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The map label for this gene is gpmI

Identifier: 209396260

GI number: 209396260

Start: 4635196

End: 4636740

Strand: Direct

Name: gpmI

Synonym: ECH74115_4985

Alternate gene names: 209396260

Gene position: 4635196-4636740 (Clockwise)

Preceding gene: 209400099

Following gene: 209398044

Centisome position: 83.19

GC content: 53.27

Gene sequence:

>1545_bases
ATGTCGGTTTCTAAAAAACCTATGGTACTGGTGATTCTGGATGGCTATGGCTATCGTGAAGAACAGCAGGATAACGCCAT
TTTTAGTGCTAAAACCCCGGTAATGGATGCACTGTGGGCCAATCGTCCGCATACCCTGATCGACGCTTCCGGTCTGGAAG
TCGGTCTGCCTGACCGTCAGATGGGTAACTCCGAAGTAGGCCACGTTAACCTGGGTGCCGGCCGCATCGTGTATCAGGAC
CTGACTCGTCTGGACGTTGAAATCAAAGATCGCGCTTTCTTTGCTAATCCAGTGCTGACTGGCGCGGTAGATAAAGCGAA
AAACGCAGGTAAAGCAGTACACATTATGGGTCTGCTCTCCGCAGGCGGCGTACACAGCCACGAAGATCACATCATGGCGA
TGGTAGAACTGGCAGCTGAACGCGGCGCAGAAAAAATCTACCTGCACGCATTCCTTGACGGTCGCGACACCCCGCCGCGC
AGTGCTGAATCCTCGCTGAAAAAATTTGAAGAGAAATTTGCTGCGCTGGGTAAAGGCCGCGTAGCGTCCATCATTGGTCG
TTACTACGCGATGGACCGCGATAACCGTTGGGATCGCGTTGAAAAAGCCTATGACCTGCTGACTCTGGCGCAGGGTGAGT
TCCAGGCCGATACTGCCGTTGCTGGTTTGCAGGCAGCTTATGCTCGCGACGAAAACGACGAGTTCGTGAAAGCGACCGTT
ATTCGTGCAGAAGGTCAGCCAGATGCGGCAATGGAAGACGGCGATGCGCTGATTTTCATGAACTTCCGTGCTGACCGCGC
GCGCGAAATCACTCGTGCATTCGTAAACGCAGATTTCGACGGCTTCGCGCGTAAGAAAGTGGTTAACGTCGATTTCGTGA
TGCTGACCGAATACGCCGCTGACATCAAAACTGCGGTTGCTTACCCACCCGCTTCCCTGGTTAACACCTTCGGCGAGTGG
ATGGCGAAAAACGACAAAACTCAGTTGCGTATTTCCGAAACCGAAAAATATGCCCACGTTACTTTCTTCTTCAACGGTGG
CGTAGAAGAGTCGTTCAAAGGCGAAGATCGCATTCTGATCAACTCACCGAAAGTGGCTACCTACGATCTGCAACCGGAAA
TGAGCTCCGCAGAGCTGACCGAAAAACTGGTTGCGGCCATCAAGAGCGGCAAATACGACACCATTATCTGTAACTATCCG
AACGGCGACATGGTAGGTCACACCGGGGTGATGGAAGCGGCGGTTAAAGCGGTTGAAGCACTGGATCACTGCGTGGAAGA
AGTCGCGAAAGCGGTTGAGTCCGTGGGTGGACAACTGCTGATCACCGCTGACCACGGTAACGCTGAACAGATGCGCGATC
CGGCAACGGGTCAGGCACACACGGCACACACCAACCTGCCAGTTCCGCTGATTTACGTTGGTGATAAGAACGTGAAAGCG
GTTGCAGGCGGCAAACTTTCTGACATCGCGCCGACCATGTTGTCGCTGATGGGTATGGAAATCCCGCAAGAGATGACTGG
TAAGCCGCTGTTCATCGTGGAATAA

Upstream 100 bases:

>100_bases
GCCGCGAGCGGTCGTATATTTTGATCTTCAGAGGCTATTTTATCGATTCAGCTGTAGTAAAATTACGCAAATTTTGACTC
TTGAGTATGAGGTTGTCGCA

Downstream 100 bases:

>100_bases
TCCCTCCCCATGAGGGGAAAGGCGATTAATACCATGACACGGGCCGTGAAACCGCGCAGGTTTGCAATCAGGCCCATCAT
CTACGCCAGCGTTCTTAGCG

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-independent PGAM; Phosphoglyceromutase; iPGM

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MSVSKKPMVLVILDGYGYREEQQDNAIFSAKTPVMDALWANRPHTLIDASGLEVGLPDRQMGNSEVGHVNLGAGRIVYQD
LTRLDVEIKDRAFFANPVLTGAVDKAKNAGKAVHIMGLLSAGGVHSHEDHIMAMVELAAERGAEKIYLHAFLDGRDTPPR
SAESSLKKFEEKFAALGKGRVASIIGRYYAMDRDNRWDRVEKAYDLLTLAQGEFQADTAVAGLQAAYARDENDEFVKATV
IRAEGQPDAAMEDGDALIFMNFRADRAREITRAFVNADFDGFARKKVVNVDFVMLTEYAADIKTAVAYPPASLVNTFGEW
MAKNDKTQLRISETEKYAHVTFFFNGGVEESFKGEDRILINSPKVATYDLQPEMSSAELTEKLVAAIKSGKYDTIICNYP
NGDMVGHTGVMEAAVKAVEALDHCVEEVAKAVESVGGQLLITADHGNAEQMRDPATGQAHTAHTNLPVPLIYVGDKNVKA
VAGGKLSDIAPTMLSLMGMEIPQEMTGKPLFIVE

Sequences:

>Translated_514_residues
MSVSKKPMVLVILDGYGYREEQQDNAIFSAKTPVMDALWANRPHTLIDASGLEVGLPDRQMGNSEVGHVNLGAGRIVYQD
LTRLDVEIKDRAFFANPVLTGAVDKAKNAGKAVHIMGLLSAGGVHSHEDHIMAMVELAAERGAEKIYLHAFLDGRDTPPR
SAESSLKKFEEKFAALGKGRVASIIGRYYAMDRDNRWDRVEKAYDLLTLAQGEFQADTAVAGLQAAYARDENDEFVKATV
IRAEGQPDAAMEDGDALIFMNFRADRAREITRAFVNADFDGFARKKVVNVDFVMLTEYAADIKTAVAYPPASLVNTFGEW
MAKNDKTQLRISETEKYAHVTFFFNGGVEESFKGEDRILINSPKVATYDLQPEMSSAELTEKLVAAIKSGKYDTIICNYP
NGDMVGHTGVMEAAVKAVEALDHCVEEVAKAVESVGGQLLITADHGNAEQMRDPATGQAHTAHTNLPVPLIYVGDKNVKA
VAGGKLSDIAPTMLSLMGMEIPQEMTGKPLFIVE
>Mature_513_residues
SVSKKPMVLVILDGYGYREEQQDNAIFSAKTPVMDALWANRPHTLIDASGLEVGLPDRQMGNSEVGHVNLGAGRIVYQDL
TRLDVEIKDRAFFANPVLTGAVDKAKNAGKAVHIMGLLSAGGVHSHEDHIMAMVELAAERGAEKIYLHAFLDGRDTPPRS
AESSLKKFEEKFAALGKGRVASIIGRYYAMDRDNRWDRVEKAYDLLTLAQGEFQADTAVAGLQAAYARDENDEFVKATVI
RAEGQPDAAMEDGDALIFMNFRADRAREITRAFVNADFDGFARKKVVNVDFVMLTEYAADIKTAVAYPPASLVNTFGEWM
AKNDKTQLRISETEKYAHVTFFFNGGVEESFKGEDRILINSPKVATYDLQPEMSSAELTEKLVAAIKSGKYDTIICNYPN
GDMVGHTGVMEAAVKAVEALDHCVEEVAKAVESVGGQLLITADHGNAEQMRDPATGQAHTAHTNLPVPLIYVGDKNVKAV
AGGKLSDIAPTMLSLMGMEIPQEMTGKPLFIVE

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0696

COG function: function code G; Phosphoglyceromutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BPG-independent phosphoglycerate mutase family

Homologues:

Organism=Escherichia coli, GI1790041, Length=514, Percent_Identity=99.6108949416342, Blast_Score=1054, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32564249, Length=519, Percent_Identity=45.4720616570328, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17507741, Length=519, Percent_Identity=45.4720616570328, Blast_Score=440, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPMI_ECO24 (A7ZTG6)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001465095.1
- ProteinModelPortal:   A7ZTG6
- SMR:   A7ZTG6
- STRING:   A7ZTG6
- EnsemblBacteria:   EBESCT00000020799
- GeneID:   5589900
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_4116
- eggNOG:   COG0696
- GeneTree:   EBGT00050000009045
- HOGENOM:   HBG613255
- OMA:   DNKTDEF
- ProtClustDB:   PRK05434
- BioCyc:   ECOL331111:ECE24377A_4116-MONOMER
- GO:   GO:0005737
- GO:   GO:0006096
- HAMAP:   MF_01038
- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR011258
- InterPro:   IPR006124
- InterPro:   IPR005995
- Gene3D:   G3DSA:3.40.720.10
- Gene3D:   G3DSA:3.40.1450.10
- PIRSF:   PIRSF001492
- TIGRFAMs:   TIGR01307

Pfam domain/function: PF06415 iPGM_N; PF01676 Metalloenzyme; SSF53649 Alkaline_phosphatase_core; SSF64158 BPG-indep_PGM_N

EC number: =5.4.2.1

Molecular weight: Translated: 56110; Mature: 55979

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: ACT_SITE 64-64

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSKKPMVLVILDGYGYREEQQDNAIFSAKTPVMDALWANRPHTLIDASGLEVGLPDRQ
CCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCHHHHHHCCCCCEEEECCCCEECCCCCC
MGNSEVGHVNLGAGRIVYQDLTRLDVEIKDRAFFANPVLTGAVDKAKNAGKAVHIMGLLS
CCCCCCCEEECCCCHHHHHHHHHCCEEEECCEEECCCCHHCCHHHHCCCCCEEEEEEECC
AGGVHSHEDHIMAMVELAAERGAEKIYLHAFLDGRDTPPRSAESSLKKFEEKFAALGKGR
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCH
VASIIGRYYAMDRDNRWDRVEKAYDLLTLAQGEFQADTAVAGLQAAYARDENDEFVKATV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
IRAEGQPDAAMEDGDALIFMNFRADRAREITRAFVNADFDGFARKKVVNVDFVMLTEYAA
EEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHEEEEEEEEEEHHHHH
DIKTAVAYPPASLVNTFGEWMAKNDKTQLRISETEKYAHVTFFFNGGVEESFKGEDRILI
HHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEE
NSPKVATYDLQPEMSSAELTEKLVAAIKSGKYDTIICNYPNGDMVGHTGVMEAAVKAVEA
ECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
LDHCVEEVAKAVESVGGQLLITADHGNAEQMRDPATGQAHTAHTNLPVPLIYVGDKNVKA
HHHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCEEEECCCCEEEEEECCCCEEE
VAGGKLSDIAPTMLSLMGMEIPQEMTGKPLFIVE
ECCCCCHHHHHHHHHHHCCCCCHHHCCCCEEEEC
>Mature Secondary Structure 
SVSKKPMVLVILDGYGYREEQQDNAIFSAKTPVMDALWANRPHTLIDASGLEVGLPDRQ
CCCCCCEEEEEECCCCCCCCCCCCCEEECCCCHHHHHHCCCCCEEEECCCCEECCCCCC
MGNSEVGHVNLGAGRIVYQDLTRLDVEIKDRAFFANPVLTGAVDKAKNAGKAVHIMGLLS
CCCCCCCEEECCCCHHHHHHHHHCCEEEECCEEECCCCHHCCHHHHCCCCCEEEEEEECC
AGGVHSHEDHIMAMVELAAERGAEKIYLHAFLDGRDTPPRSAESSLKKFEEKFAALGKGR
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCH
VASIIGRYYAMDRDNRWDRVEKAYDLLTLAQGEFQADTAVAGLQAAYARDENDEFVKATV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
IRAEGQPDAAMEDGDALIFMNFRADRAREITRAFVNADFDGFARKKVVNVDFVMLTEYAA
EEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHEEEEEEEEEEHHHHH
DIKTAVAYPPASLVNTFGEWMAKNDKTQLRISETEKYAHVTFFFNGGVEESFKGEDRILI
HHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEE
NSPKVATYDLQPEMSSAELTEKLVAAIKSGKYDTIICNYPNGDMVGHTGVMEAAVKAVEA
ECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
LDHCVEEVAKAVESVGGQLLITADHGNAEQMRDPATGQAHTAHTNLPVPLIYVGDKNVKA
HHHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCEEEECCCCEEEEEECCCCEEE
VAGGKLSDIAPTMLSLMGMEIPQEMTGKPLFIVE
ECCCCCHHHHHHHHHHHCCCCCHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA