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The map label for this gene is panE-1 [C]

Identifier: 197117182

GI number: 197117182

Start: 924141

End: 925064

Strand: Reverse

Name: panE-1 [C]

Synonym: Gbem_0788

Alternate gene names: 197117182

Gene position: 925064-924141 (Counterclockwise)

Preceding gene: 197117183

Following gene: 197117181

Centisome position: 20.04

GC content: 58.23

Gene sequence:

>924_bases
ATGGGCGAATCAACTTACAAAACAACCATCATCGGTGCGGGGGCACTAGGGGCGGTTTACGGAAGCCTTCTCTTCAACAT
GAACCCCGACGACGTCTGCTTTATCGCCAGCGGCGAACGTCACGACAGGCTGAAGAACGACGGGGTCACAGTCAACGGCA
GGCGCTATGCGATAAAGGTGGCAAAGCCTGAAGAAGCAACGGCTGCAGATCTGGTCATTGTGGCCGTGAAGCACCACCAT
CTTGACGAAGCGATTGCCGATATGAGCAAGGCGGTCGGATCCCAAACAGTCATTCTCTCGGTCATGAACGGCATCGACAG
CGAGGAGCGCATCGGCGCTGCCTACGGAATGGAGAAGGTTCTGTATGGGCTCTCGCTCGGAATAGACGCCTTGAGGGAGG
GGGGCGCCGTAACCTACAAGAACCTCGGCCGCATCCTGTTCGGCGAGCGGGAAAACAGGGAGTCGACCGAACGGGTCCGG
CGCATCGCTTCCCTCTTCGACAGGGCCGGCATCGCCCATGAGGTCCCCCCCGACATGGTCCGCAGCCTCTGGTTCAAATA
CATGATCAACGTAGGGGTGAACCAGGTCTCCGCACTCCTCGGGGCAACCTACGGCGCATTGAGAAACTCGCCCGAGGCAA
GGGAGTTGATGGATACCGCCATGAGGGAAGTCATAGCCGTCGCCGTAGCAAAGAAGGTGAATCTGTCGGAAGACGATATA
GGCGAGTGGTACAAGGTGCTGGCGACCTTGAGCGCGGAAGGAAAGACCTCGATGCTGCAGGACGTGGAGGCTGGAAGAAA
GACGGAAGTCGAGATGCTGGCAGGTACAGTCATCGAGTTGGGCGGGCGCTGCGGCATACCGACGCCGGTAAACCGGAAGC
TCTTTGACGACCTGAAACGTATAGAGTCCTTGCAGGAAGGATAG

Upstream 100 bases:

>100_bases
TCCTCAGGGGCGGTTTTTTATTGTCCTATCCGACATTGACGAAAACACTCCTCCTGTGACACATTGGCGCGGCAGAAAAC
TTCCAGATCCAGAGGCGGCA

Downstream 100 bases:

>100_bases
CGACCCCGCCCTGGTTAACGCGGCGAATCAGCAAAAATCAGCACGAGAGGAAATCAACAGATGCAACAGATCGTGGACTT
CATACTGGAACTGGACAAAC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MGESTYKTTIIGAGALGAVYGSLLFNMNPDDVCFIASGERHDRLKNDGVTVNGRRYAIKVAKPEEATAADLVIVAVKHHH
LDEAIADMSKAVGSQTVILSVMNGIDSEERIGAAYGMEKVLYGLSLGIDALREGGAVTYKNLGRILFGERENRESTERVR
RIASLFDRAGIAHEVPPDMVRSLWFKYMINVGVNQVSALLGATYGALRNSPEARELMDTAMREVIAVAVAKKVNLSEDDI
GEWYKVLATLSAEGKTSMLQDVEAGRKTEVEMLAGTVIELGGRCGIPTPVNRKLFDDLKRIESLQEG

Sequences:

>Translated_307_residues
MGESTYKTTIIGAGALGAVYGSLLFNMNPDDVCFIASGERHDRLKNDGVTVNGRRYAIKVAKPEEATAADLVIVAVKHHH
LDEAIADMSKAVGSQTVILSVMNGIDSEERIGAAYGMEKVLYGLSLGIDALREGGAVTYKNLGRILFGERENRESTERVR
RIASLFDRAGIAHEVPPDMVRSLWFKYMINVGVNQVSALLGATYGALRNSPEARELMDTAMREVIAVAVAKKVNLSEDDI
GEWYKVLATLSAEGKTSMLQDVEAGRKTEVEMLAGTVIELGGRCGIPTPVNRKLFDDLKRIESLQEG
>Mature_306_residues
GESTYKTTIIGAGALGAVYGSLLFNMNPDDVCFIASGERHDRLKNDGVTVNGRRYAIKVAKPEEATAADLVIVAVKHHHL
DEAIADMSKAVGSQTVILSVMNGIDSEERIGAAYGMEKVLYGLSLGIDALREGGAVTYKNLGRILFGERENRESTERVRR
IASLFDRAGIAHEVPPDMVRSLWFKYMINVGVNQVSALLGATYGALRNSPEARELMDTAMREVIAVAVAKKVNLSEDDIG
EWYKVLATLSAEGKTSMLQDVEAGRKTEVEMLAGTVIELGGRCGIPTPVNRKLFDDLKRIESLQEG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=312, Percent_Identity=25.3205128205128, Blast_Score=84, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320057, Length=334, Percent_Identity=24.251497005988, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33361; Mature: 33229

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGESTYKTTIIGAGALGAVYGSLLFNMNPDDVCFIASGERHDRLKNDGVTVNGRRYAIKV
CCCCCEEEEEEECHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHCCCCEEECCCEEEEEE
AKPEEATAADLVIVAVKHHHLDEAIADMSKAVGSQTVILSVMNGIDSEERIGAAYGMEKV
ECCCCCCHHHEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHH
LYGLSLGIDALREGGAVTYKNLGRILFGERENRESTERVRRIASLFDRAGIAHEVPPDMV
HHHHHHCHHHHHCCCCEEHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RSLWFKYMINVGVNQVSALLGATYGALRNSPEARELMDTAMREVIAVAVAKKVNLSEDDI
HHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
GEWYKVLATLSAEGKTSMLQDVEAGRKTEVEMLAGTVIELGGRCGIPTPVNRKLFDDLKR
HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
IESLQEG
HHHHHCC
>Mature Secondary Structure 
GESTYKTTIIGAGALGAVYGSLLFNMNPDDVCFIASGERHDRLKNDGVTVNGRRYAIKV
CCCCEEEEEEECHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHCCCCEEECCCEEEEEE
AKPEEATAADLVIVAVKHHHLDEAIADMSKAVGSQTVILSVMNGIDSEERIGAAYGMEKV
ECCCCCCHHHEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHH
LYGLSLGIDALREGGAVTYKNLGRILFGERENRESTERVRRIASLFDRAGIAHEVPPDMV
HHHHHHCHHHHHCCCCEEHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RSLWFKYMINVGVNQVSALLGATYGALRNSPEARELMDTAMREVIAVAVAKKVNLSEDDI
HHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
GEWYKVLATLSAEGKTSMLQDVEAGRKTEVEMLAGTVIELGGRCGIPTPVNRKLFDDLKR
HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
IESLQEG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]