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The map label for this gene is lpxK [H]

Identifier: 194737504

GI number: 194737504

Start: 1080687

End: 1081664

Strand: Direct

Name: lpxK [H]

Synonym: SeSA_A1099

Alternate gene names: 194737504

Gene position: 1080687-1081664 (Clockwise)

Preceding gene: 194734585

Following gene: 194736176

Centisome position: 22.95

GC content: 59.3

Gene sequence:

>978_bases
ATGATAGCGCGTATCTGGTCTGGTGAATCCCCTCTATGGCGGTTACTGCTGCCGCTCTCCTGGCTGTATGGCCTGGTGAG
CGGGGCGATTCGTCTGAGCTATAAGCTTGGTTTTAAACGCGCCTGGCGAGCGCCGGTACCGGTGGTTGTGGTAGGGAATC
TTACGGCTGGCGGTAACGGTAAAACACCCGTAGTCATTTGGCTGGTGGAAAAGCTGCAACAGCGTGGCGTGCGCGTGGGG
GTCGTTTCCCGCGGCTACGGCGGGAAAGCTGCCGCTTATCCGCTGCTCCTGACGCCGGAGACGACAACCGCAAAAGCGGG
AGATGAACCGGTATTGATTTATCAACGGACCGGCGCGCCTGTCGCGGTGGCGCCTGAACGCGCCGCGGCGGTGAAAGCGA
TTCTGGCGGCGCATAATGTGCAGATTATTATCACCGACGATGGGTTGCAGCATTACCGACTAGCGCGAGATATTGAAATT
GTGGTGATTGACGGCGTGCGCCGTTTTGGCAACGGCTGGTGGCTTCCTGCCGGTCCTATGCGCGAACGCGCCAGTCGCCT
GAAAACCGTGGATGCCGCTATCGTGAATGGCGGCGTCGCCCGGGCGGGCGAAATCCCCATGCAGCTAACGCCTGGACTGG
CGGTGAACTTACGTACGGGAGCGCGTTGCGATGTGGCGCAACTGAGCAATATTGTGGCGATGGCGGGCATCGGTCATCCG
CCGCGATTTTTCGCGACGCTGGAAGCCTGTGGCGCGCATCCGCAAAAGTGTGTCCCGCTGGCCGATCATCAAACGCTCGC
CCCTGCTGACGTTCAGGCGTTGGTCGGTGAAGGGCAGACCCTGGTAATGACGGAAAAAGACGCGGTGAAATGCCGTGCTT
TTGCCGAAGATAACTGGTGGTTCTTACCGGTTGATGCGCGTTTGTCCGGTGAGCAGCCTGATAAGTTGCTTCAACATATC
ACCTCGCTGGTTCGCTAG

Upstream 100 bases:

>100_bases
TTGTGGTCGAAGACGGCATTATCGTTGAGCGCGGCACTCATAGCGAGTTGCTGGCACAACACGGCGTTTACGCCCAGCTA
CATAAGATGCAATTTGGCCA

Downstream 100 bases:

>100_bases
CGTACCCCAATGCAGCGGCAGTGATGAATTTATGGAGCCATGAATGTCATTGCCGTACCTTTCTCTTTCCCAGGCCCGGT
GTCTTCACCTTGCTGCGCAG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGFKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEKLQQRGVRVG
VVSRGYGGKAAAYPLLLTPETTTAKAGDEPVLIYQRTGAPVAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEI
VVIDGVRRFGNGWWLPAGPMRERASRLKTVDAAIVNGGVARAGEIPMQLTPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWWFLPVDARLSGEQPDKLLQHI
TSLVR

Sequences:

>Translated_325_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGFKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEKLQQRGVRVG
VVSRGYGGKAAAYPLLLTPETTTAKAGDEPVLIYQRTGAPVAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEI
VVIDGVRRFGNGWWLPAGPMRERASRLKTVDAAIVNGGVARAGEIPMQLTPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWWFLPVDARLSGEQPDKLLQHI
TSLVR
>Mature_325_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGFKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEKLQQRGVRVG
VVSRGYGGKAAAYPLLLTPETTTAKAGDEPVLIYQRTGAPVAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEI
VVIDGVRRFGNGWWLPAGPMRERASRLKTVDAAIVNGGVARAGEIPMQLTPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWWFLPVDARLSGEQPDKLLQHI
TSLVR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=324, Percent_Identity=82.4074074074074, Blast_Score=548, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 35024; Mature: 35024

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGFKRAWRAPVPVVVVGNLTAGGNG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEKLQQRGVRVGVVSRGYGGKAAAYPLLLTPETTTAKAGDEPVLIYQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCHHCEEEEECCCCCCCCCCCCCEEEEEECCCC
VAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEIVVIDGVRRFGNGWWLPAGPM
EEECCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCEEEEEEECHHHHCCCEECCCCHH
RERASRLKTVDAAIVNGGVARAGEIPMQLTPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
HHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEECCCCCCCHHHHHCCCEECCCCCC
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWW
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCEEEEEEECCCEE
FLPVDARLSGEQPDKLLQHITSLVR
EEEECCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGFKRAWRAPVPVVVVGNLTAGGNG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEKLQQRGVRVGVVSRGYGGKAAAYPLLLTPETTTAKAGDEPVLIYQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCHHCEEEEECCCCCCCCCCCCCEEEEEECCCC
VAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEIVVIDGVRRFGNGWWLPAGPM
EEECCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCEEEEEEECHHHHCCCEECCCCHH
RERASRLKTVDAAIVNGGVARAGEIPMQLTPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
HHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEEECCCCCCCHHHHHCCCEECCCCCC
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWW
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCEEEEEEECCCEE
FLPVDARLSGEQPDKLLQHITSLVR
EEEECCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA