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The map label for this gene is dctR

Identifier: 209396199

GI number: 209396199

Start: 4490873

End: 4491403

Strand: Direct

Name: dctR

Synonym: ECH74115_4855

Alternate gene names: 209396199

Gene position: 4490873-4491403 (Clockwise)

Preceding gene: 209400492

Following gene: 209397132

Centisome position: 80.6

GC content: 39.36

Gene sequence:

>531_bases
ATGTTTCTTATAATTACCAGGGATACGATGTTCTTCACCGCGATGAAAAACATTCTGAGTAAAGGTAATGTCGTTCATAT
ACAGAACGAAGAAGAGATCGACGTAATGTTGCATCAGAATGCCTTCGTCATTATTGATACATTAATGAATAATGTATTTC
ATTCTAATTTTCTCACTCAAATTGAACGATTAAAACCTGTCCATGTCATTATTTTCTCCCCCTTTAATATTAAACGCTGC
CTGGGGAAAGTGCCGGTGACCTTTGTTCCGCGGACTATCACTATCATTGATTTTGTCGCACTCATCAATGGCAGTTACTG
CTCTGTGCCTGAAGCGAATGTGTCACTTTCGCGCAAGCAACATCAGGTTCTGAGCTGCATTGCGAATCAAATGACAACGG
AAGATATTCTGGAGAAACTGAAAATATCGCTAAAAACGTTCTACTGCCATAAACACAATATCATGATGATCCTCAATCTT
AAGCGGATCAATGAGCTGGTACGCCATCAGCATATTGATTATCTGGTGTGA

Upstream 100 bases:

>100_bases
TTAATACACAGTAAGCTAACTATTATTATTATAAGCCCTGTCCTGTTAATTACCTTTGGCAAACTGATTATAAAGTTAAT
GTCCGCACCAGGAGTCGGTT

Downstream 100 bases:

>100_bases
ACGATTGATCAATATAAAGAGGCCCAGCAATAAATAGCCAGACCTCCCGTTAATTATACGTTATGCAGCAACGCCTTCCG
GTATCAGCGAAGCAATTTGC

Product: transcriptional regulator DctR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVIIDTLMNNVFHSNFLTQIERLKPVHVIIFSPFNIKRC
LGKVPVTFVPRTITIIDFVALINGSYCSVPEANVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNL
KRINELVRHQHIDYLV

Sequences:

>Translated_176_residues
MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVIIDTLMNNVFHSNFLTQIERLKPVHVIIFSPFNIKRC
LGKVPVTFVPRTITIIDFVALINGSYCSVPEANVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNL
KRINELVRHQHIDYLV
>Mature_176_residues
MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVIIDTLMNNVFHSNFLTQIERLKPVHVIIFSPFNIKRC
LGKVPVTFVPRTITIIDFVALINGSYCSVPEANVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNL
KRINELVRHQHIDYLV

Specific function: May act as a transcriptional regulator of dctA. Could be involved in the regulation of the genes coding for the type III secretion system in enterohaemorragic strains

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH luxR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1789923, Length=176, Percent_Identity=99.4318181818182, Blast_Score=355, Evalue=1e-100,
Organism=Escherichia coli, GI1789928, Length=167, Percent_Identity=23.9520958083832, Blast_Score=67, Evalue=7e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): DCTR_ECO57 (Q8X5P3)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B91176
- PIR:   C86022
- RefSeq:   NP_290078.1
- RefSeq:   NP_312405.1
- ProteinModelPortal:   Q8X5P3
- SMR:   Q8X5P3
- EnsemblBacteria:   EBESCT00000024407
- EnsemblBacteria:   EBESCT00000057587
- GeneID:   915765
- GeneID:   961181
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4909
- KEGG:   ecs:ECs4378
- GeneTree:   EBGT00050000009146
- HOGENOM:   HBG469218
- OMA:   HAFVIID
- ProtClustDB:   CLSK880693
- BioCyc:   ECOL83334:ECS4378-MONOMER
- GO:   GO:0005622
- InterPro:   IPR016032
- InterPro:   IPR000792
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00421

Pfam domain/function: PF00196 GerE; SSF46894 Bipartite_resp_reg_C-effector

EC number: NA

Molecular weight: Translated: 20452; Mature: 20452

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00622 HTH_LUXR_1; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVIIDTLMNNVFHSNFLTQ
CEEEEECCHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHH
IERLKPVHVIIFSPFNIKRCLGKVPVTFVPRTITIIDFVALINGSYCSVPEANVSLSRKQ
HHHCCCEEEEEECCCCHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
HQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNLKRINELVRHQHIDYLV
HHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCEEEEEEHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVIIDTLMNNVFHSNFLTQ
CEEEEECCHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHH
IERLKPVHVIIFSPFNIKRCLGKVPVTFVPRTITIIDFVALINGSYCSVPEANVSLSRKQ
HHHCCCEEEEEECCCCHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
HQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNLKRINELVRHQHIDYLV
HHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCEEEEEEHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796