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The map label for this gene is thrC [H]

Identifier: 195952702

GI number: 195952702

Start: 282548

End: 283606

Strand: Direct

Name: thrC [H]

Synonym: HY04AAS1_0324

Alternate gene names: 195952702

Gene position: 282548-283606 (Clockwise)

Preceding gene: 195952701

Following gene: 195952717

Centisome position: 18.12

GC content: 40.79

Gene sequence:

>1059_bases
ATGGGATATTGGAAAGGACTAATACACGCATATAGAGAATATTTGCCGGTTTCTGAAAAGACACCTATTATAACCCTTTA
CGAAGGCAACACGCCTCTTATAAAAGCTCAAAGAATACCAGACATGCTAAAAGTAGGGGTGGAGCTTTATTTTAAGTTTG
AAGGCCTAAACCCCACAGGTTCTTTTAAGGATAGAGGCATGACAATGGCTATATCAAAAGCCGCCGAATCTGGTAAAAGA
GCCGTTATATGTGCATCCACTGGCAATACCTCAGCTTCGGCTGCTGCTTACGCTGCAAGAGCTGGTATGAAAGCTTTTGT
GGTACTTCCAAAAGGTGCTGTAGCTCTTGGTAAACTATCCCAAGCTATCATATACGGTGCCAAGGTAATAGCGCTTCTTG
GAAATTTTGATGATGCTTTGTTTATAGTAAGAAAAATAGGTGAGATATTACCAGTAGAAGTGGTAAATTCTGTAAACCCT
TATCGTATAGAAGGTCAAAAAACCGCTGCCTTTGAAATAGTAGATGCTTTAGGGGATGCTCCCACTTATCATTTTATACC
TGTTGGAAACGCTGGTAACATAACAGCCTATTGGAAAGGTTATAAAGAGTATCATGCTATAGGAAAATCAAAAAAACTTC
CCATTATGATGGGTTATCAGGCAGAAGGATCGGCTCCTATAGTAAAAGGTTATCCTATAAAAAACCCTCAAACCATAGCC
ACCGCTATAAAAATAGGCAATCCTTACAGCTGGAGAAATGCCATCCAAGCCGCCAAAGAATCAAACGGTAAAATTGATGC
GGTTACCGATGATGAGATACTTTACGCTTACAACCTTGTGGCTTCTTGTGAAGGGGTTTTTTGTGAACCAGCTTCCGCTG
CATCTGTGGCAGGCTTTATTAAAAGCGCCAAAGAAGGTATTTTTAAAGAAGGCGATGTGGTAGTCTGCACATTGACGGGT
TCTGGCTTAAAAGACCCAGATACCGCTATGAAATCCGCCCAAAGCCCTATAGAAGTACCTCCAGATTTAAACCAGGTTTT
GAAGCTTATAGAGATTTAA

Upstream 100 bases:

>100_bases
AGAAGAGATAAGACAAAAGATAGGATAACAGTTTTTGTAGAAAAGGTGTAAGTCTCTTTTATGTATATAAAACATAAACG
GTGTGGTAAAATATTTGGAT

Downstream 100 bases:

>100_bases
AGCTTTTCTATTATAATGTCTCCGTAGTGTTCTTTTTGATATATATCTGCATGTTTGTCGTATTGGATAAACATAAGGGC
TGTAAATTGGACTGAGGCTT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MGYWKGLIHAYREYLPVSEKTPIITLYEGNTPLIKAQRIPDMLKVGVELYFKFEGLNPTGSFKDRGMTMAISKAAESGKR
AVICASTGNTSASAAAYAARAGMKAFVVLPKGAVALGKLSQAIIYGAKVIALLGNFDDALFIVRKIGEILPVEVVNSVNP
YRIEGQKTAAFEIVDALGDAPTYHFIPVGNAGNITAYWKGYKEYHAIGKSKKLPIMMGYQAEGSAPIVKGYPIKNPQTIA
TAIKIGNPYSWRNAIQAAKESNGKIDAVTDDEILYAYNLVASCEGVFCEPASAASVAGFIKSAKEGIFKEGDVVVCTLTG
SGLKDPDTAMKSAQSPIEVPPDLNQVLKLIEI

Sequences:

>Translated_352_residues
MGYWKGLIHAYREYLPVSEKTPIITLYEGNTPLIKAQRIPDMLKVGVELYFKFEGLNPTGSFKDRGMTMAISKAAESGKR
AVICASTGNTSASAAAYAARAGMKAFVVLPKGAVALGKLSQAIIYGAKVIALLGNFDDALFIVRKIGEILPVEVVNSVNP
YRIEGQKTAAFEIVDALGDAPTYHFIPVGNAGNITAYWKGYKEYHAIGKSKKLPIMMGYQAEGSAPIVKGYPIKNPQTIA
TAIKIGNPYSWRNAIQAAKESNGKIDAVTDDEILYAYNLVASCEGVFCEPASAASVAGFIKSAKEGIFKEGDVVVCTLTG
SGLKDPDTAMKSAQSPIEVPPDLNQVLKLIEI
>Mature_351_residues
GYWKGLIHAYREYLPVSEKTPIITLYEGNTPLIKAQRIPDMLKVGVELYFKFEGLNPTGSFKDRGMTMAISKAAESGKRA
VICASTGNTSASAAAYAARAGMKAFVVLPKGAVALGKLSQAIIYGAKVIALLGNFDDALFIVRKIGEILPVEVVNSVNPY
RIEGQKTAAFEIVDALGDAPTYHFIPVGNAGNITAYWKGYKEYHAIGKSKKLPIMMGYQAEGSAPIVKGYPIKNPQTIAT
AIKIGNPYSWRNAIQAAKESNGKIDAVTDDEILYAYNLVASCEGVFCEPASAASVAGFIKSAKEGIFKEGDVVVCTLTGS
GLKDPDTAMKSAQSPIEVPPDLNQVLKLIEI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI2367138, Length=291, Percent_Identity=28.8659793814433, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789505, Length=137, Percent_Identity=34.3065693430657, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322631, Length=311, Percent_Identity=24.7588424437299, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37667; Mature: 37536

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYWKGLIHAYREYLPVSEKTPIITLYEGNTPLIKAQRIPDMLKVGVELYFKFEGLNPTG
CCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEHHCCHHHHHCCEEEEEEEECCCCCC
SFKDRGMTMAISKAAESGKRAVICASTGNTSASAAAYAARAGMKAFVVLPKGAVALGKLS
CCCCCCEEEEEEHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHH
QAIIYGAKVIALLGNFDDALFIVRKIGEILPVEVVNSVNPYRIEGQKTAAFEIVDALGDA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCEEECCCCHHHHHHHHHHCCC
PTYHFIPVGNAGNITAYWKGYKEYHAIGKSKKLPIMMGYQAEGSAPIVKGYPIKNPQTIA
CCEEEEEECCCCCEEEEECCHHHHHHCCCCCCCCEEEEECCCCCCCEEECCCCCCCCEEE
TAIKIGNPYSWRNAIQAAKESNGKIDAVTDDEILYAYNLVASCEGVFCEPASAASVAGFI
EEEEECCCHHHHHHHHHHHHCCCEEEEECCCCEEEEEEHHHHCCCCEECCCCHHHHHHHH
KSAKEGIFKEGDVVVCTLTGSGLKDPDTAMKSAQSPIEVPPDLNQVLKLIEI
HHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
GYWKGLIHAYREYLPVSEKTPIITLYEGNTPLIKAQRIPDMLKVGVELYFKFEGLNPTG
CHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEHHCCHHHHHCCEEEEEEEECCCCCC
SFKDRGMTMAISKAAESGKRAVICASTGNTSASAAAYAARAGMKAFVVLPKGAVALGKLS
CCCCCCEEEEEEHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHH
QAIIYGAKVIALLGNFDDALFIVRKIGEILPVEVVNSVNPYRIEGQKTAAFEIVDALGDA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCEEECCCCHHHHHHHHHHCCC
PTYHFIPVGNAGNITAYWKGYKEYHAIGKSKKLPIMMGYQAEGSAPIVKGYPIKNPQTIA
CCEEEEEECCCCCEEEEECCHHHHHHCCCCCCCCEEEEECCCCCCCEEECCCCCCCCEEE
TAIKIGNPYSWRNAIQAAKESNGKIDAVTDDEILYAYNLVASCEGVFCEPASAASVAGFI
EEEEECCCHHHHHHHHHHHHCCCEEEEECCCCEEEEEEHHHHCCCCEECCCCHHHHHHHH
KSAKEGIFKEGDVVVCTLTGSGLKDPDTAMKSAQSPIEVPPDLNQVLKLIEI
HHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3098560; 9384377; 3139660 [H]