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The map label for this gene is fruA [H]

Identifier: 194738383

GI number: 194738383

Start: 2324047

End: 2325735

Strand: Reverse

Name: fruA [H]

Synonym: SeSA_A2443

Alternate gene names: 194738383

Gene position: 2325735-2324047 (Counterclockwise)

Preceding gene: 194734375

Following gene: 194735526

Centisome position: 49.39

GC content: 58.97

Gene sequence:

>1689_bases
ATGAAAACGCTGCTGATAATTGACGCTAATCTCGGCCAGGCTCGCGCTTACATGGCGAAAACCCTGCTTGGAGCGGCGGC
GCATAAAGCAAATCTGGAAATTATCGACAATCCGAATGATGCTGAACTGGCGATCGTGCTGGGCGAATCTCTGCCGAACG
ACAATGCTCTGAACGGCAAAAAGGTTTGGCTGGGGGATATTGGTCGCGCCGTCGCGCATCCGGAACTGTTTCTGAGTGAA
GCCAAAAGCCATGCGACCCCTTACAGCGCTCCTGCTGCGGTTGCTCCTGCGGCGAGCGGCGGTCCGAAACGCGTGGTCGC
GGTAACGGCCTGCCCGACCGGCGTCGCTCATACTTTTATGGCGGCTGAAGCCATTGAAACAGAAGCGAAAAAACGCGGCT
GGTGGGTAAAAGTCGAAACGCGCGGCTCCGTGGGGGCCGGCAATGCCATCACCCCGGAAGAGGTGGCGGAAGCGGATTTA
GTGATTGTGGCGGCGGATATCGAAGTGGATCTGGCGAAGTTTGCCGGTCTCCCAATGTACCGCACGTCGACCGGCCTGGC
GCTGAAAAAGACGGCGCAGGAGCTGGATAAAGCCGTAGCGGAAGCGACGCCGTATCAACCGGCGGGTAAGGCATCGCAAG
CGGCGACCGAAGGGAAGAAAGAGAGCGCTGGCGCATACCGGCATCTGTTGACGGGCGTTTCTTACATGCTGCCTATGGTG
GTTGCCGGGGGACTGTGTATTGCGCTTTCCTTCGCCTTTGGTATTGAAGCCTTTAAGGTGCCGGACACGCTGGCGGCGGC
GCTGATGCAGATTGGCGGCGGTTCGGCGTTTGCGCTGATGGTGCCGGTACTGGCGGGTTATATCGCTTTCTCCATCGCGG
ATCGCCCAGGCCTTACGCCAGGTCTGATTGGCGGTATGCTGGCGGTTAGCACCGGTTCCGGTTTTATCGGCGGGATCATT
GCCGGCTTCCTTGCCGGGTATATGGCGAAGCTTATCAGTACCAAACTGAAACTTCCGCAAAGTATGGAAGCGCTGAAGCC
AATCCTGATCATCCCGTTAATTTCCAGTCTGGTGGTGGGGCTGGCGATGATTTACCTGATCGGTAAACCGGTTGCCGGGA
TTCTGGAAGGGCTCACCCACTGGCTGCAAACGATGGGGACGGCAAATGCGGTGCTGCTGGGCGCGATTCTCGGCGGGATG
ATGTGTACCGACATGGGCGGCCCGGTGAACAAAGCGGCGTATGCGTTTGGCGTTGGTCTGCTGAGTACGCAAACTTACGC
GCCGATGGCGGCGATCATGGCCGCAGGTATGGTACCGCCGTTAGCGCTGGGTCTGGCGACGATGGTGGCGCATCGTAAGT
TCGACAAAGCGCAGCAGGAAGGCGGTAAAGCGGCGTTGGTGCTGGGGCTGTGCTTTATCACTGAAGGCGCTATTCCGTTT
GCGGCGCGCGACCCGATGCGTGTACTGCCGTGCTGTATCGTTGGCGGCGCGTTGACCGGGGCTATTTCTATGGCGGTAGG
CGCAAAATTGATGGCGCCGCATGGCGGTCTGTTTGTTCTGCTTATCCCAGGCGCAATTACGCCGGTATTGGGATACCTGC
TGGCAATTGTGGCCGGTACGCTGGTGGCAGGGCTGGCTTATGCCGTCCTGAAACGTCCGGAGACGGAAGTCGCGGCAAAA
GCGGCGTAA

