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The map label for this gene is argC

Identifier: 20094513

GI number: 20094513

Start: 1044460

End: 1045491

Strand: Direct

Name: argC

Synonym: MK1077

Alternate gene names: 20094513

Gene position: 1044460-1045491 (Clockwise)

Preceding gene: 20094511

Following gene: 20094516

Centisome position: 61.62

GC content: 64.24

Gene sequence:

>1032_bases
GTGGTCGTGGTCGGCATCGTGGGTGCATCAGGTTACACCGGAGGCGAGCTCCTTAGACTCCTCGCCCGACACCCGGAGGT
GGAAGAGGTCCGCTACGCGACCTCCAGGAGGCTCGAGGGAAAGCCAGTCTGGAAGGTACACCCGAACCTGCGGCGTGACT
ACCCCGACCTCGAGTTCTCGGACCCTGATCCCGTTGAAATCGGCGAAGACTGCGACGTCGTATTCACCGCCGTCCCACAC
ACCGCCGCCATGGAGCTGGTCCCGGATCTACTGGAAGGAGGGGCCGTGGTGATCGATCTCAGCGCCGATTTCCGGTTCGA
CGACGTGGATGTCTACGAGGAGTGGTACGGCGTCGAACACGCGGCTCCGGAGCTGAACGACGAGGCCGTTTACGGGCTGC
CCGAGCTACACCGGGACGAGATACGGCGCACAGACCTCATCGCCAACCCGGGGTGCTACCCGACAGGCGCTATCCTGGCC
GCCGCACCGCTAGTCGAGGAAGGGCTCGTCGACGTCGTGATCTTCGACTCCAAGAGCGGTACCTCCGGGGCCGGTGCGAA
GCCTTCGGAGGTCACCCACCACCCGGAGTGCGCCGAGGACCTGACACCCTACAACCCGACGGATCACCGTCACTTACCCG
AAATACGGCAGGAGCTGGGGAAGTTGGGCGACGTCGAGGTTCACTTCACCCCGCACCTGGCGCCGCTCGTCCGGGGTATC
GAGACCACGGCCCACGGTCTAGGGGATGTAGAGATCGAGCCGAAGGAGCTCCGGGAGCTTTACGTGGAATACTACGACGG
TGAGCCTTTCATCCGTGTCTGCGAGGTCGGTGAGGCTCCGCGGCTCTGGGCCGTCCGTGGGACCAACTACTGCGACGTGG
GCGTCTTCGCGGTAGGTGATGGCAGGGTCGTCGTAGCGTCGGCGATCGACAACCTCACCAAGGGCGCGTCCGGTCAGGCG
ATTCAGAACATGAACGTGAGGTTCGGGTTCGAGGAGACCGCGGGGTTAGAGGAGCCCGGGTATCATCCCTGA

Upstream 100 bases:

>100_bases
GAACGAGGCGGCCCACAGGTCCTCGGACTCCTTATAACCTAGGTCCGCCCGGATCTCCTCGATTATCCCCTTCAACGGAT
CCGACAAGGGGGAACCCCGC

Downstream 100 bases:

>100_bases
ACCCGCTCCCGTACGAGCTCCTGGACCTTCCGACATCCCTCCTTGTCTCCCTTGGGTACCAGGGCGAAGGCGCAGCGCCT
GTCACCGAGCCCCCAACATG

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MVVVGIVGASGYTGGELLRLLARHPEVEEVRYATSRRLEGKPVWKVHPNLRRDYPDLEFSDPDPVEIGEDCDVVFTAVPH
TAAMELVPDLLEGGAVVIDLSADFRFDDVDVYEEWYGVEHAAPELNDEAVYGLPELHRDEIRRTDLIANPGCYPTGAILA
AAPLVEEGLVDVVIFDSKSGTSGAGAKPSEVTHHPECAEDLTPYNPTDHRHLPEIRQELGKLGDVEVHFTPHLAPLVRGI
ETTAHGLGDVEIEPKELRELYVEYYDGEPFIRVCEVGEAPRLWAVRGTNYCDVGVFAVGDGRVVVASAIDNLTKGASGQA
IQNMNVRFGFEETAGLEEPGYHP

Sequences:

