Click here to switch to the map view.

The map label for this gene is dsbD [H]

Identifier: 194737618

GI number: 194737618

Start: 1159239

End: 1161125

Strand: Direct

Name: dsbD [H]

Synonym: SeSA_A1178

Alternate gene names: 194737618

Gene position: 1159239-1161125 (Clockwise)

Preceding gene: 194734173

Following gene: 194738162

Centisome position: 24.62

GC content: 57.92

Gene sequence:

>1887_bases
ATGATGATTTTGTTCAGGCGGATACTGTTCTGCCTGTTATGGCTTTGGCTGCCCGTCTCCTGGGCGGCGGAAAGCGGCTG
GCTGCGTTCGCCCGATAACGACCATGCCAGCATACGGCTACGTGCCGATACGTCCGCTAACGGTGAGACCCGGCTGTTGC
TGGATGTCAAACTGGAAAACGGCTGGAAAACCTACTGGCGCGCGCCGGGGGAAGGGGGCGTGGCACCCTCTATCGCCTGG
AAAGGCGACATGCCTGAGGTAAGCTGGTTCTGGCCAACCCCCTCGCGCTTTGATGTGGCGAATATCACCACCCAGGGATA
TCACGACGAGGTGACCTTTCCGATGATCGTGCGCGGTACGCCGCCGGCGACCTTGAGCGGCGTGTTGACGTTATCAACCT
GCAGCAATGTTTGTCTGTTGACCGATTACCCCTTTTCCGTGACGCCCACTGTGCAGAATGCCGATTTTGCCCATGACTAT
GCGCGGGCGATGGGTAAAGTTCCGCTCCGCAGTGGGCTAACGGACTCGCTTGAGGTCGGCTATCGCCCGGGAGAACTGGT
GGTCACTGCTACGCGAGCGGCGGGCTGGTCATCGCCCGGGCTCTATCTTGACACCATAGATGACGTCGATTTTGCGAAGC
CTCGCCTGCGCGTAGAGGGCGACAGGTTACAGGCGACGGTGCCGGTGACGGACAGTTGGGGCGAAAAGGCGCCCGATTTG
CGCAACAAATCGCTGACCCTCGTGTTAGCCGATGGCGCTATCGCCCAGGAGAGCACGCAAACCATTGGCGCTGCGCCAGC
GCAAACGCCGGACAATGCGGCGCTACCTTTCTGGCAAGTTGTAATGATGGCGCTGATCGGCGGACTGATTCTTAATTTAA
TGCCCTGCGTGCTGCCGGTTCTGGGCATGAAACTTGGCTCTATTTTATTGGTAGAGGAAAAAAGCCGCTCTCACATCAGG
CGACAATTTTTGGCTTCGGTCGCCGGTATCATTGCGTCATTTATGGCGCTGGCGGCGTTTATGACCCTCCTTCGCCTGTC
AAACCATGCGCTGGCTTGGGGAGTCCAGTTCCAGAATGCATGGTTTATTGGTTTTATGGCTCTGGTGATGTTGTTGTTTA
GCGCCAGCCTGTTCGGGCTTTTTGAGTTCAGGCTTCCCTCATCTATGACCACGAAACTGGCCACTTACGGCGGTAACGGT
ATGTCGGGACATTTCTGGCAGGGGGCGTTCGCCACGCTGCTGGCGACGCCTTGTAGCGCGCCGTTTCTGGGTACGGCGGT
GGCGGTGGCGCTCACGGCGTCGTTGCCGACGCTATGGGGGCTGTTCCTTGCGCTTGGCCTGGGAATGAGCGCGCCGTGGC
TACTGGTCGCGATACGACCAGGGCTTGCGCTACGTTTACCGCGCCCCGGGCGTTGGATGAATGTCCTGCGCAGGATCCTC
GGTCTGATGATGCTGGGGTCGGCTATCTGGCTGGCGACGTTACTCCTGCCGCATTTCGGCTTCACTGCGTCAAAGAGCGC
GCAAGACACGGTTCAGTGGCAACCGTTGAGTGAACAGGCAATCCAGTCGGCGCTGGCGCAGCATAAGCGGGTATTTGTCG
ATGTTACTGCGGACTGGTGTATTACCTGTAAAGTGAATAAATACAACGTCCTGCAAAAAGAGGATGTGCAGGACGCCTTG
CAACAGCCGGATGTTGTGGCGCTGCGGGGAGACTGGACGCTGCCGTCCGATGCCATTACAGATTTTCTGAAAACGCGTGG
TCAGGTCGCCGTGCCGTTTAATCAGGTATATGGCCCCGGCTTGCCGGAAGGGGAGGCACTGCCCACTTTGCTGACCCGCG
ATGCGGTATTACAAACGTTGAAAAAAGCGAAAGGAATAACCCAATGA

Upstream 100 bases:

>100_bases
TTCGCCGCCCACATTACGGGTACATCTACGATTTTGTGTCTTCCGTGAATGACAGACCGGTTATTGCTAACGGTTAATTA
CTCATTCACGGAGAAAAAAT

Downstream 100 bases:

>100_bases
AATACATGATTGTTTTACTGCTGGCGCTGTTTTCGACGCTGAGCATCGCGCAAGAAACTGCTCCTTTTACGCCGGATCAG
GAAAAGCAGATTGAAAATCT

Product: membrane protein, suppressor for copper-sensitivity B

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MMILFRRILFCLLWLWLPVSWAAESGWLRSPDNDHASIRLRADTSANGETRLLLDVKLENGWKTYWRAPGEGGVAPSIAW
KGDMPEVSWFWPTPSRFDVANITTQGYHDEVTFPMIVRGTPPATLSGVLTLSTCSNVCLLTDYPFSVTPTVQNADFAHDY
ARAMGKVPLRSGLTDSLEVGYRPGELVVTATRAAGWSSPGLYLDTIDDVDFAKPRLRVEGDRLQATVPVTDSWGEKAPDL
RNKSLTLVLADGAIAQESTQTIGAAPAQTPDNAALPFWQVVMMALIGGLILNLMPCVLPVLGMKLGSILLVEEKSRSHIR
RQFLASVAGIIASFMALAAFMTLLRLSNHALAWGVQFQNAWFIGFMALVMLLFSASLFGLFEFRLPSSMTTKLATYGGNG
MSGHFWQGAFATLLATPCSAPFLGTAVAVALTASLPTLWGLFLALGLGMSAPWLLVAIRPGLALRLPRPGRWMNVLRRIL
GLMMLGSAIWLATLLLPHFGFTASKSAQDTVQWQPLSEQAIQSALAQHKRVFVDVTADWCITCKVNKYNVLQKEDVQDAL
QQPDVVALRGDWTLPSDAITDFLKTRGQVAVPFNQVYGPGLPEGEALPTLLTRDAVLQTLKKAKGITQ

Sequences:

>Translated_628_residues
MMILFRRILFCLLWLWLPVSWAAESGWLRSPDNDHASIRLRADTSANGETRLLLDVKLENGWKTYWRAPGEGGVAPSIAW
KGDMPEVSWFWPTPSRFDVANITTQGYHDEVTFPMIVRGTPPATLSGVLTLSTCSNVCLLTDYPFSVTPTVQNADFAHDY
ARAMGKVPLRSGLTDSLEVGYRPGELVVTATRAAGWSSPGLYLDTIDDVDFAKPRLRVEGDRLQATVPVTDSWGEKAPDL
RNKSLTLVLADGAIAQESTQTIGAAPAQTPDNAALPFWQVVMMALIGGLILNLMPCVLPVLGMKLGSILLVEEKSRSHIR
RQFLASVAGIIASFMALAAFMTLLRLSNHALAWGVQFQNAWFIGFMALVMLLFSASLFGLFEFRLPSSMTTKLATYGGNG
MSGHFWQGAFATLLATPCSAPFLGTAVAVALTASLPTLWGLFLALGLGMSAPWLLVAIRPGLALRLPRPGRWMNVLRRIL
GLMMLGSAIWLATLLLPHFGFTASKSAQDTVQWQPLSEQAIQSALAQHKRVFVDVTADWCITCKVNKYNVLQKEDVQDAL
QQPDVVALRGDWTLPSDAITDFLKTRGQVAVPFNQVYGPGLPEGEALPTLLTRDAVLQTLKKAKGITQ
>Mature_628_residues
MMILFRRILFCLLWLWLPVSWAAESGWLRSPDNDHASIRLRADTSANGETRLLLDVKLENGWKTYWRAPGEGGVAPSIAW
KGDMPEVSWFWPTPSRFDVANITTQGYHDEVTFPMIVRGTPPATLSGVLTLSTCSNVCLLTDYPFSVTPTVQNADFAHDY
ARAMGKVPLRSGLTDSLEVGYRPGELVVTATRAAGWSSPGLYLDTIDDVDFAKPRLRVEGDRLQATVPVTDSWGEKAPDL
RNKSLTLVLADGAIAQESTQTIGAAPAQTPDNAALPFWQVVMMALIGGLILNLMPCVLPVLGMKLGSILLVEEKSRSHIR
RQFLASVAGIIASFMALAAFMTLLRLSNHALAWGVQFQNAWFIGFMALVMLLFSASLFGLFEFRLPSSMTTKLATYGGNG
MSGHFWQGAFATLLATPCSAPFLGTAVAVALTASLPTLWGLFLALGLGMSAPWLLVAIRPGLALRLPRPGRWMNVLRRIL
GLMMLGSAIWLATLLLPHFGFTASKSAQDTVQWQPLSEQAIQSALAQHKRVFVDVTADWCITCKVNKYNVLQKEDVQDAL
QQPDVVALRGDWTLPSDAITDFLKTRGQVAVPFNQVYGPGLPEGEALPTLLTRDAVLQTLKKAKGITQ

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=418, Percent_Identity=25.1196172248804, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 68583; Mature: 68583

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMILFRRILFCLLWLWLPVSWAAESGWLRSPDNDHASIRLRADTSANGETRLLLDVKLEN
CHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECC
GWKTYWRAPGEGGVAPSIAWKGDMPEVSWFWPTPSRFDVANITTQGYHDEVTFPMIVRGT
CCEEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCEEEECEECCCCCCCCCEEEEECC
PPATLSGVLTLSTCSNVCLLTDYPFSVTPTVQNADFAHDYARAMGKVPLRSGLTDSLEVG
CCCHHHHEEEEECCCCEEEEECCCCEECCCCCCCCHHHHHHHHHCCCCHHCCCCCHHHCC
YRPGELVVTATRAAGWSSPGLYLDTIDDVDFAKPRLRVEGDRLQATVPVTDSWGEKAPDL
CCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCC
RNKSLTLVLADGAIAQESTQTIGAAPAQTPDNAALPFWQVVMMALIGGLILNLMPCVLPV
CCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGMKLGSILLVEEKSRSHIRRQFLASVAGIIASFMALAAFMTLLRLSNHALAWGVQFQNA
HHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCH
WFIGFMALVMLLFSASLFGLFEFRLPSSMTTKLATYGGNGMSGHFWQGAFATLLATPCSA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
PFLGTAVAVALTASLPTLWGLFLALGLGMSAPWLLVAIRPGLALRLPRPGRWMNVLRRIL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHH
GLMMLGSAIWLATLLLPHFGFTASKSAQDTVQWQPLSEQAIQSALAQHKRVFVDVTADWC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCEEEEEEECCEE
ITCKVNKYNVLQKEDVQDALQQPDVVALRGDWTLPSDAITDFLKTRGQVAVPFNQVYGPG
EEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCEEECHHHHCCCC
LPEGEALPTLLTRDAVLQTLKKAKGITQ
CCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMILFRRILFCLLWLWLPVSWAAESGWLRSPDNDHASIRLRADTSANGETRLLLDVKLEN
CHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECC
GWKTYWRAPGEGGVAPSIAWKGDMPEVSWFWPTPSRFDVANITTQGYHDEVTFPMIVRGT
CCEEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCEEEECEECCCCCCCCCEEEEECC
PPATLSGVLTLSTCSNVCLLTDYPFSVTPTVQNADFAHDYARAMGKVPLRSGLTDSLEVG
CCCHHHHEEEEECCCCEEEEECCCCEECCCCCCCCHHHHHHHHHCCCCHHCCCCCHHHCC
YRPGELVVTATRAAGWSSPGLYLDTIDDVDFAKPRLRVEGDRLQATVPVTDSWGEKAPDL
CCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCC
RNKSLTLVLADGAIAQESTQTIGAAPAQTPDNAALPFWQVVMMALIGGLILNLMPCVLPV
CCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGMKLGSILLVEEKSRSHIRRQFLASVAGIIASFMALAAFMTLLRLSNHALAWGVQFQNA
HHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCH
WFIGFMALVMLLFSASLFGLFEFRLPSSMTTKLATYGGNGMSGHFWQGAFATLLATPCSA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
PFLGTAVAVALTASLPTLWGLFLALGLGMSAPWLLVAIRPGLALRLPRPGRWMNVLRRIL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHH
GLMMLGSAIWLATLLLPHFGFTASKSAQDTVQWQPLSEQAIQSALAQHKRVFVDVTADWC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCEEEEEEECCEE
ITCKVNKYNVLQKEDVQDALQQPDVVALRGDWTLPSDAITDFLKTRGQVAVPFNQVYGPG
EEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCEEECHHHHCCCC
LPEGEALPTLLTRDAVLQTLKKAKGITQ
CCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA