Click here to switch to the map view.

The map label for this gene is ispD [H]

Identifier: 194738080

GI number: 194738080

Start: 2976083

End: 2976793

Strand: Reverse

Name: ispD [H]

Synonym: SeSA_A3081

Alternate gene names: 194738080

Gene position: 2976793-2976083 (Counterclockwise)

Preceding gene: 194736412

Following gene: 194738272

Centisome position: 63.21

GC content: 57.81

Gene sequence:

>711_bases
ATGGCAGCCACTTTATTGGACGTTTGCGCCGTGGTGCCGGCGGCCGGATTTGGCCGCCGAATGCAAACAGAATGTCCTAA
GCAGTATCTCTCAATCGGTAATAAAACCATTCTGGAGCACTCAGTTCATGCGCTGCTGGCGCATCCTCGGGTGACACGCG
TTGTTATTGCTATCAGTCCTGGCGATCATCGCTTTGCCCAACTTCCGCTGGCGAATCATCCGCAAATCACCGTTGTGGAT
GGCGGCAACGAACGCGCTGATTCCGTTTTGGCCGGGTTACAGGCCGTTGCAAAGGCGCAGTGGGTGCTGGTGCACGACGC
GGCAAGACCCTGTTTGCATCAGGATGACCTTGCGCGGTTGCTGGCTATCAGCGAAAACAGCCGGGTCGGCGGTATCCTCG
CCAGTCCGGTGCGCGACACCATGAAACGCGGCGAACCAGGGAAAAACGCTATTGCCCATACCGTAGAGCGCGCCGATTTA
TGGCACGCGCTCACCCCGCAGTTTTTCCCCCGCGAGCTCTTGCACGATTGTCTGACGCGTGCGCTGAATGAAGGCGCGAC
CATCACCGACGAGGCGTCAGCGCTGGAGTATTGTGGTTTTCATCCGGCGCTGGTAGAAGGTCGCGCGGATAACATCAAGG
TCACCCGTCCGGAAGATCTGGCGCTGGCGGAATTTTATCTGACCCGAACCATCCACCAGGAGAAAGCATAA

Upstream 100 bases:

>100_bases
GACCAAACCGGGCGAAACCTTCTATCGTCTGGTGCCTGACGCCTCAAAACGCGCGGCAACGGCGGGGCAAACTCATCGAT
AAACCATCCAGGGATTTAAC

Downstream 100 bases:

>100_bases
TGCGAATTGGACACGGTTTTGACGTACACGCGTTTGGCGGAGAAGGGCCGATTATTATTGGCGGCGTGCGTATCCCTTAT
GAAAAAGGGCTATTGGCGCA

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MAATLLDVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHSVHALLAHPRVTRVVIAISPGDHRFAQLPLANHPQITVVD
GGNERADSVLAGLQAVAKAQWVLVHDAARPCLHQDDLARLLAISENSRVGGILASPVRDTMKRGEPGKNAIAHTVERADL
WHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPALVEGRADNIKVTRPEDLALAEFYLTRTIHQEKA

Sequences:

>Translated_236_residues
MAATLLDVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHSVHALLAHPRVTRVVIAISPGDHRFAQLPLANHPQITVVD
GGNERADSVLAGLQAVAKAQWVLVHDAARPCLHQDDLARLLAISENSRVGGILASPVRDTMKRGEPGKNAIAHTVERADL
WHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPALVEGRADNIKVTRPEDLALAEFYLTRTIHQEKA
>Mature_235_residues
AATLLDVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHSVHALLAHPRVTRVVIAISPGDHRFAQLPLANHPQITVVDG
GNERADSVLAGLQAVAKAQWVLVHDAARPCLHQDDLARLLAISENSRVGGILASPVRDTMKRGEPGKNAIAHTVERADLW
HALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPALVEGRADNIKVTRPEDLALAEFYLTRTIHQEKA

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=240, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1789104, Length=235, Percent_Identity=91.4893617021277, Blast_Score=444, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25730; Mature: 25599

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATLLDVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHSVHALLAHPRVTRVVIAISP
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEECC
GDHRFAQLPLANHPQITVVDGGNERADSVLAGLQAVAKAQWVLVHDAARPCLHQDDLARL
CCCCEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHH
LAISENSRVGGILASPVRDTMKRGEPGKNAIAHTVERADLWHALTPQFFPRELLHDCLTR
HHHCCCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ALNEGATITDEASALEYCGFHPALVEGRADNIKVTRPEDLALAEFYLTRTIHQEKA
HHHCCCCCCCHHHHHHHCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AATLLDVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHSVHALLAHPRVTRVVIAISP
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEECC
GDHRFAQLPLANHPQITVVDGGNERADSVLAGLQAVAKAQWVLVHDAARPCLHQDDLARL
CCCCEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHH
LAISENSRVGGILASPVRDTMKRGEPGKNAIAHTVERADLWHALTPQFFPRELLHDCLTR
HHHCCCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ALNEGATITDEASALEYCGFHPALVEGRADNIKVTRPEDLALAEFYLTRTIHQEKA
HHHCCCCCCCHHHHHHHCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA