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The map label for this gene is sgrR

Identifier: 209397844

GI number: 209397844

Start: 81450

End: 83108

Strand: Reverse

Name: sgrR

Synonym: ECH74115_0076

Alternate gene names: 209397844

Gene position: 83108-81450 (Counterclockwise)

Preceding gene: 209397741

Following gene: 209399031

Centisome position: 1.49

GC content: 55.21

Gene sequence:

>1659_bases
ATGCCATCTGCTCGTCTGCAACAACAGTTCATCCGCCTGTGGCAATGCTGCGAGGGTAAATCGCAGGACACAACGCTCAA
CGAACTGGCAGCGTTATTGAGCTGCTCGCGTCGTCATATGCGTACCCTGCTCAACACCATGCAGGATCGCGGCTGGCTGA
CGTGGGAAGCGGAAGTCGGGCGTGGTAAACGCTCGCGTCTGACATTCCTCTATACCGGGCTGGCGCTTCAGCAACAGCGG
GCGGAAGACCTGCTGGAGCAGGACCGTATCGACCAACTAGTGCAGTTAGTTGGCGACAAAGCGACTGTGAGGCAAATGCT
GGTTTCTCATCTGGGCCGCAGCTTCCGCCAGGGGCGGCACATCCTGCGCGTGCTCTACTATCGTCCGTTGCGTAATCTGC
TACCTGGCAGCGCATTGCGCCGTTCCGAAACCCATATCGCCCGGCAAATCTTCAGTTCGCTAACGCGCATAAATGAGGAA
AATGGGGAACTGGAAGCAGACATCGCCCACCACTGGCAGCAAATATCACCGCTTCACTGGCGTTTCTTTTTGCGTCCAGG
AGTCCATTTTCATCATGGTCGTGAACTGGAAATGGACGACGTGATCGCCTCTTTAAAACGAATCAATACGCTGCCGCTCT
ATTCGCATATTGCTGACATTGTGTCGCCGACGCCCTGGACGCTGGATATCCACCTCACGCAGCCGGATCGCTGGTTGCCG
TTACTGCTGGGACAAGTTCCGGCGATGATCCTGCCGCGCGAATGGGAAACCCTCAGTAACTTTGCCAGCCATCCCATCGG
CACCGGTCCGTATGCGGTGATTCGCAACAGCACCAATCAACTGAAAATTCAGGCATTCGATGACTTCTTCGGTTACCGGG
CATTAATCGATGAAGTTAACGTCTGGGTTCTGCCGGAAATTGCCGACGAGCCAGCCGGAGGGCTGATGCTAAAAGGTCCA
CAGGGCGAGGAAAAAGAGATTGAAAGCCGCCTGGAGGAAGGTTGCTACTATTTACTGTTCGATAGCCGCACCCATCGCGG
GGCGAATCAGCAAGTCAGGGACTGGGTAAGCTATGTGCTTTCTCCAACTAATCTGGTCTATTTCGCTGAGGAACAGTACC
AGCAACTGTGGTTCCCGGCTTATGGACTGCTCCCCCGTTGGCATCATGCCCGCACCATAACGAGCGAAAAACCGGCTGGT
CTGGAAAGCCTCACCCTGACCTTTTATCAGGATCACAGTGAGCATCGGGTGATTGCCGGGATCATGCAGCAGATTCTGGC
AAGCCACCAGGTCACACTGGAAATCAAAGAGATCAGCTACGATCAGTGGCATGAAGGAGAGATCGAGAGCGATATCTGGC
TTAACAGCGCCAACTTTACGCTGCCGCTGGATTTTTCGCTGTTCGCGCACCTGTGCGAGGTACCGCTGCTCCAACACTGT
ATTCCAATCGACTGGCAAGTCGACGCCGCCCGCTGGCGCAATGGCGAAATGAACCTGGCGAACTGGTGCCAACAACTGGT
CGCCAGCAAAGCAATGGTGCCACTTATCCACCACTGGCTGATCATTCAGGGACAACGCAGTATGCGCGGCCTGCGCATGA
ACACCCTCGGCTGGTTTGATTTTAAATCAGCGTGGTTTGCGCCGCCGGATCCAGAGTAG

Upstream 100 bases:

>100_bases
AAACTGACGAATGGGGCACCTCCTTGCTTCATCGTTAGGAATTATTGACTTAATATAGGGAAAATAAAATTGCTGTCTTT
TGCGCAGGAGTTCCCCTTTT

Downstream 100 bases:

