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The map label for this gene is UbiA [C]

Identifier: 20094389

GI number: 20094389

Start: 915262

End: 916077

Strand: Direct

Name: UbiA [C]

Synonym: MK0953

Alternate gene names: 20094389

Gene position: 915262-916077 (Clockwise)

Preceding gene: 20094388

Following gene: 20094393

Centisome position: 54.0

GC content: 68.14

Gene sequence:

>816_bases
GTGAGGGCTTACCTCGAGCTCGCACGGCCTATCAACTGCGCGATGGCCGCTTTGGGAGTGGTCGTGGGTGAACTGATCGC
GGGAGCCAGGCTCGACGTCGGGGCGGTCCTCGCGCCGGTGGTCGCCGCGGTCGTGTGTGCGGGAGGGAACGCCATCAACG
ACTACTTCGACGCCGAGGTCGACGCCGTGAACAGGCCGGATAGGCCGATCCCGAGCGGTAGGGTGTCCCCACGGTCGGCC
CGGATGTTCGCCCTCGGCTGCTTCGCCGTCGGGGTCGGGATGGCCACCGTAATCAACCGGATGTGTCTGGCGATCGCCGC
CCTGAACTCCGTTCTACTCTACCTGTACTCGTGGCGCCTGAAGGGGACTCCCTTGATCGGGAACGTCATGGTCTCCTACC
TGGTGGGATCCTGCTTCCTGTTCGGAGCCGCGGTGGGTCAGCGGCCGGCGCCCGCGGTGTGGCTCTTCTTACTGGCTTTC
CTGGCGAACCTGGTGCGCGAGATCCTCAAGGACCTGGAGGACGTCGAGGGGGACGCGGCGCTCGGTCTCAAGACGCTCCC
GATCGCGTACGGCGAGGGGGTCGCCCTCCGGGTGGCGACGGTGTTCGCGATCGCGCTGGCCGTCCTCACGCCGCTACCCT
ACCTGGACGGTGTCGTCGGGTGGCCGTATCTGGTCCTGGCCCTACCCGCCGCCGCGGTCATACTCCTGGCCTCGGTCCTA
GCGGTCGCCGGGAGCTGGGACGCGGGTAAGGCGCAGCGGGTGGTCAAGGTGGGGATGCTGCTGGGGCTGCTGGCCTTCCT
GGCGTCACTCCTCTAG

Upstream 100 bases:

>100_bases
GGGGGTGTGTGAACGCGTTCCGTGACTCCGGTGGAGGTCGGGGACGCACCGGGCGGAGCGAGTTTAAGGCAGGTACCGGG
GCGGCGGTCGGGGTGAGAGC

Downstream 100 bases:

>100_bases
ATCCTCGAACCTGTCCTCGAGCTTCTTCAGTACGTCCGGTAGCGTCGTGTACTCCAGCTCCTCCTCGGACAGCAGGTGCG
GCTGGAACGGTCCGTGTCTC

Product: 4-hydroxybenzoate polyprenyltransferase

Products: NA

Alternate protein names: DGGGP synthase; DGGGPS; (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Geranylgeranylglycerol-phosphate geranylgeranyltransferase

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MRAYLELARPINCAMAALGVVVGELIAGARLDVGAVLAPVVAAVVCAGGNAINDYFDAEVDAVNRPDRPIPSGRVSPRSA
RMFALGCFAVGVGMATVINRMCLAIAALNSVLLYLYSWRLKGTPLIGNVMVSYLVGSCFLFGAAVGQRPAPAVWLFLLAF
LANLVREILKDLEDVEGDAALGLKTLPIAYGEGVALRVATVFAIALAVLTPLPYLDGVVGWPYLVLALPAAAVILLASVL
AVAGSWDAGKAQRVVKVGMLLGLLAFLASLL

Sequences:

>Translated_271_residues
MRAYLELARPINCAMAALGVVVGELIAGARLDVGAVLAPVVAAVVCAGGNAINDYFDAEVDAVNRPDRPIPSGRVSPRSA
RMFALGCFAVGVGMATVINRMCLAIAALNSVLLYLYSWRLKGTPLIGNVMVSYLVGSCFLFGAAVGQRPAPAVWLFLLAF
LANLVREILKDLEDVEGDAALGLKTLPIAYGEGVALRVATVFAIALAVLTPLPYLDGVVGWPYLVLALPAAAVILLASVL
AVAGSWDAGKAQRVVKVGMLLGLLAFLASLL
>Mature_271_residues
MRAYLELARPINCAMAALGVVVGELIAGARLDVGAVLAPVVAAVVCAGGNAINDYFDAEVDAVNRPDRPIPSGRVSPRSA
RMFALGCFAVGVGMATVINRMCLAIAALNSVLLYLYSWRLKGTPLIGNVMVSYLVGSCFLFGAAVGQRPAPAVWLFLLAF
LANLVREILKDLEDVEGDAALGLKTLPIAYGEGVALRVATVFAIALAVLTPLPYLDGVVGWPYLVLALPAAAVILLASVL
AVAGSWDAGKAQRVVKVGMLLGLLAFLASLL

Specific function: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesi

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. DGGGP synthase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DGGGP_METKA (Q8TWS9)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614236.1
- ProteinModelPortal:   Q8TWS9
- GeneID:   1477054
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0953
- NMPDR:   fig|190192.1.peg.949
- HOGENOM:   HBG667825
- OMA:   EVDRIND
- BioCyc:   MKAN190192:MK0953-MONOMER
- HAMAP:   MF_01286
- InterPro:   IPR000537

Pfam domain/function: PF01040 UbiA

EC number: =2.5.1.42

Molecular weight: Translated: 28174; Mature: 28174

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd6a06bc)-; HASH(0xcab023c)-; HASH(0xdc23b88)-; HASH(0xd8d2514)-; HASH(0xc9c7ecc)-; HASH(0xd914ef4)-; HASH(0xd217ba4)-; HASH(0xd3e7570)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYLELARPINCAMAALGVVVGELIAGARLDVGAVLAPVVAAVVCAGGNAINDYFDAEV
CCCHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCHH
DAVNRPDRPIPSGRVSPRSARMFALGCFAVGVGMATVINRMCLAIAALNSVLLYLYSWRL
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KGTPLIGNVMVSYLVGSCFLFGAAVGQRPAPAVWLFLLAFLANLVREILKDLEDVEGDAA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LGLKTLPIAYGEGVALRVATVFAIALAVLTPLPYLDGVVGWPYLVLALPAAAVILLASVL
CCCHHCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAGSWDAGKAQRVVKVGMLLGLLAFLASLL
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure
MRAYLELARPINCAMAALGVVVGELIAGARLDVGAVLAPVVAAVVCAGGNAINDYFDAEV
CCCHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCHH
DAVNRPDRPIPSGRVSPRSARMFALGCFAVGVGMATVINRMCLAIAALNSVLLYLYSWRL
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KGTPLIGNVMVSYLVGSCFLFGAAVGQRPAPAVWLFLLAFLANLVREILKDLEDVEGDAA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LGLKTLPIAYGEGVALRVATVFAIALAVLTPLPYLDGVVGWPYLVLALPAAAVILLASVL
CCCHHCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAGSWDAGKAQRVVKVGMLLGLLAFLASLL
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11930014