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The map label for this gene is rnpA [H]

Identifier: 209396527

GI number: 209396527

Start: 4773830

End: 4774189

Strand: Direct

Name: rnpA [H]

Synonym: ECH74115_5134

Alternate gene names: 209396527

Gene position: 4773830-4774189 (Clockwise)

Preceding gene: 209396814

Following gene: 209400160

Centisome position: 85.67

GC content: 55.56

Gene sequence:

>360_bases
GTGGTTAAGCTCGCATTTCCCAGGGAGTTACGCTTGTTAACTCCCAGTCAATTCACATTCGTCTTCCAGCAGCCACAACG
GGCTGGCACGCCGCAAATTACCATTCTCGGCCGCCTGAATTCGCTGGGGCATCCCCGTATCGGTCTTACAGTCGCCAAGA
AAAACGTTCGACGCGCCCATGAACGCAATCGGATTAAACGTCTGACGCGTGAAAGCTTCCGTCTGCGCCAACATGAACTC
CCGGCTATGGATTTCGTGGTGGTGGCGAAAAAAGGGGTTGCCAACCTCGATAACCGTGCTCTCTCGGAAGCGTTGGAAAA
ATTATGGCGCCGCCACTGTCGCCTGGCTCGCGGGTCCTGA

Upstream 100 bases:

>100_bases
GCTCGTATGGCTACTAAAAATGGTCGTCAGGTTCTGGCACGTCGTCGTGCTAAAGGCCGCGCTCGTCTGACCGTTTCTAA
GTAATAAAGCTAACCCCTGA

Downstream 100 bases:

>100_bases
TAGCCCTCATTCGGGTCTATCAACGCCTGATTAGTCCGCTACTCGGGCCGCATTGTCGTTTCACTCCAACCTGTTCAAGC
TACGGAATTGAGGCATTGCG

Product: ribonuclease P

Products: NA

Alternate protein names: RNase P protein; RNaseP protein; Protein C5 [H]

Number of amino acids: Translated: 119; Mature: 119

Protein sequence:

>119_residues
MVKLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHEL
PAMDFVVVAKKGVANLDNRALSEALEKLWRRHCRLARGS

Sequences:

>Translated_119_residues
MVKLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHEL
PAMDFVVVAKKGVANLDNRALSEALEKLWRRHCRLARGS
>Mature_119_residues
MVKLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHEL
PAMDFVVVAKKGVANLDNRALSEALEKLWRRHCRLARGS

Specific function: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-lead

COG id: COG0594

COG function: function code J; RNase P protein component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rnpA family [H]

Homologues:

Organism=Escherichia coli, GI1790139, Length=119, Percent_Identity=99.1596638655462, Blast_Score=239, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR000100
- InterPro:   IPR020539
- ProDom:   PD003629 [H]

Pfam domain/function: PF00825 Ribonuclease_P [H]

EC number: =3.1.26.5 [H]

Molecular weight: Translated: 13788; Mature: 13788

Theoretical pI: Translated: 12.42; Mature: 12.42

Prosite motif: PS00648 RIBONUCLEASE_P

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAH
CCCCCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEHEEHHHHHHHHH
ERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVANLDNRALSEALEKLWRRHCRLARGS
HHHHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVKLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAH
CCCCCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEHEEHHHHHHHHH
ERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVANLDNRALSEALEKLWRRHCRLARGS
HHHHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA