Click here to switch to the map view.

The map label for this gene is rspB [H]

Identifier: 194737903

GI number: 194737903

Start: 1550935

End: 1551954

Strand: Direct

Name: rspB [H]

Synonym: SeSA_A1608

Alternate gene names: 194737903

Gene position: 1550935-1551954 (Clockwise)

Preceding gene: 194735816

Following gene: 194736310

Centisome position: 32.94

GC content: 51.57

Gene sequence:

>1020_bases
ATGAAAAGCATCGTAATCGAAAAACCGAATACATTAACTATCGAAACGCGCGCGCTTCCGCAGCCTGCGCCGGGTGAAGT
TCGTATTAAAGTGAAACTGGCGGGTATCTGCGGTTCCGACAGTCATATTTATCGGGGACATAATCCCTTTGCAAAATATC
CCCGTGTCATAGGCCATGAATTTTTCGGTGTCATCGACGCGGTAGGCGACAACGTCAATCACGACCGGATAGGAGAACGG
GTATCCGTCGATCCGGTGATCAGTTGCGGGCATTGTTACCCTTGTTCAGTCGGTAAACCCAATGTGTGTACCTCGCTGGT
GGTGCTGGGCGTGCATCGTGACGGCGGTTTCAGCGAGTATGCGGTGGCGCCGGCCCGTAATGCTCATCGCATACCGGACA
ACATCGCAGATCATCATGCCGTCATGGTTGAGCCGTTTACCATTGCGGCAAATGTGACGGGGCAGGTGAATCCAACCGAG
CAGGACGTGGCGCTTATCTATGGCGCAGGCCCGATGGGACTGACGACCGTACAGGCGCTGAAGGGGGTTTATCAGGTTAA
AACGGTCATAGTCGTTGATCGCATTGAAGAGCGTTTAGCGATGGCGAAGCAGAGCGGCGCTGACTGGACCCTCAATAATG
GTCAACATTCACTGGCGGAATTTCTACAACAGAAGGCGCTAAAGCCGACCTTGATTGTCGATGCCGCCTGTCATCCCGCT
ATCCTGCAAGAGGCGATTACCCTTGCATCGCCTGCGGCACGCATTGTCCTGATGGGGTTTTCCAGCGACCCGTGTGAGAT
TGTACAGCAGGGTATTACCGGAAAAGAGCTGGCTATTTATTCATCGCGTCTTAATGCCAATAAATTCCCGGTCGTGATTG
ACTGGCTGAATAAAGGGCTTATTGATCCGGATAAGCTGATAACGCATACATTTGATTATCAACATGTCACCGACGCGATT
GAGCTTTTCGAGAAAGACCAGCGTCAATGCTGCAAAGTCTTACTCACGTTTGCGAAATAA

Upstream 100 bases:

>100_bases
TTCGATGAAAAACTGGCGGCGAAATATCCGTACGATCCAGCCTATTTGCCGGTGGCCCGCCTGGAAGACGGCACACTGTG
GAACTGGTAAGGAGCGAAAA

Downstream 100 bases:

>100_bases
TATAAATAATTGCGAGTAAGTGGTACGCATCTTACCTCTTAGAGATTGCCTATATGACACAAATAAAGCATGAACGATCG
ACTCAGGATTTAGTGCGCGC

Product: putative dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKSIVIEKPNTLTIETRALPQPAPGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGDNVNHDRIGER
VSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEYAVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTE
QDVALIYGAGPMGLTTVQALKGVYQVKTVIVVDRIEERLAMAKQSGADWTLNNGQHSLAEFLQQKALKPTLIVDAACHPA
ILQEAITLASPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVVIDWLNKGLIDPDKLITHTFDYQHVTDAI
ELFEKDQRQCCKVLLTFAK

Sequences:

>Translated_339_residues
MKSIVIEKPNTLTIETRALPQPAPGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGDNVNHDRIGER
VSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEYAVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTE
QDVALIYGAGPMGLTTVQALKGVYQVKTVIVVDRIEERLAMAKQSGADWTLNNGQHSLAEFLQQKALKPTLIVDAACHPA
ILQEAITLASPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVVIDWLNKGLIDPDKLITHTFDYQHVTDAI
ELFEKDQRQCCKVLLTFAK
>Mature_339_residues
MKSIVIEKPNTLTIETRALPQPAPGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGDNVNHDRIGER
VSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEYAVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTE
QDVALIYGAGPMGLTTVQALKGVYQVKTVIVVDRIEERLAMAKQSGADWTLNNGQHSLAEFLQQKALKPTLIVDAACHPA
ILQEAITLASPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVVIDWLNKGLIDPDKLITHTFDYQHVTDAI
ELFEKDQRQCCKVLLTFAK

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=331, Percent_Identity=28.0966767371601, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI262073058, Length=374, Percent_Identity=22.7272727272727, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI71743840, Length=374, Percent_Identity=22.7272727272727, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI156523966, Length=370, Percent_Identity=24.0540540540541, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=23.7569060773481, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI71565154, Length=363, Percent_Identity=23.6914600550964, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4501929, Length=365, Percent_Identity=22.7397260273973, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787863, Length=339, Percent_Identity=75.2212389380531, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1788073, Length=345, Percent_Identity=30.1449275362319, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI226510992, Length=350, Percent_Identity=30, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1790045, Length=332, Percent_Identity=29.5180722891566, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788407, Length=335, Percent_Identity=28.6567164179104, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1790718, Length=344, Percent_Identity=24.4186046511628, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082125, Length=357, Percent_Identity=29.6918767507003, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788075, Length=339, Percent_Identity=28.6135693215339, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=23.469387755102, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081918, Length=264, Percent_Identity=28.7878787878788, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=349, Percent_Identity=24.6418338108883, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786518, Length=122, Percent_Identity=34.4262295081967, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI87082401, Length=115, Percent_Identity=33.0434782608696, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=28.955223880597, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17562878, Length=338, Percent_Identity=26.0355029585799, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=365, Percent_Identity=22.7397260273973, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=171, Percent_Identity=30.4093567251462, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=316, Percent_Identity=23.4177215189873, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=334, Percent_Identity=25.1497005988024, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323099, Length=337, Percent_Identity=25.5192878338279, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319955, Length=334, Percent_Identity=25.1497005988024, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319258, Length=232, Percent_Identity=32.7586206896552, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=372, Percent_Identity=26.0752688172043, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=137, Percent_Identity=36.4963503649635, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=21.4092140921409, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=329, Percent_Identity=23.7082066869301, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=188, Percent_Identity=30.8510638297872, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=182, Percent_Identity=30.2197802197802, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137530, Length=334, Percent_Identity=26.6467065868263, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17737897, Length=336, Percent_Identity=25, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45550770, Length=322, Percent_Identity=21.7391304347826, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551930, Length=322, Percent_Identity=21.7391304347826, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221457811, Length=322, Percent_Identity=21.7391304347826, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737895, Length=104, Percent_Identity=31.7307692307692, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 36915; Mature: 36915

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIVIEKPNTLTIETRALPQPAPGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHE
CCCEEEECCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCEECCCCCHHHHHHHHHHH
FFGVIDAVGDNVNHDRIGERVSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEY
HHHHHHHHCCCCCHHHCCCCCCCCCEEECCCEEECCCCCCCHHEEEEEEEEECCCCCCCE
AVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTEQDVALIYGAGPMGLTTVQAL
EECCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHH
KGVYQVKTVIVVDRIEERLAMAKQSGADWTLNNGQHSLAEFLQQKALKPTLIVDAACHPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCHH
ILQEAITLASPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVVIDWLNKGL
HHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEHHCCC
IDPDKLITHTFDYQHVTDAIELFEKDQRQCCKVLLTFAK
CCHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSIVIEKPNTLTIETRALPQPAPGEVRIKVKLAGICGSDSHIYRGHNPFAKYPRVIGHE
CCCEEEECCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCEECCCCCHHHHHHHHHHH
FFGVIDAVGDNVNHDRIGERVSVDPVISCGHCYPCSVGKPNVCTSLVVLGVHRDGGFSEY
HHHHHHHHCCCCCHHHCCCCCCCCCEEECCCEEECCCCCCCHHEEEEEEEEECCCCCCCE
AVAPARNAHRIPDNIADHHAVMVEPFTIAANVTGQVNPTEQDVALIYGAGPMGLTTVQAL
EECCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHH
KGVYQVKTVIVVDRIEERLAMAKQSGADWTLNNGQHSLAEFLQQKALKPTLIVDAACHPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCHH
ILQEAITLASPAARIVLMGFSSDPCEIVQQGITGKELAIYSSRLNANKFPVVIDWLNKGL
HHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEHHCCC
IDPDKLITHTFDYQHVTDAIELFEKDQRQCCKVLLTFAK
CCHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]