Click here to switch to the map view.

The map label for this gene is sfrA [H]

Identifier: 197117056

GI number: 197117056

Start: 784185

End: 786653

Strand: Direct

Name: sfrA [H]

Synonym: Gbem_0660

Alternate gene names: 197117056

Gene position: 784185-786653 (Clockwise)

Preceding gene: 197117055

Following gene: 197117057

Centisome position: 16.99

GC content: 66.42

Gene sequence:

>2469_bases
ATGGTCAGCTTAACCATCGATGGCAAAAGCGTGCAGGTCGAAAAAGGTACCACCATACTGGAGGCCGCGGCCACAGTCGG
GATCAAGATCCCGACCCTTTGCTGGCTGCAGAAGGTCTCCCCGACCGGCGCCTGCCGCGTCTGCGCCGTGGAGGTAGCCG
GCGTGGAGCGCACCATGACCGCCTGCAACACCCCGGTCAAGGAAGGGATACAGGTCACCACCGACACCCCGGCGCTCAGG
GAAGCGCGCAAGAAGATCATGGAGCTCATGCTGGTGAACCACCCGCTGGACTGCCCGGTCTGCGACGCCGGCGGCGAGTG
CGACCTGCAGGATTCCTGCTACGCGCTGGACGCGAACAAGCAGGAGTACTCGGCGGTCCTCGAGCGCCGCCCGATCCGCT
ACGACTGGCCGCTCATCGAAAGCGACCCGAACCGCTGCATCCTCTGCGAGAAGTGCGTCAAGGTGGACCACGAGATCGTC
GGCTGCGACGCCATCGAGGTGGTGAACAAGGGTGAGGCGGCCATCATCGACACGGTGGACGGCAAACCGCTCAACTGCGA
GTTCTGCGGCAACTGCGTCGCCGCCTGCCCGACCGGGGCTCTCATCACCAAGCCCTTCAAGTTCAAGGGTCGCCCCTGGT
CCTTCAACACGGTCCCCAGCGTCTGCGCCTTCTGCGGCGCCGGCTGCCAGATCGATTACCATGCCAAAAACGGCCGCATC
GAGCGGGTCACGAGCGACGACGGCAGCTACAACAACGGCAACCTCTGCATCAACGGCCGCTTCGGCTACCGCTACCTCCA
CTCGCTGGAGCGGATCTCGGACCCGATGCTGCGCGACGGCTCCGGCCGCCTGGCCAAAGCCGACTGGGAGACCGCCCTCA
CCGCCGCGGCCGACAAGCTGAAGCAGATCGTCTCCCAAAACGGCGGCAAGGCCGTCGCAGGCCTTAGCTCGCCCAGGGTG
ACCAACGAGGAGAACTTCCTCTTCAAAAAGTTCCTCACCGAGGCGATAGGCTCCGCGAACGTCGACTCCGAGGCACGCTT
GGGCTTCGCCCAGGCCCAGGCCCAGATGTCGCGCCGCTTCGGCTTCACCGGTGCCAGCACCACCATCGACGCCCTCGACA
ACGCCCAGGCCATCCTGGTCTTCGGCTGCGACCTGAACGCCGAGGCCACCGGCCTCGAATACCGGGTGATCAAGGCCGCC
ACCAAGAAGGACGCGCGGCTCGTCCTGGTCAACATGCGCGACGTGAAGCTGAGGAAGTTCTCCAACGCGCAGCTGAAGCA
CCTCCCGGGGAGCGAGCTCTCCGTGATCTACGCCCTGATGAAGGGGATCCTCGCCGCAGGCGGCGTGCTTCCGGCCGGCT
CCGAGGCGATCAAGGACGCCCTCGACAAGCTCACCATGGCCGAGCTCTGCAGCCAGGCAGGGGTTACCGAAAAGGCCGTG
GCCGACGCCGCCTCGCTCATCGCGGGCAAAAGCCGCGTCTCCATCGTCTTCGGCGCCGACCTGATCAGAAGCGCAGACGC
CGCCCAGAAGATATCGGCGCTCGCCGATCTCGCCATCCTGACCGGTTCGGCCGCGAAGGAAGGCGGTGGGCTCTTCCCGG
TCGACGCCAAGAACAACACGGTCGGCCTCCTCGACATGGGGGTCGCCCCCGGCGCCGACGGAAAGGACCTCTGGGGGATG
GTCGAGGGTATCGAAGAGGGCTCGATCAAGGCGCTCTACCTTCTCGGGTGCGACCTGGCCTCCTTCCCGGACAACCAGAG
GATCAGGAAGGCGCTCGGAAAGCTCGAACTCCTCATCGTCCAGGACGTGTTCCAGGGTGATTCCCTCGAGTTCGCCCACG
TGGTCTTCCCCGCCTCCGCCGCCGCCGAGAAGAGCGGAAGCTTCACCTCGCTCGACAACCGGGTGCAGCCGATCTTCAAG
TCGACCGCCGCCCCCGGCGCCGCCCGCGAGGACTGGGCCATCGTCTCCGACCTCTACGGCAAGGTCACCGGGACCGTCCC
CTCCTTCACCCCGGCAAGCCTCATGGCGCAGATCAAGAGCGAAATCCCGGCCTACCAGCCGTTCGACGGCTCCAGGAACG
GCTTCGTGAAGTCCGGTAACGGCAAGGTGGCGCCCGCCCTCGCCCCCATCGCCAAGCCGGCCGCGCCCACACAGGCGACG
TTCCAGCTCCTGGTCGGCCCGATCGGGTTCCACAACGGCACCTCCACCACCCGCTCCGACGCGAACCTGAGCGTCGCCCC
GGCAGGGTTCGTCGAGCTGCACCCGGCCGACGCCGGCAAGCTCGGCATAGAAGAGGGGGGGAGCGTCAAGGTGATCTCGG
CTAACGCGTCCTTCACCGCGCCGGCGAAGATCAGCGACAAGCTGCAGCCGGGGCTCCTCTTCGCCCCCTCGCACTTCCGG
GAACTGAACGCCAACGCGCTTCTTGCCGGCGGCTGCAACCTGGCCGAGGTGAAGGTGGAGAAGGGGTAG

