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The map label for this gene is ghr [H]

Identifier: 197116751

GI number: 197116751

Start: 432686

End: 433549

Strand: Reverse

Name: ghr [H]

Synonym: Gbem_0351

Alternate gene names: 197116751

Gene position: 433549-432686 (Counterclockwise)

Preceding gene: 197116752

Following gene: 197116750

Centisome position: 9.39

GC content: 63.77

Gene sequence:

>864_bases
ATGGAACAATACGGATTTTTAGGATTGGGGATCATGGGAAGCGCGATGGCCAAAAACCTGCTCAAGGCGGGTTTCAAGGT
GACGGTCTGGAACCGGTCGCAGGAAAAGTGCGCCGAGTTCGCGGCGCTCGGGGCCACGGTTGCCGCCACCCCCGCCGAGG
TGACCTCCTCCTGCAGCGTCACCATCGCCATGCTGGCCGACCCGGCAGCGGCACACGCGGTCTGCTTCGGCCCTGAAGGC
GCGCTGGAAGGGATCGGCGCCGGAAGGGGTTACGTCGACATGTCGACGGTCGACGCCGCGACGGCGCAGGAGATCGGCGC
TGCCGTGACCGGCAAGGGTGGGAGGTTCCTGGAAGCTCCCGTTTCCGGCAGCAAGAAGCCGGCCGAGGACGGCACCCTGA
TCATCCTCGCCGCAGGCGACCGGGGGCTCTTCGATCAGGCGCTCCCGCTCTTCGAAAAGATGGGAAAGAAAAGCCTTTAT
CTTGGCGAGGTGGGGCGCGGCGCGCAGATGAAGCTCATCGTCAACATGGTCATGGGAGGGATGATGACCATCTTCTGCGA
GGGGCTCGCGCTCGCTGACAAGGCGGGGCTCGAATGCAGCGACCTATTGGACGTCATCGACGCCGGCGCCATGGCGAACC
CGATGTTCAAGCTGAAGGGGGCGCAGATCGGGCAGGAAAACTTCGCCACGGCCTTTCCCCTCAAGCACATGCAAAAGGAC
ATGCGCCTCGCCGTGGCGCTCGGGGATCAGTTGGGGCAGCCGCTTTTTTCCGCCTCCGCCGCCAATGAAAGCTTCAAAAG
GGCGAGGTCGCAAGGGTTCTCGGACCAGGACTTCAGCGCCGTCTTCAAGGCGATCGCCTCGTGA

Upstream 100 bases:

>100_bases
CGGAGGCGCTCTTTCTGATAAACTCGGTGCGCAAGTGGCGCCCGGCGGCGCTGGCATCGAAGAGATAGCAGTCGATAAAT
CTATTTCCAAGGAGAAGAAG

Downstream 100 bases:

>100_bases
AAAAGCTCCTCTCCCTGGCCGCAGTGACGCTCCTCACCAGCGCCTTCCTCGATCCCCTGATCTACTCCGGGCTGGACAAG
CCCATACCGTGGGGGCGCGA

Product: glyoxalate/succinic semialdehyde reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MEQYGFLGLGIMGSAMAKNLLKAGFKVTVWNRSQEKCAEFAALGATVAATPAEVTSSCSVTIAMLADPAAAHAVCFGPEG
ALEGIGAGRGYVDMSTVDAATAQEIGAAVTGKGGRFLEAPVSGSKKPAEDGTLIILAAGDRGLFDQALPLFEKMGKKSLY
LGEVGRGAQMKLIVNMVMGGMMTIFCEGLALADKAGLECSDLLDVIDAGAMANPMFKLKGAQIGQENFATAFPLKHMQKD
MRLAVALGDQLGQPLFSASAANESFKRARSQGFSDQDFSAVFKAIAS

Sequences:

>Translated_287_residues
MEQYGFLGLGIMGSAMAKNLLKAGFKVTVWNRSQEKCAEFAALGATVAATPAEVTSSCSVTIAMLADPAAAHAVCFGPEG
ALEGIGAGRGYVDMSTVDAATAQEIGAAVTGKGGRFLEAPVSGSKKPAEDGTLIILAAGDRGLFDQALPLFEKMGKKSLY
LGEVGRGAQMKLIVNMVMGGMMTIFCEGLALADKAGLECSDLLDVIDAGAMANPMFKLKGAQIGQENFATAFPLKHMQKD
MRLAVALGDQLGQPLFSASAANESFKRARSQGFSDQDFSAVFKAIAS
>Mature_287_residues
MEQYGFLGLGIMGSAMAKNLLKAGFKVTVWNRSQEKCAEFAALGATVAATPAEVTSSCSVTIAMLADPAAAHAVCFGPEG
ALEGIGAGRGYVDMSTVDAATAQEIGAAVTGKGGRFLEAPVSGSKKPAEDGTLIILAAGDRGLFDQALPLFEKMGKKSLY
LGEVGRGAQMKLIVNMVMGGMMTIFCEGLALADKAGLECSDLLDVIDAGAMANPMFKLKGAQIGQENFATAFPLKHMQKD
MRLAVALGDQLGQPLFSASAANESFKRARSQGFSDQDFSAVFKAIAS

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=51.2367491166078, Blast_Score=287, Evalue=7e-78,
Organism=Homo sapiens, GI23308751, Length=286, Percent_Identity=30.0699300699301, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI145693186, Length=279, Percent_Identity=32.9749103942652, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=30.0353356890459, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790315, Length=298, Percent_Identity=29.5302013422819, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1789092, Length=283, Percent_Identity=27.9151943462898, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17557316, Length=292, Percent_Identity=29.1095890410959, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=38.2978723404255, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24655230, Length=288, Percent_Identity=29.8611111111111, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI19922568, Length=288, Percent_Identity=29.8611111111111, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29767; Mature: 29767

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQYGFLGLGIMGSAMAKNLLKAGFKVTVWNRSQEKCAEFAALGATVAATPAEVTSSCSV
CCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHCCCCHHHHCCCCE
TIAMLADPAAAHAVCFGPEGALEGIGAGRGYVDMSTVDAATAQEIGAAVTGKGGRFLEAP
EEEEECCCCHHCEEEECCCHHHHCCCCCCCEEECHHHHHHHHHHHCCEEECCCCEEEECC
VSGSKKPAEDGTLIILAAGDRGLFDQALPLFEKMGKKSLYLGEVGRGAQMKLIVNMVMGG
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHH
MMTIFCEGLALADKAGLECSDLLDVIDAGAMANPMFKLKGAQIGQENFATAFPLKHMQKD
HHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHCCHHCCHHHHHHH
MRLAVALGDQLGQPLFSASAANESFKRARSQGFSDQDFSAVFKAIAS
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEQYGFLGLGIMGSAMAKNLLKAGFKVTVWNRSQEKCAEFAALGATVAATPAEVTSSCSV
CCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHCCCCHHHHCCCCE
TIAMLADPAAAHAVCFGPEGALEGIGAGRGYVDMSTVDAATAQEIGAAVTGKGGRFLEAP
EEEEECCCCHHCEEEECCCHHHHCCCCCCCEEECHHHHHHHHHHHCCEEECCCCEEEECC
VSGSKKPAEDGTLIILAAGDRGLFDQALPLFEKMGKKSLYLGEVGRGAQMKLIVNMVMGG
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHH
MMTIFCEGLALADKAGLECSDLLDVIDAGAMANPMFKLKGAQIGQENFATAFPLKHMQKD
HHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHCCHHCCHHHHHHH
MRLAVALGDQLGQPLFSASAANESFKRARSQGFSDQDFSAVFKAIAS
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]