANWKGADRTDAIFISRRGSRLSRQQAYRIIRDAGIEAGTVTQTHPHMLRHACGYELAERGADTRLIQDYLG
HRNIRHTVRYTASNAARFAGLWERNNLINEKLKREEV

Specific function: FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches f

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790768, Length=198, Percent_Identity=99.4949494949495, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1790767, Length=183, Percent_Identity=52.4590163934426, Blast_Score=197, Evalue=5e-52,
Organism=Escherichia coli, GI1790244, Length=167, Percent_Identity=29.940119760479, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1789261, Length=184, Percent_Identity=27.7173913043478, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 23102; Mature: 22970

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRYLTGKEVQAMMQAVCYGATGARDYCLILLAYRHGMRISELLDLHYQDLDLNEGRI
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
NIRRLKNGFSTVHPLRFDEREAVERWTLERANWKGADRTDAIFISRRGSRLSRQQAYRII
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
RDAGIEAGTVTQTHPHMLRHACGYELAERGADTRLIQDYLGHRNIRHTVRYTASNAARFA
HHCCCCCCCCCCCCHHHHHHHHCHHHHHCCCCHHHHHHHHCCCCHHHHHEECCCCHHHHH
GLWERNNLINEKLKREEV
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKRRYLTGKEVQAMMQAVCYGATGARDYCLILLAYRHGMRISELLDLHYQDLDLNEGRI
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
NIRRLKNGFSTVHPLRFDEREAVERWTLERANWKGADRTDAIFISRRGSRLSRQQAYRII
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
RDAGIEAGTVTQTHPHMLRHACGYELAERGADTRLIQDYLGHRNIRHTVRYTASNAARFA
HHCCCCCCCCCCCCHHHHHHHHCHHHHHCCCCHHHHHHHHCCCCHHHHHEECCCCHHHHH
GLWERNNLINEKLKREEV
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]