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The map label for this gene is adiC [H]

Identifier: 197104419

GI number: 197104419

Start: 1048085

End: 1049386

Strand: Direct

Name: adiC [H]

Synonym: PHZ_c0953

Alternate gene names: 197104419

Gene position: 1048085-1049386 (Clockwise)

Preceding gene: 197104418

Following gene: 197104420

Centisome position: 26.23

GC content: 73.89

Gene sequence:

>1302_bases
ATGGCCGCGCACAACGACGGCGCCGGGCACGGCCGGATCGGCGTCCTGGGCGCCACGGCCCTCGTGGCCGGGAGCATGAT
CGGCTCGGGCGTCTACCTGCTGCCCGCGACCCTGGGCGCGGTGGGATCCATCTCGATCCTGGGCTGGCTGGCGGCCACCG
CCGCCGCCCTGGCCATCGGCGGCCTCTTCGCCTTCCTGGGTCCGGCCGCGCCCGAGGCGCGCAGCCTGGCCGGCTACGTC
CAGGCGGGACTCGGACGGCTGTTCGGCGTCCAGACCACCGTCGTCTACTGGTCGCTCTGCTGGTTCGGGAACGTGGCCAT
CGCCCTGGCCGTCGCGGGCTACGCCGGCTTCCTCGCGCCGGCGCTGGCGGGGGAGGGGCCCCGCCTCGCCGTCACCCTGG
CCGCCATCTGGGTCTCGGTGTTTGCGAGCTGGATCGGACCGCGCACGGTGGCCCGGATCGAGGGCTGGACCCTGGCGCTC
GGCCTGCTTCCCGTCGTCCTGGCGGCGAGCCTGGGTTGGCTCTGGTTCAGTTCGGAGACCTTCCTGGCCTCGTGGAATCC
TCGGGACCTCAGCGTCCCCGCGGCGATCCGCGACTCGGGCCTCAATGCCTTCTGGGCCTTCCTGGGGCTGGAGAGCGCCG
CGGCGGTGGCCGCCGTGGTGCGGAACCCGGCCCGCAACGTGCCCCGCGCCACGCTCTTCGGGGTGTTGGCGGCGGCGGCG
ATCTACATCTCGGCCAGCGCCGCGCTGATGGGCCTCCTGCCCGCGGCCGAACTCGCCAGGTCGGACGCCCCGTTCGCCGA
CGCCGCGCGGCTGATGCTGGGCGTCGGCGGGGCGGCGCTGATCGCGCTGTTCGCCTTCGTCCGCACCTCGGGCTGCCTGG
TGGGCTGGACCCTGGTGGCCGCCGAGACCAGCCGCGGCGCCGCCGACGAGGGGGCGTTCCTGCGCGTCTTCCGCACCCGG
CCCGGCGAGAAGGCCTCGGCGGTCAACCTGCTGGCGGTCGGCGTCCTGATGAGCCTCGTGGCCGTGATGACCGTCTCGCC
GACGCTGGGCGAGCAGTTCGGAGTGCTGATCAACGTCGCGGTGCTGCTCAGCCTCTACGCCTACATCCTGGCGGGCCTCT
CGCTCATCCGACTCTCGGGGAGCTTCCCGCCCGGCAAACGGGCGGCCGCTGTGGCGACGGCGGCGGTCGCCATCGCCTGC
TCGGCCGGCCTCATCGCCACCGGCAAGCCGATCGAGCTCGCCTACAGCCTCGTTCCGATCCTAGCCGGCGCGGCGCTGTA
TCTCGTCATCCGGCGGCGCTAG

Upstream 100 bases:

>100_bases
TACGTCCCGCCGCCGCCGAAGTGGGGCGTGGCCCCCGTCGAGCAGCGCTACTAGGCGGGGCGCCGGCGCCGGGCTAGCCT
CCCCAAAGGGGAGAACAGTC

Downstream 100 bases:

>100_bases
AACAGGTCCGCGGAACGGAGGGGCCCATGCTGGCGGTCGATCTCTATCGCGGGGAAGAGGCGCTGAAGGCCGATCGCGCC
CGCATCCTGCGGCGCACCTG

Product: amino acid transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MAAHNDGAGHGRIGVLGATALVAGSMIGSGVYLLPATLGAVGSISILGWLAATAAALAIGGLFAFLGPAAPEARSLAGYV
QAGLGRLFGVQTTVVYWSLCWFGNVAIALAVAGYAGFLAPALAGEGPRLAVTLAAIWVSVFASWIGPRTVARIEGWTLAL
GLLPVVLAASLGWLWFSSETFLASWNPRDLSVPAAIRDSGLNAFWAFLGLESAAAVAAVVRNPARNVPRATLFGVLAAAA
IYISASAALMGLLPAAELARSDAPFADAARLMLGVGGAALIALFAFVRTSGCLVGWTLVAAETSRGAADEGAFLRVFRTR
PGEKASAVNLLAVGVLMSLVAVMTVSPTLGEQFGVLINVAVLLSLYAYILAGLSLIRLSGSFPPGKRAAAVATAAVAIAC
SAGLIATGKPIELAYSLVPILAGAALYLVIRRR

Sequences:

>Translated_433_residues
MAAHNDGAGHGRIGVLGATALVAGSMIGSGVYLLPATLGAVGSISILGWLAATAAALAIGGLFAFLGPAAPEARSLAGYV
QAGLGRLFGVQTTVVYWSLCWFGNVAIALAVAGYAGFLAPALAGEGPRLAVTLAAIWVSVFASWIGPRTVARIEGWTLAL
GLLPVVLAASLGWLWFSSETFLASWNPRDLSVPAAIRDSGLNAFWAFLGLESAAAVAAVVRNPARNVPRATLFGVLAAAA
IYISASAALMGLLPAAELARSDAPFADAARLMLGVGGAALIALFAFVRTSGCLVGWTLVAAETSRGAADEGAFLRVFRTR
PGEKASAVNLLAVGVLMSLVAVMTVSPTLGEQFGVLINVAVLLSLYAYILAGLSLIRLSGSFPPGKRAAAVATAAVAIAC
SAGLIATGKPIELAYSLVPILAGAALYLVIRRR
>Mature_432_residues
AAHNDGAGHGRIGVLGATALVAGSMIGSGVYLLPATLGAVGSISILGWLAATAAALAIGGLFAFLGPAAPEARSLAGYVQ
AGLGRLFGVQTTVVYWSLCWFGNVAIALAVAGYAGFLAPALAGEGPRLAVTLAAIWVSVFASWIGPRTVARIEGWTLALG
LLPVVLAASLGWLWFSSETFLASWNPRDLSVPAAIRDSGLNAFWAFLGLESAAAVAAVVRNPARNVPRATLFGVLAAAAI
YISASAALMGLLPAAELARSDAPFADAARLMLGVGGAALIALFAFVRTSGCLVGWTLVAAETSRGAADEGAFLRVFRTRP
GEKASAVNLLAVGVLMSLVAVMTVSPTLGEQFGVLINVAVLLSLYAYILAGLSLIRLSGSFPPGKRAAAVATAAVAIACS
AGLIATGKPIELAYSLVPILAGAALYLVIRRR

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI2367353, Length=430, Percent_Identity=33.7209302325581, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1786908, Length=431, Percent_Identity=34.5707656612529, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1790575, Length=374, Percent_Identity=34.4919786096257, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1787890, Length=438, Percent_Identity=27.8538812785388, Blast_Score=108, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 43879; Mature: 43748

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHNDGAGHGRIGVLGATALVAGSMIGSGVYLLPATLGAVGSISILGWLAATAAALAIG
CCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFAFLGPAAPEARSLAGYVQAGLGRLFGVQTTVVYWSLCWFGNVAIALAVAGYAGFLAP
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAGEGPRLAVTLAAIWVSVFASWIGPRTVARIEGWTLALGLLPVVLAASLGWLWFSSET
HHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCC
FLASWNPRDLSVPAAIRDSGLNAFWAFLGLESAAAVAAVVRNPARNVPRATLFGVLAAAA
EEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IYISASAALMGLLPAAELARSDAPFADAARLMLGVGGAALIALFAFVRTSGCLVGWTLVA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEE
AETSRGAADEGAFLRVFRTRPGEKASAVNLLAVGVLMSLVAVMTVSPTLGEQFGVLINVA
EECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VLLSLYAYILAGLSLIRLSGSFPPGKRAAAVATAAVAIACSAGLIATGKPIELAYSLVPI
HHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHH
LAGAALYLVIRRR
HHHHHHHHEEECC
>Mature Secondary Structure 
AAHNDGAGHGRIGVLGATALVAGSMIGSGVYLLPATLGAVGSISILGWLAATAAALAIG
CCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFAFLGPAAPEARSLAGYVQAGLGRLFGVQTTVVYWSLCWFGNVAIALAVAGYAGFLAP
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAGEGPRLAVTLAAIWVSVFASWIGPRTVARIEGWTLALGLLPVVLAASLGWLWFSSET
HHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCC
FLASWNPRDLSVPAAIRDSGLNAFWAFLGLESAAAVAAVVRNPARNVPRATLFGVLAAAA
EEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IYISASAALMGLLPAAELARSDAPFADAARLMLGVGGAALIALFAFVRTSGCLVGWTLVA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEE
AETSRGAADEGAFLRVFRTRPGEKASAVNLLAVGVLMSLVAVMTVSPTLGEQFGVLINVA
EECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VLLSLYAYILAGLSLIRLSGSFPPGKRAAAVATAAVAIACSAGLIATGKPIELAYSLVPI
HHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHH
LAGAALYLVIRRR
HHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]