Click here to switch to the map view.

The map label for this gene is pcaK [H]

Identifier: 194737859

GI number: 194737859

Start: 2295864

End: 2297222

Strand: Reverse

Name: pcaK [H]

Synonym: SeSA_A2418

Alternate gene names: 194737859

Gene position: 2297222-2295864 (Counterclockwise)

Preceding gene: 194735096

Following gene: 194736424

Centisome position: 48.78

GC content: 58.72

Gene sequence:

>1359_bases
ATGACTCAACGACGTGATCTACAAGCCCTTATTGATGCCGCGCCCGTCGGCAAAATGCAGTGGCGCGTTATCATCTGCTG
TTTTCTGGTGGTTATGCTCGATGGTTTCGACACCGCCGCGATTGGCTTCATCGCCCCGGATATTCGTACCCACTGGCAGC
TAAGCGCCAGCGAACTTGCGCCGCTGTTTGGCGCAGGGCTGCTGGGGCTTACGGCCGGCGCGCTGCTATGCGGGCCGCTG
GCGGATCGCTTTGGCCGCAAGCGGGTCATTGAGCTTTGCGTGGCGCTATTCGGCGCATTGAGCCTGCTTTCCGCTTTCTC
GCCGGATATAGAAACCCTGGTGTTGCTGCGCTTCTTAACCGGTCTGGGACTGGGTGGAGCGATGCCGAATACCATCACCA
TGACGTCGGAATACCTTCCCGCTCGTCGACGCGGAGCGCTGGTCACGCTGATGTTCTGCGGTTTTACCCTGGGGTCGGCG
ATGGGTGGGATTGTGAGCGCGCAACTGGTGCCGCTGATTGGCTGGCACGGAATTCTGGCGCTAGGCGGCATCTTGCCTTT
GATGCTGTTTTTCGGCCTGTTGTTCGCGCTGCCGGAATCTCCCCGCTGGCAGGTACGTCGCCAACTACCGCAAGCCGTTG
TCGCCCGGACGGTCAGCGCCATTACCGGCGAGCGCTATCACGATACGCACTTCTTTCTGCATGAGACGGCAGCCGTCGCC
AAAGGCAGTATTCGCCAGCTTTTTGCCGGGCGACAGCTTGTCATTACCCTGATGTTATGGGTGGTGTTCTTTATGAGCCT
GCTCATTATTTATCTGCTTTCCAGCTGGATGCCGACGTTACTTAACCATCGCGGTATTGATCTGCAACAGGCGTCGTGGG
TGACTGCCGCATTCCAGGTTGGCGGCACGCTTGGCGCGCTGTTACTCGGCGTGTTGATGGACCGGCTTAACCCGTTCCGG
GTACTGGCGGTGAGCTATGCGCTGGGCGCGGTTTGCATTGTCATGATAGGCCTGAGCGAAAACGGCCTTTGGCTGATGGC
GCTGGCGATTTTTGGTACCGGCATCGGTATTAGCGGTTCCCAGGTAGGGCTGAATGCTCTGACGGCGACGCTGTACCCCA
CCCAAAGCCGGGCGACGGGCGTGAGCTGGTCGAACGCCATTGGACGCTGCGGGGCGATTGTCGGTTCGCTCTCCGGCGGC
ATGATGATGGCCCTCAATTTCTCTTTCGATACGTTGTTTTTTGTCATTGCTATTCCGGCGGCTATCAGCGCGGTAATGCT
TACCCTGCTGACGGTGGTTGTCCGCCTTTCGATTTCTGTACCTGACGACCTGCCGCGTGCCAGCGTCGTAAACGAATAA

Upstream 100 bases:

>100_bases
CTGCCTGAAAAGCCATTGTACATTTTATCGCTCACTCTACAAACTCGTAACATAGCAAACATAAAAACAACATCTATCTC
CCTGCACTGAGGCATTAGCT

Downstream 100 bases:

>100_bases
GGAGAATCTCCATGTCTGAAATAAATCAGAACGTAAAAGATAGCCGTCAGCAGTATTACCAGCATATTTCCGGGCAGAAT
CTGACGCCGCTGTGGGAGTC

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTQRRDLQALIDAAPVGKMQWRVIICCFLVVMLDGFDTAAIGFIAPDIRTHWQLSASELAPLFGAGLLGLTAGALLCGPL
ADRFGRKRVIELCVALFGALSLLSAFSPDIETLVLLRFLTGLGLGGAMPNTITMTSEYLPARRRGALVTLMFCGFTLGSA
MGGIVSAQLVPLIGWHGILALGGILPLMLFFGLLFALPESPRWQVRRQLPQAVVARTVSAITGERYHDTHFFLHETAAVA
KGSIRQLFAGRQLVITLMLWVVFFMSLLIIYLLSSWMPTLLNHRGIDLQQASWVTAAFQVGGTLGALLLGVLMDRLNPFR
VLAVSYALGAVCIVMIGLSENGLWLMALAIFGTGIGISGSQVGLNALTATLYPTQSRATGVSWSNAIGRCGAIVGSLSGG
MMMALNFSFDTLFFVIAIPAAISAVMLTLLTVVVRLSISVPDDLPRASVVNE

Sequences:

