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The map label for this gene is lysA [H]

Identifier: 194738024

GI number: 194738024

Start: 3076971

End: 3078233

Strand: Reverse

Name: lysA [H]

Synonym: SeSA_A3181

Alternate gene names: 194738024

Gene position: 3078233-3076971 (Counterclockwise)

Preceding gene: 194735136

Following gene: 194735617

Centisome position: 65.37

GC content: 57.09

Gene sequence:

>1263_bases
ATGTCATTGCCGCATTATCACGCTGAAACTGACCTTAACGCTGAAAATTTGCTCAGATTGCCTGCTGAATTCGGCTGTCC
GGTCTGGGTCTATGACGCGCACATTATTCGCCGTCAGATAGCCGCCCTGCAGCAGTTTGACGTCGTGCGTTTTGCGCAAA
AAGCCTGTTCGAACATTCATATCCTGCGCTTAATGCGCGCGCAGGACGTCAAGGTGGATTCTGTTTCATTGGGGGAGATC
GAACGTGCGCTGGCGGCGGGCTACGATCCGCAAACGTGCCCTGATGATATCGTTTTTACCGCCGATGTGATTGATGCCGC
CACGCTGGCGCGCGTCAGTGAACTGCATATTCCGGTCAATGCCGGCTCGGTAGATATGCTGACGCAGCTTGGTCAGGTTT
CGCCTGGGCATCGCGTCTGGTTGCGCGTGAATCCTGGCTTTGGTCACGGCCACAGCCAGAAAACCAACACCGGGGGCGAA
AACAGCAAACACGGCATCTGGCATAGCGATCTTCCGGCGGCGCTGGCGGTAATGCAGAAATACCGACTGAAACTTGTCGG
TATCCATATGCACATTGGTTCCGGCGTCGATTATGGCCATCTGGAGCAGGTTTGCGGCGCGATGGTACGCCAGGTGCTGG
AATGTGGTCAGGATGTGGAGGCGATTTCGGCAGGCGGCGGACTCTCGATACCTTATCGTGAGGGAGAAGAGCCCGTTGAT
ACGCGTCATTACTATGGCCTGTGGAACGCGGCGCGCGAGCAAATCGCCCGCCATCTGGGACATGCGGTCAAACTTGAGAT
CGAACCCGGACGTTTTCTGGTGGCGCAATCAGGCGTGCTGGTAACGCAGGTGCGTAGCGTAAAACAGATGGGAAGCCGCC
ATTTCGTGCTGGTAGATGCGGGTTTTAACGATCTGATGCGCCCGGCGATGTACGGTAGCTATCACCGTATTTCGGCGCTG
GCGGCGGATGGTCGCGCGCTTGAAAATGGCCCGTGGGTCGAGACGGTGGTCGCCGGGCCGCTATGCGAATCAGGCGATGT
TTTTACGCAGCAGGAAGGGGGAATGGTTGAAACATGCGCCTTACCTGCGGTCATCCCCGGCGATTACCTCGTATTGCACG
ATACCGGCGCGTACGGCGCGTCTATGTCATCGAATTACAATAGCCGCCCGCTCCTGCCGGAAGTGCTGTTTGACAATGGA
CAGGCGCGGCTGATCCGCCGTCGTCAGACCATTGAAGAGCTGTTAGCGCTGGAGATGCTCTGA

Upstream 100 bases:

>100_bases
TTATCCCATATCATTTTTGCATAGACTGACAATAAAACGATATTTTTTATTCTTTCTAAGGTATGGCGTAATCGTTAAAA
AGCCTGTTCCGGAGTTTGTT

Downstream 100 bases:

>100_bases
AGCGCATCATTAGGCCGGACGTTGAAAAAACGGGCCTGCGGCGACGGACTCGCGCAGAATCAGCGTGCCGGTAAAGGGCG
GGATCGGGGCGACCGGCTCG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIHILRLMRAQDVKVDSVSLGEI
ERALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVNAGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGE
NSKHGIWHSDLPAALAVMQKYRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYREGEEPVD
TRHYYGLWNAAREQIARHLGHAVKLEIEPGRFLVAQSGVLVTQVRSVKQMGSRHFVLVDAGFNDLMRPAMYGSYHRISAL
AADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETCALPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNG
QARLIRRRQTIEELLALEML

Sequences:

>Translated_420_residues
MSLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIHILRLMRAQDVKVDSVSLGEI
ERALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVNAGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGE
NSKHGIWHSDLPAALAVMQKYRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYREGEEPVD
TRHYYGLWNAAREQIARHLGHAVKLEIEPGRFLVAQSGVLVTQVRSVKQMGSRHFVLVDAGFNDLMRPAMYGSYHRISAL
AADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETCALPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNG
QARLIRRRQTIEELLALEML
>Mature_419_residues
SLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIHILRLMRAQDVKVDSVSLGEIE
RALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVNAGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGEN
SKHGIWHSDLPAALAVMQKYRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYREGEEPVDT
RHYYGLWNAAREQIARHLGHAVKLEIEPGRFLVAQSGVLVTQVRSVKQMGSRHFVLVDAGFNDLMRPAMYGSYHRISALA
ADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETCALPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQ
ARLIRRRQTIEELLALEML

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=88.3211678832117, Blast_Score=745, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46019; Mature: 45888

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIH
CCCCCCCCCCCCCHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
ILRLMRAQDVKVDSVSLGEIERALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVN
EEEEHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEECC
AGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWHSDLPAALAVMQK
CCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
YRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYREGEEPVD
HCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCC
TRHYYGLWNAAREQIARHLGHAVKLEIEPGRFLVAQSGVLVTQVRSVKQMGSRHFVLVDA
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEC
GFNDLMRPAMYGSYHRISALAADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETCA
CHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCEEEEEC
LPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQARLIRRRQTIEELLALEML
CCEECCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIH
CCCCCCCCCCCCHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
ILRLMRAQDVKVDSVSLGEIERALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVN
EEEEHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEECC
AGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWHSDLPAALAVMQK
CCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
YRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYREGEEPVD
HCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCC
TRHYYGLWNAAREQIARHLGHAVKLEIEPGRFLVAQSGVLVTQVRSVKQMGSRHFVLVDA
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEC
GFNDLMRPAMYGSYHRISALAADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETCA
CHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCEEEEEC
LPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQARLIRRRQTIEELLALEML
CCEECCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]