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The map label for this gene is rio2 [H]

Identifier: 20094112

GI number: 20094112

Start: 631691

End: 632797

Strand: Direct

Name: rio2 [H]

Synonym: MK0674

Alternate gene names: 20094112

Gene position: 631691-632797 (Clockwise)

Preceding gene: 20094111

Following gene: 20094113

Centisome position: 37.27

GC content: 61.88

Gene sequence:

>1107_bases
GTGGCAGGAGACAACGAAGCGACCGAAGTCGACAAGCGCGATATCGCCCTACTCCGCGCCTTAGAGGGCCTGAGCAGGGC
CTTCGAGTGGGTTCCCGAGGACAAGCTGCTGGAACGGTTGCCGATGGATTACTCGGAGCTGGCAACCCGGCTGGAGAAGC
TGGATTCCCTGGGGCTGATCGATTACCGGTACATACCGACGTACCAGACCTACGCCGCCAGGATGAAGGAGCGGGCCTAC
GACACCCTCGCTCTGTGGGACATGAAGAAGCACGACGTCTACGAGCGGCTCGGAACGATCATAGGCGAGGGCAAAGAGGC
GACGATCGTGAACGCGAAGGACCCTGAGGACGAGTGGGTGGCCATCAAACTGCACAGGTACCACGCCCCGGAATTCAGGA
GGATCAAGAAGACGCTCGCGTACGCCGCCGTGAAGGTTCGCGGGGAAGAACTTCGGGTGGACGACCACCGCATCGACGTA
CCGCGCGCCAAGGCCCAGGTCGAGATGAAGGTGCTCCAGCGCCTCCACTCCAAGGGGTTCCCCGTACCGGGGCCCCGAGC
CATCAACCGTCACGCGGTCGCCATGGACATGATCGAGGGGCACGCCCCGGGTATACCGGCCCCACTGCTCGCCAAGATCA
AGGTTAAGAACCCCGAAGAGGCCCTCGAGGTTATCCTGGAGGACTACCGGGAGATCGTCCTGGAGGGCCACTATGTCCAC
GGCGACTTCAGCGAGCACAACATCCTGGTTACACCTGACGGCGAACTGTACTACGTCGACTGGCCTCAGGCCGTGCCGAT
CGAGCACCCTTCCGCACCGAAGCTCTGCTACCGCGACCTCAAGAACGTAATCGAGCATTTCAGGCGTAAGTACAGGATCC
GCGTCCCCGACCCGAAGGAAGTGTACGACGAGATAGCGGACGACCTCCAGTCGCTGATGGAGGAGAAGAAGGAGGAGTAC
GAACGGCACAAGAAAGCCGCCGAGAGAACCCTCGAGAGGTTCGAGGAGAGCGTCGAGCGGGTGGAAGGTAAGCGTGAAGG
TCGTAAGGCCGGACCGACGGAGGACGAGGAGGACAGGGTTCCCGGAGGTGGTGATGGCGGAGGGTAA

Upstream 100 bases:

>100_bases
GTCGCGGTAATCGAGCGTCGCCACTGACAATTTAGTGTACGACCGTCACCCTCCGAGTGGGACTTAATCACGTCCACCTC
CACTCTCTGCGGGTGATCAC

Downstream 100 bases:

>100_bases
AACCCCCGAGCAGGTCTCGGAGGCCCTGGAGGCGCTCCTACGGAGCGAGGGGATCGCGATAGCGTCCCGCGTCGATCCGG
AGCTCCTCGACGACCTGGAG

Product: fused RIO1-like serine/threonine protein kinase/DNA-binding HTH domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MAGDNEATEVDKRDIALLRALEGLSRAFEWVPEDKLLERLPMDYSELATRLEKLDSLGLIDYRYIPTYQTYAARMKERAY
DTLALWDMKKHDVYERLGTIIGEGKEATIVNAKDPEDEWVAIKLHRYHAPEFRRIKKTLAYAAVKVRGEELRVDDHRIDV
PRAKAQVEMKVLQRLHSKGFPVPGPRAINRHAVAMDMIEGHAPGIPAPLLAKIKVKNPEEALEVILEDYREIVLEGHYVH
GDFSEHNILVTPDGELYYVDWPQAVPIEHPSAPKLCYRDLKNVIEHFRRKYRIRVPDPKEVYDEIADDLQSLMEEKKEEY
ERHKKAAERTLERFEESVERVEGKREGRKAGPTEDEEDRVPGGGDGGG

Sequences:

