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The map label for this gene is loN-1

Identifier: 197117085

GI number: 197117085

Start: 815350

End: 817734

Strand: Reverse

Name: loN-1

Synonym: Gbem_0689

Alternate gene names: 197117085

Gene position: 817734-815350 (Counterclockwise)

Preceding gene: 197117086

Following gene: 197117083

Centisome position: 17.72

GC content: 60.88

Gene sequence:

>2385_bases
ATGACAGAGAACATCACCATAAATATGCCGGAGATCGTCCCGCTTTATCCCTTGCGGGAAATCATTGCTTTTCCGTACAT
GGTCTTCACCATTTTCCTCAAACAGGAGGACATGCCTCCATTCGAGGAAGCGGTGCTGTTCAACAACCTGGTGGCACTGG
TCAAACTCCGGGAAGAGCCGACCGGAGAGTTGTTTCCGGCACTGCATGAAATCGGCACACTGTGCAAGGTGATGCAGATC
AACAAACTGGCCGGCGGCGGAGCCAAGGTCGTCCTTGAAGGGGTGATCAGAGTCAGGTTGCTGGCCATCGTGCAGCAGAC
GCCGGTGGCGCTCTCCAGGCTGGAACCGGTGCGCGAGTTCGCCGAAAAGTCCATGGTGTCCGAGGCGCTGGTAGGAAGCC
TCAACGCCCTCCTCAAGATCGCCCTCTCCTACGGCCGCCCCCTCCCTGACGACGTCATGAAGATGATCGACTTTATCGAC
AACCCGGCGCGCCTTTCCGACCTGGTAGCACTCTACCTGAACCTCCCCATCGATGAACTGCAGAAGCTCCTTGAAACCGT
CGACCCCCTGGAGCGGCTGAAAAAGGTCTACATGCACCTGACCAACGAGGTCCAGCGCCTGCAGATCAAGGGTGAGGTGC
AGGCTGAGGTAACCAAGAAGGTCGGGAAGAGCCAGAAAGAGTTCCTGCTGCGCGAGCAGATGAAGCAGATCCAGGAGGAA
CTGGGGGAGGAAGACTCCAGGCTGGGCGAGGCGAACGAACTGAGGTCCAAAGTCGAAAGCGCCCATATGCCCGAAGACGT
GCGCAGGATCGCCGAAAAGGAGATGCGCAGGCTGGAGCGGATCAACCCAGCCTCCCCCGAGTACACCGTCTCCCGCACCT
ACCTCGACTACCTGACCACCATCCCCTGGCAGGTCAGCACCCCGGACAACCGTGACATCAACCAGGCCGAGACCATCCTC
AACGAGGACCACTACGACCTGAAGAAGGTGAAGGAACGCATCCTGGAATACCTGGCGGTGCGGTCGCTCAAGGACAAGAT
GAAGGGTCCGATCCTCTGCTTCGTGGGGCCTCCAGGCGTAGGCAAGACCAGCCTCGGGAAATCCATAGCACGTACCCTCG
GGCGCAAGTTCATCAGGATCTCTTTGGGCGGCATGCGCGACGAGGCCGAGATCAGGGGGCACCGGCGCACCTACATCGGC
GCACTTCCCGGGCGCATCATCCAGGAGATCAACCGGGCCGGCTCCAACAACCCCGTCTTCATGCTGGACGAAGTAGACAA
GATCGGCGCGGATTTCCGGGGCGACCCGGCCAGCGCGCTCCTCGAAGTGCTAGACCCCGAGCAGAACTTCTCCTTCACGG
ACCACTATTTGGACGTCCCGTTCGACCTCACCAACGTGATGTTCATCACCACGGCAAACCAGCTCGACCCCATCCCGGCG
CCACTCAAGGACAGGATGGAAGTGATCACCCTCTCCGGGTACACCGACGAGGAGAAGCTGAATATCGCCAAGAGCTATCT
GGTCGCACGCGAGGTCGAGGAGAACGGGCTCGCCAGCATGGCGCCCCAGTTCACCGACGAGGCCATCTACCGGGTCACCC
ACGACTACACCCGCGAGGCCGGCGTCAGGAACCTGCAACGCAACATCGCCTCCATCTGCCGCAAGATCGCCAAGGAAGTG
GCCCAAGGGAAGAAGGCGCGCCCCATTGTCAATCCCGAAACCGTCTCCGAGCTCTTAGGGGCGCCGAAGTTCTTCGACGA
GGTCGCCTCGGAAAAGGACCGGGTCGGCGTAGCGACGGGGCTTGCCTGGACCGAAAGCGGTGGGGACATCATCTTCGTGG
AAGCGACCAAGATGAAGGGAAAAGAGGACCTGATCCTCACCGGCTCGCTGGGCGAGGTGATGAAGGAATCGGTGCGGGCC
GCGCTTTCCTTCGTGAAGGCCAACTGCGCTGAACTCGGTATCGACAAGAAGATGTTCGACGAGACCACGCTCCACATTCA
CGTCCCGGCCGGGAGCATCCCTAAGGACGGCCCTTCCGCCGGGATCACCATGGCCACCGCAATCGTCTCGCTCTTCTCCG
GACGCGCAGCGCGAAGGGATGTGGCCATGACCGGCGAGATGAGCCTCACCGGGCGGGTCCTCGCCATCGGCGGGCTCAAG
GAGAAGGTGCTGGCCGCGCGGCGCGCCGGGGTGAAGAAGGTGCTGGCCCCCGCCAAGAACAAGAAGGACCTTGAGGACAT
CCCCGAGAACGTGAAGAACGAACTGGAATTCTTCTTCGTAGAGGATATCCGCGAGGTGTTCGTTCAGGCTCTCAACCCCA
CTTCCCCTGCTCCTACCGCCGCCACTTCTGCCCGTACTCCGGCGGGAGCGCCTCCTCCTCAATAA

Upstream 100 bases:

>100_bases
ATGGGAGTCAGCGTAAACGGCAGTTGCGGTTGACACTGCAAAGGGTTCCAGTACTCTATTAAAGTTTTAAACCCCCTAAC
AAAAACACCTGGAACCCGCC

Downstream 100 bases:

>100_bases
CTAAATCGTCCCCCCTCCCCACCCAGCTGGGCGAGGGGGGATTCCCCGCCATCCCCAAGCTATCCTCCCCAGCATCTTTA
AGCCCCCTTCCCCCCTTGCG

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 794; Mature: 793

Protein sequence:

>794_residues
MTENITINMPEIVPLYPLREIIAFPYMVFTIFLKQEDMPPFEEAVLFNNLVALVKLREEPTGELFPALHEIGTLCKVMQI
NKLAGGGAKVVLEGVIRVRLLAIVQQTPVALSRLEPVREFAEKSMVSEALVGSLNALLKIALSYGRPLPDDVMKMIDFID
NPARLSDLVALYLNLPIDELQKLLETVDPLERLKKVYMHLTNEVQRLQIKGEVQAEVTKKVGKSQKEFLLREQMKQIQEE
LGEEDSRLGEANELRSKVESAHMPEDVRRIAEKEMRRLERINPASPEYTVSRTYLDYLTTIPWQVSTPDNRDINQAETIL
NEDHYDLKKVKERILEYLAVRSLKDKMKGPILCFVGPPGVGKTSLGKSIARTLGRKFIRISLGGMRDEAEIRGHRRTYIG
ALPGRIIQEINRAGSNNPVFMLDEVDKIGADFRGDPASALLEVLDPEQNFSFTDHYLDVPFDLTNVMFITTANQLDPIPA
PLKDRMEVITLSGYTDEEKLNIAKSYLVAREVEENGLASMAPQFTDEAIYRVTHDYTREAGVRNLQRNIASICRKIAKEV
AQGKKARPIVNPETVSELLGAPKFFDEVASEKDRVGVATGLAWTESGGDIIFVEATKMKGKEDLILTGSLGEVMKESVRA
ALSFVKANCAELGIDKKMFDETTLHIHVPAGSIPKDGPSAGITMATAIVSLFSGRAARRDVAMTGEMSLTGRVLAIGGLK
EKVLAARRAGVKKVLAPAKNKKDLEDIPENVKNELEFFFVEDIREVFVQALNPTSPAPTAATSARTPAGAPPPQ

Sequences:

>Translated_794_residues
MTENITINMPEIVPLYPLREIIAFPYMVFTIFLKQEDMPPFEEAVLFNNLVALVKLREEPTGELFPALHEIGTLCKVMQI
NKLAGGGAKVVLEGVIRVRLLAIVQQTPVALSRLEPVREFAEKSMVSEALVGSLNALLKIALSYGRPLPDDVMKMIDFID
NPARLSDLVALYLNLPIDELQKLLETVDPLERLKKVYMHLTNEVQRLQIKGEVQAEVTKKVGKSQKEFLLREQMKQIQEE
LGEEDSRLGEANELRSKVESAHMPEDVRRIAEKEMRRLERINPASPEYTVSRTYLDYLTTIPWQVSTPDNRDINQAETIL
NEDHYDLKKVKERILEYLAVRSLKDKMKGPILCFVGPPGVGKTSLGKSIARTLGRKFIRISLGGMRDEAEIRGHRRTYIG
ALPGRIIQEINRAGSNNPVFMLDEVDKIGADFRGDPASALLEVLDPEQNFSFTDHYLDVPFDLTNVMFITTANQLDPIPA
PLKDRMEVITLSGYTDEEKLNIAKSYLVAREVEENGLASMAPQFTDEAIYRVTHDYTREAGVRNLQRNIASICRKIAKEV
AQGKKARPIVNPETVSELLGAPKFFDEVASEKDRVGVATGLAWTESGGDIIFVEATKMKGKEDLILTGSLGEVMKESVRA
ALSFVKANCAELGIDKKMFDETTLHIHVPAGSIPKDGPSAGITMATAIVSLFSGRAARRDVAMTGEMSLTGRVLAIGGLK
EKVLAARRAGVKKVLAPAKNKKDLEDIPENVKNELEFFFVEDIREVFVQALNPTSPAPTAATSARTPAGAPPPQ
>Mature_793_residues
TENITINMPEIVPLYPLREIIAFPYMVFTIFLKQEDMPPFEEAVLFNNLVALVKLREEPTGELFPALHEIGTLCKVMQIN
KLAGGGAKVVLEGVIRVRLLAIVQQTPVALSRLEPVREFAEKSMVSEALVGSLNALLKIALSYGRPLPDDVMKMIDFIDN
PARLSDLVALYLNLPIDELQKLLETVDPLERLKKVYMHLTNEVQRLQIKGEVQAEVTKKVGKSQKEFLLREQMKQIQEEL
GEEDSRLGEANELRSKVESAHMPEDVRRIAEKEMRRLERINPASPEYTVSRTYLDYLTTIPWQVSTPDNRDINQAETILN
EDHYDLKKVKERILEYLAVRSLKDKMKGPILCFVGPPGVGKTSLGKSIARTLGRKFIRISLGGMRDEAEIRGHRRTYIGA
LPGRIIQEINRAGSNNPVFMLDEVDKIGADFRGDPASALLEVLDPEQNFSFTDHYLDVPFDLTNVMFITTANQLDPIPAP
LKDRMEVITLSGYTDEEKLNIAKSYLVAREVEENGLASMAPQFTDEAIYRVTHDYTREAGVRNLQRNIASICRKIAKEVA
QGKKARPIVNPETVSELLGAPKFFDEVASEKDRVGVATGLAWTESGGDIIFVEATKMKGKEDLILTGSLGEVMKESVRAA
LSFVKANCAELGIDKKMFDETTLHIHVPAGSIPKDGPSAGITMATAIVSLFSGRAARRDVAMTGEMSLTGRVLAIGGLKE
KVLAARRAGVKKVLAPAKNKKDLEDIPENVKNELEFFFVEDIREVFVQALNPTSPAPTAATSARTPAGAPPPQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=768, Percent_Identity=39.84375, Blast_Score=555, Evalue=1e-158,
Organism=Homo sapiens, GI21396489, Length=619, Percent_Identity=44.5880452342488, Blast_Score=544, Evalue=1e-154,
Organism=Escherichia coli, GI1786643, Length=778, Percent_Identity=45.3727506426735, Blast_Score=688, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=721, Percent_Identity=40.7766990291262, Blast_Score=534, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17556486, Length=542, Percent_Identity=41.6974169741697, Blast_Score=455, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6319449, Length=671, Percent_Identity=41.2816691505216, Blast_Score=503, Evalue=1e-143,
Organism=Drosophila melanogaster, GI221513036, Length=682, Percent_Identity=40.6158357771261, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24666867, Length=682, Percent_Identity=40.6158357771261, Blast_Score=535, Evalue=1e-152,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_GEOBB (B5EDX8)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137512.1
- ProteinModelPortal:   B5EDX8
- MEROPS:   S16.001
- GeneID:   6783522
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0689
- HOGENOM:   HBG566281
- OMA:   YLLREQM
- ProtClustDB:   CLSK828095
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 88191; Mature: 88060