>Translated_452_residues
MTQRRDLQALIDAAPVGKMQWRVIICCFLVVMLDGFDTAAIGFIAPDIRTHWQLSASELAPLFGAGLLGLTAGALLCGPL
ADRFGRKRVIELCVALFGALSLLSAFSPDIETLVLLRFLTGLGLGGAMPNTITMTSEYLPARRRGALVTLMFCGFTLGSA
MGGIVSAQLVPLIGWHGILALGGILPLMLFFGLLFALPESPRWQVRRQLPQAVVARTVSAITGERYHDTHFFLHETAAVA
KGSIRQLFAGRQLVITLMLWVVFFMSLLIIYLLSSWMPTLLNHRGIDLQQASWVTAAFQVGGTLGALLLGVLMDRLNPFR
VLAVSYALGAVCIVMIGLSENGLWLMALAIFGTGIGISGSQVGLNALTATLYPTQSRATGVSWSNAIGRCGAIVGSLSGG
MMMALNFSFDTLFFVIAIPAAISAVMLTLLTVVVRLSISVPDDLPRASVVNE
>Mature_451_residues
TQRRDLQALIDAAPVGKMQWRVIICCFLVVMLDGFDTAAIGFIAPDIRTHWQLSASELAPLFGAGLLGLTAGALLCGPLA
DRFGRKRVIELCVALFGALSLLSAFSPDIETLVLLRFLTGLGLGGAMPNTITMTSEYLPARRRGALVTLMFCGFTLGSAM
GGIVSAQLVPLIGWHGILALGGILPLMLFFGLLFALPESPRWQVRRQLPQAVVARTVSAITGERYHDTHFFLHETAAVAK
GSIRQLFAGRQLVITLMLWVVFFMSLLIIYLLSSWMPTLLNHRGIDLQQASWVTAAFQVGGTLGALLLGVLMDRLNPFRV
LAVSYALGAVCIVMIGLSENGLWLMALAIFGTGIGISGSQVGLNALTATLYPTQSRATGVSWSNAIGRCGAIVGSLSGGM
MMALNFSFDTLFFVIAIPAAISAVMLTLLTVVVRLSISVPDDLPRASVVNE

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=421, Percent_Identity=24.9406175771971, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI213021148, Length=456, Percent_Identity=25.6578947368421, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI7662270, Length=327, Percent_Identity=24.1590214067278, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI216548223, Length=325, Percent_Identity=24, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI166064021, Length=341, Percent_Identity=26.9794721407625, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI24497476, Length=376, Percent_Identity=27.3936170212766, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI20070188, Length=376, Percent_Identity=27.3936170212766, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4507005, Length=375, Percent_Identity=25.6, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI296080721, Length=370, Percent_Identity=26.4864864864865, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI262399383, Length=264, Percent_Identity=24.6212121212121, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI296080719, Length=370, Percent_Identity=26.4864864864865, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI24497499, Length=370, Percent_Identity=26.4864864864865, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI8923870, Length=369, Percent_Identity=27.10027100271, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI296080734, Length=342, Percent_Identity=26.0233918128655, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI203098995, Length=160, Percent_Identity=35, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI11415038, Length=334, Percent_Identity=27.2455089820359, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI73695465, Length=210, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI211059435, Length=182, Percent_Identity=29.6703296703297, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081723, Length=385, Percent_Identity=37.9220779220779, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI87082159, Length=396, Percent_Identity=29.040404040404, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87082231, Length=420, Percent_Identity=23.0952380952381, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788068, Length=458, Percent_Identity=24.8908296943231, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788074, Length=337, Percent_Identity=25.2225519287834, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786229, Length=375, Percent_Identity=23.7333333333333, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789312, Length=198, Percent_Identity=30.8080808080808, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082404, Length=378, Percent_Identity=19.8412698412698, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789152, Length=409, Percent_Identity=22.2493887530562, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32564663, Length=404, Percent_Identity=23.019801980198, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320595, Length=136, Percent_Identity=30.1470588235294, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922874, Length=406, Percent_Identity=23.1527093596059, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24640198, Length=461, Percent_Identity=24.7288503253796, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24640196, Length=461, Percent_Identity=24.7288503253796, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24640200, Length=461, Percent_Identity=24.7288503253796, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI161077756, Length=448, Percent_Identity=24.1071428571429, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48326; Mature: 48195

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQRRDLQALIDAAPVGKMQWRVIICCFLVVMLDGFDTAAIGFIAPDIRTHWQLSASELA
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHCCCCHHHHH
PLFGAGLLGLTAGALLCGPLADRFGRKRVIELCVALFGALSLLSAFSPDIETLVLLRFLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GLGLGGAMPNTITMTSEYLPARRRGALVTLMFCGFTLGSAMGGIVSAQLVPLIGWHGILA
HCCCCCCCCCCEEECHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGGILPLMLFFGLLFALPESPRWQVRRQLPQAVVARTVSAITGERYHDTHFFLHETAAVA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KGSIRQLFAGRQLVITLMLWVVFFMSLLIIYLLSSWMPTLLNHRGIDLQQASWVTAAFQV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
GGTLGALLLGVLMDRLNPFRVLAVSYALGAVCIVMIGLSENGLWLMALAIFGTGIGISGS
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCC
QVGLNALTATLYPTQSRATGVSWSNAIGRCGAIVGSLSGGMMMALNFSFDTLFFVIAIPA
CCCHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHH
AISAVMLTLLTVVVRLSISVPDDLPRASVVNE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]