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The map label for this gene is pgi

Identifier: 197119779

GI number: 197119779

Start: 3933014

End: 3934606

Strand: Direct

Name: pgi

Synonym: Gbem_3417

Alternate gene names: 197119779

Gene position: 3933014-3934606 (Clockwise)

Preceding gene: 197119771

Following gene: 197119780

Centisome position: 85.22

GC content: 63.53

Gene sequence:

>1593_bases
ATGCAGAAACAGCAGCTTTGGGAGCGGTACAAGAACCTGCTCTACCATGACGCCGAACTAGAGCTGAGCGTCGACACCAG
CCGTATCGATTTCCCGGAGGGGTTCCTGGAGAAGATGGACCCGCGACTGCAGCAGGCGTACCAAGAGATGGAAGCGCTGG
AACAAGGTGCAGTCGCCAACCCGGACGAACATCGGATGGTGGGGCACTACTGGCTCAGGGCTCCCGAACTGGCACCGGAG
GCGACCCTTGCCGAGGAGATAACGTCGACACTGGCCGCTATCGAGGCGTTTGCCTCCTCAGTGCACGGGGGGAACATCGC
CGCCCCCGACGGCCACCGCTTCACCGACCTTTTGATCATCGGCATCGGAGGCTCCGCGCTGGGGCCTCAGTTCCTCGCCG
ACAGCCTGGGAGGGCCCAAGGATCTCCTGCGGATCTGGTTCTTCGACAACACCGACCCGGACGGTATGGACAAGGTCCTC
TCCGGGATCGGCGCCGCTCTGAAACAGACCCTGGTGGTGGTCATATCCAAGAGCGGCGGCACCAAAGAGACCCGCAACGG
AATGCTGGAGGCGTGCCAGGCGTTCGAGCGCGCCGGGCTGCATTTCGCCGGGCACGCCGTCGCCGTAACCGGCAGCGGCA
GCGAGCTGGACAGGACTGCATCCAGGGAAAACTGGCTCGGGGTCTTCCCGATGTGGGACTGGGTCGGCGGGCGCACCTCG
GTCACCTCAGCGGTGGGGCTCCTCCCCGCTGCCCTGCAAGGGATCGACGTGGACCGGTTGCTCGCCGGAGCGCGCGCCTG
CGACCAAAAAACCCGTTCCCGGGTGACACGGGAAAACCCCGCCGCACTCCTAGCCCTCTCCTGGTTCCACGCCACCCAGG
GGAAAGGCACCCGTGACATGGTGCTGCTCCCCTACAAGGACAGGCTTCTTTTGTTCTCCCGCTACCTGCAGCAGCTCATC
ATGGAGTCCCTCGGCAAGGGGTTGGACCGCGACGGGAAAGAGGTGCTGCAGGGGATCGCCGTTTACGGCAACAAGGGCTC
CACCGACCAGCACGCCTACGTGCAGCAGCTGCGGGAAGGGGTGCACAACTTCTTCGTCACCTTCATCGAGGTGCTCAAGG
ACCGCCAGGGCCCATCCATGGAAGTGGAGCCTGGTGCGACCTCCGGCGATTATCTCTCGGGCTTTTTCCAGGGAACGCGA
TCCGCGCTCTATGAAAAAGGACGGGAATCGGTTACTATCACCGTCCGCGAGCTCTCCCCTGCAAGCATCGGTGCCCTTAT
CGCCCTTTACGAGCGCGCGGTGGGGCTGTACGCCTCGCTCGTCAATGTTAACGCCTACCACCAGCCGGGAGTCGAGGCAG
GGAAGGAGGCCGCCGGCGCCGTGCTCAAACTGCAGGGGGAGATCATGGAGTTGCTCAGGCGTCAGCCGAACCGGGACTTC
ACCGGTGAGGAGATGGCGCTGGCACTGGCGCGCCCGGAAGAGGTGGAGACCACCTTCATGATCTTGAGGCACCTTGCCGC
CAACGGCGACCACGGGGTGAGCGTCACCGAAAAGGACAAGATCTGGGAAAACAAGTACCGCAGCAAAGATTAG

Upstream 100 bases:

>100_bases
CCGCTACGCAGACTTGAATAAAAACTAATACATGCTATCATCCCCCGACGCACATGAGAATCGACCTGCCACCAGCCTAA
CCAAACGCAGCGGAGGGGAC

Downstream 100 bases:

>100_bases
CAAGGTAGGGGAACAGATGAAGACGGTAGATCTGAGAAGCGACACGGTGACATCGCCGTCGCAGGCGATGCGTCGGGAAA
TGGCGAATGCCCCGGTAGGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MQKQQLWERYKNLLYHDAELELSVDTSRIDFPEGFLEKMDPRLQQAYQEMEALEQGAVANPDEHRMVGHYWLRAPELAPE
ATLAEEITSTLAAIEAFASSVHGGNIAAPDGHRFTDLLIIGIGGSALGPQFLADSLGGPKDLLRIWFFDNTDPDGMDKVL
SGIGAALKQTLVVVISKSGGTKETRNGMLEACQAFERAGLHFAGHAVAVTGSGSELDRTASRENWLGVFPMWDWVGGRTS
VTSAVGLLPAALQGIDVDRLLAGARACDQKTRSRVTRENPAALLALSWFHATQGKGTRDMVLLPYKDRLLLFSRYLQQLI
MESLGKGLDRDGKEVLQGIAVYGNKGSTDQHAYVQQLREGVHNFFVTFIEVLKDRQGPSMEVEPGATSGDYLSGFFQGTR
SALYEKGRESVTITVRELSPASIGALIALYERAVGLYASLVNVNAYHQPGVEAGKEAAGAVLKLQGEIMELLRRQPNRDF
TGEEMALALARPEEVETTFMILRHLAANGDHGVSVTEKDKIWENKYRSKD

Sequences:

>Translated_530_residues
MQKQQLWERYKNLLYHDAELELSVDTSRIDFPEGFLEKMDPRLQQAYQEMEALEQGAVANPDEHRMVGHYWLRAPELAPE
ATLAEEITSTLAAIEAFASSVHGGNIAAPDGHRFTDLLIIGIGGSALGPQFLADSLGGPKDLLRIWFFDNTDPDGMDKVL
SGIGAALKQTLVVVISKSGGTKETRNGMLEACQAFERAGLHFAGHAVAVTGSGSELDRTASRENWLGVFPMWDWVGGRTS
VTSAVGLLPAALQGIDVDRLLAGARACDQKTRSRVTRENPAALLALSWFHATQGKGTRDMVLLPYKDRLLLFSRYLQQLI
MESLGKGLDRDGKEVLQGIAVYGNKGSTDQHAYVQQLREGVHNFFVTFIEVLKDRQGPSMEVEPGATSGDYLSGFFQGTR
SALYEKGRESVTITVRELSPASIGALIALYERAVGLYASLVNVNAYHQPGVEAGKEAAGAVLKLQGEIMELLRRQPNRDF
TGEEMALALARPEEVETTFMILRHLAANGDHGVSVTEKDKIWENKYRSKD
>Mature_530_residues
MQKQQLWERYKNLLYHDAELELSVDTSRIDFPEGFLEKMDPRLQQAYQEMEALEQGAVANPDEHRMVGHYWLRAPELAPE
ATLAEEITSTLAAIEAFASSVHGGNIAAPDGHRFTDLLIIGIGGSALGPQFLADSLGGPKDLLRIWFFDNTDPDGMDKVL
SGIGAALKQTLVVVISKSGGTKETRNGMLEACQAFERAGLHFAGHAVAVTGSGSELDRTASRENWLGVFPMWDWVGGRTS
VTSAVGLLPAALQGIDVDRLLAGARACDQKTRSRVTRENPAALLALSWFHATQGKGTRDMVLLPYKDRLLLFSRYLQQLI
MESLGKGLDRDGKEVLQGIAVYGNKGSTDQHAYVQQLREGVHNFFVTFIEVLKDRQGPSMEVEPGATSGDYLSGFFQGTR
SALYEKGRESVTITVRELSPASIGALIALYERAVGLYASLVNVNAYHQPGVEAGKEAAGAVLKLQGEIMELLRRQPNRDF
TGEEMALALARPEEVETTFMILRHLAANGDHGVSVTEKDKIWENKYRSKD

