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The map label for this gene is cysQ

Identifier: 209397330

GI number: 209397330

Start: 5367418

End: 5368158

Strand: Direct

Name: cysQ

Synonym: ECH74115_5731

Alternate gene names: 209397330

Gene position: 5367418-5368158 (Clockwise)

Preceding gene: 209398203

Following gene: 209397922

Centisome position: 96.33

GC content: 55.74

Gene sequence:

>741_bases
ATGTTAGATCAAGTATGCCAGCTTGCACGGAATGCAGGCGATGCCATTATGCAGGTCTACGACGGGGCGAAACCGATGGA
CGTCGTCAGCAAAGCGGACAATTCTCCGGTAACGGCAGCGGATATTGCCGCTCACACCGTTATCATGGACGGTTTACGTA
CGCTGACACCGGATATTCCGGTCCTTTCTGAAGAAGATCCTCCCGGTTGGGAAGTCCGTCAGCACTGGCAGCGTTACTGG
CTGGTAGACCCGCTGGATGGTACGAAAGAGTTTATTAAACGTAATGGCGAATTCACCGTTAACATTGCGCTCATTGACCA
TGGCAAACCGATTTTAGGTGTGGTGTATGCGCCGGTAATGAACGTAATGTACAGCGCGGCAGAAGGCAAGGCCTGGAAAG
AAGAGTGCGGCGTGCGCAAGCAGATTCAGGTCCGCGATGCGCGCCCGCCGCTGGTGGTGATCAGCCGCTCTCATGCGGAT
GCGGAGCTGAAAGAGTATCTGCAACAGCTTGGCGAACATCAGACCACGTCCATCGGCTCTTCGCTGAAGTTCTGCCTGGT
GGCGGAAGGACAGGCGCAGCTGTACCCGCGTTTCGGACCAACGAATATTTGGGACACCGCCGCTGGACATGCTGTGGCTG
CAGCTGCCGGAGCGCACGTTCACGACTGGCAGGGTAAACCGCTGGATTACACTCCGCGCGAGTCGTTCCTGAATCCGGGG
TTCAGAGTGTCTATTTACTAA

Upstream 100 bases:

>100_bases
GCTTTGAAAATGATGACACTATCACAGTTGGCGCATTCATTAATGATAGGGTATAAGTAAAACAATAAGTTAACACCGCT
CACAGAGACGAGGTGGAGAA

Downstream 100 bases:

>100_bases
ATTCAGATGGCAGAAACAGTGTATTTCCTGATTCTGCCATCCTGATTTCTCCCAACCTAAAAAGTTATAAATAAAAAGAG
ATTGTATTTAAAGTGCAAAA

Product: adenosine-3'(2'),5'-bisphosphate nucleotidase

Products: NA

Alternate protein names: 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; DPNPase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLDQVCQLARNAGDAIMQVYDGAKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
FRVSIY

Sequences:

>Translated_246_residues
MLDQVCQLARNAGDAIMQVYDGAKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
FRVSIY
>Mature_246_residues
MLDQVCQLARNAGDAIMQVYDGAKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
FRVSIY

Specific function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS)

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family

Homologues:

Organism=Homo sapiens, GI221625487, Length=247, Percent_Identity=28.3400809716599, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI5031789, Length=247, Percent_Identity=28.3400809716599, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1790659, Length=246, Percent_Identity=99.1869918699187, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1788882, Length=233, Percent_Identity=28.3261802575107, Blast_Score=87, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71995897, Length=264, Percent_Identity=27.6515151515151, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71995905, Length=264, Percent_Identity=27.6515151515151, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=249, Percent_Identity=25.7028112449799, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641722, Length=270, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357303, Length=162, Percent_Identity=29.6296296296296, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24664926, Length=238, Percent_Identity=23.9495798319328, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSQ_ECO57 (Q8XCG6)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   H86118
- PIR:   H91277
- RefSeq:   NP_290846.1
- RefSeq:   NP_313219.1
- ProteinModelPortal:   Q8XCG6
- SMR:   Q8XCG6
- EnsemblBacteria:   EBESCT00000026983
- EnsemblBacteria:   EBESCT00000059919
- GeneID:   913943
- GeneID:   959907
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5825
- KEGG:   ecs:ECs5192
- GeneTree:   EBGT00050000010909
- HOGENOM:   HBG730251
- OMA:   FISAQLT
- ProtClustDB:   PRK10931
- BioCyc:   ECOL83334:ECS5192-MONOMER
- GO:   GO:0005737
- InterPro:   IPR006240
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550
- PANTHER:   PTHR20854
- TIGRFAMs:   TIGR01331

Pfam domain/function: PF00459 Inositol_P

EC number: =3.1.3.7

Molecular weight: Translated: 27160; Mature: 27160

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00629 IMP_1; PS00630 IMP_2

Important sites: BINDING 64-64 BINDING 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQVCQLARNAGDAIMQVYDGAKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIP
CHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVM
CCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
NVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGS
HHHHHHHCCCHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
CEEEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCHHHHCCCC
FRVSIY
EEEEEC
>Mature Secondary Structure
MLDQVCQLARNAGDAIMQVYDGAKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIP
CHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVM
CCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
NVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGS
HHHHHHHCCCHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPG
CEEEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCHHHHCCCC
FRVSIY
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796