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 679-679 ACT_SITE 722-722

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENITINMPEIVPLYPLREIIAFPYMVFTIFLKQEDMPPFEEAVLFNNLVALVKLREEP
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
TGELFPALHEIGTLCKVMQINKLAGGGAKVVLEGVIRVRLLAIVQQTPVALSRLEPVREF
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AEKSMVSEALVGSLNALLKIALSYGRPLPDDVMKMIDFIDNPARLSDLVALYLNLPIDEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
QKLLETVDPLERLKKVYMHLTNEVQRLQIKGEVQAEVTKKVGKSQKEFLLREQMKQIQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LGEEDSRLGEANELRSKVESAHMPEDVRRIAEKEMRRLERINPASPEYTVSRTYLDYLTT
HCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
IPWQVSTPDNRDINQAETILNEDHYDLKKVKERILEYLAVRSLKDKMKGPILCFVGPPGV
CCEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGKSIARTLGRKFIRISLGGMRDEAEIRGHRRTYIGALPGRIIQEINRAGSNNPVF
CHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCEE
MLDEVDKIGADFRGDPASALLEVLDPEQNFSFTDHYLDVPFDLTNVMFITTANQLDPIPA
EEECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHCEEEEEECCCCCCCCC
PLKDRMEVITLSGYTDEEKLNIAKSYLVAREVEENGLASMAPQFTDEAIYRVTHDYTREA
CHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHH
GVRNLQRNIASICRKIAKEVAQGKKARPIVNPETVSELLGAPKFFDEVASEKDRVGVATG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCC
LAWTESGGDIIFVEATKMKGKEDLILTGSLGEVMKESVRAALSFVKANCAELGIDKKMFD
CEEECCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
ETTLHIHVPAGSIPKDGPSAGITMATAIVSLFSGRAARRDVAMTGEMSLTGRVLAIGGLK
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHCCCEEECCCEECCCEEEECCHH
EKVLAARRAGVKKVLAPAKNKKDLEDIPENVKNELEFFFVEDIREVFVQALNPTSPAPTA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ATSARTPAGAPPPQ
CCCCCCCCCCCCCC
>Mature Secondary Structure 
TENITINMPEIVPLYPLREIIAFPYMVFTIFLKQEDMPPFEEAVLFNNLVALVKLREEP
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
TGELFPALHEIGTLCKVMQINKLAGGGAKVVLEGVIRVRLLAIVQQTPVALSRLEPVREF
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AEKSMVSEALVGSLNALLKIALSYGRPLPDDVMKMIDFIDNPARLSDLVALYLNLPIDEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
QKLLETVDPLERLKKVYMHLTNEVQRLQIKGEVQAEVTKKVGKSQKEFLLREQMKQIQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LGEEDSRLGEANELRSKVESAHMPEDVRRIAEKEMRRLERINPASPEYTVSRTYLDYLTT
HCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
IPWQVSTPDNRDINQAETILNEDHYDLKKVKERILEYLAVRSLKDKMKGPILCFVGPPGV
CCEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGKSIARTLGRKFIRISLGGMRDEAEIRGHRRTYIGALPGRIIQEINRAGSNNPVF
CHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCEE
MLDEVDKIGADFRGDPASALLEVLDPEQNFSFTDHYLDVPFDLTNVMFITTANQLDPIPA
EEECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHCEEEEEECCCCCCCCC
PLKDRMEVITLSGYTDEEKLNIAKSYLVAREVEENGLASMAPQFTDEAIYRVTHDYTREA
CHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHH
GVRNLQRNIASICRKIAKEVAQGKKARPIVNPETVSELLGAPKFFDEVASEKDRVGVATG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCC
LAWTESGGDIIFVEATKMKGKEDLILTGSLGEVMKESVRAALSFVKANCAELGIDKKMFD
CEEECCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
ETTLHIHVPAGSIPKDGPSAGITMATAIVSLFSGRAARRDVAMTGEMSLTGRVLAIGGLK
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHCCCEEECCCEECCCEEEECCHH
EKVLAARRAGVKKVLAPAKNKKDLEDIPENVKNELEFFFVEDIREVFVQALNPTSPAPTA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ATSARTPAGAPPPQ
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA