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The map label for this gene is proC [H]

Identifier: 197119747

GI number: 197119747

Start: 3890968

End: 3891771

Strand: Direct

Name: proC [H]

Synonym: Gbem_3383

Alternate gene names: 197119747

Gene position: 3890968-3891771 (Clockwise)

Preceding gene: 197119738

Following gene: 197119748

Centisome position: 84.31

GC content: 63.56

Gene sequence:

>804_bases
ATGGACAAGAGAACAGGTTTCATCGGGGGCGGCAATATGGCCGAGGCGATCATCAAGGGCCTAGTCGCCGGAGGAGTCCC
GGCAGGAGAATTGACCGTGTCCGAACCTTCGGAGCCGCGCAGGAAGCTGCTGGCCGAGAGGTACGGGGTCAAGGCCATCA
ACGACAACAAGGCACTGATCCAGATGAGCGACACCATCGTCCTCGCCGTCAAGCCGCAGGTAGCAGGCCAGGTGCTGGGA
GCGATAGGGACCGGGTTCGTCGACAAGCTGTTCATCTCCATCATGGCCGGCGTTAAGAGCGCCGCCATAGAGGGCATTCT
CGGTTCCGGCGCCCGGGTGGTCCGGGTGATGCCGAACACCCCCGCCTTGGTCCTAAGCGGTGCATCCGCCCTATCCCGCG
GCGACAATGCCACCGAAGACGACCTCACCCTTGCACGCAGGATCTTCGACCTGATCGGTACCACCTGTGTGGTGGACGAG
AAGCTGCTCGATGCCGTAACCGGCGTCTCCGGCAGCGGCCCCGCCTACGTCCTCACCTTCATCGAGGCGCTAAGCGACGC
AGGGGTGAAGCACGGGCTGACGCGGGAAGTGGCGACCCAGTTGGCGACCCAGACCGTGTACGGTACGGCGAAGCTTCTTC
TTGAGACGCACGAGCATCCAGCGGTGCTGAAGAGCAACGTAGCCTCCCCGGGCGGGACCACCATTGCCGCCATGCACTCC
CTCGACCAGGACGGTTTCCGCGCCGCCACCATCAACGCCGTCGACGTCTGCGTGGCCAAATCGAAGGAACTGGGGCAAAA
GTGA

Upstream 100 bases:

>100_bases
GAGATAGTCCGGCAATGGTCTCCCCCGAGAGGAGTTAGAGATCCTCTGCCGCAGGAGACAGTCGCTGATCTGAAATTATT
GAGTAACTGGAGGCACTGGC

Downstream 100 bases:

>100_bases
GAACCAGGTCGACCGTCATAGTGCGGGGGAGGGTTCAGGGTGTCTCCTTTCGTTACCACACAACGCGCGCAGCAGCCCGC
AACCAGGTTTCAGGGTGGGT

Product: delta-1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MDKRTGFIGGGNMAEAIIKGLVAGGVPAGELTVSEPSEPRRKLLAERYGVKAINDNKALIQMSDTIVLAVKPQVAGQVLG
AIGTGFVDKLFISIMAGVKSAAIEGILGSGARVVRVMPNTPALVLSGASALSRGDNATEDDLTLARRIFDLIGTTCVVDE
KLLDAVTGVSGSGPAYVLTFIEALSDAGVKHGLTREVATQLATQTVYGTAKLLLETHEHPAVLKSNVASPGGTTIAAMHS
LDQDGFRAATINAVDVCVAKSKELGQK

Sequences:

>Translated_267_residues
MDKRTGFIGGGNMAEAIIKGLVAGGVPAGELTVSEPSEPRRKLLAERYGVKAINDNKALIQMSDTIVLAVKPQVAGQVLG
AIGTGFVDKLFISIMAGVKSAAIEGILGSGARVVRVMPNTPALVLSGASALSRGDNATEDDLTLARRIFDLIGTTCVVDE
KLLDAVTGVSGSGPAYVLTFIEALSDAGVKHGLTREVATQLATQTVYGTAKLLLETHEHPAVLKSNVASPGGTTIAAMHS
LDQDGFRAATINAVDVCVAKSKELGQK
>Mature_267_residues
MDKRTGFIGGGNMAEAIIKGLVAGGVPAGELTVSEPSEPRRKLLAERYGVKAINDNKALIQMSDTIVLAVKPQVAGQVLG
AIGTGFVDKLFISIMAGVKSAAIEGILGSGARVVRVMPNTPALVLSGASALSRGDNATEDDLTLARRIFDLIGTTCVVDE
KLLDAVTGVSGSGPAYVLTFIEALSDAGVKHGLTREVATQLATQTVYGTAKLLLETHEHPAVLKSNVASPGGTTIAAMHS
LDQDGFRAATINAVDVCVAKSKELGQK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=265, Percent_Identity=42.6415094339623, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI24797095, Length=265, Percent_Identity=42.6415094339623, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=37.8277153558052, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI21361454, Length=265, Percent_Identity=40, Blast_Score=181, Evalue=8e-46,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=42.5373134328358, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=38.2899628252788, Blast_Score=180, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=33.0960854092527, Blast_Score=134, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320861, Length=241, Percent_Identity=31.1203319502075, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=41.5730337078652, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=38.4892086330935, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=43.859649122807, Blast_Score=144, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27519; Mature: 27519

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRTGFIGGGNMAEAIIKGLVAGGVPAGELTVSEPSEPRRKLLAERYGVKAINDNKALI
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCEEECCCCEEE
QMSDTIVLAVKPQVAGQVLGAIGTGFVDKLFISIMAGVKSAAIEGILGSGARVVRVMPNT
EECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
PALVLSGASALSRGDNATEDDLTLARRIFDLIGTTCVVDEKLLDAVTGVSGSGPAYVLTF
CEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHH
IEALSDAGVKHGLTREVATQLATQTVYGTAKLLLETHEHPAVLKSNVASPGGTTIAAMHS
HHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHH
LDQDGFRAATINAVDVCVAKSKELGQK
CCCCCCEEEEHHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MDKRTGFIGGGNMAEAIIKGLVAGGVPAGELTVSEPSEPRRKLLAERYGVKAINDNKALI
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCEEECCCCEEE
QMSDTIVLAVKPQVAGQVLGAIGTGFVDKLFISIMAGVKSAAIEGILGSGARVVRVMPNT
EECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
PALVLSGASALSRGDNATEDDLTLARRIFDLIGTTCVVDEKLLDAVTGVSGSGPAYVLTF
CEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHH
IEALSDAGVKHGLTREVATQLATQTVYGTAKLLLETHEHPAVLKSNVASPGGTTIAAMHS
HHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHH
LDQDGFRAATINAVDVCVAKSKELGQK
CCCCCCEEEEHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]