Click here to switch to the map view.

The map label for this gene is ubiB [C]

Identifier: 197116836

GI number: 197116836

Start: 521603

End: 523024

Strand: Reverse

Name: ubiB [C]

Synonym: Gbem_0438

Alternate gene names: 197116836

Gene position: 523024-521603 (Counterclockwise)

Preceding gene: 197116837

Following gene: 197116835

Centisome position: 11.33

GC content: 63.92

Gene sequence:

>1422_bases
ATGTCCTGTAACGTCGCAGTGGCACCCGCCAGCCGCGAGCGCCTTATGCAGCTCCTGCCGCGAGACGAAGACGCCGCCGC
TCGCCAGAGGCTTGCCGAGCTGGTCGAGACCGCCTGCAGCAACAGGCCCCCGACGAGCTCGCTTTCCCGCCTCTGGATCC
TGGGATCCATGCAGGCGAAGGTCGCCGGCGCCTACGTCGCCTGGTGGCTCAGGAGCCGCTTGGTCGATCCCGACGAGAAG
GAGCGGACCAAGAACGAGACCCACCTCAAGGCGGCGCTGGAGCTGTTCGGCACCATGGGGTACCTGCGCGGCGCGGTCAT
GAAGGTTGGGCAGATGCTGACGCTCCCCGAGATGGTTCCCGAGCAGTACGCCCGCCTGCTCTCCTCGCTCAGCTTCGAGG
CCCCGCCGATGCACTACGCCATGGTACGCGAGGTGTTTTTCGACGAATTCGGCCGGGAACCCGAAGAGATGTTCGCCAGC
TTCGAGAAGAAGGCCTTCGCCGCCGCATCCCTGGGGCAGGTGCACCGCGCCCGGCTCCATACGGGAGAGCAGGTGGCGGT
GAAGATCCAGTATCCCGGGATCGCCCGTACCATCCAGGCAGATCTCAAGAACCTCCGCCTGCTGCTGCAGCCGATGCGCA
TGGGGGACGATTGGCCGAACCTCCTCGACAAGCTGGCCGAGGTCGAGAGCGTGCTTCTGGCAGAAACCGACTACCTGAAG
GAGGCCGAGTTGGCCCAGGCGGTGCGCAGCCATTTTGAGCCGGGGGACGGGATCGTGGTTCCGAGGGTATATACCGAGTG
CTCCAGCCTCCGGGTCTTGACCACCGAATATCTGCAAGGGGTACACATAGACGAATTTCTCGCTTCCGACCCGTCGCAGG
AACTGCGAGATCGCTTCACCCACCTGATGACCATGGCCACCATCCGTCTTTTGTACCGGACACACTGCATCATGGCCGAT
CCCAATCCGGGCAACTACATTTTCATGCCGGACGGCAGGCTGGGGGTGATCGACTTCGGCTGCGCCCGCATGTACACCGA
CGAAGAATGGCGGATGCAGTGCGAGGCCGAAGCGGCAGCGTTCCGGCAGGACGAGAAGGAGATGGAACGCATCATCGTGG
AAGCATCGCTCTACGAGTCGGCGCAGGAGATGGGGGCGGAGCGGGTGGAACTGGTGGGGCGGGTGATAAGTTGGCAGTTG
GAGCCCTGGCTTTCCGAGGGGCTCTTCGACTTCGGCGACAGGGACTTCTTCCTTCGGGGGATGGAGGCCATGCGGCAAGC
CACCAAGAAGGGGTACCTGCGCGGCATGCCATTGCACATCTGGACCACGCGCTTCGTCCTGGGCGCCCGCGCCGTAGTCT
ATCGGCTCAAGGGGCGCTGCCATTTCAAGGAGATCTACCGGCAGGAGTCGGCACCGAGGTAG

Upstream 100 bases:

>100_bases
CCGTCACCGAACCAGGAAGCCAGCCAGGCGCTGGTCGACTACTCGGTCCGTACTTTTGTGCATATTATCTCCGGCAGCGC
CGGGGTAGATGGAGGTGAGC

Downstream 100 bases:

>100_bases
TAATCGCGCGCCCCCTCCCTGTCCGCGAACACGGGGGGAAGCGGAAGTCCATCCCCTCGCCCTCTGGGAGAGGGGCAGGG
GTGAGGGATGTGGGTGAAGC

Product: protein kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSCNVAVAPASRERLMQLLPRDEDAAARQRLAELVETACSNRPPTSSLSRLWILGSMQAKVAGAYVAWWLRSRLVDPDEK
ERTKNETHLKAALELFGTMGYLRGAVMKVGQMLTLPEMVPEQYARLLSSLSFEAPPMHYAMVREVFFDEFGREPEEMFAS
FEKKAFAAASLGQVHRARLHTGEQVAVKIQYPGIARTIQADLKNLRLLLQPMRMGDDWPNLLDKLAEVESVLLAETDYLK
EAELAQAVRSHFEPGDGIVVPRVYTECSSLRVLTTEYLQGVHIDEFLASDPSQELRDRFTHLMTMATIRLLYRTHCIMAD
PNPGNYIFMPDGRLGVIDFGCARMYTDEEWRMQCEAEAAAFRQDEKEMERIIVEASLYESAQEMGAERVELVGRVISWQL
EPWLSEGLFDFGDRDFFLRGMEAMRQATKKGYLRGMPLHIWTTRFVLGARAVVYRLKGRCHFKEIYRQESAPR

Sequences:

>Translated_473_residues
MSCNVAVAPASRERLMQLLPRDEDAAARQRLAELVETACSNRPPTSSLSRLWILGSMQAKVAGAYVAWWLRSRLVDPDEK
ERTKNETHLKAALELFGTMGYLRGAVMKVGQMLTLPEMVPEQYARLLSSLSFEAPPMHYAMVREVFFDEFGREPEEMFAS
FEKKAFAAASLGQVHRARLHTGEQVAVKIQYPGIARTIQADLKNLRLLLQPMRMGDDWPNLLDKLAEVESVLLAETDYLK
EAELAQAVRSHFEPGDGIVVPRVYTECSSLRVLTTEYLQGVHIDEFLASDPSQELRDRFTHLMTMATIRLLYRTHCIMAD
PNPGNYIFMPDGRLGVIDFGCARMYTDEEWRMQCEAEAAAFRQDEKEMERIIVEASLYESAQEMGAERVELVGRVISWQL
EPWLSEGLFDFGDRDFFLRGMEAMRQATKKGYLRGMPLHIWTTRFVLGARAVVYRLKGRCHFKEIYRQESAPR
>Mature_472_residues
SCNVAVAPASRERLMQLLPRDEDAAARQRLAELVETACSNRPPTSSLSRLWILGSMQAKVAGAYVAWWLRSRLVDPDEKE
RTKNETHLKAALELFGTMGYLRGAVMKVGQMLTLPEMVPEQYARLLSSLSFEAPPMHYAMVREVFFDEFGREPEEMFASF
EKKAFAAASLGQVHRARLHTGEQVAVKIQYPGIARTIQADLKNLRLLLQPMRMGDDWPNLLDKLAEVESVLLAETDYLKE
AELAQAVRSHFEPGDGIVVPRVYTECSSLRVLTTEYLQGVHIDEFLASDPSQELRDRFTHLMTMATIRLLYRTHCIMADP
NPGNYIFMPDGRLGVIDFGCARMYTDEEWRMQCEAEAAAFRQDEKEMERIIVEASLYESAQEMGAERVELVGRVISWQLE
PWLSEGLFDFGDRDFFLRGMEAMRQATKKGYLRGMPLHIWTTRFVLGARAVVYRLKGRCHFKEIYRQESAPR

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=410, Percent_Identity=28.0487804878049, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI27363457, Length=326, Percent_Identity=30.9815950920245, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI217416386, Length=312, Percent_Identity=30.4487179487179, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI40254938, Length=325, Percent_Identity=27.0769230769231, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI41393593, Length=314, Percent_Identity=27.3885350318471, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI217035081, Length=290, Percent_Identity=25.1724137931034, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI2367309, Length=323, Percent_Identity=26.9349845201238, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32565180, Length=398, Percent_Identity=28.643216080402, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17559152, Length=305, Percent_Identity=26.2295081967213, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=333, Percent_Identity=27.3273273273273, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323282, Length=261, Percent_Identity=27.2030651340996, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18859849, Length=332, Percent_Identity=33.1325301204819, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI22024280, Length=318, Percent_Identity=29.559748427673, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24662575, Length=316, Percent_Identity=31.3291139240506, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 54109; Mature: 53978

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCNVAVAPASRERLMQLLPRDEDAAARQRLAELVETACSNRPPTSSLSRLWILGSMQAK
CCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHH
VAGAYVAWWLRSRLVDPDEKERTKNETHLKAALELFGTMGYLRGAVMKVGQMLTLPEMVP
HHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EQYARLLSSLSFEAPPMHYAMVREVFFDEFGREPEEMFASFEKKAFAAASLGQVHRARLH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGEQVAVKIQYPGIARTIQADLKNLRLLLQPMRMGDDWPNLLDKLAEVESVLLAETDYLK
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
EAELAQAVRSHFEPGDGIVVPRVYTECSSLRVLTTEYLQGVHIDEFLASDPSQELRDRFT
HHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHH
HLMTMATIRLLYRTHCIMADPNPGNYIFMPDGRLGVIDFGCARMYTDEEWRMQCEAEAAA
HHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCEEEEECCHHHHCCCHHHHHHHHHHHHH
FRQDEKEMERIIVEASLYESAQEMGAERVELVGRVISWQLEPWLSEGLFDFGDRDFFLRG
HHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHCCHHCCCCHHHHHHH
MEAMRQATKKGYLRGMPLHIWTTRFVLGARAVVYRLKGRCHFKEIYRQESAPR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SCNVAVAPASRERLMQLLPRDEDAAARQRLAELVETACSNRPPTSSLSRLWILGSMQAK
CCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHH
VAGAYVAWWLRSRLVDPDEKERTKNETHLKAALELFGTMGYLRGAVMKVGQMLTLPEMVP
HHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EQYARLLSSLSFEAPPMHYAMVREVFFDEFGREPEEMFASFEKKAFAAASLGQVHRARLH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGEQVAVKIQYPGIARTIQADLKNLRLLLQPMRMGDDWPNLLDKLAEVESVLLAETDYLK
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
EAELAQAVRSHFEPGDGIVVPRVYTECSSLRVLTTEYLQGVHIDEFLASDPSQELRDRFT
HHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHH
HLMTMATIRLLYRTHCIMADPNPGNYIFMPDGRLGVIDFGCARMYTDEEWRMQCEAEAAA
HHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCEEEEECCHHHHCCCHHHHHHHHHHHHH
FRQDEKEMERIIVEASLYESAQEMGAERVELVGRVISWQLEPWLSEGLFDFGDRDFFLRG
HHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHCCHHCCCCHHHHHHH
MEAMRQATKKGYLRGMPLHIWTTRFVLGARAVVYRLKGRCHFKEIYRQESAPR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]