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The map label for this gene is ftsI [H]

Identifier: 197116883

GI number: 197116883

Start: 584180

End: 586162

Strand: Direct

Name: ftsI [H]

Synonym: Gbem_0485

Alternate gene names: 197116883

Gene position: 584180-586162 (Clockwise)

Preceding gene: 197116882

Following gene: 197116884

Centisome position: 12.66

GC content: 64.15

Gene sequence:

>1983_bases
GTGATCGAGAAAAAGGAGAAATGGGCCAGAGTCCGGATGCGTTTCGTGGCCCTCTTGTTCGTGGTCGTCTTCGTGGCTAC
CACGGGTCGCGCCTTTTACCTCCAGGTGCTCAACAACGACCGGCTGGTGAAGCTCGCGGAAAAACAGCACCAAAGGATCG
TGGCGCTCACGCCTGCCCGCGGCGCCATCTACGACAGAACCAACGCCCCGTTCGCCGTCTCGATAGAGATGGATTCCTGC
TACGCCGAGACGCGCAACATGGAAAACATCCCGCAGGAGGCGGCGCAGCTGGCGCCCCTTTTGGGTTACGGCGCGCAGGA
GCTCGAGTCGAAGCTCAAGGGAGCCAAGAACTTCGTGTGGCTCGCGCGGCGCATCCCGCCGGAGCAGGCCGGGAAGGTGA
AGGCGCTTGGGCTTGAGGGAGTCGGCTTCGTCAAGGAAAGCAAACGCTTCTACCCGAATTCCCAGGTGGCGGCCCATGTG
GTGGGCTTTACCGGTGTCGATCCCGGCGGCCTGGAGGGGGTGGAGAAGAAGTACGACGCCACCATCCTCGGCAACACGGG
ATTCCTGGTCACCGAGCGCGACGCCCTCGGGCGCGACATAGCACTCAAGAAGGGGAGCGAGGGCAAAAGCGGTTCCAAGG
GAAACAACGTCGTCCTCACCCTGGATAAGAACGTTCAGTACATAGCGGAAAAGGAGCTGACCAACGCGGTGGTGAAAAAC
GGCGCCAAGGCCGGCATCGCCATCGTGATGGAGCCCGACACCGGGCGGGTTTTGGCCATGGCCAACTACCCTTCCTTCAA
CCCGAACAGCTTTGCCGAGTACGGGCAGGCGGCGCTTAGAAACCGCGCCATCGCCGACAGCTTCGAGCCCGGCTCCACCT
TCAAGATCTTCCTGGTAGCTTCCGCACTCGAGGCGGGGGTGATCAGGCCCGGCGACATGTTCAACTGCGAAAACGGCAGC
TACAGCGTGTACGGCAGGACCATTCACGATACGCACAAATACGGGGCGCTCAGCGTGCCCCAGATCCTCAAGTACTCCAG
CAACATCGGCGCCGCCAAGATCGGCAGCCGGCTGGGGCCCGAAAGGCTCTACGCGGCCCTTACCGGCTTCGGTTTCGGCG
AAAAGAGCAGCATCGATCTTCCGGGGGAGGCCTCCGGGATGTTGCGGCCGCAGTCCAAGTGGTACGGCATCGACCTCGCC
ACCATCTCGTTCGGCCAGGGGGTGACGGCTACCGCGCTGCAGATCACCAACGCGGTGTCGGCTGTCGCCAACGGCGGCAA
CCTGATGAAGCCGTACCTGGTGGATAGGATCGTCGACGACAACGGCGTGGTGCTGCAGCAGTTCGCACCCCAGGTGAAAA
GGCGCATCATCTCGCCGGAGACGGCGAAGACGGTGGCCCGCATGCTGGAGGGGGTCGTGGTGGAAGGGGGGACCGGCACC
GGGGCCGCGGTCGAAGGTTACCGCGTCGCGGGGAAAACCGGGACCGCCCAGAAGGTCGAGGGGCACGGCTACTCGGCCAG
CAAGCGCACCGCCTCCTTTGTCGGTTTCGTTCCCCTGGACAAGCCGCGGCTCGCCATAATGGTCGTGGTGGACGAGCCGA
CCACGAGCTCCTACGGCGGGGTGGTAGCGGCCCCGGCCTTCAGCGCCATAGCGCAGCAGACCCTCTGCTACCTGAACGTG
GCACCGGACAAGAACGTCGTTGCCAAGAAGAAAAGCGGTGCCGCACCCGAGAAAAGCGCGCCCAAACCGGAGCCGGTGGC
CGAGGGAGGGAGCGTCGAAGGGGGGAGCGTGGAAGGGACGGCGGCCGGTGCCATGCCGAACTTCCGGGGAATGAGCATGC
GGCAGGTGCTCAAGGTGATGGAAAAGCGCGGTCTCAACGTCAAGCTGCAGGGAAGCGGCAGGGCGGTCGAGCAGAACCCG
GCCCCCGGGAGCCGCATCACCACGCAGGATCAGGTCTGGGTCAAGTTCGTCCCTTCGGCCTGA

Upstream 100 bases:

>100_bases
TCGAGGTGGCTTCGCTCAAGGCGCCGGCCCGGATCGAGGCGCTGGCCAAGGGTGAACTTGGCATGGCGCTCCCCTCCGAT
CAGCAGGTGGTCCTGGTCAA

Downstream 100 bases:

>100_bases
CAATGGGGGTAGCATGAAACTCGCACAACTTCTGAATTGCCTCGCCTCGCCCGAGCTCTCCGGAGACGCCGGTATCGAGA
TAGAGTCGCTTTGCTACGAC

Product: bifunctional peptidoglycan transglycosylase/transpeptidase FtsI

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MIEKKEKWARVRMRFVALLFVVVFVATTGRAFYLQVLNNDRLVKLAEKQHQRIVALTPARGAIYDRTNAPFAVSIEMDSC
YAETRNMENIPQEAAQLAPLLGYGAQELESKLKGAKNFVWLARRIPPEQAGKVKALGLEGVGFVKESKRFYPNSQVAAHV
VGFTGVDPGGLEGVEKKYDATILGNTGFLVTERDALGRDIALKKGSEGKSGSKGNNVVLTLDKNVQYIAEKELTNAVVKN
GAKAGIAIVMEPDTGRVLAMANYPSFNPNSFAEYGQAALRNRAIADSFEPGSTFKIFLVASALEAGVIRPGDMFNCENGS
YSVYGRTIHDTHKYGALSVPQILKYSSNIGAAKIGSRLGPERLYAALTGFGFGEKSSIDLPGEASGMLRPQSKWYGIDLA
TISFGQGVTATALQITNAVSAVANGGNLMKPYLVDRIVDDNGVVLQQFAPQVKRRIISPETAKTVARMLEGVVVEGGTGT
GAAVEGYRVAGKTGTAQKVEGHGYSASKRTASFVGFVPLDKPRLAIMVVVDEPTTSSYGGVVAAPAFSAIAQQTLCYLNV
APDKNVVAKKKSGAAPEKSAPKPEPVAEGGSVEGGSVEGTAAGAMPNFRGMSMRQVLKVMEKRGLNVKLQGSGRAVEQNP
APGSRITTQDQVWVKFVPSA

Sequences:

>Translated_660_residues
MIEKKEKWARVRMRFVALLFVVVFVATTGRAFYLQVLNNDRLVKLAEKQHQRIVALTPARGAIYDRTNAPFAVSIEMDSC
YAETRNMENIPQEAAQLAPLLGYGAQELESKLKGAKNFVWLARRIPPEQAGKVKALGLEGVGFVKESKRFYPNSQVAAHV
VGFTGVDPGGLEGVEKKYDATILGNTGFLVTERDALGRDIALKKGSEGKSGSKGNNVVLTLDKNVQYIAEKELTNAVVKN
GAKAGIAIVMEPDTGRVLAMANYPSFNPNSFAEYGQAALRNRAIADSFEPGSTFKIFLVASALEAGVIRPGDMFNCENGS
YSVYGRTIHDTHKYGALSVPQILKYSSNIGAAKIGSRLGPERLYAALTGFGFGEKSSIDLPGEASGMLRPQSKWYGIDLA
TISFGQGVTATALQITNAVSAVANGGNLMKPYLVDRIVDDNGVVLQQFAPQVKRRIISPETAKTVARMLEGVVVEGGTGT
GAAVEGYRVAGKTGTAQKVEGHGYSASKRTASFVGFVPLDKPRLAIMVVVDEPTTSSYGGVVAAPAFSAIAQQTLCYLNV
APDKNVVAKKKSGAAPEKSAPKPEPVAEGGSVEGGSVEGTAAGAMPNFRGMSMRQVLKVMEKRGLNVKLQGSGRAVEQNP
APGSRITTQDQVWVKFVPSA
>Mature_660_residues
MIEKKEKWARVRMRFVALLFVVVFVATTGRAFYLQVLNNDRLVKLAEKQHQRIVALTPARGAIYDRTNAPFAVSIEMDSC
YAETRNMENIPQEAAQLAPLLGYGAQELESKLKGAKNFVWLARRIPPEQAGKVKALGLEGVGFVKESKRFYPNSQVAAHV
VGFTGVDPGGLEGVEKKYDATILGNTGFLVTERDALGRDIALKKGSEGKSGSKGNNVVLTLDKNVQYIAEKELTNAVVKN
GAKAGIAIVMEPDTGRVLAMANYPSFNPNSFAEYGQAALRNRAIADSFEPGSTFKIFLVASALEAGVIRPGDMFNCENGS
YSVYGRTIHDTHKYGALSVPQILKYSSNIGAAKIGSRLGPERLYAALTGFGFGEKSSIDLPGEASGMLRPQSKWYGIDLA
TISFGQGVTATALQITNAVSAVANGGNLMKPYLVDRIVDDNGVVLQQFAPQVKRRIISPETAKTVARMLEGVVVEGGTGT
GAAVEGYRVAGKTGTAQKVEGHGYSASKRTASFVGFVPLDKPRLAIMVVVDEPTTSSYGGVVAAPAFSAIAQQTLCYLNV
APDKNVVAKKKSGAAPEKSAPKPEPVAEGGSVEGGSVEGTAAGAMPNFRGMSMRQVLKVMEKRGLNVKLQGSGRAVEQNP
APGSRITTQDQVWVKFVPSA

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=565, Percent_Identity=34.5132743362832, Blast_Score=332, Evalue=6e-92,
Organism=Escherichia coli, GI1786854, Length=617, Percent_Identity=24.9594813614263, Blast_Score=126, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70304; Mature: 70304

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKKEKWARVRMRFVALLFVVVFVATTGRAFYLQVLNNDRLVKLAEKQHQRIVALTPAR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEHHHCCCEEEEECCCC
GAIYDRTNAPFAVSIEMDSCYAETRNMENIPQEAAQLAPLLGYGAQELESKLKGAKNFVW
CCEEECCCCCEEEEEECHHHHHHHCCHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEE
LARRIPPEQAGKVKALGLEGVGFVKESKRFYPNSQVAAHVVGFTGVDPGGLEGVEKKYDA
EECCCCHHHCCCEEEECCCCCCCHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCE
TILGNTGFLVTERDALGRDIALKKGSEGKSGSKGNNVVLTLDKNVQYIAEKELTNAVVKN
EEECCCCEEEECHHHCCCCEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHC
GAKAGIAIVMEPDTGRVLAMANYPSFNPNSFAEYGQAALRNRAIADSFEPGSTFKIFLVA
CCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEE
SALEAGVIRPGDMFNCENGSYSVYGRTIHDTHKYGALSVPQILKYSSNIGAAKIGSRLGP
EHHHCCCCCCCCCCCCCCCCEEEEECEECCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCH
ERLYAALTGFGFGEKSSIDLPGEASGMLRPQSKWYGIDLATISFGQGVTATALQITNAVS
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHH
AVANGGNLMKPYLVDRIVDDNGVVLQQFAPQVKRRIISPETAKTVARMLEGVVVEGGTGT
HHHCCCCCCCHHHHHHEECCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEECCCCC
GAAVEGYRVAGKTGTAQKVEGHGYSASKRTASFVGFVPLDKPRLAIMVVVDEPTTSSYGG
CCEECCEEEECCCCCCCEECCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCC
VVAAPAFSAIAQQTLCYLNVAPDKNVVAKKKSGAAPEKSAPKPEPVAEGGSVEGGSVEGT
EEEHHHHHHHHHCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAGAMPNFRGMSMRQVLKVMEKRGLNVKLQGSGRAVEQNPAPGSRITTQDQVWVKFVPSA
CCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MIEKKEKWARVRMRFVALLFVVVFVATTGRAFYLQVLNNDRLVKLAEKQHQRIVALTPAR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEHHHCCCEEEEECCCC
GAIYDRTNAPFAVSIEMDSCYAETRNMENIPQEAAQLAPLLGYGAQELESKLKGAKNFVW
CCEEECCCCCEEEEEECHHHHHHHCCHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEE
LARRIPPEQAGKVKALGLEGVGFVKESKRFYPNSQVAAHVVGFTGVDPGGLEGVEKKYDA
EECCCCHHHCCCEEEECCCCCCCHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCE
TILGNTGFLVTERDALGRDIALKKGSEGKSGSKGNNVVLTLDKNVQYIAEKELTNAVVKN
EEECCCCEEEECHHHCCCCEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHC
GAKAGIAIVMEPDTGRVLAMANYPSFNPNSFAEYGQAALRNRAIADSFEPGSTFKIFLVA
CCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEE
SALEAGVIRPGDMFNCENGSYSVYGRTIHDTHKYGALSVPQILKYSSNIGAAKIGSRLGP
EHHHCCCCCCCCCCCCCCCCEEEEECEECCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCH
ERLYAALTGFGFGEKSSIDLPGEASGMLRPQSKWYGIDLATISFGQGVTATALQITNAVS
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHH
AVANGGNLMKPYLVDRIVDDNGVVLQQFAPQVKRRIISPETAKTVARMLEGVVVEGGTGT
HHHCCCCCCCHHHHHHEECCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEECCCCC
GAAVEGYRVAGKTGTAQKVEGHGYSASKRTASFVGFVPLDKPRLAIMVVVDEPTTSSYGG
CCEECCEEEECCCCCCCEECCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCC
VVAAPAFSAIAQQTLCYLNVAPDKNVVAKKKSGAAPEKSAPKPEPVAEGGSVEGGSVEGT
EEEHHHHHHHHHCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAGAMPNFRGMSMRQVLKVMEKRGLNVKLQGSGRAVEQNPAPGSRITTQDQVWVKFVPSA
CCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]