>100_bases
CTTGCGCCTTTTGGCGGTCATGAGCGCATTTTTTATATTCAGACGGAATGATAAAATACATTACTTTTATATTTTCTCTG
TTTTATGCATCGTCTGATTA

Product: transcriptional regulator SgrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MPSARLQQQFIRLWQCCEGKSQDTTLNELAALLSCSRRHMRTLLNTMQDRGWLTWEAEVGRGKRSRLTFLYTGLALQQQR
AEDLLEQDRIDQLVQLVGDKATVRQMLVSHLGRSFRQGRHILRVLYYRPLRNLLPGSALRRSETHIARQIFSSLTRINEE
NGELEADIAHHWQQISPLHWRFFLRPGVHFHHGRELEMDDVIASLKRINTLPLYSHIADIVSPTPWTLDIHLTQPDRWLP
LLLGQVPAMILPREWETLSNFASHPIGTGPYAVIRNSTNQLKIQAFDDFFGYRALIDEVNVWVLPEIADEPAGGLMLKGP
QGEEKEIESRLEEGCYYLLFDSRTHRGANQQVRDWVSYVLSPTNLVYFAEEQYQQLWFPAYGLLPRWHHARTITSEKPAG
LESLTLTFYQDHSEHRVIAGIMQQILASHQVTLEIKEISYDQWHEGEIESDIWLNSANFTLPLDFSLFAHLCEVPLLQHC
IPIDWQVDAARWRNGEMNLANWCQQLVASKAMVPLIHHWLIIQGQRSMRGLRMNTLGWFDFKSAWFAPPDPE

Sequences:

>Translated_552_residues
MPSARLQQQFIRLWQCCEGKSQDTTLNELAALLSCSRRHMRTLLNTMQDRGWLTWEAEVGRGKRSRLTFLYTGLALQQQR
AEDLLEQDRIDQLVQLVGDKATVRQMLVSHLGRSFRQGRHILRVLYYRPLRNLLPGSALRRSETHIARQIFSSLTRINEE
NGELEADIAHHWQQISPLHWRFFLRPGVHFHHGRELEMDDVIASLKRINTLPLYSHIADIVSPTPWTLDIHLTQPDRWLP
LLLGQVPAMILPREWETLSNFASHPIGTGPYAVIRNSTNQLKIQAFDDFFGYRALIDEVNVWVLPEIADEPAGGLMLKGP
QGEEKEIESRLEEGCYYLLFDSRTHRGANQQVRDWVSYVLSPTNLVYFAEEQYQQLWFPAYGLLPRWHHARTITSEKPAG
LESLTLTFYQDHSEHRVIAGIMQQILASHQVTLEIKEISYDQWHEGEIESDIWLNSANFTLPLDFSLFAHLCEVPLLQHC
IPIDWQVDAARWRNGEMNLANWCQQLVASKAMVPLIHHWLIIQGQRSMRGLRMNTLGWFDFKSAWFAPPDPE
>Mature_551_residues
PSARLQQQFIRLWQCCEGKSQDTTLNELAALLSCSRRHMRTLLNTMQDRGWLTWEAEVGRGKRSRLTFLYTGLALQQQRA
EDLLEQDRIDQLVQLVGDKATVRQMLVSHLGRSFRQGRHILRVLYYRPLRNLLPGSALRRSETHIARQIFSSLTRINEEN
GELEADIAHHWQQISPLHWRFFLRPGVHFHHGRELEMDDVIASLKRINTLPLYSHIADIVSPTPWTLDIHLTQPDRWLPL
LLGQVPAMILPREWETLSNFASHPIGTGPYAVIRNSTNQLKIQAFDDFFGYRALIDEVNVWVLPEIADEPAGGLMLKGPQ
GEEKEIESRLEEGCYYLLFDSRTHRGANQQVRDWVSYVLSPTNLVYFAEEQYQQLWFPAYGLLPRWHHARTITSEKPAGL
ESLTLTFYQDHSEHRVIAGIMQQILASHQVTLEIKEISYDQWHEGEIESDIWLNSANFTLPLDFSLFAHLCEVPLLQHCI
PIDWQVDAARWRNGEMNLANWCQQLVASKAMVPLIHHWLIIQGQRSMRGLRMNTLGWFDFKSAWFAPPDPE

Specific function: Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding

COG id: COG4533

COG function: function code R; ABC-type uncharacterized transport system, periplasmic component

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1786256, Length=551, Percent_Identity=98.7295825771325, Blast_Score=1127, Evalue=0.0,
Organism=Escherichia coli, GI1786650, Length=579, Percent_Identity=27.1157167530225, Blast_Score=178, Evalue=8e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SGRR_ECO57 (Q8XA02)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B85489
- PIR:   B90638
- RefSeq:   NP_285766.1
- RefSeq:   NP_308101.1
- ProteinModelPortal:   Q8XA02
- EnsemblBacteria:   EBESCT00000025226
- EnsemblBacteria:   EBESCT00000056162
- GeneID:   913502
- GeneID:   956753
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z0079
- KEGG:   ecs:ECs0074
- GeneTree:   EBGT00050000010130
- HOGENOM:   HBG303837
- OMA:   QRSMRGV
- ProtClustDB:   PRK13626
- BioCyc:   ECOL83334:ECS0074-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_01449
- InterPro:   IPR000914

Pfam domain/function: PF00496 SBP_bac_5

EC number: NA

Molecular weight: Translated: 64121; Mature: 63990

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS01117 HTH_MARR_1; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSARLQQQFIRLWQCCEGKSQDTTLNELAALLSCSRRHMRTLLNTMQDRGWLTWEAEVG
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
RGKRSRLTFLYTGLALQQQRAEDLLEQDRIDQLVQLVGDKATVRQMLVSHLGRSFRQGRH
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ILRVLYYRPLRNLLPGSALRRSETHIARQIFSSLTRINEENGELEADIAHHWQQISPLHW
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCEE
RFFLRPGVHFHHGRELEMDDVIASLKRINTLPLYSHIADIVSPTPWTLDIHLTQPDRWLP
EEEECCCCEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHH
LLLGQVPAMILPREWETLSNFASHPIGTGPYAVIRNSTNQLKIQAFDDFFGYRALIDEVN
HHHHCCCHHCCCCHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEHHHHHHHHHHHCCC
VWVLPEIADEPAGGLMLKGPQGEEKEIESRLEEGCYYLLFDSRTHRGANQQVRDWVSYVL
EEEECCCCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHH
SPTNLVYFAEEQYQQLWFPAYGLLPRWHHARTITSEKPAGLESLTLTFYQDHSEHRVIAG
CCCCEEEEEHHHHHHHHCCHHHCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHH
IMQQILASHQVTLEIKEISYDQWHEGEIESDIWLNSANFTLPLDFSLFAHLCEVPLLQHC
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCEEEEECHHHHHHHHHHHHHHHC
IPIDWQVDAARWRNGEMNLANWCQQLVASKAMVPLIHHWLIIQGQRSMRGLRMNTLGWFD
CCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHCCCEECCCCCCC
FKSAWFAPPDPE
CCCCCCCCCCCC
>Mature Secondary Structure 
PSARLQQQFIRLWQCCEGKSQDTTLNELAALLSCSRRHMRTLLNTMQDRGWLTWEAEVG
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
RGKRSRLTFLYTGLALQQQRAEDLLEQDRIDQLVQLVGDKATVRQMLVSHLGRSFRQGRH
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ILRVLYYRPLRNLLPGSALRRSETHIARQIFSSLTRINEENGELEADIAHHWQQISPLHW
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCEE
RFFLRPGVHFHHGRELEMDDVIASLKRINTLPLYSHIADIVSPTPWTLDIHLTQPDRWLP
EEEECCCCEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHH
LLLGQVPAMILPREWETLSNFASHPIGTGPYAVIRNSTNQLKIQAFDDFFGYRALIDEVN
HHHHCCCHHCCCCHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEHHHHHHHHHHHCCC
VWVLPEIADEPAGGLMLKGPQGEEKEIESRLEEGCYYLLFDSRTHRGANQQVRDWVSYVL
EEEECCCCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHH
SPTNLVYFAEEQYQQLWFPAYGLLPRWHHARTITSEKPAGLESLTLTFYQDHSEHRVIAG
CCCCEEEEEHHHHHHHHCCHHHCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHH
IMQQILASHQVTLEIKEISYDQWHEGEIESDIWLNSANFTLPLDFSLFAHLCEVPLLQHC
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCEEEEECHHHHHHHHHHHHHHHC
IPIDWQVDAARWRNGEMNLANWCQQLVASKAMVPLIHHWLIIQGQRSMRGLRMNTLGWFD
CCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHCCCEECCCCCCC
FKSAWFAPPDPE
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796