Click here to switch to the map view.

The map label for this gene is creC [H]

Identifier: 209396415

GI number: 209396415

Start: 5567119

End: 5568543

Strand: Direct

Name: creC [H]

Synonym: ECH74115_5914

Alternate gene names: 209396415

Gene position: 5567119-5568543 (Clockwise)

Preceding gene: 209399995

Following gene: 209396151

Centisome position: 99.91

GC content: 54.39

Gene sequence:

>1425_bases
ATGCGTATCGGCATGCGGTTGTTGCTGGGCTATTTTTTACTGGTGGCGGTGGCGGCCTGGTTCGTACTGGCTATTTTTGT
CAAAGAAGTTAAACCGGGCGTGCGAAGAGCAACGGAGGGGACGCTGATCGACACCGCAACGTTGCTGGCGGAGCTGGCGC
GTCCCGATTTGCTCTCTGGGGACCCAACGCATGGGCAACTGGCGCAGGCGTTTAATCAGCTACAACATCGCCCGTTTCGC
GCTAATATCGGTGGCATTAACAAAGTGCGCAATGAATATCATGTCTATATGACCGATGCGCAGGGCAAAGTATTGTTCGA
TTCGGCAAATAAAGCCGTTGGGCAGGATTATTCGCGCTGGAATGACGTCTGGCTAACGTTGCGTGGTCAGTATGGTGCGC
GCAGCACGTTGCAAAATCCTGCCGATCCCGAAAGTTCGGTGATGTATGTTGCCGCGCCGATTATGGACGGCTCGCGGCTT
ATTGGCGTTTTGAGCGTAGGCAAACCGAACGCGGCGATGGCTCCGGTCATTAAGCGCAGCGAGCGGCGAATTTTATGGGC
CAGCGCCATTTTGCTGGGGATTGCACTGGTGATTGGCGCAGGCATGGTTTGGTGGATCAACCGCTCCATTGCCCGGCTCA
CTCGCTATGCCGATTCCGTCACTGACAATAAGCCCGTTCCTCTTCCTGAACTCGGCAGTAGCGAGTTGCGTAAGCTTGCG
CAGGCGCTGGAAAGTATGCGCGTGAAGCTGGAAGGGAAAAACTATATTGAGCAGTATGTTTATGCGTTAACCCATGAGCT
AAAAAGCCCACTGGCGGCGATTCGTGGCGCGGCGGAAATTTTACGCGAAGGTCCGCCACCGGAAGTGGTGGCTCGTTTTA
CCGACAACATTCTGACGCAAAATGCGCGTATGCAGGCATTGGTAGAAACGTTACTACGCCAGGCAAGACTGGAGAATCGT
CAGGAAGTCGTTCTGACTGCTGTTGATGTGGCGGCATTATTTCGCCGCGTCAGCGAAGCGCGCACCGTGCAGTTGGCAGA
AAAAAACATCACTTTGCATGTTATGCCTACTGAGGTTAACGTTGCTGCTGAACCGGCGTTACTGGAGCAGGCGCTGGGGA
ATTTACTGGATAACGCCATCGATTTTACCCCCAAGAGCGGTCGCATAACGCTAAGCGCCGAAGTGGATCAGGAACACGTC
GCCCTTAAGGTGCTGGATACCGGTAGTGGTATTCCTGACTACGCGCTGTCACGTATTTTTGAACGCTTTTACTCTTTGCC
GCGTGCAAATGGGCAAAAAAGCAGCGGTCTGGGGTTGGCGTTTGTCAGTGAGGTCGCCCGTTTGTTTAACGGCGAAGTCA
CGCTGCGCAACGTGCAGGAAGGTGGCGTGCTGGCCTCGCTTCGGCTTCACCGTCACTTCACATAG

Upstream 100 bases:

>100_bases
CCCACATTAAAACGCTGCGTGCCAAGCTGCGCGCCATCAACCCCGATCTTTCACCGATTAATACTCATCGCGGCATGGGA
TACAGCCTGAGGAGCCTGTA

Downstream 100 bases:

>100_bases
CTTCAAATTCTTCCCACATAGCCTTCGTATCCTGCTGCCATTGCAAAGGAGAAGACTATGTTGAAATCCCCCCTGTTCTG
GAAAATGACCACCCTGTTTG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFR
ANIGGINKVRNEYHVYMTDAQGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRL
IGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPELGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENR
QEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVNVAAEPALLEQALGNLLDNAIDFTPKSGRITLSAEVDQEHV
ALKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT

Sequences:

>Translated_474_residues
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFR
ANIGGINKVRNEYHVYMTDAQGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRL
IGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPELGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENR
QEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVNVAAEPALLEQALGNLLDNAIDFTPKSGRITLSAEVDQEHV
ALKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
>Mature_474_residues
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFR
ANIGGINKVRNEYHVYMTDAQGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRL
IGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPELGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENR
QEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVNVAAEPALLEQALGNLLDNAIDFTPKSGRITLSAEVDQEHV
ALKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=474, Percent_Identity=98.7341772151899, Blast_Score=947, Evalue=0.0,
Organism=Escherichia coli, GI87082128, Length=302, Percent_Identity=31.4569536423841, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=29.6, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=201, Percent_Identity=29.8507462686567, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=24.5454545454545, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=24.3362831858407, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789403, Length=477, Percent_Identity=25.3668763102725, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=25.6410256410256, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=28.75, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=25.1677852348993, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=240, Percent_Identity=25.4166666666667, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=261, Percent_Identity=24.904214559387, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=268, Percent_Identity=25, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1790436, Length=203, Percent_Identity=28.0788177339901, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52229; Mature: 52229

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
DPTHGQLAQAFNQLQHRPFRANIGGINKVRNEYHVYMTDAQGKVLFDSANKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECCCCEEEEECCCHHHCCCHHCC
NDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRLIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHC
ERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPELGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NARMQALVETLLRQARLENRQEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVN
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEECCCC
VAAEPALLEQALGNLLDNAIDFTPKSGRITLSAEVDQEHVALKVLDTGSGIPDYALSRIF
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHH
ERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHCCC
>Mature Secondary Structure
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
DPTHGQLAQAFNQLQHRPFRANIGGINKVRNEYHVYMTDAQGKVLFDSANKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECCCCEEEEECCCHHHCCCHHCC
NDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRLIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHC
ERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPELGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NARMQALVETLLRQARLENRQEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVMPTEVN
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEECCCC
VAAEPALLEQALGNLLDNAIDFTPKSGRITLSAEVDQEHVALKVLDTGSGIPDYALSRIF
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHH
ERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]