>Translated_343_residues
MVVVGIVGASGYTGGELLRLLARHPEVEEVRYATSRRLEGKPVWKVHPNLRRDYPDLEFSDPDPVEIGEDCDVVFTAVPH
TAAMELVPDLLEGGAVVIDLSADFRFDDVDVYEEWYGVEHAAPELNDEAVYGLPELHRDEIRRTDLIANPGCYPTGAILA
AAPLVEEGLVDVVIFDSKSGTSGAGAKPSEVTHHPECAEDLTPYNPTDHRHLPEIRQELGKLGDVEVHFTPHLAPLVRGI
ETTAHGLGDVEIEPKELRELYVEYYDGEPFIRVCEVGEAPRLWAVRGTNYCDVGVFAVGDGRVVVASAIDNLTKGASGQA
IQNMNVRFGFEETAGLEEPGYHP
>Mature_343_residues
MVVVGIVGASGYTGGELLRLLARHPEVEEVRYATSRRLEGKPVWKVHPNLRRDYPDLEFSDPDPVEIGEDCDVVFTAVPH
TAAMELVPDLLEGGAVVIDLSADFRFDDVDVYEEWYGVEHAAPELNDEAVYGLPELHRDEIRRTDLIANPGCYPTGAILA
AAPLVEEGLVDVVIFDSKSGTSGAGAKPSEVTHHPECAEDLTPYNPTDHRHLPEIRQELGKLGDVEVHFTPHLAPLVRGI
ETTAHGLGDVEIEPKELRELYVEYYDGEPFIRVCEVGEAPRLWAVRGTNYCDVGVFAVGDGRVVVASAIDNLTKGASGQA
IQNMNVRFGFEETAGLEEPGYHP

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=343, Percent_Identity=38.4839650145773, Blast_Score=209, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320913, Length=345, Percent_Identity=34.2028985507246, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_METKA (Q8TWF8)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614360.1
- ProteinModelPortal:   Q8TWF8
- GeneID:   1477178
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1077
- NMPDR:   fig|190192.1.peg.1073
- HOGENOM:   HBG294213
- OMA:   VCRIAVH
- ProtClustDB:   PRK00436
- BioCyc:   MKAN190192:MK1077-MONOMER
- BRENDA:   1.2.1.38
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 37556; Mature: 37556

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 152-152

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVVGIVGASGYTGGELLRLLARHPEVEEVRYATSRRLEGKPVWKVHPNLRRDYPDLEFS
CEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCHHCCCCCCCCC
DPDPVEIGEDCDVVFTAVPHTAAMELVPDLLEGGAVVIDLSADFRFDDVDVYEEWYGVEH
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCC
AAPELNDEAVYGLPELHRDEIRRTDLIANPGCYPTGAILAAAPLVEEGLVDVVIFDSKSG
CCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCC
TSGAGAKPSEVTHHPECAEDLTPYNPTDHRHLPEIRQELGKLGDVEVHFTPHLAPLVRGI
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHH
ETTAHGLGDVEIEPKELRELYVEYYDGEPFIRVCEVGEAPRLWAVRGTNYCDVGVFAVGD
HHHHCCCCCCEECHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCEEEEEEEEECC
GRVVVASAIDNLTKGASGQAIQNMNVRFGFEETAGLEEPGYHP
CCEEEEEHHHHHHCCCCCCEEECCCEEECCHHHCCCCCCCCCC
>Mature Secondary Structure
MVVVGIVGASGYTGGELLRLLARHPEVEEVRYATSRRLEGKPVWKVHPNLRRDYPDLEFS
CEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCHHCCCCCCCCC
DPDPVEIGEDCDVVFTAVPHTAAMELVPDLLEGGAVVIDLSADFRFDDVDVYEEWYGVEH
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCC
AAPELNDEAVYGLPELHRDEIRRTDLIANPGCYPTGAILAAAPLVEEGLVDVVIFDSKSG
CCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCC
TSGAGAKPSEVTHHPECAEDLTPYNPTDHRHLPEIRQELGKLGDVEVHFTPHLAPLVRGI
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHH
ETTAHGLGDVEIEPKELRELYVEYYDGEPFIRVCEVGEAPRLWAVRGTNYCDVGVFAVGD
HHHHCCCCCCEECHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCEEEEEEEEECC
GRVVVASAIDNLTKGASGQAIQNMNVRFGFEETAGLEEPGYHP
CCEEEEEHHHHHHCCCCCCEEECCCEEECCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014