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The map label for this gene is kefC [H]

Identifier: 194737490

GI number: 194737490

Start: 98925

End: 100787

Strand: Direct

Name: kefC [H]

Synonym: SeSA_A0096

Alternate gene names: 194737490

Gene position: 98925-100787 (Clockwise)

Preceding gene: 194735745

Following gene: 194738108

Centisome position: 2.1

GC content: 58.24

Gene sequence:

>1863_bases
ATGGATAGCCATACTCTACTGCAGGCGCTGATCTATCTTGGTTCGGCGGCGTTGATTGTGCCGATTGCGGTACGTTTGGG
CTTAGGATCGGTGCTGGGGTATCTGATTGCGGGGTGTATTATCGGCCCCTGGGGACTACGGCTGGTGACGGACGCCGAAT
CTATTCTGCATTTTGCGGAAATCGGCGTCGTGCTGATGTTGTTTGTTATTGGGCTTGAGCTGGACCCGCAACGGTTATGG
AAGCTGCGCGCCTCGGTATTTGGCGGCGGCGCGTTACAGATGGTGGTCTGCGGCGGACTGATTGGTCTGTTCTGTATGTT
TCTTGGCCTGCGTTGGCAGGTGGCGGAACTGATTGGCATGACGCTGGCGCTTTCGTCCACGGCTATCGCCATGCAGGCAA
TGAATGAGCGTAACCTGACCGTTTCGCAAGTAGGGCGTAGCGCATTTGCAGTGCTCTTGTTCCAGGATATCGCGGCGATC
CCGCTGGTGGCGATGATTCCTCTGCTGGCCGCCAGCGGCGCATCCACCACGCTTGGCGCGTTTGCGCTATCGGCGTTGAA
AGTCGCAGGCGCGTTGGCGCTGGTGGTGCTGCTGGGACGCTACGTCACGCGCCCGGCGCTGCGCTTTGTCGCGCGTTCTG
GTTTGCGGGAAGTGTTCAGCGCCGTGGCGCTATTTCTGGTGTTTGGTTTCGGCCTGTTGCTGGAAGAGGTTGGGCTGTCA
ATGGCGATGGGCGCGTTCCTGGCGGGCGTTCTGCTGGCGAGTTCGGAATATCGTCATGCGCTGGAAAGCGATATTGAACC
CTTTAAGGGGTTGCTGCTGGGGCTGTTCTTTATTGGCGTCGGCATGTCGATTGATTTCGGCACGCTGGTGGAGAATCCGC
TGCGCATTCTGCTGTTGTTGGCCGGTTTTCTGACAATCAAAATCGTCATGCTGTGGCTGGTCGCGAGGCCCCTGGGTGTA
CCGGCAAAACAGCGTCGCTGGTTTGCCGTCTTATTAGGCCAGGGAAGTGAGTTTGCGTTTGTGGTTTTTGGCGCGGCGCA
AATGGCGGGTGTACTTGAGCCGGAATGGGCAAAAGCGCTGACGCTGGCGGTCGCGCTGTCGATGGCGGCAACGCCGATTT
TTCTGGTGCTGCTGACGCGCATGGAGAAGACCGCGACGGGTGAAGCGCGCGAGGCGGATGAAATCGACGAAGAGCAGCCG
CGGGTTATTGTGGCCGGGTTTGGACGATTTGGGCAGATAGCCGGGCGTCTGCTGCTGTCGAGCGGGGTGAAGATGGTGGT
GCTCGATCACGACCCCGATCATATCGAAACGCTGCGTAAATTCGGCATGAAGGTTTTTTATGGCGACGCGACGCGTATGG
ATTTGCTGGAATCTGCCGGAGCGGCGAAGGCGGAGGTATTGATTAACGCCATTGACGATCCGCAAACCAATTTGCAACTG
AGTGAACTGGTGAAGTCGCATTTCCCGCATCTGCAGATTATCGCCCGCGCCCGTGATGTCGATCATTACATTCGCCTGCG
CCAGGCTGGTGTGGCGATGCCCGAACGTGAAACCTTCGAAGGCGCGCTCAAAAGCGGACGACAGGCGCTGGAAGCGCTGG
GGCTGGGGCGTTATGAAGCTCGCGAGCGCGCGGATCTGTTCCGCCATTTTAATACCCGGATGGTGGAAGAGATGGCGAAA
GGGGAAAACGATCCGTTATCTCGCGCCGCCGCCTATAAACGTACCAGCGCGATGTTGAGCGAAATTATTACCGAGGACCG
GGAGCATCTGTCGTTGATTCAGCGCCACGGCTGGCAGGGAACGGCTGAGGGCAAACATTCCGGGGAGGCCGCTGATGAAC
CCGAGGTCAAACCGTCAATCTAA

