Click here to switch to the map view.

The map label for this gene is ung [H]

Identifier: 197117200

GI number: 197117200

Start: 957817

End: 958512

Strand: Direct

Name: ung [H]

Synonym: Gbem_0808

Alternate gene names: 197117200

Gene position: 957817-958512 (Clockwise)

Preceding gene: 197117197

Following gene: 197117202

Centisome position: 20.75

GC content: 58.62

Gene sequence:

>696_bases
ATGACAACGGAAAGACAGATTCAACTGGAAGCTGGCTGGAAATCGCACTTGCTGGAGGAGTTCCAGAAGCTTTACATGTC
TGAGTTGAAGGAGTTCCTGCGCCTTGAGATAGCGCGCAAGAAGACCATCTATCCCAAGGGGAGCGAGTACTTCAACGCCT
TCAACTCCACCTCCTTTGATAAAGTGAAGGTGGTGGTGCTCGGGCAAGATCCCTACCACGGGCCGGGCCAAGCCCACGGG
CTTAGCTTCTCCGTTCCGCGCGGGGTAGATATTCCGCCTTCGCTGGTGAACATCTTCAAGGAGATCCAGACGGATCTCGG
GCTTACGCAGGAGGACTTCAGGCACGGCTACCTGAAGTCCTGGGCGGACCAGGGCGTTCTTCTCTTGAACAGCGTGCTGA
CGGTCGAGGCTGGACGCGCCGCTTCCCATCAGGCGAAGGGGTGGGAAATCTTCACCGACCGCGCCGTCTCAATGCTCAAC
GAGAAGAAGGATCACCTCGTTTTCATGCTTTGGGGAGCCTACGCCCAGAGAAAAGGGGGCGTAATCGACGAGAAGAGGCA
CCTGGTACTGAGGGCGCCGCATCCGTCGCCCCTGTCCGCTCACCGCGGTTTCCTCGGTTGCCGGCACTTCTCCCAGGCCA
ACGCCTACCTGGCACGGCACGGAAGGGATCCTATAGATTGGCGTCTCCCCGACTAG

Upstream 100 bases:

>100_bases
GCTCATTGCCTGCACTTTATGAGAAAGCTTGGCTGGTGCCGGTGGGGTGTGATAATTTCTTTCTGCGTGAGCAGCAATAA
AAGGTGGCGGGGTATTGGAT

Downstream 100 bases:

>100_bases
TAGCGGCTGCGCGCCGTCTCCCCCCGCCAGGAAGGGGAGGGCGGCTTAATACCTGAATCTGCAGATCTGCAGCCTCAGAC
TCTCCGAGAGCCGGTTCAAC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTTERQIQLEAGWKSHLLEEFQKLYMSELKEFLRLEIARKKTIYPKGSEYFNAFNSTSFDKVKVVVLGQDPYHGPGQAHG
LSFSVPRGVDIPPSLVNIFKEIQTDLGLTQEDFRHGYLKSWADQGVLLLNSVLTVEAGRAASHQAKGWEIFTDRAVSMLN
EKKDHLVFMLWGAYAQRKGGVIDEKRHLVLRAPHPSPLSAHRGFLGCRHFSQANAYLARHGRDPIDWRLPD

Sequences:

>Translated_231_residues
MTTERQIQLEAGWKSHLLEEFQKLYMSELKEFLRLEIARKKTIYPKGSEYFNAFNSTSFDKVKVVVLGQDPYHGPGQAHG
LSFSVPRGVDIPPSLVNIFKEIQTDLGLTQEDFRHGYLKSWADQGVLLLNSVLTVEAGRAASHQAKGWEIFTDRAVSMLN
EKKDHLVFMLWGAYAQRKGGVIDEKRHLVLRAPHPSPLSAHRGFLGCRHFSQANAYLARHGRDPIDWRLPD
>Mature_230_residues
TTERQIQLEAGWKSHLLEEFQKLYMSELKEFLRLEIARKKTIYPKGSEYFNAFNSTSFDKVKVVVLGQDPYHGPGQAHGL
SFSVPRGVDIPPSLVNIFKEIQTDLGLTQEDFRHGYLKSWADQGVLLLNSVLTVEAGRAASHQAKGWEIFTDRAVSMLNE
KKDHLVFMLWGAYAQRKGGVIDEKRHLVLRAPHPSPLSAHRGFLGCRHFSQANAYLARHGRDPIDWRLPD

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=219, Percent_Identity=55.2511415525114, Blast_Score=236, Evalue=1e-62,
Organism=Homo sapiens, GI6224979, Length=219, Percent_Identity=55.2511415525114, Blast_Score=235, Evalue=2e-62,
Organism=Escherichia coli, GI1788934, Length=219, Percent_Identity=55.2511415525114, Blast_Score=253, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=45.8715596330275, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323620, Length=236, Percent_Identity=41.9491525423729, Blast_Score=175, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26309; Mature: 26178

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTERQIQLEAGWKSHLLEEFQKLYMSELKEFLRLEIARKKTIYPKGSEYFNAFNSTSFD
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCC
KVKVVVLGQDPYHGPGQAHGLSFSVPRGVDIPPSLVNIFKEIQTDLGLTQEDFRHGYLKS
EEEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
WADQGVLLLNSVLTVEAGRAASHQAKGWEIFTDRAVSMLNEKKDHLVFMLWGAYAQRKGG
HHCCCCEEHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHCCC
VIDEKRHLVLRAPHPSPLSAHRGFLGCRHFSQANAYLARHGRDPIDWRLPD
CCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTERQIQLEAGWKSHLLEEFQKLYMSELKEFLRLEIARKKTIYPKGSEYFNAFNSTSFD
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCC
KVKVVVLGQDPYHGPGQAHGLSFSVPRGVDIPPSLVNIFKEIQTDLGLTQEDFRHGYLKS
EEEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
WADQGVLLLNSVLTVEAGRAASHQAKGWEIFTDRAVSMLNEKKDHLVFMLWGAYAQRKGG
HHCCCCEEHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHCCC
VIDEKRHLVLRAPHPSPLSAHRGFLGCRHFSQANAYLARHGRDPIDWRLPD
CCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]