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The map label for this gene is zraS [H]

Identifier: 197104162

GI number: 197104162

Start: 760709

End: 762331

Strand: Direct

Name: zraS [H]

Synonym: PHZ_c0696

Alternate gene names: 197104162

Gene position: 760709-762331 (Clockwise)

Preceding gene: 197104161

Following gene: 197104163

Centisome position: 19.04

GC content: 73.2

Gene sequence:

>1623_bases
GTGAGCGAGGCGCCCCGCATCCTCGTGGTCGAGGACTCCGAGACCCAGGCCCTCGCCCTGCGCGGCGTGCTCGAGCAGGA
GGGGTTCGAGGTGGACGTCGCCGCCACCGCCGAGGCCGCCCTGGACCGGCTGAACGGCGAGCTGCCCGACCTGGTCGTGG
CGGACTTCCACCTGCCGGGCATGGACGGGCGCGAGCTGTCGCGCCAGATCCGCCTGAACGGCCGCACCCGAGCGCTTCCC
GTTCTGATGCTGACCAGCGCCCGGGAGGTGGACCTGGAGCGTCAGGGCCTCGAGAGCGGCGTCGACGCCTACCTGCCGAA
GTCGGCCAACGTCGAGGTGATGCTGGCGCGGCTCCGGGCCCTGCTGCGCCGTCCGCAGGCCGCTGGGGCCGAGCGCGGGC
GGGCCTTCCGCCGGGCGCGGGTCCTGCTCGCCCACGACAGCGCGACCGCGCGGCTGCGCCTGCGGCACTTGCTCGATCAG
GAGGGATATGAGGTCGTCGAAGCCTCGACGGAGCGGGAGGCGGTCCAGTCCCTGGATGAGGAGACCGACTGCGTGGTCCT
GCCGATCGCCGCCGCCGCCTGGGACGGCCTGCTGCTGGCGCGCGATCTGAACGCCCAGCGGCAGCGGCTGGGATTCCCGT
TCCAGATCGTGGTGATCGGGCCGGGGCCGGACCAGCCGGCCGAACTGGCGGCCGCCTTCGAGGCCGGCGCCGACGAGGTG
GTCCGCACGCTCGAGAGCGACGACGTGGTGCTCGTTCGCCTCCGCGCCCTGCTGCGCCGCAAGCTGCTGCAGGACGAGGC
CCGCCGCGCCCAGGCGGCCGAGGCGCGCGCCGCCGCGGCCGACCAGCTGGCCCGCGCCAACGCCGACCTGCAGGCCGCCA
ACCGCCAGCTGCGCGACGCCCAGGCCCAGCTCGTCCAGTCGGCGAAGATGGCCTCGCTCGGCGAGCTGGTCGCGGGGATC
GCCCACGAGATCAACAATCCGCTGGCCTTCATCCTCGGCCATCAGGACACCGTCGAGCGGCTCGTGGGCGAAGCGCTGGC
GGCGCCGGACTTGGCGACCGCCGGGCCGGCGCTGACCAAGGCCCAGGACCGTCTGCGATCCATGCGGCTGGGGCTCCAGC
GCATCCAGACGCTGGTGCTGAACCTGCGCAAGTTCTCGCGCCTGGACGAGGCCGAGAAGCAGCTGCTGGACGTGCCGGAT
GCGATCGAGACCGTGCTCGCGCTGCTGAAGCCCAAGCTGGCCGACATCGAGGTCCGCCGACGGTTCGAGGCGGGCCCCGC
GCTCTACGGCTCGCCGGCTCTGCTGAACCAGGTGGTGATGAACATCGTCTCGAACGCCGCCGACGCGCTGGGCGGGACCG
GCGTCATCGAGGTCGCCACCCACGAGGCGGACGGCCGCTACCGCATCGAGATCAGCGACTCCGGCCCGGGCGTGCCGCCC
GAGCTCCGCGACAGGATCTTCGATCCGTTCTTCACGACCAAGCCGGTGGGGGCCGGGACCGGTCTGGGCCTGGCGATCGC
TTTTTCCGTCGTGCGGGCCCATGACGGCGCGATCTCGGTGGACGAGGGGCCGCTGGGCGGCGCACGCTTCGTCATCGACC
TGCCGGCGGGAGGCGCCGCATGA

Upstream 100 bases:

>100_bases
GCATGCCCGCCGCGGCGGTGCGGCTGAAGGCGGCCAAGGAGATCCTGCCGCTCGACATGATCGGACCGCGGCTCGTCCAT
CTGGCGCAGAGGGCCCGCCC

Downstream 100 bases:

>100_bases
CCGCCCAGCGCGCCCGGCTGATGATGGTGGACGACGAGGCCGACATCCTCGTCGCCCTGCAGGATCTGTTCGAGACGACC
TACGACGTCAGCGCCTTCAC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MSEAPRILVVEDSETQALALRGVLEQEGFEVDVAATAEAALDRLNGELPDLVVADFHLPGMDGRELSRQIRLNGRTRALP
VLMLTSAREVDLERQGLESGVDAYLPKSANVEVMLARLRALLRRPQAAGAERGRAFRRARVLLAHDSATARLRLRHLLDQ
EGYEVVEASTEREAVQSLDEETDCVVLPIAAAAWDGLLLARDLNAQRQRLGFPFQIVVIGPGPDQPAELAAAFEAGADEV
VRTLESDDVVLVRLRALLRRKLLQDEARRAQAAEARAAAADQLARANADLQAANRQLRDAQAQLVQSAKMASLGELVAGI
AHEINNPLAFILGHQDTVERLVGEALAAPDLATAGPALTKAQDRLRSMRLGLQRIQTLVLNLRKFSRLDEAEKQLLDVPD
AIETVLALLKPKLADIEVRRRFEAGPALYGSPALLNQVVMNIVSNAADALGGTGVIEVATHEADGRYRIEISDSGPGVPP
ELRDRIFDPFFTTKPVGAGTGLGLAIAFSVVRAHDGAISVDEGPLGGARFVIDLPAGGAA

Sequences:

>Translated_540_residues
MSEAPRILVVEDSETQALALRGVLEQEGFEVDVAATAEAALDRLNGELPDLVVADFHLPGMDGRELSRQIRLNGRTRALP
VLMLTSAREVDLERQGLESGVDAYLPKSANVEVMLARLRALLRRPQAAGAERGRAFRRARVLLAHDSATARLRLRHLLDQ
EGYEVVEASTEREAVQSLDEETDCVVLPIAAAAWDGLLLARDLNAQRQRLGFPFQIVVIGPGPDQPAELAAAFEAGADEV
VRTLESDDVVLVRLRALLRRKLLQDEARRAQAAEARAAAADQLARANADLQAANRQLRDAQAQLVQSAKMASLGELVAGI
AHEINNPLAFILGHQDTVERLVGEALAAPDLATAGPALTKAQDRLRSMRLGLQRIQTLVLNLRKFSRLDEAEKQLLDVPD
AIETVLALLKPKLADIEVRRRFEAGPALYGSPALLNQVVMNIVSNAADALGGTGVIEVATHEADGRYRIEISDSGPGVPP
ELRDRIFDPFFTTKPVGAGTGLGLAIAFSVVRAHDGAISVDEGPLGGARFVIDLPAGGAA
>Mature_539_residues
SEAPRILVVEDSETQALALRGVLEQEGFEVDVAATAEAALDRLNGELPDLVVADFHLPGMDGRELSRQIRLNGRTRALPV
LMLTSAREVDLERQGLESGVDAYLPKSANVEVMLARLRALLRRPQAAGAERGRAFRRARVLLAHDSATARLRLRHLLDQE
GYEVVEASTEREAVQSLDEETDCVVLPIAAAAWDGLLLARDLNAQRQRLGFPFQIVVIGPGPDQPAELAAAFEAGADEVV
RTLESDDVVLVRLRALLRRKLLQDEARRAQAAEARAAAADQLARANADLQAANRQLRDAQAQLVQSAKMASLGELVAGIA
HEINNPLAFILGHQDTVERLVGEALAAPDLATAGPALTKAQDRLRSMRLGLQRIQTLVLNLRKFSRLDEAEKQLLDVPDA
IETVLALLKPKLADIEVRRRFEAGPALYGSPALLNQVVMNIVSNAADALGGTGVIEVATHEADGRYRIEISDSGPGVPPE
LRDRIFDPFFTTKPVGAGTGLGLAIAFSVVRAHDGAISVDEGPLGGARFVIDLPAGGAA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=33.0612244897959, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=33.0612244897959, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1790300, Length=260, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693157, Length=263, Percent_Identity=28.5171102661597, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=27.8008298755187, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=28.6231884057971, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786599, Length=121, Percent_Identity=38.0165289256198, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=238, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788393, Length=235, Percent_Identity=25.9574468085106, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=271, Percent_Identity=26.5682656826568, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789809, Length=124, Percent_Identity=39.5161290322581, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790860, Length=119, Percent_Identity=41.1764705882353, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=28.0701754385965, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787375, Length=119, Percent_Identity=36.1344537815126, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789402, Length=139, Percent_Identity=35.9712230215827, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87082012, Length=129, Percent_Identity=34.8837209302326, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58023; Mature: 57892

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAPRILVVEDSETQALALRGVLEQEGFEVDVAATAEAALDRLNGELPDLVVADFHLPG
CCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCCCC
MDGRELSRQIRLNGRTRALPVLMLTSAREVDLERQGLESGVDAYLPKSANVEVMLARLRA
CCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
LLRRPQAAGAERGRAFRRARVLLAHDSATARLRLRHLLDQEGYEVVEASTEREAVQSLDE
HHHCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
ETDCVVLPIAAAAWDGLLLARDLNAQRQRLGFPFQIVVIGPGPDQPAELAAAFEAGADEV
CCCEEEEEEHHHHHCCCCEECCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCHHHH
VRTLESDDVVLVRLRALLRRKLLQDEARRAQAAEARAAAADQLARANADLQAANRQLRDA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QAQLVQSAKMASLGELVAGIAHEINNPLAFILGHQDTVERLVGEALAAPDLATAGPALTK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHH
AQDRLRSMRLGLQRIQTLVLNLRKFSRLDEAEKQLLDVPDAIETVLALLKPKLADIEVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHH
RFEAGPALYGSPALLNQVVMNIVSNAADALGGTGVIEVATHEADGRYRIEISDSGPGVPP
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCH
ELRDRIFDPFFTTKPVGAGTGLGLAIAFSVVRAHDGAISVDEGPLGGARFVIDLPAGGAA
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SEAPRILVVEDSETQALALRGVLEQEGFEVDVAATAEAALDRLNGELPDLVVADFHLPG
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCCCC
MDGRELSRQIRLNGRTRALPVLMLTSAREVDLERQGLESGVDAYLPKSANVEVMLARLRA
CCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
LLRRPQAAGAERGRAFRRARVLLAHDSATARLRLRHLLDQEGYEVVEASTEREAVQSLDE
HHHCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
ETDCVVLPIAAAAWDGLLLARDLNAQRQRLGFPFQIVVIGPGPDQPAELAAAFEAGADEV
CCCEEEEEEHHHHHCCCCEECCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCHHHH
VRTLESDDVVLVRLRALLRRKLLQDEARRAQAAEARAAAADQLARANADLQAANRQLRDA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
QAQLVQSAKMASLGELVAGIAHEINNPLAFILGHQDTVERLVGEALAAPDLATAGPALTK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHH
AQDRLRSMRLGLQRIQTLVLNLRKFSRLDEAEKQLLDVPDAIETVLALLKPKLADIEVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHH
RFEAGPALYGSPALLNQVVMNIVSNAADALGGTGVIEVATHEADGRYRIEISDSGPGVPP
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCH
ELRDRIFDPFFTTKPVGAGTGLGLAIAFSVVRAHDGAISVDEGPLGGARFVIDLPAGGAA
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]