Upstream 100 bases:

>100_bases
ACGCTGCCTGCGCTGCTACCGCGTCGCCATGGTTGCGGTCTAAGGGGCTCGCTGGCAGGACCTGTTAAATTCAATTCACG
GAAATATTGAGGTTTCTTAT

Downstream 100 bases:

>100_bases
CGCCTACGCGCAACCGCTCATGCAACGAAAAAGGCCCCGGTTTCCGACCGGGGCCTTTTTGCTGGCAAGCCTTGACGGCA
AATGTTAGGCTGGCATTCGA

Product: Fe(III) reductase subunit alpha

Products: NA

Alternate protein names: NADH dehydrogenase I subunit G 2; NDH-1 subunit G 2 [H]

Number of amino acids: Translated: 822; Mature: 822

Protein sequence:

>822_residues
MVSLTIDGKSVQVEKGTTILEAAATVGIKIPTLCWLQKVSPTGACRVCAVEVAGVERTMTACNTPVKEGIQVTTDTPALR
EARKKIMELMLVNHPLDCPVCDAGGECDLQDSCYALDANKQEYSAVLERRPIRYDWPLIESDPNRCILCEKCVKVDHEIV
GCDAIEVVNKGEAAIIDTVDGKPLNCEFCGNCVAACPTGALITKPFKFKGRPWSFNTVPSVCAFCGAGCQIDYHAKNGRI
ERVTSDDGSYNNGNLCINGRFGYRYLHSLERISDPMLRDGSGRLAKADWETALTAAADKLKQIVSQNGGKAVAGLSSPRV
TNEENFLFKKFLTEAIGSANVDSEARLGFAQAQAQMSRRFGFTGASTTIDALDNAQAILVFGCDLNAEATGLEYRVIKAA
TKKDARLVLVNMRDVKLRKFSNAQLKHLPGSELSVIYALMKGILAAGGVLPAGSEAIKDALDKLTMAELCSQAGVTEKAV
ADAASLIAGKSRVSIVFGADLIRSADAAQKISALADLAILTGSAAKEGGGLFPVDAKNNTVGLLDMGVAPGADGKDLWGM
VEGIEEGSIKALYLLGCDLASFPDNQRIRKALGKLELLIVQDVFQGDSLEFAHVVFPASAAAEKSGSFTSLDNRVQPIFK
STAAPGAAREDWAIVSDLYGKVTGTVPSFTPASLMAQIKSEIPAYQPFDGSRNGFVKSGNGKVAPALAPIAKPAAPTQAT
FQLLVGPIGFHNGTSTTRSDANLSVAPAGFVELHPADAGKLGIEEGGSVKVISANASFTAPAKISDKLQPGLLFAPSHFR
ELNANALLAGGCNLAEVKVEKG

Sequences:

>Translated_822_residues
MVSLTIDGKSVQVEKGTTILEAAATVGIKIPTLCWLQKVSPTGACRVCAVEVAGVERTMTACNTPVKEGIQVTTDTPALR
EARKKIMELMLVNHPLDCPVCDAGGECDLQDSCYALDANKQEYSAVLERRPIRYDWPLIESDPNRCILCEKCVKVDHEIV
