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The map label for this gene is galE [C]

Identifier: 197120086

GI number: 197120086

Start: 4252477

End: 4253343

Strand: Direct

Name: galE [C]

Synonym: Gbem_3725

Alternate gene names: 197120086

Gene position: 4252477-4253343 (Clockwise)

Preceding gene: 197120085

Following gene: 197120087

Centisome position: 92.14

GC content: 67.36

Gene sequence:

>867_bases
ATGACCGTGCACAACGCCCAGAAGCAGGTCCTCGTCACCGGCGCCACCGGCTTCATCGGCCGGCACGCCGTCTCTCTCCT
GGAGAGCCGCGGCATCGCGACCCACAGCTGCGCCCGCTCCACCGGCTGCGACCTCGAACAAAACGGCGCCCTCGCCCCCT
TCCAGGGGCGGGGGATCACCCACGTCATCCACCTTGGGGGGCGCACCTTCGTCCCTCACAGCTGGGAAGACCCGGGGGCC
TTCTACCGCGCCAACACGCTCGGGACCCAGCAGCTGCTCGATTTCTGCCGCATAAGCGGCGCAAGGCTCGTGTACGTCAG
CGCCTACGTCTACGGCGTGCCGCACACCCTCCCCATCGCAGAATCGCACCCGGTAGCCCCGAACACCCCCTACAACCACT
CGAAATGGCTCGCGGAAGAGCTCTGCCGCTTCTACGCCGATCACTTCGAGGTCCCGGTCACCGTGCTGCGCCCCTTCAAC
ATCTTCGGCCCCGGCCAGGGGGAGGATTTCCTGATCCCGACCATCCTGAAGCAGGCCAAAAGCGGCGGGACGATCACGGT
GAAGGACGCGGCACCCAGGCGCGACTACCTCCACGTGGACGACCTCGCCGAGGCGCTGCTCCTGGCCCTCGACCTGGAGC
CCCGCTTCTCGCTCTTCAACGTCGGCTCGGGACGGTCGATCTCGGTGGGGGAGCTTTTGGACATGGCGGTCCGCTACTCC
CCGCGCCCGCTCTGCTGGCAAGCGACGGGCGAGATCCGGGTGAACGAGGTCCCCGACACCGTCGCCGACATTTCGGCCAT
CACCAGGGCGCTCGGCTGGCTTCCCAGGCGCACCCTGGAGCAATTCCTGAAATCGGAGCTCGCATGA

Upstream 100 bases:

>100_bases
GCTACCTCCCGAGGCAGACCGAGAGCACGGAAGCCGCCACCGTGAACGGCGTCAGCGTCGCCGTCAACAACTACGTAAAC
CGCTCCCAGACCATCGGCTC

Downstream 100 bases:

>100_bases
AACTTTCCTTCGCACCGAGACAGCCGATCTACATCATCGCCGAGATCGGCGGCAACTTCACCACCTTCGAGGAGGCAAAG
GCGCTGGTCGATGCCGCCGC

Product: NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTVHNAQKQVLVTGATGFIGRHAVSLLESRGIATHSCARSTGCDLEQNGALAPFQGRGITHVIHLGGRTFVPHSWEDPGA
FYRANTLGTQQLLDFCRISGARLVYVSAYVYGVPHTLPIAESHPVAPNTPYNHSKWLAEELCRFYADHFEVPVTVLRPFN
IFGPGQGEDFLIPTILKQAKSGGTITVKDAAPRRDYLHVDDLAEALLLALDLEPRFSLFNVGSGRSISVGELLDMAVRYS
PRPLCWQATGEIRVNEVPDTVADISAITRALGWLPRRTLEQFLKSELA

Sequences:

>Translated_288_residues
MTVHNAQKQVLVTGATGFIGRHAVSLLESRGIATHSCARSTGCDLEQNGALAPFQGRGITHVIHLGGRTFVPHSWEDPGA
FYRANTLGTQQLLDFCRISGARLVYVSAYVYGVPHTLPIAESHPVAPNTPYNHSKWLAEELCRFYADHFEVPVTVLRPFN
IFGPGQGEDFLIPTILKQAKSGGTITVKDAAPRRDYLHVDDLAEALLLALDLEPRFSLFNVGSGRSISVGELLDMAVRYS
PRPLCWQATGEIRVNEVPDTVADISAITRALGWLPRRTLEQFLKSELA
>Mature_287_residues
TVHNAQKQVLVTGATGFIGRHAVSLLESRGIATHSCARSTGCDLEQNGALAPFQGRGITHVIHLGGRTFVPHSWEDPGAF
YRANTLGTQQLLDFCRISGARLVYVSAYVYGVPHTLPIAESHPVAPNTPYNHSKWLAEELCRFYADHFEVPVTVLRPFNI
FGPGQGEDFLIPTILKQAKSGGTITVKDAAPRRDYLHVDDLAEALLLALDLEPRFSLFNVGSGRSISVGELLDMAVRYSP
RPLCWQATGEIRVNEVPDTVADISAITRALGWLPRRTLEQFLKSELA

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=331, Percent_Identity=29.0030211480363, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI56118217, Length=331, Percent_Identity=29.0030211480363, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI189083684, Length=331, Percent_Identity=29.0030211480363, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI7657641, Length=318, Percent_Identity=25.1572327044025, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI42516563, Length=304, Percent_Identity=25.3289473684211, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786974, Length=324, Percent_Identity=27.4691358024691, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI48994969, Length=325, Percent_Identity=25.2307692307692, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788353, Length=335, Percent_Identity=25.3731343283582, Blast_Score=75, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=332, Percent_Identity=28.9156626506024, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19923002, Length=332, Percent_Identity=26.8072289156627, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356223, Length=315, Percent_Identity=24.1269841269841, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 31612; Mature: 31481

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVHNAQKQVLVTGATGFIGRHAVSLLESRGIATHSCARSTGCDLEQNGALAPFQGRGIT
CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCE
HVIHLGGRTFVPHSWEDPGAFYRANTLGTQQLLDFCRISGARLVYVSAYVYGVPHTLPIA
EEEEECCCEECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCC
ESHPVAPNTPYNHSKWLAEELCRFYADHFEVPVTVLRPFNIFGPGQGEDFLIPTILKQAK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHHHHHCC
SGGTITVKDAAPRRDYLHVDDLAEALLLALDLEPRFSLFNVGSGRSISVGELLDMAVRYS
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCC
PRPLCWQATGEIRVNEVPDTVADISAITRALGWLPRRTLEQFLKSELA
CCCEEEECCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TVHNAQKQVLVTGATGFIGRHAVSLLESRGIATHSCARSTGCDLEQNGALAPFQGRGIT
CCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCE
HVIHLGGRTFVPHSWEDPGAFYRANTLGTQQLLDFCRISGARLVYVSAYVYGVPHTLPIA
EEEEECCCEECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCC
ESHPVAPNTPYNHSKWLAEELCRFYADHFEVPVTVLRPFNIFGPGQGEDFLIPTILKQAK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHHHHHCC
SGGTITVKDAAPRRDYLHVDDLAEALLLALDLEPRFSLFNVGSGRSISVGELLDMAVRYS
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCC
PRPLCWQATGEIRVNEVPDTVADISAITRALGWLPRRTLEQFLKSELA
CCCEEEECCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]