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The map label for this gene is apt

Identifier: 20094048

GI number: 20094048

Start: 568264

End: 568827

Strand: Direct

Name: apt

Synonym: MK0610

Alternate gene names: 20094048

Gene position: 568264-568827 (Clockwise)

Preceding gene: 20094047

Following gene: 20094050

Centisome position: 33.53

GC content: 60.46

Gene sequence:

>564_bases
ATGCTCCTCGAGAAGTCCTTGGAGGAGGCACCTGTGGTGAACCGTAACGGGTACTGGTACTTCATTCACCCTATTACGGA
CGGTGTCCCGGAGCTCCCGCCCGAGTTACTCCGTGAAGTCGCGTACAGGATCGTCCGCGCCTTAGACAGCACGGACTTCG
ATAAGATCGTGTGTGTAGAGGCCATGGGGATCCACCTGGGAGCCCTCCTATCAGACATGCTGGATCGTCCGTTGGTCATA
GTCAGGAAACGGGAGTACGGGTTGGACGGCGAGGTGGAGATTACCCAGGAGAAAGGGTACGGTGTGGAGAAGCTGTACCT
GAACGGCGTGTCCGAAGGGGACAGAGTCGTGGTCGTGGACGACGTGATCAGCACGGGTGGGACCCTCGTCGGGTTGATCA
ACGCCCTCGACGACGTCGGGGCCGAGATCGAGGACGTGGTGGTCGTGGTGGCCAGGGGAGGCCTCGATAGGGTCAGGGAG
GAAACCGGGGTCGACGTCAAGTACTTGGTCCGAGTGGAGGTGTCGGAGGATGGTGTGAGCGTCGTCGAGTCGCGCTATCG
CTGA

Upstream 100 bases:

>100_bases
CCCGTTCAGGCTGGCGTTATGGCCGTCATGGCTATCTCTGACGCCGGAGTCTTCGACCTTTCCAGGGTTCGAGGTAGGAA
GTTCTGATGGGGGTGCTTCC

Downstream 100 bases:

>100_bases
TCTTTGAGAACGCGGATCCACTCCCCTTCCGCCTCCCTGGAGCTTCCGACGATCGCTATCAGTTCCCCCGAGTTCCTCTC
CCGCTCGAGCTTTCCGGAGA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MLLEKSLEEAPVVNRNGYWYFIHPITDGVPELPPELLREVAYRIVRALDSTDFDKIVCVEAMGIHLGALLSDMLDRPLVI
VRKREYGLDGEVEITQEKGYGVEKLYLNGVSEGDRVVVVDDVISTGGTLVGLINALDDVGAEIEDVVVVVARGGLDRVRE
ETGVDVKYLVRVEVSEDGVSVVESRYR

Sequences:

>Translated_187_residues
MLLEKSLEEAPVVNRNGYWYFIHPITDGVPELPPELLREVAYRIVRALDSTDFDKIVCVEAMGIHLGALLSDMLDRPLVI
VRKREYGLDGEVEITQEKGYGVEKLYLNGVSEGDRVVVVDDVISTGGTLVGLINALDDVGAEIEDVVVVVARGGLDRVRE
ETGVDVKYLVRVEVSEDGVSVVESRYR
>Mature_187_residues
MLLEKSLEEAPVVNRNGYWYFIHPITDGVPELPPELLREVAYRIVRALDSTDFDKIVCVEAMGIHLGALLSDMLDRPLVI
VRKREYGLDGEVEITQEKGYGVEKLYLNGVSEGDRVVVVDDVISTGGTLVGLINALDDVGAEIEDVVVVVARGGLDRVRE
ETGVDVKYLVRVEVSEDGVSVVESRYR

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_METKA (Q8TXQ0)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613895.1
- ProteinModelPortal:   Q8TXQ0
- SMR:   Q8TXQ0
- GeneID:   1476711
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0610
- NMPDR:   fig|190192.1.peg.608
- HOGENOM:   HBG496859
- OMA:   TGYSKGE
- ProtClustDB:   PRK02304
- BioCyc:   MKAN190192:MK0610-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20687; Mature: 20687

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLEKSLEEAPVVNRNGYWYFIHPITDGVPELPPELLREVAYRIVRALDSTDFDKIVCVE
CCCCCCHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEHH
AMGIHLGALLSDMLDRPLVIVRKREYGLDGEVEITQEKGYGVEKLYLNGVSEGDRVVVVD
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEEEEE
DVISTGGTLVGLINALDDVGAEIEDVVVVVARGGLDRVREETGVDVKYLVRVEVSEDGVS
CHHHCCCHHHHHHHHHHHHCCCHHHEEEEEECCCHHHHHHHHCCCEEEEEEEEECCCCHH
VVESRYR
HHHHCCC
>Mature Secondary Structure
MLLEKSLEEAPVVNRNGYWYFIHPITDGVPELPPELLREVAYRIVRALDSTDFDKIVCVE
CCCCCCHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEHH
AMGIHLGALLSDMLDRPLVIVRKREYGLDGEVEITQEKGYGVEKLYLNGVSEGDRVVVVD
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEEEEE
DVISTGGTLVGLINALDDVGAEIEDVVVVVARGGLDRVREETGVDVKYLVRVEVSEDGVS
CHHHCCCHHHHHHHHHHHHCCCHHHEEEEEECCCHHHHHHHHCCCEEEEEEEEECCCCHH
VVESRYR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014