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The map label for this gene is phbA [H]

Identifier: 197104259

GI number: 197104259

Start: 875670

End: 876860

Strand: Direct

Name: phbA [H]

Synonym: PHZ_c0793

Alternate gene names: 197104259

Gene position: 875670-876860 (Clockwise)

Preceding gene: 197104258

Following gene: 197104261

Centisome position: 21.91

GC content: 72.8

Gene sequence:

>1191_bases
ATGACCCAAGCCTCCGATCCCGTCGTCATCGCGTCGTACGCCCGCACGCCCATGGGCGGCTTCCAGGGCGTGCTGTCCGC
CGCCAAGGCCACCGAGCTCGGCGCCGCCGCCGTCAGGGCCGCCGTCGAGCGCGCCGGGGCCCAGCCGGACCAGATCGAGC
AGATCGTCATGGGCTGCGTCCTGCCCGCGGGCCTCGGCCAGGCGCCGGCGCGCCAGGCCGCCCTCGGCGCGGGCCTGCCC
AAGTCGGTCGAGGCGACCACGGTCAACAAGATGTGCGGTTCGGGCATGCAGGCCGCGATCCTGGCGCACGACGCCCTCGC
CGCCGGCTCGGCGGACGTGATCGTCGCGGGCGGTATGGAGAGCATGACGAACGCCCCGTACCTGATGCTGAAGCACCGCG
CCGGCGCCCGCATCGGCCACGACACCATGTACGACCACATGTACCTCGACGGGCTGGAGGACGCCTACGAACCCGGCCGG
CTGATGGGCTCCTTCGCCGAGGAGACGGCGAAGCAGTACCAGTTCACCCGCGAGGCCATGGACGAGTACGCGATCGGCTC
GCTCAAGCGCGCCAAGGCGGCCACGGAGTCCGGCGCCTTCGCGAAGGAGATCGTCCCGGTCCAGGTCACCGACCGCAAGG
GGACGGCCACCGTCGAGCATGACGAGCAGCCGCTGAAGGCCGACCCGGCCAAGATCCCGACCCTGAAGCCGGCCTTCGCC
AGGGACGGCGCCATCACGGCGGCCAACGCCAGCTCGATCTCGGACGGCGCCGCGGCCCTCGTCATGACCCGCGAGAGCGT
GGCGAAGGCGCTTGGCCTGAAGGTCGTCGCGCGCATCGCCGGCCACGGCGCCCACGCCCACGAGCCGGGCCTGTTCACCA
CCGCCCCGGTCCCCGCCATGCAGAAGGCGCTGAAGCGCGCCGGCTGGAGCGTGGACGACGTCGACCTGTTCGAGGTCAAC
GAGGCCTTCGCCGTCGTCGCCATGATCGCCGAGCGCGAGCTGGGCATCGACCGCGACAAGCTCAACGTCAACGGCGGCGC
CTGCGCCCTCGGCCACCCGATCGGCGCCTCGGGCGCCCGCATCCTCGCCACCCTGCTGGCCGCCTTGGAAGCGCGCGGCG
GCAAGCGCGGCCTCGCCTCCCTCTGCATCGGCGGCGGCGAAGCCACCGCGATGGCGGTGGAGCTGGCCTGA

Upstream 100 bases:

>100_bases
GGAGCCGCCGCTGGCGCGGCGTCTCCGGCGGTCTTCTTGATCGTTGCGCCGTCCGCAACGTGACCTTCTGTTTCACCGGC
CGCTGAATTATATCGGCGGC

Downstream 100 bases:

>100_bases
GCCGACCCCCTCCTCCCCCGTCGGGGGAGGGGGACCGCGAAGCGGTGGAGGGGGCCTAGCCCCATCCGCCGAGCCGCCGG
CAAGCCCCCACCACCATGCT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTQASDPVVIASYARTPMGGFQGVLSAAKATELGAAAVRAAVERAGAQPDQIEQIVMGCVLPAGLGQAPARQAALGAGLP
KSVEATTVNKMCGSGMQAAILAHDALAAGSADVIVAGGMESMTNAPYLMLKHRAGARIGHDTMYDHMYLDGLEDAYEPGR
LMGSFAEETAKQYQFTREAMDEYAIGSLKRAKAATESGAFAKEIVPVQVTDRKGTATVEHDEQPLKADPAKIPTLKPAFA
RDGAITAANASSISDGAAALVMTRESVAKALGLKVVARIAGHGAHAHEPGLFTTAPVPAMQKALKRAGWSVDDVDLFEVN
EAFAVVAMIAERELGIDRDKLNVNGGACALGHPIGASGARILATLLAALEARGGKRGLASLCIGGGEATAMAVELA

Sequences:

>Translated_396_residues
MTQASDPVVIASYARTPMGGFQGVLSAAKATELGAAAVRAAVERAGAQPDQIEQIVMGCVLPAGLGQAPARQAALGAGLP
KSVEATTVNKMCGSGMQAAILAHDALAAGSADVIVAGGMESMTNAPYLMLKHRAGARIGHDTMYDHMYLDGLEDAYEPGR
LMGSFAEETAKQYQFTREAMDEYAIGSLKRAKAATESGAFAKEIVPVQVTDRKGTATVEHDEQPLKADPAKIPTLKPAFA
RDGAITAANASSISDGAAALVMTRESVAKALGLKVVARIAGHGAHAHEPGLFTTAPVPAMQKALKRAGWSVDDVDLFEVN
EAFAVVAMIAERELGIDRDKLNVNGGACALGHPIGASGARILATLLAALEARGGKRGLASLCIGGGEATAMAVELA
>Mature_395_residues
TQASDPVVIASYARTPMGGFQGVLSAAKATELGAAAVRAAVERAGAQPDQIEQIVMGCVLPAGLGQAPARQAALGAGLPK
SVEATTVNKMCGSGMQAAILAHDALAAGSADVIVAGGMESMTNAPYLMLKHRAGARIGHDTMYDHMYLDGLEDAYEPGRL
MGSFAEETAKQYQFTREAMDEYAIGSLKRAKAATESGAFAKEIVPVQVTDRKGTATVEHDEQPLKADPAKIPTLKPAFAR
DGAITAANASSISDGAAALVMTRESVAKALGLKVVARIAGHGAHAHEPGLFTTAPVPAMQKALKRAGWSVDDVDLFEVNE
AFAVVAMIAERELGIDRDKLNVNGGACALGHPIGASGARILATLLAALEARGGKRGLASLCIGGGEATAMAVELA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=45.5919395465995, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=47.0437017994859, Blast_Score=324, Evalue=8e-89,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=38.0462724935733, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4501853, Length=402, Percent_Identity=35.8208955223881, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4504327, Length=421, Percent_Identity=30.8788598574822, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI194353979, Length=397, Percent_Identity=29.2191435768262, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1788554, Length=388, Percent_Identity=51.2886597938144, Blast_Score=341, Evalue=4e-95,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=44.8453608247423, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1787663, Length=395, Percent_Identity=40, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=37.8712871287129, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1788683, Length=438, Percent_Identity=31.0502283105023, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=42.5974025974026, Blast_Score=298, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=43.7017994858612, Blast_Score=293, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=40.7216494845361, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=33.9240506329114, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=30.4038004750594, Blast_Score=158, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=47.103274559194, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=33.0788804071247, Blast_Score=189, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=48.2051282051282, Blast_Score=338, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=44.7300771208226, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=34.4221105527638, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=30.2816901408451, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40638; Mature: 40507

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQASDPVVIASYARTPMGGFQGVLSAAKATELGAAAVRAAVERAGAQPDQIEQIVMGCV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LPAGLGQAPARQAALGAGLPKSVEATTVNKMCGSGMQAAILAHDALAAGSADVIVAGGME
HCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHH
SMTNAPYLMLKHRAGARIGHDTMYDHMYLDGLEDAYEPGRLMGSFAEETAKQYQFTREAM
HHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
DEYAIGSLKRAKAATESGAFAKEIVPVQVTDRKGTATVEHDEQPLKADPAKIPTLKPAFA
HHHHHHHHHHHHHHHHCCCHHHHEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCHHH
RDGAITAANASSISDGAAALVMTRESVAKALGLKVVARIAGHGAHAHEPGLFTTAPVPAM
CCCCEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCHHH
QKALKRAGWSVDDVDLFEVNEAFAVVAMIAERELGIDRDKLNVNGGACALGHPIGASGAR
HHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEEECCCCEEECCCCCCCCHHH
ILATLLAALEARGGKRGLASLCIGGGEATAMAVELA
HHHHHHHHHHHCCCCCCHHHHEECCCCEEEEEEEEC
>Mature Secondary Structure 
TQASDPVVIASYARTPMGGFQGVLSAAKATELGAAAVRAAVERAGAQPDQIEQIVMGCV
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LPAGLGQAPARQAALGAGLPKSVEATTVNKMCGSGMQAAILAHDALAAGSADVIVAGGME
HCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHH
SMTNAPYLMLKHRAGARIGHDTMYDHMYLDGLEDAYEPGRLMGSFAEETAKQYQFTREAM
HHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
DEYAIGSLKRAKAATESGAFAKEIVPVQVTDRKGTATVEHDEQPLKADPAKIPTLKPAFA
HHHHHHHHHHHHHHHHCCCHHHHEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCHHH
RDGAITAANASSISDGAAALVMTRESVAKALGLKVVARIAGHGAHAHEPGLFTTAPVPAM
CCCCEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCHHH
QKALKRAGWSVDDVDLFEVNEAFAVVAMIAERELGIDRDKLNVNGGACALGHPIGASGAR
HHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEEECCCCEEECCCCCCCCHHH
ILATLLAALEARGGKRGLASLCIGGGEATAMAVELA
HHHHHHHHHHHCCCCCCHHHHEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1396692 [H]