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The map label for this gene is lrp

Identifier: 209396383

GI number: 209396383

Start: 1067028

End: 1067522

Strand: Direct

Name: lrp

Synonym: ECH74115_1051

Alternate gene names: 209396383

Gene position: 1067028-1067522 (Clockwise)

Preceding gene: 209399660

Following gene: 209396855

Centisome position: 19.15

GC content: 47.68

Gene sequence:

>495_bases
ATGGTAGATAGCAAGAAGCGCCCTGGCAAAGATCTCGACCGTATCGATCGTAACATTCTTAATGAGTTGCAAAAGGATGG
GCGTATTTCTAACGTCGAGCTTTCTAAACGTGTGGGACTTTCCCCAACGCCGTGCCTTGAGCGTGTGCGTCGGCTGGAAA
GACAAGGGTTTATTCAGGGCTATACGGCGCTGCTTAACCCCCATTATCTGGATGCATCACTTCTGGTATTCGTTGAGATT
ACTCTGAATCGTGGCGCACCGGATGTGTTTGAACAATTCAATACCGCTGTACAAAAACTTGAAGAAATTCAGGAGTGTCA
TTTAGTATCTGGTGATTTCGACTACCTGTTGAAAACACGCGTGCCGGATATGTCAGCCTACCGTAAGTTGCTGGGGGAAA
CCCTGCTGCGTCTGCCTGGCGTCAATGACACACGGACATACGTTGTTATGGAAGAAGTCAAGCAGAGTAATCGTCTGGTT
ATTAAGACGCGCTAA

Upstream 100 bases:

>100_bases
AATCTTCATGATTTCGGTCTATCGTGACGGGTAGCGACTCTGAACAGTGATGTTTCAGGGTCAGACAGGAGTAGGGAAGG
AATACAGAGAGACAATAATA

Downstream 100 bases:

>100_bases
CACGGAACAGGTGCAAAATCGGCGTATTTTGATTACACTCCTGTTAATCCATACAGCAACAGTACTGGGGTAACCTGGTA
CTGTTGTCCGTTTTAGCATC

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI
TLNRGAPDVFEQFNTAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR

Sequences:

>Translated_164_residues
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI
TLNRGAPDVFEQFNTAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR
>Mature_164_residues
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI
TLNRGAPDVFEQFNTAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787116, Length=164, Percent_Identity=100, Blast_Score=333, Evalue=2e-93,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=33.112582781457, Blast_Score=97, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LRP_ECO57 (P0ACJ2)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   D85614
- PIR:   F90750
- RefSeq:   NP_286766.1
- RefSeq:   NP_309001.1
- ProteinModelPortal:   P0ACJ2
- SMR:   P0ACJ2
- EnsemblBacteria:   EBESCT00000024228
- EnsemblBacteria:   EBESCT00000059218
- GeneID:   917724
- GeneID:   958847
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z1234
- KEGG:   ecs:ECs0974
- GeneTree:   EBGT00050000010711
- HOGENOM:   HBG740878
- OMA:   MVNNKKS
- ProtClustDB:   PRK11169
- BioCyc:   ECOL83334:ECS0974-MONOMER
- GO:   GO:0005622
- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00033
- SMART:   SM00344

Pfam domain/function: PF01037 AsnC_trans_reg; SSF54909 Dimer_A_B_barrel

EC number: NA

Molecular weight: Translated: 18887; Mature: 18887

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00519 HTH_ASNC_1; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
YTALLNPHYLDASLLVFVEITLNRGAPDVFEQFNTAVQKLEEIQECHLVSGDFDYLLKTR
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
YTALLNPHYLDASLLVFVEITLNRGAPDVFEQFNTAVQKLEEIQECHLVSGDFDYLLKTR
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796