GCDAIEVVNKGEAAIIDTVDGKPLNCEFCGNCVAACPTGALITKPFKFKGRPWSFNTVPSVCAFCGAGCQIDYHAKNGRI
ERVTSDDGSYNNGNLCINGRFGYRYLHSLERISDPMLRDGSGRLAKADWETALTAAADKLKQIVSQNGGKAVAGLSSPRV
TNEENFLFKKFLTEAIGSANVDSEARLGFAQAQAQMSRRFGFTGASTTIDALDNAQAILVFGCDLNAEATGLEYRVIKAA
TKKDARLVLVNMRDVKLRKFSNAQLKHLPGSELSVIYALMKGILAAGGVLPAGSEAIKDALDKLTMAELCSQAGVTEKAV
ADAASLIAGKSRVSIVFGADLIRSADAAQKISALADLAILTGSAAKEGGGLFPVDAKNNTVGLLDMGVAPGADGKDLWGM
VEGIEEGSIKALYLLGCDLASFPDNQRIRKALGKLELLIVQDVFQGDSLEFAHVVFPASAAAEKSGSFTSLDNRVQPIFK
STAAPGAAREDWAIVSDLYGKVTGTVPSFTPASLMAQIKSEIPAYQPFDGSRNGFVKSGNGKVAPALAPIAKPAAPTQAT
FQLLVGPIGFHNGTSTTRSDANLSVAPAGFVELHPADAGKLGIEEGGSVKVISANASFTAPAKISDKLQPGLLFAPSHFR
ELNANALLAGGCNLAEVKVEKG
>Mature_822_residues
MVSLTIDGKSVQVEKGTTILEAAATVGIKIPTLCWLQKVSPTGACRVCAVEVAGVERTMTACNTPVKEGIQVTTDTPALR
EARKKIMELMLVNHPLDCPVCDAGGECDLQDSCYALDANKQEYSAVLERRPIRYDWPLIESDPNRCILCEKCVKVDHEIV
GCDAIEVVNKGEAAIIDTVDGKPLNCEFCGNCVAACPTGALITKPFKFKGRPWSFNTVPSVCAFCGAGCQIDYHAKNGRI
ERVTSDDGSYNNGNLCINGRFGYRYLHSLERISDPMLRDGSGRLAKADWETALTAAADKLKQIVSQNGGKAVAGLSSPRV
TNEENFLFKKFLTEAIGSANVDSEARLGFAQAQAQMSRRFGFTGASTTIDALDNAQAILVFGCDLNAEATGLEYRVIKAA
TKKDARLVLVNMRDVKLRKFSNAQLKHLPGSELSVIYALMKGILAAGGVLPAGSEAIKDALDKLTMAELCSQAGVTEKAV
ADAASLIAGKSRVSIVFGADLIRSADAAQKISALADLAILTGSAAKEGGGLFPVDAKNNTVGLLDMGVAPGADGKDLWGM
VEGIEEGSIKALYLLGCDLASFPDNQRIRKALGKLELLIVQDVFQGDSLEFAHVVFPASAAAEKSGSFTSLDNRVQPIFK
STAAPGAAREDWAIVSDLYGKVTGTVPSFTPASLMAQIKSEIPAYQPFDGSRNGFVKSGNGKVAPALAPIAKPAAPTQAT
FQLLVGPIGFHNGTSTTRSDANLSVAPAGFVELHPADAGKLGIEEGGSVKVISANASFTAPAKISDKLQPGLLFAPSHFR
ELNANALLAGGCNLAEVKVEKG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG3383

COG function: function code R; Uncharacterized anaerobic dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=761, Percent_Identity=25.7555847568988, Blast_Score=249, Evalue=8e-66,
Organism=Escherichia coli, GI145693161, Length=666, Percent_Identity=28.6786786786787, Blast_Score=214, Evalue=2e-56,
Organism=Escherichia coli, GI3868721, Length=669, Percent_Identity=23.9162929745889, Blast_Score=189, Evalue=6e-49,
Organism=Escherichia coli, GI1788534, Length=521, Percent_Identity=19.7696737044146, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI171474008, Length=213, Percent_Identity=26.7605633802817, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1787870, Length=212, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565758, Length=671, Percent_Identity=29.3591654247392, Blast_Score=246, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI32566231, Length=643, Percent_Identity=28.6158631415241, Blast_Score=229, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI193209088, Length=245, Percent_Identity=35.9183673469388, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24640559, Length=676, Percent_Identity=28.8461538461538, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24640557, Length=676, Percent_Identity=28.8461538461538, Blast_Score=238, Evalue=1e-62,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR009010
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR000283
- InterPro:   IPR019574 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 86695; Mature: 86695

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00641 COMPLEX1_75K_1 ; PS00642 COMPLEX1_75K_2 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLTIDGKSVQVEKGTTILEAAATVGIKIPTLCWLQKVSPTGACRVCAVEVAGVERTMT
CEEEEECCCEEEEECCCCCEEHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEECCHHHHHH
ACNTPVKEGIQVTTDTPALREARKKIMELMLVNHPLDCPVCDAGGECDLQDSCYALDANK
HCCCCHHCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCH
QEYSAVLERRPIRYDWPLIESDPNRCILCEKCVKVDHEIVGCDAIEVVNKGEAAIIDTVD
HHHHHHHHCCCCEECCCEEECCCCCEEEEHHHHHCCCEEECCCHHHHHCCCCEEEEECCC
GKPLNCEFCGNCVAACPTGALITKPFKFKGRPWSFNTVPSVCAFCGAGCQIDYHAKNGRI
CCCCCHHHHCCCHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCEE
ERVTSDDGSYNNGNLCINGRFGYRYLHSLERISDPMLRDGSGRLAKADWETALTAAADKL
EEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCHHCCCCCCEECCHHHHHHHHHHHHH
KQIVSQNGGKAVAGLSSPRVTNEENFLFKKFLTEAIGSANVDSEARLGFAQAQAQMSRRF
HHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
GFTGASTTIDALDNAQAILVFGCDLNAEATGLEYRVIKAATKKDARLVLVNMRDVKLRKF
CCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCEEEEEECCCEEEEEC
SNAQLKHLPGSELSVIYALMKGILAAGGVLPAGSEAIKDALDKLTMAELCSQAGVTEKAV
CCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
ADAASLIAGKSRVSIVFGADLIRSADAAQKISALADLAILTGSAAKEGGGLFPVDAKNNT
HHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCE
VGLLDMGVAPGADGKDLWGMVEGIEEGSIKALYLLGCDLASFPDNQRIRKALGKLELLIV
EEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCHHCCCCHHHHHHHHCCEEEEEE
QDVFQGDSLEFAHVVFPASAAAEKSGSFTSLDNRVQPIFKSTAAPGAAREDWAIVSDLYG
HHHHCCCCCEEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
KVTGTVPSFTPASLMAQIKSEIPAYQPFDGSRNGFVKSGNGKVAPALAPIAKPAAPTQAT
HHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCHHHHHCCCCCCCCHHH
FQLLVGPIGFHNGTSTTRSDANLSVAPAGFVELHPADAGKLGIEEGGSVKVISANASFTA
HHEEEECCCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCC
PAKISDKLQPGLLFAPSHFRELNANALLAGGCNLAEVKVEKG
CCCCCCCCCCCEEECCHHHHHCCCCEEEECCCCEEEEEEECC
>Mature Secondary Structure
MVSLTIDGKSVQVEKGTTILEAAATVGIKIPTLCWLQKVSPTGACRVCAVEVAGVERTMT
CEEEEECCCEEEEECCCCCEEHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEECCHHHHHH
ACNTPVKEGIQVTTDTPALREARKKIMELMLVNHPLDCPVCDAGGECDLQDSCYALDANK
HCCCCHHCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCH
QEYSAVLERRPIRYDWPLIESDPNRCILCEKCVKVDHEIVGCDAIEVVNKGEAAIIDTVD
HHHHHHHHCCCCEECCCEEECCCCCEEEEHHHHHCCCEEECCCHHHHHCCCCEEEEECCC
GKPLNCEFCGNCVAACPTGALITKPFKFKGRPWSFNTVPSVCAFCGAGCQIDYHAKNGRI
CCCCCHHHHCCCHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCEE
ERVTSDDGSYNNGNLCINGRFGYRYLHSLERISDPMLRDGSGRLAKADWETALTAAADKL
EEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCHHCCCCCCEECCHHHHHHHHHHHHH
KQIVSQNGGKAVAGLSSPRVTNEENFLFKKFLTEAIGSANVDSEARLGFAQAQAQMSRRF
HHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
GFTGASTTIDALDNAQAILVFGCDLNAEATGLEYRVIKAATKKDARLVLVNMRDVKLRKF
CCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCEEEEEECCCEEEEEC
SNAQLKHLPGSELSVIYALMKGILAAGGVLPAGSEAIKDALDKLTMAELCSQAGVTEKAV
CCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
ADAASLIAGKSRVSIVFGADLIRSADAAQKISALADLAILTGSAAKEGGGLFPVDAKNNT
HHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCE
VGLLDMGVAPGADGKDLWGMVEGIEEGSIKALYLLGCDLASFPDNQRIRKALGKLELLIV
EEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCHHCCCCHHHHHHHHCCEEEEEE
QDVFQGDSLEFAHVVFPASAAAEKSGSFTSLDNRVQPIFKSTAAPGAAREDWAIVSDLYG
HHHHCCCCCEEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
KVTGTVPSFTPASLMAQIKSEIPAYQPFDGSRNGFVKSGNGKVAPALAPIAKPAAPTQAT
HHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCHHHHHCCCCCCCCHHH
FQLLVGPIGFHNGTSTTRSDANLSVAPAGFVELHPADAGKLGIEEGGSVKVISANASFTA
HHEEEECCCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCC
PAKISDKLQPGLLFAPSHFRELNANALLAGGCNLAEVKVEKG
CCCCCCCCCCCEEECCHHHHHCCCCEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]