Upstream 100 bases:

>100_bases
CCGTTTGCCATGCACTGCACGTTCATTTGCGATGACGACACCTTACAGGCGCAGGCGCGTCAGTATAAACAGCGTTTACT
GACATGGCAGGAGGTGAATC

Downstream 100 bases:

>100_bases
AGTAAAAAATGTGATGTTCTGCAAACTTTACTGCTAATTGGCTGTTTTTGAACTACTGTAATGCTGGCGCTCCACATCAA
ATGAGTGGCGTCGCCAGCAG

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 620; Mature: 620

Protein sequence:

>620_residues
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFVIGLELDPQRLW
KLRASVFGGGALQMVVCGGLIGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAI
PLVAMIPLLAASGASTTLGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLLAGFLTIKIVMLWLVARPLGV
PAKQRRWFAVLLGQGSEFAFVVFGAAQMAGVLEPEWAKALTLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQP
RVIVAGFGRFGQIAGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEARERADLFRHFNTRMVEEMAK
GENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQGTAEGKHSGEAADEPEVKPSI

Sequences:

>Translated_620_residues
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFVIGLELDPQRLW
KLRASVFGGGALQMVVCGGLIGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAI
PLVAMIPLLAASGASTTLGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLLAGFLTIKIVMLWLVARPLGV
PAKQRRWFAVLLGQGSEFAFVVFGAAQMAGVLEPEWAKALTLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQP
RVIVAGFGRFGQIAGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEARERADLFRHFNTRMVEEMAK
GENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQGTAEGKHSGEAADEPEVKPSI
>Mature_620_residues
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFVIGLELDPQRLW
KLRASVFGGGALQMVVCGGLIGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAI
PLVAMIPLLAASGASTTLGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLLAGFLTIKIVMLWLVARPLGV
PAKQRRWFAVLLGQGSEFAFVVFGAAQMAGVLEPEWAKALTLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQP
RVIVAGFGRFGQIAGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEARERADLFRHFNTRMVEEMAK
GENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQGTAEGKHSGEAADEPEVKPSI

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=382, Percent_Identity=25.3926701570681, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1786232, Length=619, Percent_Identity=90.4684975767367, Blast_Score=1129, Evalue=0.0,
Organism=Escherichia coli, GI1789749, Length=604, Percent_Identity=44.0397350993377, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1786685, Length=517, Percent_Identity=30.3675048355899, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67041; Mature: 67041

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAE
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
IGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMVVCGGLIGLFCMFLGLRWQVAELIGM
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAIPLVAMIPLLAASGASTTLGA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AGFLTIKIVMLWLVARPLGVPAKQRRWFAVLLGQGSEFAFVVFGAAQMAGVLEPEWAKAL
HHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEECCCCCEEEEEEEHHHHHCCCCHHHHHHH
TLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQPRVIVAGFGRFGQIAGRLLLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEEECCCHHHHHHHHHHHH
SGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
CCCEEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCHH
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
RERADLFRHFNTRMVEEMAKGENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
TAEGKHSGEAADEPEVKPSI
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAE
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
IGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMVVCGGLIGLFCMFLGLRWQVAELIGM
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAIPLVAMIPLLAASGASTTLGA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AGFLTIKIVMLWLVARPLGVPAKQRRWFAVLLGQGSEFAFVVFGAAQMAGVLEPEWAKAL
HHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEECCCCCEEEEEEEHHHHHCCCCHHHHHHH
TLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQPRVIVAGFGRFGQIAGRLLLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEEECCCHHHHHHHHHHHH
SGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
CCCEEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCHH
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
RERADLFRHFNTRMVEEMAKGENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
TAEGKHSGEAADEPEVKPSI
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA