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The map label for this gene is sdaA [H]

Identifier: 194737592

GI number: 194737592

Start: 2313148

End: 2314515

Strand: Reverse

Name: sdaA [H]

Synonym: SeSA_A2435

Alternate gene names: 194737592

Gene position: 2314515-2313148 (Counterclockwise)

Preceding gene: 194735726

Following gene: 194736688

Centisome position: 49.15

GC content: 54.75

Gene sequence:

>1368_bases
ATGGAGAGTTGCCTTGATATATTCAAAATAGTAATAGGTCCATCCAGCTCACGTACCGTAGGGCCGATGCGCGCCGCCTG
TCACTTTATTTCATTGCTCAGAGAACAAGAGACGTTGCCGCTAATTCGGGAAATAGAAATCGAGCTGTATGGCGCGTTAT
CGTTAAGCCGCAAGTGCCACAATGTGGATACCGCCCTTTATCTTGGGCTGCTGGGTTGCCAGCCGGAGAATGTCGATCTC
CGTTCGCATATGGCGGTGATTAAGCGTGCGGAAAATGAAAACAAAATCGAACTCCCGCTCTCCGACGCGGGCGGAATCAC
GATAAAAGTCAAGATTATCGCCAATCACCAGGCGCATCCAGGCCATCCTTATGCCATGACGTTTCGCGCCAGAGATGATT
ATTTCACGGTGTATGAAGAGACCTGGTTTTCGACCGGCGCCGGGCAGGTCCGCAAACATGGCGAGCCGCTGACGCCATCG
CTTCCTTTGCGTACAGTGTCGCCCTTTGAATTTAGTCATGCCGCGCAGTTGCTGGCGCTGTGTCGGCGTAACGGCCTGTC
CGTGGCGGCGCTGATGATGAAAAATGAGCTGTGCCGCCACTCGCCACAGACGTTGCAGAATTATCTGGCGCAAATATGGA
ACGTGATGCAGCAGGCGGTTTATCGCGGCCTGCATACTGAGGGGGTATTACCCGGTCCCTATCAGGTACCGCGGCGCGCC
TGTGCGTTACATAAGACGTTACAGGCTAACCGCTCCGCCAGCGATTTTTTAACCGCGCTGAACTGGGTCAATGCCTTCGC
GATTGCGGTAAGCGAAGAAAATGCCAGCGGCGGACAGATTGTTACCGCACCAACCAATGGCGCGTGCGGCATCATTCCGG
CAGCGCTCTGCTGGTATGATAAATTTGTCACGCCGCTGGAACCCGGTGCTCTGACCCGTTTCTTCCTGACCGCCGCCGCT
ATCGCGATGTTGTTTAAACAAAACGCCTCTATTCTGGGATCTGAAGTTGGCTGTCAGGGGGAAATCGGCGTGGCGTGCTC
AATGGCGGCGGCGGGCCTGGCTGAACTGATGGGCGCATCCGTGGAGCAAACGCTGAGCGCCGCTGAAATTGCCATGGAAC
ATCATCTGGGATTGACCTGCGATCCGCTGGGCGGGCAGGTACAAATTCCCTGCATAGAGAGAAATGCCATCTCTGCCGTG
AAAGCGATAAACGCGGCGACGATGGCGATGAGTCGCGTAAGCGAACCCTGTATTTCGCTCGATGAGATCATTGCTGCGAT
GTACGAGACCGGTAAAGACATGAGCGCTAAATACCGTGAAACGTATCATGGTTCGCTGGGGAAAATTCAGCCGCGCAAGA
GAGGGTAA

Upstream 100 bases:

>100_bases
GTAAAGTTCAGACACAAAAGGTATCACTTTTGATATGCCAACTGTGCGAGGATGTTATTTATTACTGAACGCGAATGAGA
CTGAAAGGATTGATATAACG

Downstream 100 bases:

>100_bases
CAGCGTGAAATACAATACGATGAATAACGACGAGATTATTCTGTCGTTGTGCGCTCGCTTAAAGGAGACGCGTCTGTCTC
TTTCGATGACCCAGCAGCAG

Product: L-serine ammonia-lyase

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MESCLDIFKIVIGPSSSRTVGPMRAACHFISLLREQETLPLIREIEIELYGALSLSRKCHNVDTALYLGLLGCQPENVDL
RSHMAVIKRAENENKIELPLSDAGGITIKVKIIANHQAHPGHPYAMTFRARDDYFTVYEETWFSTGAGQVRKHGEPLTPS
LPLRTVSPFEFSHAAQLLALCRRNGLSVAALMMKNELCRHSPQTLQNYLAQIWNVMQQAVYRGLHTEGVLPGPYQVPRRA
CALHKTLQANRSASDFLTALNWVNAFAIAVSEENASGGQIVTAPTNGACGIIPAALCWYDKFVTPLEPGALTRFFLTAAA
IAMLFKQNASILGSEVGCQGEIGVACSMAAAGLAELMGASVEQTLSAAEIAMEHHLGLTCDPLGGQVQIPCIERNAISAV
KAINAATMAMSRVSEPCISLDEIIAAMYETGKDMSAKYRETYHGSLGKIQPRKRG

Sequences:

>Translated_455_residues
MESCLDIFKIVIGPSSSRTVGPMRAACHFISLLREQETLPLIREIEIELYGALSLSRKCHNVDTALYLGLLGCQPENVDL
RSHMAVIKRAENENKIELPLSDAGGITIKVKIIANHQAHPGHPYAMTFRARDDYFTVYEETWFSTGAGQVRKHGEPLTPS
LPLRTVSPFEFSHAAQLLALCRRNGLSVAALMMKNELCRHSPQTLQNYLAQIWNVMQQAVYRGLHTEGVLPGPYQVPRRA
CALHKTLQANRSASDFLTALNWVNAFAIAVSEENASGGQIVTAPTNGACGIIPAALCWYDKFVTPLEPGALTRFFLTAAA
IAMLFKQNASILGSEVGCQGEIGVACSMAAAGLAELMGASVEQTLSAAEIAMEHHLGLTCDPLGGQVQIPCIERNAISAV
KAINAATMAMSRVSEPCISLDEIIAAMYETGKDMSAKYRETYHGSLGKIQPRKRG
>Mature_455_residues
MESCLDIFKIVIGPSSSRTVGPMRAACHFISLLREQETLPLIREIEIELYGALSLSRKCHNVDTALYLGLLGCQPENVDL
RSHMAVIKRAENENKIELPLSDAGGITIKVKIIANHQAHPGHPYAMTFRARDDYFTVYEETWFSTGAGQVRKHGEPLTPS
LPLRTVSPFEFSHAAQLLALCRRNGLSVAALMMKNELCRHSPQTLQNYLAQIWNVMQQAVYRGLHTEGVLPGPYQVPRRA
CALHKTLQANRSASDFLTALNWVNAFAIAVSEENASGGQIVTAPTNGACGIIPAALCWYDKFVTPLEPGALTRFFLTAAA
IAMLFKQNASILGSEVGCQGEIGVACSMAAAGLAELMGASVEQTLSAAEIAMEHHLGLTCDPLGGQVQIPCIERNAISAV
KAINAATMAMSRVSEPCISLDEIIAAMYETGKDMSAKYRETYHGSLGKIQPRKRG

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=453, Percent_Identity=48.7858719646799, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI48994925, Length=450, Percent_Identity=50.4444444444444, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1789161, Length=453, Percent_Identity=50.1103752759382, Blast_Score=429, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49395; Mature: 49395

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESCLDIFKIVIGPSSSRTVGPMRAACHFISLLREQETLPLIREIEIELYGALSLSRKCH
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEHHHHHHHHH
NVDTALYLGLLGCQPENVDLRSHMAVIKRAENENKIELPLSDAGGITIKVKIIANHQAHP
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEECCCCCC
GHPYAMTFRARDDYFTVYEETWFSTGAGQVRKHGEPLTPSLPLRTVSPFEFSHAAQLLAL
CCCEEEEEEECCCEEEEEHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
CRRNGLSVAALMMKNELCRHSPQTLQNYLAQIWNVMQQAVYRGLHTEGVLPGPYQVPRRA
HHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
CALHKTLQANRSASDFLTALNWVNAFAIAVSEENASGGQIVTAPTNGACGIIPAALCWYD
HHHHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHH
KFVTPLEPGALTRFFLTAAAIAMLFKQNASILGSEVGCQGEIGVACSMAAAGLAELMGAS
HHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
VEQTLSAAEIAMEHHLGLTCDPLGGQVQIPCIERNAISAVKAINAATMAMSRVSEPCISL
HHHHHHHHHHHHHHCCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCH
DEIIAAMYETGKDMSAKYRETYHGSLGKIQPRKRG
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MESCLDIFKIVIGPSSSRTVGPMRAACHFISLLREQETLPLIREIEIELYGALSLSRKCH
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEHHHHHHHHH
NVDTALYLGLLGCQPENVDLRSHMAVIKRAENENKIELPLSDAGGITIKVKIIANHQAHP
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEECCCCCC
GHPYAMTFRARDDYFTVYEETWFSTGAGQVRKHGEPLTPSLPLRTVSPFEFSHAAQLLAL
CCCEEEEEEECCCEEEEEHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
CRRNGLSVAALMMKNELCRHSPQTLQNYLAQIWNVMQQAVYRGLHTEGVLPGPYQVPRRA
HHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
CALHKTLQANRSASDFLTALNWVNAFAIAVSEENASGGQIVTAPTNGACGIIPAALCWYD
HHHHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHH
KFVTPLEPGALTRFFLTAAAIAMLFKQNASILGSEVGCQGEIGVACSMAAAGLAELMGAS
HHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
VEQTLSAAEIAMEHHLGLTCDPLGGQVQIPCIERNAISAVKAINAATMAMSRVSEPCISL
HHHHHHHHHHHHHHCCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCH
DEIIAAMYETGKDMSAKYRETYHGSLGKIQPRKRG
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]