Upstream 100 bases:

>100_bases
GTCAGCCAGAGCAATGTGGGTATTACCGATCGTCCTCAGTTGGCCGCAATGATGGCGCGTGTCGACTTACAACCGTTTAA
CTGACAGCAGGAGAGGCATA

Downstream 100 bases:

>100_bases
GAGAAACACGCTAAAAAAGGCAGAGCGCGCTCTGCCTTTTTTATTGCCTGAAGAACATTGCGCGTCAGGCCACCGCTTCG
GCAATTTGCTGGGCTTTTAA

Product: PTS system fructose-specific transporter subunits IIBC

Products: NA

Alternate protein names: EIIBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MKTLLIIDANLGQARAYMAKTLLGAAAHKANLEIIDNPNDAELAIVLGESLPNDNALNGKKVWLGDIGRAVAHPELFLSE
AKSHATPYSAPAAVAPAASGGPKRVVAVTACPTGVAHTFMAAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEADL
VIVAADIEVDLAKFAGLPMYRTSTGLALKKTAQELDKAVAEATPYQPAGKASQAATEGKKESAGAYRHLLTGVSYMLPMV
VAGGLCIALSFAFGIEAFKVPDTLAAALMQIGGGSAFALMVPVLAGYIAFSIADRPGLTPGLIGGMLAVSTGSGFIGGII
AGFLAGYMAKLISTKLKLPQSMEALKPILIIPLISSLVVGLAMIYLIGKPVAGILEGLTHWLQTMGTANAVLLGAILGGM
MCTDMGGPVNKAAYAFGVGLLSTQTYAPMAAIMAAGMVPPLALGLATMVAHRKFDKAQQEGGKAALVLGLCFITEGAIPF
AARDPMRVLPCCIVGGALTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGTLVAGLAYAVLKRPETEVAAK
AA

Sequences:

>Translated_562_residues
MKTLLIIDANLGQARAYMAKTLLGAAAHKANLEIIDNPNDAELAIVLGESLPNDNALNGKKVWLGDIGRAVAHPELFLSE
AKSHATPYSAPAAVAPAASGGPKRVVAVTACPTGVAHTFMAAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEADL
VIVAADIEVDLAKFAGLPMYRTSTGLALKKTAQELDKAVAEATPYQPAGKASQAATEGKKESAGAYRHLLTGVSYMLPMV
VAGGLCIALSFAFGIEAFKVPDTLAAALMQIGGGSAFALMVPVLAGYIAFSIADRPGLTPGLIGGMLAVSTGSGFIGGII
AGFLAGYMAKLISTKLKLPQSMEALKPILIIPLISSLVVGLAMIYLIGKPVAGILEGLTHWLQTMGTANAVLLGAILGGM
MCTDMGGPVNKAAYAFGVGLLSTQTYAPMAAIMAAGMVPPLALGLATMVAHRKFDKAQQEGGKAALVLGLCFITEGAIPF
AARDPMRVLPCCIVGGALTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGTLVAGLAYAVLKRPETEVAAK
AA
>Mature_562_residues
MKTLLIIDANLGQARAYMAKTLLGAAAHKANLEIIDNPNDAELAIVLGESLPNDNALNGKKVWLGDIGRAVAHPELFLSE
AKSHATPYSAPAAVAPAASGGPKRVVAVTACPTGVAHTFMAAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEADL
VIVAADIEVDLAKFAGLPMYRTSTGLALKKTAQELDKAVAEATPYQPAGKASQAATEGKKESAGAYRHLLTGVSYMLPMV
VAGGLCIALSFAFGIEAFKVPDTLAAALMQIGGGSAFALMVPVLAGYIAFSIADRPGLTPGLIGGMLAVSTGSGFIGGII
AGFLAGYMAKLISTKLKLPQSMEALKPILIIPLISSLVVGLAMIYLIGKPVAGILEGLTHWLQTMGTANAVLLGAILGGM
MCTDMGGPVNKAAYAFGVGLLSTQTYAPMAAIMAAGMVPPLALGLATMVAHRKFDKAQQEGGKAALVLGLCFITEGAIPF
AARDPMRVLPCCIVGGALTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGTLVAGLAYAVLKRPETEVAAK
AA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=563, Percent_Identity=92.3623445825933, Blast_Score=1017, Evalue=0.0,
Organism=Escherichia coli, GI1786951, Length=509, Percent_Identity=34.9705304518664, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI87082348, Length=478, Percent_Identity=33.6820083682008, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1790386, Length=301, Percent_Identity=43.5215946843854, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1788729, Length=362, Percent_Identity=27.9005524861878, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790387, Length=88, Percent_Identity=52.2727272727273, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788730, Length=103, Percent_Identity=38.8349514563107, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790390, Length=65, Percent_Identity=44.6153846153846, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 57298; Mature: 57298

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLLIIDANLGQARAYMAKTLLGAAAHKANLEIIDNPNDAELAIVLGESLPNDNALNGK
CCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCCCCC
KVWLGDIGRAVAHPELFLSEAKSHATPYSAPAAVAPAASGGPKRVVAVTACPTGVAHTFM
EEEHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHH
AAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEADLVIVAADIEVDLAKFAGLPMY
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCEEEEEECCEEEHHHHCCCCCE
RTSTGLALKKTAQELDKAVAEATPYQPAGKASQAATEGKKESAGAYRHLLTGVSYMLPMV
ECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VAGGLCIALSFAFGIEAFKVPDTLAAALMQIGGGSAFALMVPVLAGYIAFSIADRPGLTP
HHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
GLIGGMLAVSTGSGFIGGIIAGFLAGYMAKLISTKLKLPQSMEALKPILIIPLISSLVVG
HHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAMIYLIGKPVAGILEGLTHWLQTMGTANAVLLGAILGGMMCTDMGGPVNKAAYAFGVGL
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LSTQTYAPMAAIMAAGMVPPLALGLATMVAHRKFDKAQQEGGKAALVLGLCFITEGAIPF
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCC
AARDPMRVLPCCIVGGALTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHH
LVAGLAYAVLKRPETEVAAKAA
HHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MKTLLIIDANLGQARAYMAKTLLGAAAHKANLEIIDNPNDAELAIVLGESLPNDNALNGK
CCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCCCCC
KVWLGDIGRAVAHPELFLSEAKSHATPYSAPAAVAPAASGGPKRVVAVTACPTGVAHTFM
EEEHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHH
AAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAEADLVIVAADIEVDLAKFAGLPMY
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCEEEEEECCEEEHHHHCCCCCE
RTSTGLALKKTAQELDKAVAEATPYQPAGKASQAATEGKKESAGAYRHLLTGVSYMLPMV
ECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VAGGLCIALSFAFGIEAFKVPDTLAAALMQIGGGSAFALMVPVLAGYIAFSIADRPGLTP
HHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
GLIGGMLAVSTGSGFIGGIIAGFLAGYMAKLISTKLKLPQSMEALKPILIIPLISSLVVG
HHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAMIYLIGKPVAGILEGLTHWLQTMGTANAVLLGAILGGMMCTDMGGPVNKAAYAFGVGL
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LSTQTYAPMAAIMAAGMVPPLALGLATMVAHRKFDKAQQEGGKAALVLGLCFITEGAIPF
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCC
AARDPMRVLPCCIVGGALTGAISMAVGAKLMAPHGGLFVLLIPGAITPVLGYLLAIVAGT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHH
LVAGLAYAVLKRPETEVAAKAA
HHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3076173; 9278503; 9097040; 1981619 [H]