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The map label for this gene is atoC [H]

Identifier: 197117069

GI number: 197117069

Start: 797278

End: 798702

Strand: Direct

Name: atoC [H]

Synonym: Gbem_0673

Alternate gene names: 197117069

Gene position: 797278-798702 (Clockwise)

Preceding gene: 197117068

Following gene: 197117070

Centisome position: 17.28

GC content: 65.61

Gene sequence:

>1425_bases
ATGGCGAAGATTCTGATTGTCGACGATGAAGAGACCGTTTGCGAGTCGATGGCGCTGATAGGAAGGCGCAGCGGCCATGA
AACGAGCTGCGCCCGCACCCTCGCGGCTGGGCTGGAGCTTGCCAATACCGGGGCCTTTGACTTGGTGTTCTTGGACGTGA
AGCTGCCGGACGGCAACGGTCTTGAATTCCTTCCCCGACTGACGCAGGCCCCTTCCAGGCCGGACATCATCATCATGACC
GGGTACGGCGATCCCCAGGGGGCGGAACTCGCCATCAACAGCGGCGCCTGGGACTACATCGAGAAGGGGTGCTCCGCCAA
GGACATCACCCTGACCCTGGCCCGCGCCCTGGAGTACCGCAAACAGAAGCTGACCCTCGCCGGGGCCAAGGGGGTGGTGG
CCCTGAAGCGGGAGAACATCGTCGGGAACAGCGCGAGCCTGAACGCCTGCCTGGACCAGGTGGCCTGCGCCGCCGGGAGC
GAGGCGGGGGTCCTCATCATGGGCGAGACCGGGACCGGCAAGGAGCTCTTCGCCCGGGCCGTGCACCAAAACAGCAAGCG
GGCGGACAAACAGTTCGTGGTGGTCGATTGCGCGAGCCTGCCGGAAACGCTCGTGGAGAGCATCCTTTTCGGGCACGACA
AGGGGGCCTTTACCGGCGCGGAACGCGCGCGCGAGGGACTCGTCGCCGAGGCCAACGGCGGAACTCTTTTCCTCGACGAG
GTAGGGGAGCTGCCGCTTGCCACGCAGAAGGCTTTCCTGAGGGTGCTCCAGGAAAGGCGCTTCCGGCCGGTGGGAAGCCC
GCGGGAGATCGAGAGCGACTTCAGGCTCGTCGCGGCGACCAACAGGGACTTGAACGCCATGGCGCAGACAGGCGAATTCA
GAAGCGACCTCCTCTTCCGGCTCAGCTCCGTGGTCATCAACCTCCCCCCTTTAAGGGAGCGCCGCGACGACATCAAGGAG
CTGGCCCGCTACTACATGGACAAGTTCTGCGAGCGCAACGGACTCTCCCCCAAAGGGAGCTGCCCCGAGTTCATGGCCAC
GCTGATGGCCTACGGCTGGCCCGGCAACATCCGGGAGTTCATCAACACCATCGAGCGCACCGTCATCTCCGCGCGCGAGG
AGCCGGTGCTCTTCGCGCAGCATCTCCCCACCGCCATCCGCGCCCAGGTCGCCCAGAGCGGCGTCGGGCACCGGGGGGCG
CCGCCTGCAGCCGAGGAGCAGAGCGCGCCGCCGGCGGTCGAGGGCGAGCTCCCGAGGCTCAACGACTTCCGCGAGACCAT
CTATGCCAAGGCCGAGAAGCAATATCTTGCCGACCTTATGTCGGTTGCCCACAACGACATCCCCGCCGCTTGCAGGCTTT
CGGGGCTGTCGCAGTCGCGGCTGTACGCGCTTTTGAAAACCCACGAGTTGCACCGCTCTCCGTAG

Upstream 100 bases:

>100_bases
GTTGGGATACGCGAGCTGGCGCTGAAGCCCTTGGACCGTGAGGAGTTCGCGTCGACGATACGGCGGGTGCTGGCGGGAAG
GGAGCAGGAGTGAAGAGGCC

Downstream 100 bases:

>100_bases
CTTTTCGCCGGTCTCCCCGGTCGTTCCCGCCGTCCCCTCACTCCCGCCATATTCTCACCTCTCTGCTCTTTCCCTCACCC
CCGCTCTCCCAGAGGGCGAG

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MAKILIVDDEETVCESMALIGRRSGHETSCARTLAAGLELANTGAFDLVFLDVKLPDGNGLEFLPRLTQAPSRPDIIIMT
GYGDPQGAELAINSGAWDYIEKGCSAKDITLTLARALEYRKQKLTLAGAKGVVALKRENIVGNSASLNACLDQVACAAGS
EAGVLIMGETGTGKELFARAVHQNSKRADKQFVVVDCASLPETLVESILFGHDKGAFTGAERAREGLVAEANGGTLFLDE
VGELPLATQKAFLRVLQERRFRPVGSPREIESDFRLVAATNRDLNAMAQTGEFRSDLLFRLSSVVINLPPLRERRDDIKE
LARYYMDKFCERNGLSPKGSCPEFMATLMAYGWPGNIREFINTIERTVISAREEPVLFAQHLPTAIRAQVAQSGVGHRGA
PPAAEEQSAPPAVEGELPRLNDFRETIYAKAEKQYLADLMSVAHNDIPAACRLSGLSQSRLYALLKTHELHRSP

Sequences:

>Translated_474_residues
MAKILIVDDEETVCESMALIGRRSGHETSCARTLAAGLELANTGAFDLVFLDVKLPDGNGLEFLPRLTQAPSRPDIIIMT
GYGDPQGAELAINSGAWDYIEKGCSAKDITLTLARALEYRKQKLTLAGAKGVVALKRENIVGNSASLNACLDQVACAAGS
EAGVLIMGETGTGKELFARAVHQNSKRADKQFVVVDCASLPETLVESILFGHDKGAFTGAERAREGLVAEANGGTLFLDE
VGELPLATQKAFLRVLQERRFRPVGSPREIESDFRLVAATNRDLNAMAQTGEFRSDLLFRLSSVVINLPPLRERRDDIKE
LARYYMDKFCERNGLSPKGSCPEFMATLMAYGWPGNIREFINTIERTVISAREEPVLFAQHLPTAIRAQVAQSGVGHRGA
PPAAEEQSAPPAVEGELPRLNDFRETIYAKAEKQYLADLMSVAHNDIPAACRLSGLSQSRLYALLKTHELHRSP
>Mature_473_residues
AKILIVDDEETVCESMALIGRRSGHETSCARTLAAGLELANTGAFDLVFLDVKLPDGNGLEFLPRLTQAPSRPDIIIMTG
YGDPQGAELAINSGAWDYIEKGCSAKDITLTLARALEYRKQKLTLAGAKGVVALKRENIVGNSASLNACLDQVACAAGSE
AGVLIMGETGTGKELFARAVHQNSKRADKQFVVVDCASLPETLVESILFGHDKGAFTGAERAREGLVAEANGGTLFLDEV
GELPLATQKAFLRVLQERRFRPVGSPREIESDFRLVAATNRDLNAMAQTGEFRSDLLFRLSSVVINLPPLRERRDDIKEL
ARYYMDKFCERNGLSPKGSCPEFMATLMAYGWPGNIREFINTIERTVISAREEPVLFAQHLPTAIRAQVAQSGVGHRGAP
PAAEEQSAPPAVEGELPRLNDFRETIYAKAEKQYLADLMSVAHNDIPAACRLSGLSQSRLYALLKTHELHRSP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=395, Percent_Identity=42.7848101265823, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1790437, Length=430, Percent_Identity=39.5348837209302, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI1788905, Length=469, Percent_Identity=34.7547974413646, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1790299, Length=387, Percent_Identity=36.1757105943152, Blast_Score=235, Evalue=6e-63,
Organism=Escherichia coli, GI87082117, Length=280, Percent_Identity=44.6428571428571, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1789087, Length=233, Percent_Identity=49.3562231759657, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1789233, Length=334, Percent_Identity=35.9281437125749, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87082152, Length=254, Percent_Identity=45.6692913385827, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI87081872, Length=339, Percent_Identity=36.5781710914454, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1787583, Length=350, Percent_Identity=34, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786524, Length=257, Percent_Identity=40.0778210116732, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1789828, Length=245, Percent_Identity=37.1428571428571, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87081858, Length=215, Percent_Identity=30.6976744186047, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51624; Mature: 51492

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKILIVDDEETVCESMALIGRRSGHETSCARTLAAGLELANTGAFDLVFLDVKLPDGNG
CEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCC
LEFLPRLTQAPSRPDIIIMTGYGDPQGAELAINSGAWDYIEKGCSAKDITLTLARALEYR
HHHHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHH
KQKLTLAGAKGVVALKRENIVGNSASLNACLDQVACAAGSEAGVLIMGETGTGKELFARA
HHHEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHH
VHQNSKRADKQFVVVDCASLPETLVESILFGHDKGAFTGAERAREGLVAEANGGTLFLDE
HHCCCCCCCCEEEEEEHHHCHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEEEEC
VGELPLATQKAFLRVLQERRFRPVGSPREIESDFRLVAATNRDLNAMAQTGEFRSDLLFR
CCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCHHHHHHCCCHHHHHHHH
LSSVVINLPPLRERRDDIKELARYYMDKFCERNGLSPKGSCPEFMATLMAYGWPGNIREF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHH
INTIERTVISAREEPVLFAQHLPTAIRAQVAQSGVGHRGAPPAAEEQSAPPAVEGELPRL
HHHHHHHHHHCCCCCEEEHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
NDFRETIYAKAEKQYLADLMSVAHNDIPAACRLSGLSQSRLYALLKTHELHRSP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKILIVDDEETVCESMALIGRRSGHETSCARTLAAGLELANTGAFDLVFLDVKLPDGNG
EEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCC
LEFLPRLTQAPSRPDIIIMTGYGDPQGAELAINSGAWDYIEKGCSAKDITLTLARALEYR
HHHHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHH
KQKLTLAGAKGVVALKRENIVGNSASLNACLDQVACAAGSEAGVLIMGETGTGKELFARA
HHHEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHH
VHQNSKRADKQFVVVDCASLPETLVESILFGHDKGAFTGAERAREGLVAEANGGTLFLDE
HHCCCCCCCCEEEEEEHHHCHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEEEEC
VGELPLATQKAFLRVLQERRFRPVGSPREIESDFRLVAATNRDLNAMAQTGEFRSDLLFR
CCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCHHHHHHCCCHHHHHHHH
LSSVVINLPPLRERRDDIKELARYYMDKFCERNGLSPKGSCPEFMATLMAYGWPGNIREF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHH
INTIERTVISAREEPVLFAQHLPTAIRAQVAQSGVGHRGAPPAAEEQSAPPAVEGELPRL
HHHHHHHHHHCCCCCEEEHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
NDFRETIYAKAEKQYLADLMSVAHNDIPAACRLSGLSQSRLYALLKTHELHRSP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]