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The map label for this gene is yscC [H]

Identifier: 209395836

GI number: 209395836

Start: 4714480

End: 4716018

Strand: Direct

Name: yscC [H]

Synonym: ECH74115_5069

Alternate gene names: 209395836

Gene position: 4714480-4716018 (Clockwise)

Preceding gene: 209400690

Following gene: 209398775

Centisome position: 84.61

GC content: 37.36

Gene sequence:

>1539_bases
ATGAAAAAAATAAGTTTTTTTATTTTTACAGCACTATTTTGCTGCAGTGCACAAGCTGCCCCGTCCTCTCTGGAAAAAAG
ATTAGGCAAGAGCGAATATTTTATTATTACTAAAAGTTCTCCAGTACGTGCAATCCTTAATGACTTTGCTGCTAACTACA
GCATTCCTGTTTTCATCAGTAGTTCCGTGAATGATGATTTCTCTGGCGAAATAAAAAATGAAAAACCTGTAAAAGTACTG
GAAAAACTGTCCAAACTATATCATCTCACATGGTATTATGATGAGAACATCTTGTATATTTATAAAACAAATGAAATATC
AAGAAGTATAATTACACCAACATATCTGGATATTGACTCACTGCTAAAATATCTGAGTGATACAATCTCAGTAAACAAAA
ACTCTTGCAATGTGAGAAAAATTACGACATTTAACTCGATTGAAGTTCGGGGTGTTCCTGAATGTATAAAATATATTACA
TCTTTATCAGAAAGTCTTGATAAAGAGGCACAGTCTAAAGCCAAAAATAAAGATGTTGTTAAGGTCTTTAAACTGAACTA
TGCGTCAGCGACAGATATAACATACAAATACCGTGACCAAAATGTTGTCGTCCCAGGTGTTGTCTCCATTCTGAAGACAA
TGGCAAGTAATGGTTCACTTCCCAGTACCGGTAAAGGTGCCGTCGAGCGAAGCGGTAACCTGTTTGATAACAGTGTAACG
ATTTCCGCTGATCCACGTCTTAATGCAGTTGTTGTAAAAGACCGCGAAATAACGATGGATATCTATCAGCAATTAATTTC
TGAGCTTGATATTGAACAAAGGCAAATTGAAATTTCTGTCTCAATTATTGATGTTGATGCAAACGATCTTCAGCAGCTCG
GCGTAAACTGGTCCGGTACGTTAAATGCAGGACAAGGTACGATTGCCTTTAATAGCTCTACCGCACAGGCTAATATCAGC
TCTTCTGTGATAAGTAATGCCAGTAATTTTATGATTAGGGTGAATGCGTTACAACAGAACTCGAAAGCTAAAATACTCTC
TCAGCCTTCAATTATAACCTTAAATAATATGCAGGCGATTCTTGATAAAAACGTAACGTTTTATACAAAAGTCTCCGGAG
AAAAGGTGGCGTCTCTGGAAAGTATTACAAGCGGAACATTGCTGAGAGTGACACCACGTATACTTGATGACAGCTCGAAT
AGCCTTACCGGAAAACGTCGGGAACGAGTTCGTTTGTTACTTGATATTCAGGATGGCAATCAATCGACTAACCAAAGCAA
TGCTCAGGATGCCAGCAGCACCTTACCTGAAGTACAAAATTCAGAAATGACAACAGAAGCGACATTAAGTGCAGGAGAAA
GTTTATTACTTGGCGGATTTATCCAAGATAAAGAAAGTTCAAGTAAAGATGGTATACCGCTGTTAAGCGACATTCCTGTT
ATTGGTAGTTTATTCTCCAGTACGGTAAAACAAAAACATAGTGTTGTTCGACTCTTTTTAATTAAAGCAACCCCGATAAA
ATCTGCATCTAGCGAATAA

Upstream 100 bases:

>100_bases
CTTTGCTCGATAAGCAATTTGATAAACTAGAGCAATTATCTTCATCAGATACAATGATGCCGCCAACACACTTGTTTTCT
GATATAGGACGAATTGTGTA

Downstream 100 bases:

>100_bases
TAAATGAGGCTTTATGAGCAGGAAATTTAGCTCTCTAGAGGATATTTATGATTTCTACCAGGATGGTGGCACATTAGCGT
CATTAACAAATCTGACACAA

Product: type III secretion outer membrane pore, YscC/HrcC family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MKKISFFIFTALFCCSAQAAPSSLEKRLGKSEYFIITKSSPVRAILNDFAANYSIPVFISSSVNDDFSGEIKNEKPVKVL
EKLSKLYHLTWYYDENILYIYKTNEISRSIITPTYLDIDSLLKYLSDTISVNKNSCNVRKITTFNSIEVRGVPECIKYIT
SLSESLDKEAQSKAKNKDVVKVFKLNYASATDITYKYRDQNVVVPGVVSILKTMASNGSLPSTGKGAVERSGNLFDNSVT
ISADPRLNAVVVKDREITMDIYQQLISELDIEQRQIEISVSIIDVDANDLQQLGVNWSGTLNAGQGTIAFNSSTAQANIS
SSVISNASNFMIRVNALQQNSKAKILSQPSIITLNNMQAILDKNVTFYTKVSGEKVASLESITSGTLLRVTPRILDDSSN
SLTGKRRERVRLLLDIQDGNQSTNQSNAQDASSTLPEVQNSEMTTEATLSAGESLLLGGFIQDKESSSKDGIPLLSDIPV
IGSLFSSTVKQKHSVVRLFLIKATPIKSASSE

Sequences:

>Translated_512_residues
MKKISFFIFTALFCCSAQAAPSSLEKRLGKSEYFIITKSSPVRAILNDFAANYSIPVFISSSVNDDFSGEIKNEKPVKVL
EKLSKLYHLTWYYDENILYIYKTNEISRSIITPTYLDIDSLLKYLSDTISVNKNSCNVRKITTFNSIEVRGVPECIKYIT
SLSESLDKEAQSKAKNKDVVKVFKLNYASATDITYKYRDQNVVVPGVVSILKTMASNGSLPSTGKGAVERSGNLFDNSVT
ISADPRLNAVVVKDREITMDIYQQLISELDIEQRQIEISVSIIDVDANDLQQLGVNWSGTLNAGQGTIAFNSSTAQANIS
SSVISNASNFMIRVNALQQNSKAKILSQPSIITLNNMQAILDKNVTFYTKVSGEKVASLESITSGTLLRVTPRILDDSSN
SLTGKRRERVRLLLDIQDGNQSTNQSNAQDASSTLPEVQNSEMTTEATLSAGESLLLGGFIQDKESSSKDGIPLLSDIPV
IGSLFSSTVKQKHSVVRLFLIKATPIKSASSE
>Mature_512_residues
MKKISFFIFTALFCCSAQAAPSSLEKRLGKSEYFIITKSSPVRAILNDFAANYSIPVFISSSVNDDFSGEIKNEKPVKVL
EKLSKLYHLTWYYDENILYIYKTNEISRSIITPTYLDIDSLLKYLSDTISVNKNSCNVRKITTFNSIEVRGVPECIKYIT
SLSESLDKEAQSKAKNKDVVKVFKLNYASATDITYKYRDQNVVVPGVVSILKTMASNGSLPSTGKGAVERSGNLFDNSVT
ISADPRLNAVVVKDREITMDIYQQLISELDIEQRQIEISVSIIDVDANDLQQLGVNWSGTLNAGQGTIAFNSSTAQANIS
SSVISNASNFMIRVNALQQNSKAKILSQPSIITLNNMQAILDKNVTFYTKVSGEKVASLESITSGTLLRVTPRILDDSSN
SLTGKRRERVRLLLDIQDGNQSTNQSNAQDASSTLPEVQNSEMTTEATLSAGESLLLGGFIQDKESSSKDGIPLLSDIPV
IGSLFSSTVKQKHSVVRLFLIKATPIKSASSE

Specific function: Very likely required for the export process of the yop proteins [H]

COG id: COG1450

COG function: function code NU; Type II secretory pathway, component PulD

Gene ontology:

Cell location: Cell outer membrane (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP D family [H]

Homologues:

Organism=Escherichia coli, GI87082242, Length=397, Percent_Identity=28.7153652392947, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789793, Length=279, Percent_Identity=25.089605734767, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005644
- InterPro:   IPR004846
- InterPro:   IPR004845
- InterPro:   IPR003522 [H]

Pfam domain/function: PF00263 Secretin; PF03958 Secretin_N [H]

EC number: NA

Molecular weight: Translated: 56199; Mature: 56199

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00875 T2SP_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISFFIFTALFCCSAQAAPSSLEKRLGKSEYFIITKSSPVRAILNDFAANYSIPVFIS
CCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEE
SSVNDDFSGEIKNEKPVKVLEKLSKLYHLTWYYDENILYIYKTNEISRSIITPTYLDIDS
CCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCEEEEEECCCCCHHHCCCCEECHHH
LLKYLSDTISVNKNSCNVRKITTFNSIEVRGVPECIKYITSLSESLDKEAQSKAKNKDVV
HHHHHHHHHCCCCCCCCEEEEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
KVFKLNYASATDITYKYRDQNVVVPGVVSILKTMASNGSLPSTGKGAVERSGNLFDNSVT
EEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCEECCEEE
ISADPRLNAVVVKDREITMDIYQQLISELDIEQRQIEISVSIIDVDANDLQQLGVNWSGT
EECCCCCEEEEEECCCEEHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHCCCCCCE
LNAGQGTIAFNSSTAQANISSSVISNASNFMIRVNALQQNSKAKILSQPSIITLNNMQAI
EECCCEEEEECCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCEEECCCCEEEECCHHHH
LDKNVTFYTKVSGEKVASLESITSGTLLRVTPRILDDSSNSLTGKRRERVRLLLDIQDGN
HCCCCEEEEEECCCHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCCCCEEEEEEEEECCC
QSTNQSNAQDASSTLPEVQNSEMTTEATLSAGESLLLGGFIQDKESSSKDGIPLLSDIPV
CCCCCCCCHHHHHHCCCCCCCCCCHHHHHHCCCCEEEECEEECCCCCCCCCCCCCCCCHH
IGSLFSSTVKQKHSVVRLFLIKATPIKSASSE
HHHHHHHHHHHHHHEEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MKKISFFIFTALFCCSAQAAPSSLEKRLGKSEYFIITKSSPVRAILNDFAANYSIPVFIS
CCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEE
SSVNDDFSGEIKNEKPVKVLEKLSKLYHLTWYYDENILYIYKTNEISRSIITPTYLDIDS
CCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCEEEEEECCCCCHHHCCCCEECHHH
LLKYLSDTISVNKNSCNVRKITTFNSIEVRGVPECIKYITSLSESLDKEAQSKAKNKDVV
HHHHHHHHHCCCCCCCCEEEEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
KVFKLNYASATDITYKYRDQNVVVPGVVSILKTMASNGSLPSTGKGAVERSGNLFDNSVT
EEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCEECCEEE
ISADPRLNAVVVKDREITMDIYQQLISELDIEQRQIEISVSIIDVDANDLQQLGVNWSGT
EECCCCCEEEEEECCCEEHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHCCCCCCE
LNAGQGTIAFNSSTAQANISSSVISNASNFMIRVNALQQNSKAKILSQPSIITLNNMQAI
EECCCEEEEECCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCEEECCCCEEEECCHHHH
LDKNVTFYTKVSGEKVASLESITSGTLLRVTPRILDDSSNSLTGKRRERVRLLLDIQDGN
HCCCCEEEEEECCCHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCCCCEEEEEEEEECCC
QSTNQSNAQDASSTLPEVQNSEMTTEATLSAGESLLLGGFIQDKESSSKDGIPLLSDIPV
CCCCCCCCHHHHHHCCCCCCCCCCHHHHHHCCCCEEEECEEECCCCCCCCCCCCCCCCHH
IGSLFSSTVKQKHSVVRLFLIKATPIKSASSE
HHHHHHHHHHHHHHEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1860816 [H]