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The map label for this gene is typA [H]

Identifier: 197116872

GI number: 197116872

Start: 572881

End: 574686

Strand: Direct

Name: typA [H]

Synonym: Gbem_0474

Alternate gene names: 197116872

Gene position: 572881-574686 (Clockwise)

Preceding gene: 197116871

Following gene: 197116873

Centisome position: 12.41

GC content: 62.79

Gene sequence:

>1806_bases
ATGCAGGAGAAGATCAGAAACATAGCGATCATCGCACACGTCGACCACGGCAAGACTACCCTGGTCGACGCGATGCTTAA
GCAGTCCGGCGTATTCAGAGAAAACGAGGCGATCACCGAGAGGGTGATGGATTCCAACGACCTGGAGAAGGAACGCGGCA
TCACCATCCTCGCCAAGAACCTTTCCATCCACCACGGCGGCTACAAGATCAACATCGTGGATACCCCGGGCCACGCCGAT
TTCGGCGGCGAGGTGGAGCGCGTGCTGAAGATGGTCGACTCGGTGCTCTTGCTGGTGGACGCCCTCGACGGCCCGATGCC
GCAGACCCGCTTCGTGCTCAAGAAGTCGCTCGACCTGGGCCTTAAGCCGATCGTCGTGATCAACAAGGTCGACCGTCCCG
GCGCCCGCCCCGCCGAGGTCGTGGACATGGTGTTCGACCTCTTCTGCGAACTGCAGGCCTCCGACGCCCAGCTCGACTTC
GCCATCTGCTATACCAGCGCCAAGATGGGTTACGCCATGCGCGAAATGGAGCATCCCTCCGAGAACATGGAGCCGCTTTT
CGAGCTGATCAAGGAAAACGTCCATCCTCCCGAGGGGGACGCGGCCGCTCCCTTCCAGCTGCTGGTTACCAACATCGACT
ACAACGACTACATCGGCCGTATCGCCACCGGGAAGATCTTCAACGGCAAGGTTAGCTCCGGCGAGACCGTCGCCCTCATC
AAGCGCGACGGCACCATCTCCAAGGCGCGCGTCACCAAGCTCTTAGGGTACGAGGGGCTGAAGCAGGTCGAGATCGCCGA
GGCGTTCACCGGCGACATCGTCACCATCGCAGGGTTCACCGAAGTGGGTATCGGCGAGAGCTTGGCTGCCGCCGACAACC
CGATCCCGCTTCCCTACGTCGCCATCGACGAGCCGACCCTCTCCATGAACTTCATCGTCAACTCCTCCCCCTTCGCCGGG
CGCGAGGGGAAGCTGGTCACCTCCAGGAACATCCGCGAGCGCCTGGACCGGGAGCTTAGGACCAACGTGTCGCTGCGGGT
TTCCGACACCTCCAACGCCGATACCTTCCAGGTCTCCGGCCGCGGCGAGCTGCACCTCTCCATCCTGATCGAGAACATGC
GCCGTGAAGGTTTCGAGATGGCGGTCTCCAAACCCGAGGTCATCATGCGCATGGTGAACGGCGTGCGCCACGAGCCGATG
GAATACCTGGTGGTGGACGTCCCCGCCGAGTACCAGGGGGCCATCATCGAGCGCATGGGACCCCGTAAGGGGGAGATGGC
AGCCATGACGCCGATGGGCGATACCATCCGTCTTGAGTTCATCGTTCCGGCCCGCGGCCTGATCGGCCTCAGGGGCGAGT
TCCTCACCGAGACCCGCGGCACCGCGGTGATCACCCATACCTTCCACGAGTACGCCCCCTACAAAGGGGAGATCCCGGGC
AGGAAGAACGGGGTGTTGATCGCCATGGAGCAGGGGGAGACAACTGCTTACTCGCTGGACGCGCTGCAGCCGCGCGGCAT
CCTGTTCCTCGGCGCGGGCGTCGAGGTGTACGGCGGCATGATCGTAGGCCAGCACGCGAAGGACAACGACCTCGAGGTGA
ACCCCTGCAAGGGGAAGAAGCTCACCAACGTGCGCGCCTCGGGCTCCGACGACGCCATCAAGCTCACTCCGCCGAGGCTG
CTCACCCTGGAACAGGCGTTGGAGTTCATCGACGAAGACGAGCTGGTCGAGGTAACCCCTATGTCCATACGCCTCCGGAA
GAAGTTTCTCGACCCCAACATGCGCAAGCGCGCCAACCGCAGCTAG

Upstream 100 bases:

>100_bases
TGTCAAGTGTGGCGAAATATGCCATATTGAGCTGTTTTTAAGACGGGCTCCATGCTCGTCTTTTTATTTTAGGTGTCCAA
GCAAAGAGGAGCTGCAACCC

Downstream 100 bases:

>100_bases
AGAAAAATAGGTCCCCGGGGCACGAGCCGTCCCGGGGACCTTTGTCGCTGGGCCACCACCACCTGGAAAGGAGTCACCTC
ATGCAGCTTCGACCCCTGCG

Product: translation-regulating membrane GTPase TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MQEKIRNIAIIAHVDHGKTTLVDAMLKQSGVFRENEAITERVMDSNDLEKERGITILAKNLSIHHGGYKINIVDTPGHAD
FGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLGLKPIVVINKVDRPGARPAEVVDMVFDLFCELQASDAQLDF
AICYTSAKMGYAMREMEHPSENMEPLFELIKENVHPPEGDAAAPFQLLVTNIDYNDYIGRIATGKIFNGKVSSGETVALI
KRDGTISKARVTKLLGYEGLKQVEIAEAFTGDIVTIAGFTEVGIGESLAAADNPIPLPYVAIDEPTLSMNFIVNSSPFAG
REGKLVTSRNIRERLDRELRTNVSLRVSDTSNADTFQVSGRGELHLSILIENMRREGFEMAVSKPEVIMRMVNGVRHEPM
EYLVVDVPAEYQGAIIERMGPRKGEMAAMTPMGDTIRLEFIVPARGLIGLRGEFLTETRGTAVITHTFHEYAPYKGEIPG
RKNGVLIAMEQGETTAYSLDALQPRGILFLGAGVEVYGGMIVGQHAKDNDLEVNPCKGKKLTNVRASGSDDAIKLTPPRL
LTLEQALEFIDEDELVEVTPMSIRLRKKFLDPNMRKRANRS

Sequences:

>Translated_601_residues
MQEKIRNIAIIAHVDHGKTTLVDAMLKQSGVFRENEAITERVMDSNDLEKERGITILAKNLSIHHGGYKINIVDTPGHAD
FGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLGLKPIVVINKVDRPGARPAEVVDMVFDLFCELQASDAQLDF
AICYTSAKMGYAMREMEHPSENMEPLFELIKENVHPPEGDAAAPFQLLVTNIDYNDYIGRIATGKIFNGKVSSGETVALI
KRDGTISKARVTKLLGYEGLKQVEIAEAFTGDIVTIAGFTEVGIGESLAAADNPIPLPYVAIDEPTLSMNFIVNSSPFAG
REGKLVTSRNIRERLDRELRTNVSLRVSDTSNADTFQVSGRGELHLSILIENMRREGFEMAVSKPEVIMRMVNGVRHEPM
EYLVVDVPAEYQGAIIERMGPRKGEMAAMTPMGDTIRLEFIVPARGLIGLRGEFLTETRGTAVITHTFHEYAPYKGEIPG
RKNGVLIAMEQGETTAYSLDALQPRGILFLGAGVEVYGGMIVGQHAKDNDLEVNPCKGKKLTNVRASGSDDAIKLTPPRL
LTLEQALEFIDEDELVEVTPMSIRLRKKFLDPNMRKRANRS
>Mature_601_residues
MQEKIRNIAIIAHVDHGKTTLVDAMLKQSGVFRENEAITERVMDSNDLEKERGITILAKNLSIHHGGYKINIVDTPGHAD
FGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLGLKPIVVINKVDRPGARPAEVVDMVFDLFCELQASDAQLDF
AICYTSAKMGYAMREMEHPSENMEPLFELIKENVHPPEGDAAAPFQLLVTNIDYNDYIGRIATGKIFNGKVSSGETVALI
KRDGTISKARVTKLLGYEGLKQVEIAEAFTGDIVTIAGFTEVGIGESLAAADNPIPLPYVAIDEPTLSMNFIVNSSPFAG
REGKLVTSRNIRERLDRELRTNVSLRVSDTSNADTFQVSGRGELHLSILIENMRREGFEMAVSKPEVIMRMVNGVRHEPM
EYLVVDVPAEYQGAIIERMGPRKGEMAAMTPMGDTIRLEFIVPARGLIGLRGEFLTETRGTAVITHTFHEYAPYKGEIPG
RKNGVLIAMEQGETTAYSLDALQPRGILFLGAGVEVYGGMIVGQHAKDNDLEVNPCKGKKLTNVRASGSDDAIKLTPPRL
LTLEQALEFIDEDELVEVTPMSIRLRKKFLDPNMRKRANRS

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=308, Percent_Identity=33.1168831168831, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=42.4242424242424, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=36.1111111111111, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=39.4557823129252, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=40.9090909090909, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=40.9090909090909, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=40.9090909090909, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI25306287, Length=134, Percent_Identity=38.8059701492537, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI19923640, Length=134, Percent_Identity=38.8059701492537, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI25306283, Length=134, Percent_Identity=38.8059701492537, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI34147630, Length=276, Percent_Identity=29.3478260869565, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI217272892, Length=138, Percent_Identity=34.0579710144928, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI217272894, Length=138, Percent_Identity=34.0579710144928, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI94966752, Length=83, Percent_Identity=40.9638554216867, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI53729339, Length=152, Percent_Identity=32.8947368421053, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI53729337, Length=152, Percent_Identity=32.8947368421053, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=57.7114427860697, Blast_Score=698, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=506, Percent_Identity=27.4703557312253, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1789738, Length=153, Percent_Identity=36.6013071895425, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1789737, Length=241, Percent_Identity=29.4605809128631, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790412, Length=241, Percent_Identity=29.4605809128631, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790835, Length=147, Percent_Identity=31.2925170068027, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789559, Length=171, Percent_Identity=29.8245614035088, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=289, Percent_Identity=31.4878892733564, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=40.7692307692308, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=40.7692307692308, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17556745, Length=143, Percent_Identity=38.4615384615385, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17506493, Length=159, Percent_Identity=32.7044025157233, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17533571, Length=145, Percent_Identity=38.6206896551724, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=34.3283582089552, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=273, Percent_Identity=30.4029304029304, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71994658, Length=131, Percent_Identity=37.4045801526718, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=514, Percent_Identity=28.0155642023346, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324707, Length=202, Percent_Identity=32.6732673267327, Blast_Score=113, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6320593, Length=202, Percent_Identity=32.6732673267327, Blast_Score=113, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=40.2684563758389, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324761, Length=268, Percent_Identity=30.2238805970149, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323098, Length=150, Percent_Identity=38, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=37.3239436619718, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324550, Length=174, Percent_Identity=32.183908045977, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI78706572, Length=530, Percent_Identity=26.0377358490566, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=38.5714285714286, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=35.0993377483444, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=35.0993377483444, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=35.0993377483444, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24582462, Length=147, Percent_Identity=38.7755102040816, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=37.3134328358209, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221458488, Length=137, Percent_Identity=40.8759124087591, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281363316, Length=268, Percent_Identity=29.4776119402985, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17864358, Length=268, Percent_Identity=29.4776119402985, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921738, Length=234, Percent_Identity=29.9145299145299, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922690, Length=244, Percent_Identity=28.6885245901639, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28572034, Length=128, Percent_Identity=32.8125, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66343; Mature: 66343

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKIRNIAIIAHVDHGKTTLVDAMLKQSGVFRENEAITERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEEEEC
LSIHHGGYKINIVDTPGHADFGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLG
EEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LKPIVVINKVDRPGARPAEVVDMVFDLFCELQASDAQLDFAICYTSAKMGYAMREMEHPS
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHHHHCCCC
ENMEPLFELIKENVHPPEGDAAAPFQLLVTNIDYNDYIGRIATGKIFNGKVSSGETVALI
CCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHCCCEEECEEECCCCCCCCEEEEE
KRDGTISKARVTKLLGYEGLKQVEIAEAFTGDIVTIAGFTEVGIGESLAAADNPIPLPYV
ECCCCCHHHHHHHHHCCCCCCCEEHHHHHCCCEEEEECCCCCCCCCHHHCCCCCCCCCEE
AIDEPTLSMNFIVNSSPFAGREGKLVTSRNIRERLDRELRTNVSLRVSDTSNADTFQVSG
EECCCCEEEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHCCEEEEEECCCCCCEEEECC
RGELHLSILIENMRREGFEMAVSKPEVIMRMVNGVRHEPMEYLVVDVPAEYQGAIIERMG
CCCEEEEEEEHHHHHCCHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHCHHHHHCC
PRKGEMAAMTPMGDTIRLEFIVPARGLIGLRGEFLTETRGTAVITHTFHEYAPYKGEIPG
CCCCCEEEECCCCCEEEEEEEECCCCCEECCCCCEECCCCCEEEEEEHHHHCCCCCCCCC
RKNGVLIAMEQGETTAYSLDALQPRGILFLGAGVEVYGGMIVGQHAKDNDLEVNPCKGKK
CCCCEEEEEECCCCEEEEECCCCCCCEEEEECCHHHHCCEEEECCCCCCCCEECCCCCCE
LTNVRASGSDDAIKLTPPRLLTLEQALEFIDEDELVEVTPMSIRLRKKFLDPNMRKRANR
EEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHHHCCC
S
C
>Mature Secondary Structure
MQEKIRNIAIIAHVDHGKTTLVDAMLKQSGVFRENEAITERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEEEEC
LSIHHGGYKINIVDTPGHADFGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLG
EEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LKPIVVINKVDRPGARPAEVVDMVFDLFCELQASDAQLDFAICYTSAKMGYAMREMEHPS
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHHHHCCCC
ENMEPLFELIKENVHPPEGDAAAPFQLLVTNIDYNDYIGRIATGKIFNGKVSSGETVALI
CCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHCCCEEECEEECCCCCCCCEEEEE
KRDGTISKARVTKLLGYEGLKQVEIAEAFTGDIVTIAGFTEVGIGESLAAADNPIPLPYV
ECCCCCHHHHHHHHHCCCCCCCEEHHHHHCCCEEEEECCCCCCCCCHHHCCCCCCCCCEE
AIDEPTLSMNFIVNSSPFAGREGKLVTSRNIRERLDRELRTNVSLRVSDTSNADTFQVSG
EECCCCEEEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHCCEEEEEECCCCCCEEEECC
RGELHLSILIENMRREGFEMAVSKPEVIMRMVNGVRHEPMEYLVVDVPAEYQGAIIERMG
CCCEEEEEEEHHHHHCCHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHCHHHHHCC
PRKGEMAAMTPMGDTIRLEFIVPARGLIGLRGEFLTETRGTAVITHTFHEYAPYKGEIPG
CCCCCEEEECCCCCEEEEEEEECCCCCEECCCCCEECCCCCEEEEEEHHHHCCCCCCCCC
RKNGVLIAMEQGETTAYSLDALQPRGILFLGAGVEVYGGMIVGQHAKDNDLEVNPCKGKK
CCCCEEEEEECCCCEEEEECCCCCCCEEEEECCHHHHCCEEEECCCCCCCCEECCCCCCE
LTNVRASGSDDAIKLTPPRLLTLEQALEFIDEDELVEVTPMSIRLRKKFLDPNMRKRANR
EEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHHHCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]