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The map label for this gene is guaB [H]

Identifier: 209397313

GI number: 209397313

Start: 3452863

End: 3454374

Strand: Reverse

Name: guaB [H]

Synonym: ECH74115_3732

Alternate gene names: 209397313

Gene position: 3454374-3452863 (Counterclockwise)

Preceding gene: 209396202

Following gene: 209397616

Centisome position: 61.99

GC content: 54.23

Gene sequence:

>1512_bases
ATGCCGCGGCAATATTTATTAACCACTCTGGTCGAGATATTGCCCATGCTACGTATCGCTAAAGAAGCTCTGACGTTTGA
CGACGTTCTCCTCGTTCCTGCTCATTCTACCGTTCTGCCGAATACTGCTGACCTCAGCACCCAGCTGACGAAAACTATTC
GTCTGAATATCCCTATGCTTTCCGCAGCAATGGATACCGTAACGGAAGCGCGCCTGGCTATTGCTCTGGCTCAGGAAGGC
GGTATCGGCTTTATCCACAAAAACATGTCCATTGAACGCCAGGCAGAAGAAGTTCGCCGTGTGAAAAAACACGAATCTGG
TGTGGTGACTGATCCGCAGACTGTTCTGCCAACCACGACGCTGCGCGAAGTGAAAGAACTGACCGAGCGTAACGGTTTTG
CGGGCTATCCGGTCGTTACCGAAGAAAACGAACTGGTGGGGATTATCACCGGTCGTGACGTGCGTTTTGTTACCGACCTG
AACCAGCCGGTTAGCGTTTACATGACGCCGAAAGAGCGTCTGGTCACCGTGCGTGAAGGTGAAGCCCGTGAAGTGGTGCT
GGCAAAAATGCACGAAAAACGCGTTGAAAAAGCGCTGGTGGTTGATGACGAATTCCACCTGATCGGCATGATCACCGTGA
AAGATTTCCAGAAAGCGGAACGTAAACCGAACGCCTGTAAAGACGAGCAAGGCCGTCTGCGTGTTGGTGCTGCAGTTGGC
GCAGGTGCGGGTAACGAAGAGCGTGTTGACGCGCTGGTTGCCGCTGGCGTTGACGTTCTGCTGATCGACTCCTCCCACGG
TCACTCAGAAGGCGTTTTGCAGCGTATCCGTGAAACCCGTGCTAAATATCCGGATCTGCAAATCATCGGCGGCAACGTGG
CAACAGCTGCAGGTGCACGCGCTCTGGCAGAAGCTGGTTGCAGCGCGGTTAAAGTCGGTATCGGCCCTGGTTCTATCTGT
ACGACTCGTATCGTTACTGGCGTAGGTGTTCCGCAGATCACTGCCGTTGCTGACGCAGTTGAAGCCCTGGAAGGCACCGG
TATTCCGGTTATCGCAGATGGTGGTATTCGCTTCTCCGGCGACATCGCCAAAGCTATCGCCGCTGGCGCAAGCGCGGTGA
TGGTAGGTTCCATGCTGGCGGGTACTGAAGAATCTCCGGGTGAAATCGAACTCTACCAGGGCCGTTCTTACAAATCTTAC
CGTGGTATGGGTTCCCTGGGCGCGATGTCCAAAGGTTCCTCTGACCGTTATTTCCAGAGCGATAACGCTGCCGACAAACT
GGTGCCGGAAGGTATCGAAGGTCGCGTAGCTTATAAAGGTCGCCTGAAAGAGATCATTCACCAGCAGATGGGCGGCCTGC
GCTCCTGTATGGGTTTGACCGGCTGTGGTACTATCGACGAACTGCGTACTAAAGCGGAGTTTGTACGTATCAGCGGTGCG
GGCATTCAGGAAAGCCACGTTCACGACGTGACCATTACTAAAGAGTCCCCGAACTACCGTCTGGGCTCCTGA

Upstream 100 bases:

>100_bases
TCTAAATCAGCAGGTTATTCAGTCGATAGTAACCCGCCCTTCGGGGATAGCAAGCATTTTTTGCAAAAAGGGGTAGATGC
AATCGGTTACGCTCTGTATA

Downstream 100 bases:

>100_bases
TTCTCTTCGCCCGACTTCATGTCGGGCGATTTATATTATCTGTTTCACTTGCCTCGGAATAAGCGTCAATGACGGAAAAC
ATTCATAAGCATCGCATCCT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MPRQYLLTTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEG
GIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDL
NQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVG
AGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPGSIC
TTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSY
RGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGA
GIQESHVHDVTITKESPNYRLGS

Sequences:

>Translated_503_residues
MPRQYLLTTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEG
GIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDL
NQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVG
AGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPGSIC
TTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSY
RGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGA
GIQESHVHDVTITKESPNYRLGS
>Mature_502_residues
PRQYLLTTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGG
IGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLN
QPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGA
GAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPGSICT
TRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYR
GMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAG
IQESHVHDVTITKESPNYRLGS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=460, Percent_Identity=41.9565217391304, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI217035146, Length=466, Percent_Identity=41.4163090128755, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI34328928, Length=466, Percent_Identity=41.2017167381974, Blast_Score=325, Evalue=9e-89,
Organism=Homo sapiens, GI156616279, Length=466, Percent_Identity=41.2017167381974, Blast_Score=324, Evalue=9e-89,
Organism=Homo sapiens, GI34328930, Length=466, Percent_Identity=41.4163090128755, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI217035152, Length=455, Percent_Identity=41.5384615384615, Blast_Score=318, Evalue=8e-87,
Organism=Homo sapiens, GI217035148, Length=466, Percent_Identity=40.5579399141631, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI217035150, Length=466, Percent_Identity=37.9828326180258, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI156104880, Length=267, Percent_Identity=34.4569288389513, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=36.0323886639676, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=36.0323886639676, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=36.0323886639676, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=36.0323886639676, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=100, Blast_Score=983, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=36.6515837104072, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=36.4016736401674, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=38.7706855791962, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=219, Percent_Identity=36.986301369863, Blast_Score=149, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322012, Length=464, Percent_Identity=39.8706896551724, Blast_Score=322, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6323585, Length=465, Percent_Identity=40, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6323464, Length=448, Percent_Identity=41.5178571428571, Blast_Score=312, Evalue=7e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=39.766081871345, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=40.6779661016949, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24641071, Length=487, Percent_Identity=41.2731006160164, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24641073, Length=487, Percent_Identity=41.2731006160164, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI28571163, Length=445, Percent_Identity=41.7977528089888, Blast_Score=292, Evalue=4e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53792; Mature: 53661

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRQYLLTTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPML
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHEEEEEEECCCHH
SAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTT
HHHHHHHHHHHEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCHH
LREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREG
HHHHHHHHHCCCCCCCCEEECCCCEEEEEECCCEEEEECCCCCEEEEECCHHHEEEEECC
EAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVG
CCHHHHHHHHHHHHHHHEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEEC
AGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGAR
CCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHH
ALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSG
HHHHCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECC
DIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQS
HHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCC
DNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGA
CCCHHHCCCCCCCCEEEHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHEEEEECC
GIQESHVHDVTITKESPNYRLGS
CCCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
PRQYLLTTLVEILPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPML
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHEEEEEEECCCHH
SAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTT
HHHHHHHHHHHEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCHH
LREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREG
HHHHHHHHHCCCCCCCCEEECCCCEEEEEECCCEEEEECCCCCEEEEECCHHHEEEEECC
EAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVG
CCHHHHHHHHHHHHHHHEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEEC
AGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGAR
CCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHH
ALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSG
HHHHCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECC
DIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQS
HHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCC
DNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGA
CCCHHHCCCCCCCCEEEHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHEEEEECC
GIQESHVHDVTITKESPNYRLGS
CCCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]