>Translated_368_residues
MAGDNEATEVDKRDIALLRALEGLSRAFEWVPEDKLLERLPMDYSELATRLEKLDSLGLIDYRYIPTYQTYAARMKERAY
DTLALWDMKKHDVYERLGTIIGEGKEATIVNAKDPEDEWVAIKLHRYHAPEFRRIKKTLAYAAVKVRGEELRVDDHRIDV
PRAKAQVEMKVLQRLHSKGFPVPGPRAINRHAVAMDMIEGHAPGIPAPLLAKIKVKNPEEALEVILEDYREIVLEGHYVH
GDFSEHNILVTPDGELYYVDWPQAVPIEHPSAPKLCYRDLKNVIEHFRRKYRIRVPDPKEVYDEIADDLQSLMEEKKEEY
ERHKKAAERTLERFEESVERVEGKREGRKAGPTEDEEDRVPGGGDGGG
>Mature_367_residues
AGDNEATEVDKRDIALLRALEGLSRAFEWVPEDKLLERLPMDYSELATRLEKLDSLGLIDYRYIPTYQTYAARMKERAYD
TLALWDMKKHDVYERLGTIIGEGKEATIVNAKDPEDEWVAIKLHRYHAPEFRRIKKTLAYAAVKVRGEELRVDDHRIDVP
RAKAQVEMKVLQRLHSKGFPVPGPRAINRHAVAMDMIEGHAPGIPAPLLAKIKVKNPEEALEVILEDYREIVLEGHYVHG
DFSEHNILVTPDGELYYVDWPQAVPIEHPSAPKLCYRDLKNVIEHFRRKYRIRVPDPKEVYDEIADDLQSLMEEKKEEYE
RHKKAAERTLERFEESVERVEGKREGRKAGPTEDEEDRVPGGGDGGG

Specific function: Unknown

COG id: COG0478

COG function: function code T; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI229331967, Length=287, Percent_Identity=28.9198606271777, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI229331971, Length=287, Percent_Identity=28.9198606271777, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI23510356, Length=228, Percent_Identity=27.1929824561404, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI22325377, Length=237, Percent_Identity=26.5822784810127, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32564178, Length=260, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17556977, Length=270, Percent_Identity=27.037037037037, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115532073, Length=234, Percent_Identity=28.6324786324786, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324122, Length=287, Percent_Identity=27.5261324041812, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24649986, Length=299, Percent_Identity=28.7625418060201, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24662811, Length=263, Percent_Identity=28.1368821292776, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356879, Length=263, Percent_Identity=28.1368821292776, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR015285
- InterPro:   IPR000687
- InterPro:   IPR018935 [H]

Pfam domain/function: PF01163 RIO1; PF09202 Rio2_N [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 42424; Mature: 42292

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00109 PROTEIN_KINASE_TYR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGDNEATEVDKRDIALLRALEGLSRAFEWVPEDKLLERLPMDYSELATRLEKLDSLGLI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCE
DYRYIPTYQTYAARMKERAYDTLALWDMKKHDVYERLGTIIGEGKEATIVNAKDPEDEWV
EEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
AIKLHRYHAPEFRRIKKTLAYAAVKVRGEELRVDDHRIDVPRAKAQVEMKVLQRLHSKGF
EEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
PVPGPRAINRHAVAMDMIEGHAPGIPAPLLAKIKVKNPEEALEVILEDYREIVLEGHYVH
CCCCCCHHCHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEE
GDFSEHNILVTPDGELYYVDWPQAVPIEHPSAPKLCYRDLKNVIEHFRRKYRIRVPDPKE
CCCCCCEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VYDEIADDLQSLMEEKKEEYERHKKAAERTLERFEESVERVEGKREGRKAGPTEDEEDRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PGGGDGGG
CCCCCCCC
>Mature Secondary Structure 
AGDNEATEVDKRDIALLRALEGLSRAFEWVPEDKLLERLPMDYSELATRLEKLDSLGLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCE
DYRYIPTYQTYAARMKERAYDTLALWDMKKHDVYERLGTIIGEGKEATIVNAKDPEDEWV
EEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
AIKLHRYHAPEFRRIKKTLAYAAVKVRGEELRVDDHRIDVPRAKAQVEMKVLQRLHSKGF
EEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
PVPGPRAINRHAVAMDMIEGHAPGIPAPLLAKIKVKNPEEALEVILEDYREIVLEGHYVH
CCCCCCHHCHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEE
GDFSEHNILVTPDGELYYVDWPQAVPIEHPSAPKLCYRDLKNVIEHFRRKYRIRVPDPKE
CCCCCCEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
VYDEIADDLQSLMEEKKEEYERHKKAAERTLERFEESVERVEGKREGRKAGPTEDEEDRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PGGGDGGG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]