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The map label for this gene is dxs

Identifier: 197104378

GI number: 197104378

Start: 1004537

End: 1006453

Strand: Direct

Name: dxs

Synonym: PHZ_c0912

Alternate gene names: 197104378

Gene position: 1004537-1006453 (Clockwise)

Preceding gene: 197104377

Following gene: 197104383

Centisome position: 25.14

GC content: 71.78

Gene sequence:

>1917_bases
ATGCCCCCTGTCACGCCCCTGCTCGACACGGTTTCCTCGCCCGCGGACACGCGCGGCCTCTCGATCGCCCAGCTGCGCCA
GCTGGCCGACGAGGTGCGTGCCGAGACCATCGACGCCGTCTCGCAGACCGGCGGGCACCTCGGCGCGGGCCTCGGCGTGG
TCGAGCTGACCGTCGCGCTGCATCACGTTTACGAGACTCCCAAGGACATCCTGATCTGGGACGTCGGCCACCAGGCCTAT
CCCCACAAGATCCTTACCGGCAGGCGCGACCGGATCCGCACGCTCCGCCAGGGGGGCGGCCTGTCGGGCTTCACCAAGCG
GGCCGAGAGCGACTACGACCCGTTCGGCGCGGCGCACGCCGCCACCTCGATCTCGGCGGCGCTCGGCTTCTGCGCCGCCC
GCGACCGCGAGGGCCGCGACAACAAGGTGGTGGCCGTCATCGGCGACGGCTCGATGAGCGCGGGCATGGCCTACGAGGCG
ATGAACAACGCCTACGAGACCACCAAGCAGCTCACCGTCATCCTGAACGACAACGACATGTCCATCGCGCCCCCAGTGGG
CGGGATGAGCGCCTACATGGCCCGGCTGGTGTCGGGCGGCGGCTACCAGTCGCTGCGCAACCTGGGCAAGGCCGTCAGCC
GCGCCTTCCCGCGCCCGCTGCAGGAGGCCGCGCGCAAGGCCGAGGAATACGCCCGCGGCATGGTGACGGGCGGCACGTTC
TTCGAGGAGCTCGGCTTCTACTACGTGGGCCCGATCGACGGACACGACATGGACGCCCTGGTCCACGTCCTGCAGAACGC
CCGCAAGATCGACGACAAGCCCGTGCTGGTCCACGTGGTGACCCAGAAGGGCAAGGGCTACGCCCCCGCCGAGAAGGCCG
CCGACAAGTACCACGGCGTGGTCAAGTTCGACGTGGTCACCGGCGCCCAGGCCAAGTCCCAGGCCGCCGCCCCCAGCTAC
ACCAAGGTGTTCGCCCAGGAGCTGGTCAAGCACGCCGAGCGCGACGAGCGGGTGGTGGCGATCACCGCCGCCATGCCCTC
GGGCACCGGGCTCGACCTGTTCGGCCAGCGCTTCCCGGAGCGCACCTTCGACGTGGGCATCGCCGAGCAGCATGCCGTGA
CCTTCGCCGCCGGCCTGGCCGCCGACGGCATGAAGCCCTTCGCGGCGATCTATTCCACCTTCCTGCAGCGCGGCTACGAC
CAGGTGGTCCACGACGTGGCGATCCAGTCGCTGCCGGTGCGCTTCGCCATCGACCGGGCGGGCCTCGTGGGCGCCGACGG
GCCGACCCATGCCGGCTCGTTCGACGTGGGCTTCATGGGCCAGCTTCCGGGCATGGTGGTGATGGGGCCGGCCGACGAGG
CCGAGCTCGCCCGCGCCATCGCCACCGCCGTGGCCATCGACGACCGCCCGTCGGCCTTCCGCTACCCGCGCGGCGAGGGG
GTGGGCGTCGAGATCCCGGCCCTGGCCGACCCGCTGGAGATCGGCCGCGGCCGCATCGTGCGCGAGGGCACGGCCGTGGC
CATCCTGTCGTTCGGCACCCGCCTGGGCGAGAGCCTGAAGGCCGCCGACATGCTGGCCGCCCGTGGGCTGTCGGCGACGG
TGGCCGACGCGCGCTTCGCCAAGCCGCTCGACGTCGACCTGCTGCTGCGGCTGGCCCGCGAGCACGAGGCGCTGATCACG
GTCGAGGAGGGTGCGGTCGGCGGTTTCGGCGGGTTCGTGCTGCACGCCCTGGCCGAGCACGGCGCGCTGGACCGCGGCCT
GAAGATCCGCACCCTGACCCTGCCCGACATCTTCCAGGACCAGGACAAGCCCGAGGCGATGTACGCCCAGGCCGGTCTCG
ATGCGGAGGGGATCGTGCGCGCCGCGCTGGCGGCGCTCGGGATCGACAACGCCTCGGTCAAGGGACGCCGCGCCTAG

Upstream 100 bases:

>100_bases
ACCTGGATCCATTCGGCCGCCGGGCCGATTTCCTGCGGGCCAGCGTCGATTTCGTGTTAGAGCGCCGGCAGTAGCCGCAA
CCGCCCCCAAAGCGTTTCCT

Downstream 100 bases:

>100_bases
GACCGGACGCTAGGCGGCCCGGCAGCTCTCCACGAACCGCCGCCCGACCGCCGGCGCGGCCGGCAGGTGGGTGCGTCGCC
CGCCGATCCCCACGGTCAGC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MPPVTPLLDTVSSPADTRGLSIAQLRQLADEVRAETIDAVSQTGGHLGAGLGVVELTVALHHVYETPKDILIWDVGHQAY
PHKILTGRRDRIRTLRQGGGLSGFTKRAESDYDPFGAAHAATSISAALGFCAARDREGRDNKVVAVIGDGSMSAGMAYEA
MNNAYETTKQLTVILNDNDMSIAPPVGGMSAYMARLVSGGGYQSLRNLGKAVSRAFPRPLQEAARKAEEYARGMVTGGTF
FEELGFYYVGPIDGHDMDALVHVLQNARKIDDKPVLVHVVTQKGKGYAPAEKAADKYHGVVKFDVVTGAQAKSQAAAPSY
TKVFAQELVKHAERDERVVAITAAMPSGTGLDLFGQRFPERTFDVGIAEQHAVTFAAGLAADGMKPFAAIYSTFLQRGYD
QVVHDVAIQSLPVRFAIDRAGLVGADGPTHAGSFDVGFMGQLPGMVVMGPADEAELARAIATAVAIDDRPSAFRYPRGEG
VGVEIPALADPLEIGRGRIVREGTAVAILSFGTRLGESLKAADMLAARGLSATVADARFAKPLDVDLLLRLAREHEALIT
VEEGAVGGFGGFVLHALAEHGALDRGLKIRTLTLPDIFQDQDKPEAMYAQAGLDAEGIVRAALAALGIDNASVKGRRA

Sequences:

>Translated_638_residues
MPPVTPLLDTVSSPADTRGLSIAQLRQLADEVRAETIDAVSQTGGHLGAGLGVVELTVALHHVYETPKDILIWDVGHQAY
PHKILTGRRDRIRTLRQGGGLSGFTKRAESDYDPFGAAHAATSISAALGFCAARDREGRDNKVVAVIGDGSMSAGMAYEA
MNNAYETTKQLTVILNDNDMSIAPPVGGMSAYMARLVSGGGYQSLRNLGKAVSRAFPRPLQEAARKAEEYARGMVTGGTF
FEELGFYYVGPIDGHDMDALVHVLQNARKIDDKPVLVHVVTQKGKGYAPAEKAADKYHGVVKFDVVTGAQAKSQAAAPSY
TKVFAQELVKHAERDERVVAITAAMPSGTGLDLFGQRFPERTFDVGIAEQHAVTFAAGLAADGMKPFAAIYSTFLQRGYD
QVVHDVAIQSLPVRFAIDRAGLVGADGPTHAGSFDVGFMGQLPGMVVMGPADEAELARAIATAVAIDDRPSAFRYPRGEG
VGVEIPALADPLEIGRGRIVREGTAVAILSFGTRLGESLKAADMLAARGLSATVADARFAKPLDVDLLLRLAREHEALIT
VEEGAVGGFGGFVLHALAEHGALDRGLKIRTLTLPDIFQDQDKPEAMYAQAGLDAEGIVRAALAALGIDNASVKGRRA
>Mature_637_residues
PPVTPLLDTVSSPADTRGLSIAQLRQLADEVRAETIDAVSQTGGHLGAGLGVVELTVALHHVYETPKDILIWDVGHQAYP
HKILTGRRDRIRTLRQGGGLSGFTKRAESDYDPFGAAHAATSISAALGFCAARDREGRDNKVVAVIGDGSMSAGMAYEAM
NNAYETTKQLTVILNDNDMSIAPPVGGMSAYMARLVSGGGYQSLRNLGKAVSRAFPRPLQEAARKAEEYARGMVTGGTFF
EELGFYYVGPIDGHDMDALVHVLQNARKIDDKPVLVHVVTQKGKGYAPAEKAADKYHGVVKFDVVTGAQAKSQAAAPSYT
KVFAQELVKHAERDERVVAITAAMPSGTGLDLFGQRFPERTFDVGIAEQHAVTFAAGLAADGMKPFAAIYSTFLQRGYDQ
VVHDVAIQSLPVRFAIDRAGLVGADGPTHAGSFDVGFMGQLPGMVVMGPADEAELARAIATAVAIDDRPSAFRYPRGEGV
GVEIPALADPLEIGRGRIVREGTAVAILSFGTRLGESLKAADMLAARGLSATVADARFAKPLDVDLLLRLAREHEALITV
EEGAVGGFGGFVLHALAEHGALDRGLKIRTLTLPDIFQDQDKPEAMYAQAGLDAEGIVRAALAALGIDNASVKGRRA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI225637463, Length=419, Percent_Identity=24.8210023866348, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI225637459, Length=419, Percent_Identity=24.8210023866348, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI225637461, Length=419, Percent_Identity=24.8210023866348, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI205277463, Length=501, Percent_Identity=23.9520958083832, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4507521, Length=501, Percent_Identity=23.9520958083832, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI133778974, Length=402, Percent_Identity=25.3731343283582, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI156564403, Length=257, Percent_Identity=24.124513618677, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=51.0433386837881, Blast_Score=610, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17539652, Length=427, Percent_Identity=26.6978922716628, Blast_Score=99, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319698, Length=249, Percent_Identity=29.718875502008, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551847, Length=426, Percent_Identity=26.5258215962441, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI45550715, Length=426, Percent_Identity=26.5258215962441, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24645119, Length=426, Percent_Identity=26.5258215962441, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24666278, Length=310, Percent_Identity=28.0645161290323, Blast_Score=93, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_PHEZH (B4RGW0)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002129755.1
- GeneID:   6790405
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c0912
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67587; Mature: 67455

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPVTPLLDTVSSPADTRGLSIAQLRQLADEVRAETIDAVSQTGGHLGAGLGVVELTVAL
CCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
HHVYETPKDILIWDVGHQAYPHKILTGRRDRIRTLRQGGGLSGFTKRAESDYDPFGAAHA
HHHHCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHH
ATSISAALGFCAARDREGRDNKVVAVIGDGSMSAGMAYEAMNNAYETTKQLTVILNDNDM
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCCCC
SIAPPVGGMSAYMARLVSGGGYQSLRNLGKAVSRAFPRPLQEAARKAEEYARGMVTGGTF
EECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHH
FEELGFYYVGPIDGHDMDALVHVLQNARKIDDKPVLVHVVTQKGKGYAPAEKAADKYHGV
HHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHCCE
VKFDVVTGAQAKSQAAAPSYTKVFAQELVKHAERDERVVAITAAMPSGTGLDLFGQRFPE
EEEEEEECCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHCCC
RTFDVGIAEQHAVTFAAGLAADGMKPFAAIYSTFLQRGYDQVVHDVAIQSLPVRFAIDRA
HHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GLVGADGPTHAGSFDVGFMGQLPGMVVMGPADEAELARAIATAVAIDDRPSAFRYPRGEG
CEECCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHEECCCCCCCCCCCCCC
VGVEIPALADPLEIGRGRIVREGTAVAILSFGTRLGESLKAADMLAARGLSATVADARFA
CCEECCCCCCHHHHCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
KPLDVDLLLRLAREHEALITVEEGAVGGFGGFVLHALAEHGALDRGLKIRTLTLPDIFQD
CCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCHHHCC
QDKPEAMYAQAGLDAEGIVRAALAALGIDNASVKGRRA
CCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PPVTPLLDTVSSPADTRGLSIAQLRQLADEVRAETIDAVSQTGGHLGAGLGVVELTVAL
CCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
HHVYETPKDILIWDVGHQAYPHKILTGRRDRIRTLRQGGGLSGFTKRAESDYDPFGAAHA
HHHHCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHH
ATSISAALGFCAARDREGRDNKVVAVIGDGSMSAGMAYEAMNNAYETTKQLTVILNDNDM
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCCCC
SIAPPVGGMSAYMARLVSGGGYQSLRNLGKAVSRAFPRPLQEAARKAEEYARGMVTGGTF
EECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHH
FEELGFYYVGPIDGHDMDALVHVLQNARKIDDKPVLVHVVTQKGKGYAPAEKAADKYHGV
HHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHCCE
VKFDVVTGAQAKSQAAAPSYTKVFAQELVKHAERDERVVAITAAMPSGTGLDLFGQRFPE
EEEEEEECCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHCCC
RTFDVGIAEQHAVTFAAGLAADGMKPFAAIYSTFLQRGYDQVVHDVAIQSLPVRFAIDRA
HHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GLVGADGPTHAGSFDVGFMGQLPGMVVMGPADEAELARAIATAVAIDDRPSAFRYPRGEG
CEECCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHEECCCCCCCCCCCCCC
VGVEIPALADPLEIGRGRIVREGTAVAILSFGTRLGESLKAADMLAARGLSATVADARFA
CCEECCCCCCHHHHCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
KPLDVDLLLRLAREHEALITVEEGAVGGFGGFVLHALAEHGALDRGLKIRTLTLPDIFQD
CCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCHHHCC
QDKPEAMYAQAGLDAEGIVRAALAALGIDNASVKGRRA
CCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA