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The map label for this gene is nreC [H]

Identifier: 197116849

GI number: 197116849

Start: 544221

End: 544871

Strand: Direct

Name: nreC [H]

Synonym: Gbem_0451

Alternate gene names: 197116849

Gene position: 544221-544871 (Clockwise)

Preceding gene: 197116848

Following gene: 197116850

Centisome position: 11.79

GC content: 61.29

Gene sequence:

>651_bases
ATGAGTATGAAGGTACTGATCGTGGACGACCACACCATAGTGAGGCAGGGGTTGCGCGTACTGATCGACAAGGAACAGGA
TATGGAGGTGATCGCCGAGGCTGCCACCGGCGCCGAGGCGATCCGATTGGCCCGCGAAAAGCGCCCCGACGTCACGGTTA
TGGATATCACCATGCCCGACCTAAATGGCATCGACGCCACGCGCGCCATCATCGCGGAGTGGCCGCAGGCGCGGGTGCTG
GCGCTTTCCATGGAGTCGGACCGGCGCTTCGTGGTGGAGGTACTGAAGGCAGGCGCCAACGGCTACGTCCTCAAGGACTC
GGCCTTTGCCGAACTCGCCACTGCGATCCGGGCCGTCGCCACGGGGGAGACCTATCTCCCTTCCAGGGTGACCACGCTTT
TGATCAAGGAGTACCTGCAGCGCATTCCCGACGAGGTGCCGGCTACCTACGAGAACCTCTCACAGCGGGAAAGGGAGATC
CTGCAGCTGATCGCCGACGGCAGAAACGCGAAGGAGATCGCCTTCAGCTTCGGTGTCAGCGTGAAGACGGTGGAGAACCA
GCGGCACAGCATCATGAAAAAGCTGGACCTTTTCAGCATCGCCGAGTTGACCAAGTACGCCGTACGCCAGGGTCTCACCT
CGCTCAGTTGA

Upstream 100 bases:

>100_bases
CATCTCGGCGGGGTGTTCAGCATAGAGTCCAGGCCGCAGGGAGGCACCAGGGCTGCCATCGAGGTTCCCGTGGAAACCGA
GACAAAATAGGAGGCGGGAT

Downstream 100 bases:

>100_bases
CCAGGCCGTGAGGGGGGTGCACCACGCACCCCCTCCTGCCGATTCCCCTGCATATTTCCTCCCCGCGCATCCCTTCCTTG
GCTGCCTAAGGCACGCCGCC

Product: LuxR family transcriptional response regulator

Products: NA

Alternate protein names: Nitrogen regulation protein C [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MSMKVLIVDDHTIVRQGLRVLIDKEQDMEVIAEAATGAEAIRLAREKRPDVTVMDITMPDLNGIDATRAIIAEWPQARVL
ALSMESDRRFVVEVLKAGANGYVLKDSAFAELATAIRAVATGETYLPSRVTTLLIKEYLQRIPDEVPATYENLSQREREI
LQLIADGRNAKEIAFSFGVSVKTVENQRHSIMKKLDLFSIAELTKYAVRQGLTSLS

Sequences:

>Translated_216_residues
MSMKVLIVDDHTIVRQGLRVLIDKEQDMEVIAEAATGAEAIRLAREKRPDVTVMDITMPDLNGIDATRAIIAEWPQARVL
ALSMESDRRFVVEVLKAGANGYVLKDSAFAELATAIRAVATGETYLPSRVTTLLIKEYLQRIPDEVPATYENLSQREREI
LQLIADGRNAKEIAFSFGVSVKTVENQRHSIMKKLDLFSIAELTKYAVRQGLTSLS
>Mature_215_residues
SMKVLIVDDHTIVRQGLRVLIDKEQDMEVIAEAATGAEAIRLAREKRPDVTVMDITMPDLNGIDATRAIIAEWPQARVLA
LSMESDRRFVVEVLKAGANGYVLKDSAFAELATAIRAVATGETYLPSRVTTLLIKEYLQRIPDEVPATYENLSQREREIL
QLIADGRNAKEIAFSFGVSVKTVENQRHSIMKKLDLFSIAELTKYAVRQGLTSLS

Specific function: Member of the two-component regulatory system nreB/nreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated nreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nit

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=212, Percent_Identity=32.0754716981132, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1788521, Length=197, Percent_Identity=34.5177664974619, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790102, Length=202, Percent_Identity=32.1782178217822, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=26.4423076923077, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1786747, Length=207, Percent_Identity=30.9178743961353, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=33.5164835164835, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1788546, Length=208, Percent_Identity=29.3269230769231, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082052, Length=103, Percent_Identity=30.0970873786408, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789937, Length=196, Percent_Identity=23.469387755102, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24060; Mature: 23929

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMKVLIVDDHTIVRQGLRVLIDKEQDMEVIAEAATGAEAIRLAREKRPDVTVMDITMPD
CCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCC
LNGIDATRAIIAEWPQARVLALSMESDRRFVVEVLKAGANGYVLKDSAFAELATAIRAVA
CCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHH
TGETYLPSRVTTLLIKEYLQRIPDEVPATYENLSQREREILQLIADGRNAKEIAFSFGVS
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCE
VKTVENQRHSIMKKLDLFSIAELTKYAVRQGLTSLS
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SMKVLIVDDHTIVRQGLRVLIDKEQDMEVIAEAATGAEAIRLAREKRPDVTVMDITMPD
CEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCC
LNGIDATRAIIAEWPQARVLALSMESDRRFVVEVLKAGANGYVLKDSAFAELATAIRAVA
CCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHH
TGETYLPSRVTTLLIKEYLQRIPDEVPATYENLSQREREILQLIADGRNAKEIAFSFGVS
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCE
VKTVENQRHSIMKKLDLFSIAELTKYAVRQGLTSLS
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA