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The map label for this gene is uvrB [H]

Identifier: 197104262

GI number: 197104262

Start: 878074

End: 880317

Strand: Direct

Name: uvrB [H]

Synonym: PHZ_c0796

Alternate gene names: 197104262

Gene position: 878074-880317 (Clockwise)

Preceding gene: 197104261

Following gene: 197104263

Centisome position: 21.97

GC content: 67.65

Gene sequence:

>2244_bases
ATGCCCCGCACAGCAGCCCCGGCCGGCGTCTCGGACATGTCCGCGGCGTTCGACTACGACGAGAACACCATGCCGCTGCT
CTGGAAGCCGCACCGTCCGGAGCGGCCGGAGAAGAGCGAGGGCGGCCGCCGGTTCAAGCTCGTCTCCGATTACCAGCCGG
CCGGCGACCAGCCGCAGGCGATCCGCGAGCTCGTCGAGGGCCTGGAGGGCCGCGAGCACGACCAGGTCCTGCTCGGTGTC
ACCGGCTCGGGCAAGACCTTCACCATGGCCAAGGTGATCGAGGAGACGCAGCGCCCGGCGCTGATCCTCGCCCCCAATAA
GACCCTCGCCGCCCAGCTCTATTCCGAGTTCAGGAGCTTCTTCCCCGAGAACGCGGTCGAGTTCTTCGTCTCGTACTACG
ACTACTACCAGCCCGAGGCCTACGTGCCCCGGACCGACACCTACATCGAGAAGGACAGCTCGATTAACGAGCAGATCGAC
CGGATGCGCCACTCGGCCACCCGCGCGATCCTGGAGCGCGACGACGTCATCGTCGTGGCCTCGGTCTCCTGCATCTACGG
CATCGGCTCGGTCGAGACCTACTCGGCCATGACCTTCCAGCTGAAGCCCGGCGACCGGGTGGACGAGAAGAAGCTGATGG
GGGACCTCGTGGCCCTCCAGTACAAGCGCAACGACCAGGCGTTCGAGCGCGGCACGTTCCGCCGCCGCGGCGACACCATC
GAGATCTTCCCGGCCCACTACGAGGATCGCGCCTGGCGCATCAGCCTCTTCGGCGACGAGGTCGAGGCGATCGTCGAGTT
CGACCCGCTGACCGGCAAGAAGACCGCCGAACTGCAGGGCGTGAAGATCTACGCCAACAGCCACTACGTGACGCCCAGGC
CGACGCTCCGCCAGGCCATCAACCAGATCAAGGTCGAGCTGAAGGAGCGTCTCGACTGGCTTGTCGCCAACGGCAAGCTG
CTGGAGGCCCAGCGCCTCGAACAGCGCACCACCTTCGACCTGGAGATGATCGAGGCCACCGGCTCCTGCGCCGGCATCGA
GAACTACTCCCGCTACCTCACCGGCCGCCGGCCCGGCGAGCCGCCGCCGACGTTCTTCGAGTACATCCCCGACAACGCCC
TGCTGTTCGTGGACGAGAGCCACCAGACGGTGCCGCAGATCGGCGCCATGTACCGGGGCGACTACCGCCGCAAGTGGACC
CTGGCCGAGTTCGGCTTCCGCCTGCCTTCCTGCATCGACAACCGCCCGCTCAAGTTCGAGGAGTGGGACGCCATGCGGCC
GGACACCGTCCACGTCTCGGCCACCCCCGGCCCGTGGGAGATGGAGAAGACCGGCGGCGTCTTCGCCGAGCAGGTGATCC
GCCCCACCGGCCTGATCGACCCGCCGGTGGAGGTGCGCCCGGTCAGCAAGGACGGCTTCTCCCAGGTGGACGACGTGATC
GACGAGGTGCGCCAGACGGCGGCCCGCGGCTACCGCAGCCTGATCACCGTCCTGACCAAGAAGATGGCCGAGGACCTGAC
GGAGTTCATGCACGAGCAGGGCCTGCGGGTCCGCTACATGCACTCCGACGTGGACACCCTGGAGCGCATCGAGATCATCC
GCGACCTGCGGCTCGGCGCCTTCGACATCCTGGTGGGCATCAACCTGCTGCGCGAGGGCCTCGACATCCCCGAGTGCGGC
CTCGTGGCCATCCTCGACGCCGACAAGGAGGGCTTCCTCCGCTCGGAGACCTCCCTGATCCAGACCATCGGCCGCGCCGC
GCGGAACGTGGACGGCCGGGTCATCCTCTACGCCGACAGCGTCACCGGCTCCATGGAACGCGCCATGGCCGAGACCCAGC
GCCGGCGCGAGAAGCAGATGGCCTACAACCTCGAGCACGGCATCACGCCCGAGAGCGTGAAGAGCCAGATCAAGGACATC
CTCGCCAGCCCCTACGAGAAGGACCGCGTCACCGTCCCCGTCGGCGTGGCCGAGGACGGCAAGCCGTTCCTGGGCGACAA
CTTCAAGACCACCCTGCGCGACCTCGAGAACCGCATGAAGGAGGCGGCCGCCAACCTCGAATTCGAGGAAGCCGCCCGCC
TGCGCGACGAGATCAAGCGCCTCAAGCTCCTCGACCTCGAGTTCGCCGCCGACGCCCTCGCCGGCGAAGGCGAGAGCGGC
GACAAGGAAGCCGTCAAACGCGTGCGCGCCGAAGCGCGCGCCGAAAAGCAGGAACAGTTCAGGAAAGGGCGAGGCCGGCG
GTAG

Upstream 100 bases:

>100_bases
GGGAAGGGTGGGCGGCGCCCCCCACCCTCCTGCCATGCCATGTCAGCAGGCCTGTGCGTTAGGGTGGCGGAGAGACCCTG
CAGAGCCTACCTTTCGCCCC

Downstream 100 bases:

>100_bases
GCGCCAGTCCGCCCCATGGCGGGAGAGGGGACAGGCCACGTCCTGCCCGCCTCCGCTGTGACGTTAGTCACACCCCTTAA
CTACACACCGTGGCCACAAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MPRTAAPAGVSDMSAAFDYDENTMPLLWKPHRPERPEKSEGGRRFKLVSDYQPAGDQPQAIRELVEGLEGREHDQVLLGV
TGSGKTFTMAKVIEETQRPALILAPNKTLAAQLYSEFRSFFPENAVEFFVSYYDYYQPEAYVPRTDTYIEKDSSINEQID
RMRHSATRAILERDDVIVVASVSCIYGIGSVETYSAMTFQLKPGDRVDEKKLMGDLVALQYKRNDQAFERGTFRRRGDTI
EIFPAHYEDRAWRISLFGDEVEAIVEFDPLTGKKTAELQGVKIYANSHYVTPRPTLRQAINQIKVELKERLDWLVANGKL
LEAQRLEQRTTFDLEMIEATGSCAGIENYSRYLTGRRPGEPPPTFFEYIPDNALLFVDESHQTVPQIGAMYRGDYRRKWT
LAEFGFRLPSCIDNRPLKFEEWDAMRPDTVHVSATPGPWEMEKTGGVFAEQVIRPTGLIDPPVEVRPVSKDGFSQVDDVI
DEVRQTAARGYRSLITVLTKKMAEDLTEFMHEQGLRVRYMHSDVDTLERIEIIRDLRLGAFDILVGINLLREGLDIPECG
LVAILDADKEGFLRSETSLIQTIGRAARNVDGRVILYADSVTGSMERAMAETQRRREKQMAYNLEHGITPESVKSQIKDI
LASPYEKDRVTVPVGVAEDGKPFLGDNFKTTLRDLENRMKEAAANLEFEEAARLRDEIKRLKLLDLEFAADALAGEGESG
DKEAVKRVRAEARAEKQEQFRKGRGRR

Sequences:

>Translated_747_residues
MPRTAAPAGVSDMSAAFDYDENTMPLLWKPHRPERPEKSEGGRRFKLVSDYQPAGDQPQAIRELVEGLEGREHDQVLLGV
TGSGKTFTMAKVIEETQRPALILAPNKTLAAQLYSEFRSFFPENAVEFFVSYYDYYQPEAYVPRTDTYIEKDSSINEQID
RMRHSATRAILERDDVIVVASVSCIYGIGSVETYSAMTFQLKPGDRVDEKKLMGDLVALQYKRNDQAFERGTFRRRGDTI
EIFPAHYEDRAWRISLFGDEVEAIVEFDPLTGKKTAELQGVKIYANSHYVTPRPTLRQAINQIKVELKERLDWLVANGKL
LEAQRLEQRTTFDLEMIEATGSCAGIENYSRYLTGRRPGEPPPTFFEYIPDNALLFVDESHQTVPQIGAMYRGDYRRKWT
LAEFGFRLPSCIDNRPLKFEEWDAMRPDTVHVSATPGPWEMEKTGGVFAEQVIRPTGLIDPPVEVRPVSKDGFSQVDDVI
DEVRQTAARGYRSLITVLTKKMAEDLTEFMHEQGLRVRYMHSDVDTLERIEIIRDLRLGAFDILVGINLLREGLDIPECG
LVAILDADKEGFLRSETSLIQTIGRAARNVDGRVILYADSVTGSMERAMAETQRRREKQMAYNLEHGITPESVKSQIKDI
LASPYEKDRVTVPVGVAEDGKPFLGDNFKTTLRDLENRMKEAAANLEFEEAARLRDEIKRLKLLDLEFAADALAGEGESG
DKEAVKRVRAEARAEKQEQFRKGRGRR
>Mature_746_residues
PRTAAPAGVSDMSAAFDYDENTMPLLWKPHRPERPEKSEGGRRFKLVSDYQPAGDQPQAIRELVEGLEGREHDQVLLGVT
GSGKTFTMAKVIEETQRPALILAPNKTLAAQLYSEFRSFFPENAVEFFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDR
MRHSATRAILERDDVIVVASVSCIYGIGSVETYSAMTFQLKPGDRVDEKKLMGDLVALQYKRNDQAFERGTFRRRGDTIE
IFPAHYEDRAWRISLFGDEVEAIVEFDPLTGKKTAELQGVKIYANSHYVTPRPTLRQAINQIKVELKERLDWLVANGKLL
EAQRLEQRTTFDLEMIEATGSCAGIENYSRYLTGRRPGEPPPTFFEYIPDNALLFVDESHQTVPQIGAMYRGDYRRKWTL
AEFGFRLPSCIDNRPLKFEEWDAMRPDTVHVSATPGPWEMEKTGGVFAEQVIRPTGLIDPPVEVRPVSKDGFSQVDDVID
EVRQTAARGYRSLITVLTKKMAEDLTEFMHEQGLRVRYMHSDVDTLERIEIIRDLRLGAFDILVGINLLREGLDIPECGL
VAILDADKEGFLRSETSLIQTIGRAARNVDGRVILYADSVTGSMERAMAETQRRREKQMAYNLEHGITPESVKSQIKDIL
ASPYEKDRVTVPVGVAEDGKPFLGDNFKTTLRDLENRMKEAAANLEFEEAARLRDEIKRLKLLDLEFAADALAGEGESGD
KEAVKRVRAEARAEKQEQFRKGRGRR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=60.2086438152012, Blast_Score=796, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 84852; Mature: 84721

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTAAPAGVSDMSAAFDYDENTMPLLWKPHRPERPEKSEGGRRFKLVSDYQPAGDQPQA
CCCCCCCCCCCHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
IRELVEGLEGREHDQVLLGVTGSGKTFTMAKVIEETQRPALILAPNKTLAAQLYSEFRSF
HHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
FPENAVEFFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDRMRHSATRAILERDDVIVVA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
SVSCIYGIGSVETYSAMTFQLKPGDRVDEKKLMGDLVALQYKRNDQAFERGTFRRRGDTI
EHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCHHHCCCEE
EIFPAHYEDRAWRISLFGDEVEAIVEFDPLTGKKTAELQGVKIYANSHYVTPRPTLRQAI
EEECCCCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCCEEEEECCEEECCCHHHHHHH
NQIKVELKERLDWLVANGKLLEAQRLEQRTTFDLEMIEATGSCAGIENYSRYLTGRRPGE
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHCCCCCCC
PPPTFFEYIPDNALLFVDESHQTVPQIGAMYRGDYRRKWTLAEFGFRLPSCIDNRPLKFE
CCCHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEHHHHCCCCCHHHCCCCCCCC
EWDAMRPDTVHVSATPGPWEMEKTGGVFAEQVIRPTGLIDPPVEVRPVSKDGFSQVDDVI
CCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHH
DEVRQTAARGYRSLITVLTKKMAEDLTEFMHEQGLRVRYMHSDVDTLERIEIIRDLRLGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCH
FDILVGINLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRAARNVDGRVILYADS
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECC
VTGSMERAMAETQRRREKQMAYNLEHGITPESVKSQIKDILASPYEKDRVTVPVGVAEDG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
KPFLGDNFKTTLRDLENRMKEAAANLEFEEAARLRDEIKRLKLLDLEFAADALAGEGESG
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DKEAVKRVRAEARAEKQEQFRKGRGRR
CHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PRTAAPAGVSDMSAAFDYDENTMPLLWKPHRPERPEKSEGGRRFKLVSDYQPAGDQPQA
CCCCCCCCCCHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
IRELVEGLEGREHDQVLLGVTGSGKTFTMAKVIEETQRPALILAPNKTLAAQLYSEFRSF
HHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
FPENAVEFFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDRMRHSATRAILERDDVIVVA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
SVSCIYGIGSVETYSAMTFQLKPGDRVDEKKLMGDLVALQYKRNDQAFERGTFRRRGDTI
EHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCHHHCCCEE
EIFPAHYEDRAWRISLFGDEVEAIVEFDPLTGKKTAELQGVKIYANSHYVTPRPTLRQAI
EEECCCCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCCEEEEECCEEECCCHHHHHHH
NQIKVELKERLDWLVANGKLLEAQRLEQRTTFDLEMIEATGSCAGIENYSRYLTGRRPGE
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHCCCCCCC
PPPTFFEYIPDNALLFVDESHQTVPQIGAMYRGDYRRKWTLAEFGFRLPSCIDNRPLKFE
CCCHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEHHHHCCCCCHHHCCCCCCCC
EWDAMRPDTVHVSATPGPWEMEKTGGVFAEQVIRPTGLIDPPVEVRPVSKDGFSQVDDVI
CCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHH
DEVRQTAARGYRSLITVLTKKMAEDLTEFMHEQGLRVRYMHSDVDTLERIEIIRDLRLGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCH
FDILVGINLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRAARNVDGRVILYADS
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECC
VTGSMERAMAETQRRREKQMAYNLEHGITPESVKSQIKDILASPYEKDRVTVPVGVAEDG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
KPFLGDNFKTTLRDLENRMKEAAANLEFEEAARLRDEIKRLKLLDLEFAADALAGEGESG
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DKEAVKRVRAEARAEKQEQFRKGRGRR
CHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]