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The map label for this gene is cpxR

Identifier: 209397017

GI number: 209397017

Start: 5008045

End: 5008743

Strand: Reverse

Name: cpxR

Synonym: ECH74115_5367

Alternate gene names: 209397017

Gene position: 5008743-5008045 (Counterclockwise)

Preceding gene: 209400083

Following gene: 209398760

Centisome position: 89.89

GC content: 51.65

Gene sequence:

>699_bases
ATGAATAAAATCCTGTTAGTTGATGATGACCGAGAGCTGACTTCCCTATTAAAGGAGCTGCTCGAGATGGAAGGCTTCAA
CGTGATTGTTGCCCACGATGGGGAACAGGCGCTTGATCTTCTGGACGACAGCATTGATTTACTTTTGCTTGACGTAATGA
TGCCGAAGAAAAATGGTATCGACACATTAAAAGCACTTCGCCAGACACACCAGACGCCTGTCATTATGTTGACGGCGCGC
GGCAGTGAACTTGATCGCGTTCTCGGCCTTGAGCTGGGCGCAGATGACTATCTCCCGAAACCGTTTAATGATCGTGAGCT
GGTGGCACGTATTCGCGCGATCCTGCGCCGTTCGCACTGGAGCGAGCAACAGCAAAACAACGACAACGGTTCACCGACAC
TGGAAGTTGATGCCTTAGTACTGAATCCAGGCCGTCAGGAAGCCAGCTTCGACGGGCAAACGCTGGAGTTAACCGGTACT
GAGTTTACCCTGCTCTATTTGCTGGCACAGCATCTGGGTCAGGTGGTTTCCCGTGAACATTTAAGCCAGGAAGTGCTGGG
CAAACGCCTGACGCCTTTCGACCGCGCTATCGATATGCACATTTCCAACCTGCGTCGTAAACTGCCGGATCGTAAAGATG
GTCACCCGTGGTTTAAAACCTTGCGTGGTCGCGGCTACCTGATGGTTTCTGCTTCATGA

Upstream 100 bases:

>100_bases
GATTCAGGCTGCAAACATGCGTCAGGGGGTGTAAAACAACGTAAAGTCATGGATTAGCGACGTCTGATGACGTAATTTCT
GCCTCGGAGGTATTTAAACA

Downstream 100 bases:

>100_bases
TAGGCAGCTTAACCGCGCGCATCTTCGCCATCTTCTGGCTGACGCTGGCGCTGGTGTTGATGTTGGTTTTGATGTTACCC
AAGCTCGATTCACGCCAGAT

Product: DNA-binding transcriptional regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS

Sequences:

>Translated_232_residues
MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS
>Mature_232_residues
MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=100, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=40.8510638297872, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=38.2222222222222, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=39.3013100436681, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI87082012, Length=233, Percent_Identity=36.9098712446352, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=38.0530973451327, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=32, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=37.9310344827586, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=35.0877192982456, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=31.7596566523605, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=34.4978165938865, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=32.9059829059829, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.4561403508772, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=29.5652173913043, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1790299, Length=139, Percent_Identity=38.8489208633094, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=39.0909090909091, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=38.9830508474576, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=36.6071428571429, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CPXR_ECO57 (P0AE89)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   F86080
- PIR:   F91233
- RefSeq:   NP_290542.1
- RefSeq:   NP_312865.1
- ProteinModelPortal:   P0AE89
- SMR:   P0AE89
- EnsemblBacteria:   EBESCT00000024579
- EnsemblBacteria:   EBESCT00000057781
- GeneID:   915041
- GeneID:   960233
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5457
- KEGG:   ecs:ECs4838
- GeneTree:   EBGT00050000008651
- HOGENOM:   HBG753323
- OMA:   RLNPGRQ
- ProtClustDB:   PRK10955
- BioCyc:   ECOL83334:ECS4838-MONOMER
- GO:   GO:0005737
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 26313; Mature: 26313

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGI
CCCEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCHHHHHHHHHHCCCCCCH
DTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
SEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREH
HHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGI
CCCEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCHHHHHHHHHHCCCCCCH
DTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
SEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREH
HHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796