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=456, Percent_Identity=28.5087719298246, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI296080693, Length=375, Percent_Identity=27.7333333333333, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790457, Length=460, Percent_Identity=30.2173913043478, Blast_Score=166, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71996708, Length=441, Percent_Identity=28.5714285714286, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71996703, Length=441, Percent_Identity=28.5714285714286, Blast_Score=142, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319673, Length=453, Percent_Identity=28.0353200883002, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24651916, Length=496, Percent_Identity=28.6290322580645, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24651914, Length=496, Percent_Identity=28.6290322580645, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17737445, Length=496, Percent_Identity=28.6290322580645, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_GEOBB (B5EBB8)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002140206.1
- ProteinModelPortal:   B5EBB8
- SMR:   B5EBB8
- GeneID:   6780279
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_3417
- HOGENOM:   HBG285902
- OMA:   RTSITSA
- ProtClustDB:   PRK14096
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 58162; Mature: 58162

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 351-351 ACT_SITE 455-455

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKQQLWERYKNLLYHDAELELSVDTSRIDFPEGFLEKMDPRLQQAYQEMEALEQGAVAN
CCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCC
PDEHRMVGHYWLRAPELAPEATLAEEITSTLAAIEAFASSVHGGNIAAPDGHRFTDLLII
CHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEE
GIGGSALGPQFLADSLGGPKDLLRIWFFDNTDPDGMDKVLSGIGAALKQTLVVVISKSGG
ECCCCCCCHHHHHHHCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEEECCCC
TKETRNGMLEACQAFERAGLHFAGHAVAVTGSGSELDRTASRENWLGVFPMWDWVGGRTS
CCHHHHHHHHHHHHHHHCCCEEECCEEEEECCCCHHHHHHCCCCCEEECCHHHHCCCCHH
VTSAVGLLPAALQGIDVDRLLAGARACDQKTRSRVTRENPAALLALSWFHATQGKGTRDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCCCE
VLLPYKDRLLLFSRYLQQLIMESLGKGLDRDGKEVLQGIAVYGNKGSTDQHAYVQQLREG
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
VHNFFVTFIEVLKDRQGPSMEVEPGATSGDYLSGFFQGTRSALYEKGRESVTITVRELSP
HHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
ASIGALIALYERAVGLYASLVNVNAYHQPGVEAGKEAAGAVLKLQGEIMELLRRQPNRDF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHCHHHEEHHHHHHHHHCCCCCCC
TGEEMALALARPEEVETTFMILRHLAANGDHGVSVTEKDKIWENKYRSKD
CCHHHHEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MQKQQLWERYKNLLYHDAELELSVDTSRIDFPEGFLEKMDPRLQQAYQEMEALEQGAVAN
CCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCC
PDEHRMVGHYWLRAPELAPEATLAEEITSTLAAIEAFASSVHGGNIAAPDGHRFTDLLII
CHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEE
GIGGSALGPQFLADSLGGPKDLLRIWFFDNTDPDGMDKVLSGIGAALKQTLVVVISKSGG
ECCCCCCCHHHHHHHCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEEECCCC
TKETRNGMLEACQAFERAGLHFAGHAVAVTGSGSELDRTASRENWLGVFPMWDWVGGRTS
CCHHHHHHHHHHHHHHHCCCEEECCEEEEECCCCHHHHHHCCCCCEEECCHHHHCCCCHH
VTSAVGLLPAALQGIDVDRLLAGARACDQKTRSRVTRENPAALLALSWFHATQGKGTRDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCCCCCCCE
VLLPYKDRLLLFSRYLQQLIMESLGKGLDRDGKEVLQGIAVYGNKGSTDQHAYVQQLREG
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
VHNFFVTFIEVLKDRQGPSMEVEPGATSGDYLSGFFQGTRSALYEKGRESVTITVRELSP
HHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
ASIGALIALYERAVGLYASLVNVNAYHQPGVEAGKEAAGAVLKLQGEIMELLRRQPNRDF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHCHHHEEHHHHHHHHHCCCCCCC
TGEEMALALARPEEVETTFMILRHLAANGDHGVSVTEKDKIWENKYRSKD
CCHHHHEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA