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The map label for this gene is gltP [H]

Identifier: 197104265

GI number: 197104265

Start: 883544

End: 884806

Strand: Direct

Name: gltP [H]

Synonym: PHZ_c0799

Alternate gene names: 197104265

Gene position: 883544-884806 (Clockwise)

Preceding gene: 197104264

Following gene: 197104269

Centisome position: 22.11

GC content: 73.56

Gene sequence:

>1263_bases
TTGCGCATCTTCAAATCCCTGAGCGTCCGCGTGCTGATCGGCCTCGTCCTGGGACTGGCGATCGGCGCGGCGGGCGCGGC
GTACGGCGGGGCGGGCGTGGCCCGGGTCATCGAGTCGGTCGAGGCGTTCGGCGGGCTGTGGCTGAACGCCCTGCGGATGA
CCGTCATCCCGCTGATCTTCGCCGTCCTGGTCACCGGCATCGCCCAGGTCTCCGACGCGGCGGCCACGGGCAAGCTCGCC
GCCCGCGCCGTGGGCTGGTTCGCCGGCCTCTTGCTGCTCGCCTGCGCCTTCAGCCTGGTGTTCGTTCACGGCGTCCTGGC
GCTCTGGCCGGTCAGCGCCGAGGGCGCGGCGGCCCTGCGCGCCGGCGCCCAGGCCGTGCCCGCCGAGGCGGCGACGCCGG
ACTTCGTCGCCTGGGTGAAGAGCCTTGCGCCCTCCAACCCGGTGAAGGCCGCCGCCGAGGACGCCGTCCTGCCGCTGGTG
GTGTTCGCCATCTTCACCGGATTTGCGCTCACCCGCCTGCCTGCCGAGCGCGGCCGCACCGTGATCGAGGTGTTCCAGAC
GCTCGGCGAGGCGATGATCATCATCGTGCGCTGGGTGCTGTGGGCCGGGCCGGTCGGCGTCTTCTGCCTGGCGCTGGGCG
TGGGCCTGCGGGCCGGCGTCGGCGCGGCCGGCGTGCTCGGCCACTACATCGCCGTGGCCTCCCTGGCCGGGGCGGGGATC
AGCGTCGTGGCCTACATCCTGGCGGTGACCATCGGGCGGGTGCCGCTGGGCCGCTGGGCGCGGGCGACGGGGCCGGTGCT
GGCCACCGCCTTCGCCACCCAGTCCTCGCTGGCCTGCCTGCCGGCGATGATCGAACGGACCCGCGACGACCTGGGCGTGC
CCCAGCGGATCGCCGGCCTCGTCCTGCCGCTGGCGGTGGCGGTGTTCCGCTTCACGAGCCCGGTGGTGAACCTGGCCGTG
GCGATCTTCGTGGCCCACGTCTACGGCATCCAGCCCTCGGCCCTGCAGTACGCCGGGGCGGTACTGGTGGCCCTGGCGGT
CAGCGTCGGCTCGGTCGGCCTGCCGGGGCAGGTCTCGTTCATCATCAGCGTGGCGCCGATCTGCCTGGCGCTGGGCCTGC
CGATCGAACTGCTGCCGATCCTGCTGGCGGTGGAGGTCGTGCCCGACATCTTCCGCACCGTCGGCAACGTCACCGGCGAC
ATGGCGGTGACCGCCATCCTCGCCCGCAACGAGGAGAAGCCGCCCGAGCCCGAGGGCGCCTAG

Upstream 100 bases:

>100_bases
CAGGAGACCACCCGCCGGATCCTGCAGGGCTGAGCCCGGCTCGGCTCTTGCGGCGCAGGCCCGTTGCGGGCCAGATCGCG
CCTCTTCCGGAGGGCTGTGG

Downstream 100 bases:

>100_bases
CCCGCGACGGCGATCCAGAGCGCCGCGGCGGCCTGGGCCGCGGCCACCGACCACAGGAGGCTGCGGAACGGCTCCTTGCG
GGTCTTGTGGCGCAGGATCT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRIFKSLSVRVLIGLVLGLAIGAAGAAYGGAGVARVIESVEAFGGLWLNALRMTVIPLIFAVLVTGIAQVSDAAATGKLA
ARAVGWFAGLLLLACAFSLVFVHGVLALWPVSAEGAAALRAGAQAVPAEAATPDFVAWVKSLAPSNPVKAAAEDAVLPLV
VFAIFTGFALTRLPAERGRTVIEVFQTLGEAMIIIVRWVLWAGPVGVFCLALGVGLRAGVGAAGVLGHYIAVASLAGAGI
SVVAYILAVTIGRVPLGRWARATGPVLATAFATQSSLACLPAMIERTRDDLGVPQRIAGLVLPLAVAVFRFTSPVVNLAV
AIFVAHVYGIQPSALQYAGAVLVALAVSVGSVGLPGQVSFIISVAPICLALGLPIELLPILLAVEVVPDIFRTVGNVTGD
MAVTAILARNEEKPPEPEGA

Sequences:

>Translated_420_residues
MRIFKSLSVRVLIGLVLGLAIGAAGAAYGGAGVARVIESVEAFGGLWLNALRMTVIPLIFAVLVTGIAQVSDAAATGKLA
ARAVGWFAGLLLLACAFSLVFVHGVLALWPVSAEGAAALRAGAQAVPAEAATPDFVAWVKSLAPSNPVKAAAEDAVLPLV
VFAIFTGFALTRLPAERGRTVIEVFQTLGEAMIIIVRWVLWAGPVGVFCLALGVGLRAGVGAAGVLGHYIAVASLAGAGI
SVVAYILAVTIGRVPLGRWARATGPVLATAFATQSSLACLPAMIERTRDDLGVPQRIAGLVLPLAVAVFRFTSPVVNLAV
AIFVAHVYGIQPSALQYAGAVLVALAVSVGSVGLPGQVSFIISVAPICLALGLPIELLPILLAVEVVPDIFRTVGNVTGD
MAVTAILARNEEKPPEPEGA
>Mature_420_residues
MRIFKSLSVRVLIGLVLGLAIGAAGAAYGGAGVARVIESVEAFGGLWLNALRMTVIPLIFAVLVTGIAQVSDAAATGKLA
ARAVGWFAGLLLLACAFSLVFVHGVLALWPVSAEGAAALRAGAQAVPAEAATPDFVAWVKSLAPSNPVKAAAEDAVLPLV
VFAIFTGFALTRLPAERGRTVIEVFQTLGEAMIIIVRWVLWAGPVGVFCLALGVGLRAGVGAAGVLGHYIAVASLAGAGI
SVVAYILAVTIGRVPLGRWARATGPVLATAFATQSSLACLPAMIERTRDDLGVPQRIAGLVLPLAVAVFRFTSPVVNLAV
AIFVAHVYGIQPSALQYAGAVLVALAVSVGSVGLPGQVSFIISVAPICLALGLPIELLPILLAVEVVPDIFRTVGNVTGD
MAVTAILARNEEKPPEPEGA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=414, Percent_Identity=31.1594202898551, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI5032093, Length=400, Percent_Identity=29.75, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI223468564, Length=271, Percent_Identity=32.1033210332103, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI223468566, Length=271, Percent_Identity=32.1033210332103, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI40254478, Length=417, Percent_Identity=24.7002398081535, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4827012, Length=292, Percent_Identity=31.5068493150685, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI169790839, Length=277, Percent_Identity=28.158844765343, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI66773030, Length=266, Percent_Identity=27.4436090225564, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI194239697, Length=430, Percent_Identity=23.7209302325581, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI301601644, Length=136, Percent_Identity=32.3529411764706, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=26.7469879518072, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789947, Length=421, Percent_Identity=26.1282660332542, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788024, Length=383, Percent_Identity=26.8929503916449, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71983106, Length=406, Percent_Identity=25.1231527093596, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71983099, Length=406, Percent_Identity=25.1231527093596, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193206505, Length=439, Percent_Identity=25.0569476082005, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17537407, Length=420, Percent_Identity=27.1428571428571, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71996953, Length=456, Percent_Identity=23.6842105263158, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17541374, Length=403, Percent_Identity=23.5732009925558, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583025, Length=444, Percent_Identity=25.2252252252252, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137668, Length=444, Percent_Identity=25.2252252252252, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24583023, Length=444, Percent_Identity=25.2252252252252, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 42814; Mature: 42814

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]