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The map label for this gene is ffh [H]

Identifier: 195952674

GI number: 195952674

Start: 255985

End: 257292

Strand: Direct

Name: ffh [H]

Synonym: HY04AAS1_0296

Alternate gene names: 195952674

Gene position: 255985-257292 (Clockwise)

Preceding gene: 195952673

Following gene: 195952675

Centisome position: 16.41

GC content: 36.62

Gene sequence:

>1308_bases
ATGCTGGAACTTTTAACGGAAAAGATTAGTGGAAGCTTAGAGAAGCTAAAAGGCGCTAAAAAGTTAAATGAAAAGTTAGT
TAACGATACTCTTAGAGATATTAGAGCCGCTTTGTTGGAAGCTGATGTAGATTACGATGTAGCAAAAGATTTTATCAAAA
GGTTAAGAGAGCGTATCTTTTCTGAAGAGATAAAAACCCACCTATCCCCCACAGATATGATTATAATGAGCGTTTACGAT
GAGCTTGTAAAAACGCTTGGTGGAAATGCTTCTCCTTTAGAAGAAGGGGTGGTAATGTTTGTTGGTCTTCAAGGTACTGG
TAAAACTACAACAATAGGTAAGCTAGCAAATCTTATGAAGAAAAACGGTAGAAGTGTTATGACAGTATCTACAGACGTAA
GAAGACCAGCAGCCATGCTTCAATTAAAGCGTGTATCTGAGTTAGCGGGTGTAGAATATTTAGAGTTTAGTCCAGACAAA
AACCCTGTTGATATAGCCAAAGAGGCGTTTGAGGCTTTTAAAAGCAAAAAATACGATTATTTGTTTTTAGACACCGCTGG
TAGGCTTCATATAGATAACGAACTAATGGAAGAGTTAAGAGCTATCAAAGAAGCCGTAAAACCATCTGAGGTTATATACG
TAGCCGATAGCATGCAAGGACAAGAAGCTCTTTCTGTAGCTAAAACTTTTAACGAAGTTGTAGGGCTTACTGGAGCTATT
CTTACCAAAATGGATGGTGATACCAGAGGTGGCGTAGCGCTTTCTATAAAAGATGCCATAGGTATCCCCATAAAGTATAT
AGGTGTGGGTGAAAAGTTAGAGGATATAGATCAATTTTATCCAGATAGAATCGCCCAAAGAATATTAGGTCTTGGTGATT
TGCAAAGTCTTATAGAGAAAGCTGAACAGGTTATTAGTGAGGATGAGGCTCAAGCTATAACCTATAAAATGATGAGAGGT
GAGTTTGATCTAAATGACTTGAAGAAAAATATAAGTTTTATGATGAACATGGGTCCTCTTGATAAAGTGCTTTCAATGTT
ACCAGGAGTTGGTTCCCAGTTGAAAAATATAAAGGTTGATCAAAAGATATTTAAACGTATTATAGCTATGGTAGATTCTA
TGACTCCTGAGGAAAGGGCAAATCCAAACGTTATAAACTTAAGTCGTAAACAAAGAATAGCGAAAGGTAGCGGTACCACT
GTTTCTGATGTTAACAAGCTTTTAAAACAGTATCAAGATATGAAAAAGATGATTAGAAAACTAAAAAATCAGAAATCACC
GTTTGGTGGTTTAGGGCTCCCGTTTTAA

Upstream 100 bases:

>100_bases
CTGTAGCTGGGCTTGATTTATCTCCAGCGGTGCTTATATTTATACTGGTGGTATTGCAGCATATTTTGAGATAGTGTTAT
ATTATGGTATAATATAGGCT

Downstream 100 bases:

>100_bases
CCTATGAAGAATATTTCAAATATAAATATCGCCGGAGTGGTAGGCGATTATAAATATCCACTCTATTTGGTTGTTAAAAG
CCAAATAAAAGGGTACTGAG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLELLTEKISGSLEKLKGAKKLNEKLVNDTLRDIRAALLEADVDYDVAKDFIKRLRERIFSEEIKTHLSPTDMIIMSVYD
ELVKTLGGNASPLEEGVVMFVGLQGTGKTTTIGKLANLMKKNGRSVMTVSTDVRRPAAMLQLKRVSELAGVEYLEFSPDK
NPVDIAKEAFEAFKSKKYDYLFLDTAGRLHIDNELMEELRAIKEAVKPSEVIYVADSMQGQEALSVAKTFNEVVGLTGAI
LTKMDGDTRGGVALSIKDAIGIPIKYIGVGEKLEDIDQFYPDRIAQRILGLGDLQSLIEKAEQVISEDEAQAITYKMMRG
EFDLNDLKKNISFMMNMGPLDKVLSMLPGVGSQLKNIKVDQKIFKRIIAMVDSMTPEERANPNVINLSRKQRIAKGSGTT
VSDVNKLLKQYQDMKKMIRKLKNQKSPFGGLGLPF

Sequences:

>Translated_435_residues
MLELLTEKISGSLEKLKGAKKLNEKLVNDTLRDIRAALLEADVDYDVAKDFIKRLRERIFSEEIKTHLSPTDMIIMSVYD
ELVKTLGGNASPLEEGVVMFVGLQGTGKTTTIGKLANLMKKNGRSVMTVSTDVRRPAAMLQLKRVSELAGVEYLEFSPDK
NPVDIAKEAFEAFKSKKYDYLFLDTAGRLHIDNELMEELRAIKEAVKPSEVIYVADSMQGQEALSVAKTFNEVVGLTGAI
LTKMDGDTRGGVALSIKDAIGIPIKYIGVGEKLEDIDQFYPDRIAQRILGLGDLQSLIEKAEQVISEDEAQAITYKMMRG
EFDLNDLKKNISFMMNMGPLDKVLSMLPGVGSQLKNIKVDQKIFKRIIAMVDSMTPEERANPNVINLSRKQRIAKGSGTT
VSDVNKLLKQYQDMKKMIRKLKNQKSPFGGLGLPF
>Mature_435_residues
MLELLTEKISGSLEKLKGAKKLNEKLVNDTLRDIRAALLEADVDYDVAKDFIKRLRERIFSEEIKTHLSPTDMIIMSVYD
ELVKTLGGNASPLEEGVVMFVGLQGTGKTTTIGKLANLMKKNGRSVMTVSTDVRRPAAMLQLKRVSELAGVEYLEFSPDK
NPVDIAKEAFEAFKSKKYDYLFLDTAGRLHIDNELMEELRAIKEAVKPSEVIYVADSMQGQEALSVAKTFNEVVGLTGAI
LTKMDGDTRGGVALSIKDAIGIPIKYIGVGEKLEDIDQFYPDRIAQRILGLGDLQSLIEKAEQVISEDEAQAITYKMMRG
EFDLNDLKKNISFMMNMGPLDKVLSMLPGVGSQLKNIKVDQKIFKRIIAMVDSMTPEERANPNVINLSRKQRIAKGSGTT
VSDVNKLLKQYQDMKKMIRKLKNQKSPFGGLGLPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=439, Percent_Identity=33.0296127562642, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI226371618, Length=388, Percent_Identity=32.9896907216495, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=35, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI295424842, Length=302, Percent_Identity=25.4966887417219, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI23308697, Length=305, Percent_Identity=25.2459016393443, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=44, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1789874, Length=203, Percent_Identity=41.3793103448276, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=439, Percent_Identity=30.2961275626424, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI193206261, Length=198, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325345, Length=419, Percent_Identity=34.6062052505967, Blast_Score=235, Evalue=8e-63,
Organism=Saccharomyces cerevisiae, GI6320498, Length=219, Percent_Identity=31.9634703196347, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17647949, Length=438, Percent_Identity=33.1050228310502, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24641198, Length=204, Percent_Identity=25.9803921568627, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 48419; Mature: 48419

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELLTEKISGSLEKLKGAKKLNEKLVNDTLRDIRAALLEADVDYDVAKDFIKRLRERIF
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SEEIKTHLSPTDMIIMSVYDELVKTLGGNASPLEEGVVMFVGLQGTGKTTTIGKLANLMK
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
KNGRSVMTVSTDVRRPAAMLQLKRVSELAGVEYLEFSPDKNPVDIAKEAFEAFKSKKYDY
HCCCEEEEEECHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCE
LFLDTAGRLHIDNELMEELRAIKEAVKPSEVIYVADSMQGQEALSVAKTFNEVVGLTGAI
EEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LTKMDGDTRGGVALSIKDAIGIPIKYIGVGEKLEDIDQFYPDRIAQRILGLGDLQSLIEK
HHHCCCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
AEQVISEDEAQAITYKMMRGEFDLNDLKKNISFMMNMGPLDKVLSMLPGVGSQLKNIKVD
HHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHCCCHH
QKIFKRIIAMVDSMTPEERANPNVINLSRKQRIAKGSGTTVSDVNKLLKQYQDMKKMIRK
HHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LKNQKSPFGGLGLPF
HHHCCCCCCCCCCCC
>Mature Secondary Structure
MLELLTEKISGSLEKLKGAKKLNEKLVNDTLRDIRAALLEADVDYDVAKDFIKRLRERIF
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SEEIKTHLSPTDMIIMSVYDELVKTLGGNASPLEEGVVMFVGLQGTGKTTTIGKLANLMK
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
KNGRSVMTVSTDVRRPAAMLQLKRVSELAGVEYLEFSPDKNPVDIAKEAFEAFKSKKYDY
HCCCEEEEEECHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCE
LFLDTAGRLHIDNELMEELRAIKEAVKPSEVIYVADSMQGQEALSVAKTFNEVVGLTGAI
EEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LTKMDGDTRGGVALSIKDAIGIPIKYIGVGEKLEDIDQFYPDRIAQRILGLGDLQSLIEK
HHHCCCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
AEQVISEDEAQAITYKMMRGEFDLNDLKKNISFMMNMGPLDKVLSMLPGVGSQLKNIKVD
HHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHCCCHH
QKIFKRIIAMVDSMTPEERANPNVINLSRKQRIAKGSGTTVSDVNKLLKQYQDMKKMIRK
HHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LKNQKSPFGGLGLPF
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]