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The map label for this gene is htpX-1 [H]

Identifier: 197119646

GI number: 197119646

Start: 3773486

End: 3774328

Strand: Direct

Name: htpX-1 [H]

Synonym: Gbem_3280

Alternate gene names: 197119646

Gene position: 3773486-3774328 (Clockwise)

Preceding gene: 197119645

Following gene: 197119647

Centisome position: 81.76

GC content: 63.11

Gene sequence:

>843_bases
ATGAACAGATTCAAGACTGCCGTTCTACTTACTTCTCTCACCTTGTTGATGGTAGGGCTCGGCGGAGCGATCGGGGGGCA
AGGGGGAATGTACCTGGCCTTCCTGATGGCCTTGGCCATGAACTTCTTTTCCTACTGGTTCTCGGACAAGATCGTCTTGC
GCATGTACGGCGCGCGCGAGATAAGCGAGATGGAGAACCCCGCCTTTTTCGGAATGATCCGGCGGCTCACCGTGCAGGCC
GGCCTGCCCATGCCGCGGGTCTACATCATCCCCTCGGAGAGCCCGAACGCCTTCGCCACCGGCAGAAACCCCGAGCATGC
GGCTGTGGCCGCGACCGAGGGTATCATGCGCATCCTCACCCCAGAGGAGCTGGAAGGGGTGATGGCCCACGAACTGAGCC
ACGTCGCCAACCGGGACATCCTGATCTCCACCATAGCGGCCACCATCGCCGGGGCCATTTCCATGCTGGCCAACATGGCG
CAGTGGGCGGCCATCTTCGGGCACAGAAGCGACGACGAGGAAGGCGGTGGCGTGATCGGCACCCTGGCACTAGCCATCCT
GGCGCCGATCGCCGCCATGCTGATCCAGCTTGCCGTTTCCAGATCGCGCGAGTATATGGCCGACGAAGGGGGCGCCAAGC
TCTGCGGCCACCCCCGCTCGCTCGCCAATGCGCTGAGAAAGCTGGACCAGGCCTCTCACCTGCTCCCGATGCAGGAAGCG
CGGCCGGCCACAGCACACATGTTCATCGTGAATCCCCTCACCGCGGGCGGTATCGCCAAGCTCTTTTCCACCCATCCGCC
GATGGAGGAGAGGATCGCGAGACTCGAGCAGATGGGGCGTTAG

Upstream 100 bases:

>100_bases
AGAGCATGCAAGACCTTTATCCAGTGCCGACGCGCCTGGATAAAGGTCTTTTTATTTGACCTGCCGGCTACTGTCAGTTC
GACCGCAAAGGAGGTACGTC

Downstream 100 bases:

>100_bases
AAGGAGGTTTATTTGTCTACCAGGGAAATGATGTGGGTTGCCTTCGCAGCCGTCATCACCGTCATGTTCGTGCTGGACCT
GTTCGTCTTCAACCGCAAGA

Product: membrane-bound zinc-dependent protease HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNRFKTAVLLTSLTLLMVGLGGAIGGQGGMYLAFLMALAMNFFSYWFSDKIVLRMYGAREISEMENPAFFGMIRRLTVQA
GLPMPRVYIIPSESPNAFATGRNPEHAAVAATEGIMRILTPEELEGVMAHELSHVANRDILISTIAATIAGAISMLANMA
QWAAIFGHRSDDEEGGGVIGTLALAILAPIAAMLIQLAVSRSREYMADEGGAKLCGHPRSLANALRKLDQASHLLPMQEA
RPATAHMFIVNPLTAGGIAKLFSTHPPMEERIARLEQMGR

Sequences:

>Translated_280_residues
MNRFKTAVLLTSLTLLMVGLGGAIGGQGGMYLAFLMALAMNFFSYWFSDKIVLRMYGAREISEMENPAFFGMIRRLTVQA
GLPMPRVYIIPSESPNAFATGRNPEHAAVAATEGIMRILTPEELEGVMAHELSHVANRDILISTIAATIAGAISMLANMA
QWAAIFGHRSDDEEGGGVIGTLALAILAPIAAMLIQLAVSRSREYMADEGGAKLCGHPRSLANALRKLDQASHLLPMQEA
RPATAHMFIVNPLTAGGIAKLFSTHPPMEERIARLEQMGR
>Mature_280_residues
MNRFKTAVLLTSLTLLMVGLGGAIGGQGGMYLAFLMALAMNFFSYWFSDKIVLRMYGAREISEMENPAFFGMIRRLTVQA
GLPMPRVYIIPSESPNAFATGRNPEHAAVAATEGIMRILTPEELEGVMAHELSHVANRDILISTIAATIAGAISMLANMA
QWAAIFGHRSDDEEGGGVIGTLALAILAPIAAMLIQLAVSRSREYMADEGGAKLCGHPRSLANALRKLDQASHLLPMQEA
RPATAHMFIVNPLTAGGIAKLFSTHPPMEERIARLEQMGR

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=287, Percent_Identity=32.404181184669, Blast_Score=117, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 30205; Mature: 30205

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.8 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFKTAVLLTSLTLLMVGLGGAIGGQGGMYLAFLMALAMNFFSYWFSDKIVLRMYGARE
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHH
ISEMENPAFFGMIRRLTVQAGLPMPRVYIIPSESPNAFATGRNPEHAAVAATEGIMRILT
HHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHCC
PEELEGVMAHELSHVANRDILISTIAATIAGAISMLANMAQWAAIFGHRSDDEEGGGVIG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
TLALAILAPIAAMLIQLAVSRSREYMADEGGAKLCGHPRSLANALRKLDQASHLLPMQEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHC
RPATAHMFIVNPLTAGGIAKLFSTHPPMEERIARLEQMGR
CCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNRFKTAVLLTSLTLLMVGLGGAIGGQGGMYLAFLMALAMNFFSYWFSDKIVLRMYGARE
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHH
ISEMENPAFFGMIRRLTVQAGLPMPRVYIIPSESPNAFATGRNPEHAAVAATEGIMRILT
HHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHCC
PEELEGVMAHELSHVANRDILISTIAATIAGAISMLANMAQWAAIFGHRSDDEEGGGVIG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
TLALAILAPIAAMLIQLAVSRSREYMADEGGAKLCGHPRSLANALRKLDQASHLLPMQEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHC
RPATAHMFIVNPLTAGGIAKLFSTHPPMEERIARLEQMGR
CCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA